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Lichen Planus Pigmentosus Inversus:Two Case Reports

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International Journal of Dermatology and Venereology 2022年第2期5卷 116-118页

作者： Se Hoon Lee Minah Cho yu jin han yu Ri Woo Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim Department of Dermatology Incheon St.Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoulSouth Korea.

Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous *** to its rarity,only a few LPPI cases are *** herein describe two rare cases of *** presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary ***:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural *** axillae and flanks were the most commonly affected areas,followed by the groin and *** half of the female patients had inframammary fold *** shows higher female predominance than Lichen planus *** were fewer cases that lasted more than 3 years compared to ***:LPPI is a rare variant of lichen planus,with a locational characteristic and female ***,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis.

关键词： lichen planus pigmentosus lichen planus pigmentosus inversus

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen yu han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

新冠肺炎疫情对经济会有多大影响--基于社会消费品零售总额的角度

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产业经济评论 2020年第2期 13-23页

作者：韩玉锦中国人民大学商学院贸经系

自武汉地区爆发新型冠状病毒肺炎疫情,恰逢春节,众多城市发布延迟开工的通知,对娱乐业和餐饮业产生重大负面影响,不可避免地导致社会消费品零售总额显著下滑。为探究此次疫情的影响程度,本文从社会消费品零售总额这一宏观经济指标分析,... 详细信息

自武汉地区爆发新型冠状病毒肺炎疫情,恰逢春节,众多城市发布延迟开工的通知,对娱乐业和餐饮业产生重大负面影响,不可避免地导致社会消费品零售总额显著下滑。为探究此次疫情的影响程度,本文从社会消费品零售总额这一宏观经济指标分析,测算此次疫情对该指标的影响大小。首先以北京、上海两地城市数据为例,借鉴2003年SARS对经济冲击是否显著来类比本次新型冠状病毒对经济的冲击。结果表明疫情在短期内会对经济产生显著影响,且在年内完成修复。后续本文采用灰色预测模型GM(1,1)预测此次新型冠状病毒对武汉地区社会消费品零售总额的影响值大小,预测约191亿元,影响有限。

关键词：社会消费品零售总额新冠肺炎灰色预测

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： yuhui Kou Zongxue jin yusong yuan Bo Ma Wenyong Xie Na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen yu jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

低氧诱导因子在类风湿关节炎发病机制中的作用

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北京大学学报（医学版） 2016年第6期48卷 1095-1099页

作者：于若寒赵金霞刘湘源北京大学第三医院风湿免疫科北京100191

类风湿关节炎（rheumatoid arthritis,RA）是一种系统性自身免疫性疾病,病理特征为异常的滑膜增生伴血管翳形成、软骨和骨的侵蚀破坏,最终导致关节畸形。目前RA确切发病机制未明,环境和遗传因素相互作用共同促进了RA的发病。低氧微环境... 详细信息

类风湿关节炎（rheumatoid arthritis,RA）是一种系统性自身免疫性疾病,病理特征为异常的滑膜增生伴血管翳形成、软骨和骨的侵蚀破坏,最终导致关节畸形。目前RA确切发病机制未明,环境和遗传因素相互作用共同促进了RA的发病。低氧微环境是RA重要的病理特点,炎症滑膜组织的高代谢需求和滑膜的快速增生共同导致了RA关节内低氧状态。

关键词：低氧诱导因子关节炎,类风湿缺氧

基层医疗机构设备配置和利用现状研究:以深圳市福田区社区健康服务中心为例

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中国卫生资源 2017年第5期20卷 418-421页

作者：何金露陶红兵喻文菡金莉华中科技大学同济医学院医药卫生管理学院湖北武汉430030

目的 :探讨基层医疗机构设备配置和利用现状。方法 :对分层随机抽样法选取的深圳市福田区32家社区健康服务中心(以下简称"社康中心")负责人进行个人深入访谈,并运用内容分析法分析访谈记录。结果:调研社康中心设备配置和利用主要存在7... 详细信息

目的 :探讨基层医疗机构设备配置和利用现状。方法 :对分层随机抽样法选取的深圳市福田区32家社区健康服务中心(以下简称"社康中心")负责人进行个人深入访谈,并运用内容分析法分析访谈记录。结果:调研社康中心设备配置和利用主要存在7类问题,包括设备配置缺乏科学论证、社康人员问题限制设备利用、设备闲置情况普遍、设备维护管理不足、设备运行状况有待改善、社康用房问题限制设备利用、设备配置更新效率低。结论 :建议制定设备配置规划标准,简化设备更新流程;加强设备成本效益论证;建立社康设备维修中心;重视人才队伍建设,突破社康中心用房困境。

关键词：医疗设备基层医疗机构内容分析法

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi Qiu Mingzhu Yang Xiuxiu jin jingyang Liu Weiping Wang Xiaoli Zhang jinfeng han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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光催化降解水中有机污染物研究现状与展望

燃料化学学报 2004年第1期32卷 123-128页

作者：崔玉民韩金霞韩山师范学院化学系广东潮州521041

光催化技术是一种新兴、高效、节能、现代污水处理技术。从半导体光催化技术研究现状、反应机理、常见有机污染物光催化降解的现状、提高半导体光催化剂活性的途径、光催化技术发展中存在问题等方面对半导体光催化技术加以综述和讨论。... 详细信息

光催化技术是一种新兴、高效、节能、现代污水处理技术。从半导体光催化技术研究现状、反应机理、常见有机污染物光催化降解的现状、提高半导体光催化剂活性的途径、光催化技术发展中存在问题等方面对半导体光催化技术加以综述和讨论。目前不论从光催化技术、光催化的基础研究以及光催化应用研究方面都需进行大量的、深入研究工作。

关键词：光催化技术反应机理有机污染物光催化降解二氧化钛