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Effects of Acetylcholine, Cytochalasin B and Amiprophosmethyl on Phloem Transport in Radish （Raphanus sativas）

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Journal of Integrative Plant Biology 2007年第4期49卷 550-555页

作者： Chong-Jun Yang Zhi-Xi Zhai yu-hai guo Peng Gao Laboratory of Crop Physiology China Agricultural University Beijing 100094 China College of Agronomy Liaocheng University Liaocheng 252000 China State Key Laboratory of Plant Physiology and Biochemistry China Agricultural University Beijing 100094 China

We investigated the role of the ＂sieve tube-companion cell complex＂ lining the tube periphery, particularly the microfilament and microtubule, in assisting the pushing of phloem sap flow. We made a simple phloem transport system with a living radish plant, in which the conducting channel was exposed for local treatment with chemicals that are effective in modulating protoplasmic movement （acetylcholine, （ACh） a neurotransmitter in animals and insects; cytochalasin B, （CB） a specific inhibitor of many cellular responses that are mediated by microfilament systems and amiprophos-methyl, （APM） a specific inhibitor of many cellular responses that are mediated by microtubule systems）. Their effects on phloem transport were estimated by two experimental devices：（i） a comparison of changes in the amount of assimilates in terms of carbohydrates and ^14C-labeled photosynthetic production that is left in the leaf blade of treated plants; and （ii） distribution patterns of ^14C-labeled leaf assimilates in the phloem transport system. The results indicate that CB and APM markedly inhibited the transfer of photosynthetic product from leaf to root via the leaf vein, while ACh enhanced the transfer of photosynthetic product in low concentrations （5.0×10^-4 mol/L） but inhibited it in higher concentrations （2.0×10^-3 mol/L） from leaf to root via the leaf vein. Autoradiograph imaging clearly reveals that ACh treatment is more effective than the control, and both CB and APM treatments effectively inhibit the passage of radioactive assimilates. All of the results support the postulation that the peripheral protoplasm in the sieve tube serves not only as a passive semi-permeable membrane, but is also directly involved in phloem transport.

关键词： assimilate phloem protoplasm translocation vascular bundle.

Involvement of P2X7 receptor signaling on regulating the differentiation of Th17 cells and type Ⅱ collagen-induced experimental arthritis in mice

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Involvement of P2X7 receptor signaling on regulating the dif...

第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： Fan Zhi-Dan Zhang Ya-yuan yu hai-guo 南京市儿童医院

Interleukin(IL)-17 producing T helper(Th17)cells have been established as major effector cells in the pathogenesis of rheumatoid arthritis(RA).The P2X7 receptor(P2X7R)has emerged as a potential site in the regulation of inflammation in RA but little is known of its functional role on the differentiation of Th17 cells.

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中国实用儿科杂志 2020年第4期35卷 262-264页

作者：俞海国南京医科大学附属儿童医院风湿免疫科江苏南京210008

干燥综合征是一种累及外分泌腺体和腺体外器官、同时伴有淋巴瘤发生率增高的特异性系统性自身免疫性疾病。该病多见于成人,儿童罕见。儿童干燥综合征的临床特征与成人有所不同,经常被误诊或诊断延迟。随着对本病的研究和认识的深入,成... 详细信息

干燥综合征是一种累及外分泌腺体和腺体外器官、同时伴有淋巴瘤发生率增高的特异性系统性自身免疫性疾病。该病多见于成人,儿童罕见。儿童干燥综合征的临床特征与成人有所不同,经常被误诊或诊断延迟。随着对本病的研究和认识的深入,成人干燥综合征分类标准在不断进行调整和修订,然而至今没有制定出针对儿童干燥综合征的诊断标准。文章回顾分析了有关成人干燥综合征分类标准和儿童原发性干燥综合征诊断标准的建议,以期对儿童干燥综合征的早期诊断和相关研究提供帮助。

关键词：干燥综合征分类标准诊断儿童

^(99m)Tc-AMD3100:A novel potential receptor-targeting radiopharmaceutical for tumor imaging

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Chinese Chemical Letters 2010年第4期21卷 461-463页

作者： Jin Ming Zhang~(a,),Jia He Tian~a,Tian Ran Li~a, hai yu guo~a,Li Shen~b a Department of Nuclear Medicine,The PLA General Hospital,Beijing,100853,China b Peking University Health Science Center,Beijing,100191,China [a] Department of Nuclear Medicine The PLA General Hospital Beijing 100853 China [b] Peking University Health Science Center Beijing 100191 China

The chemokine CXCR4 receptor is over-expressed in a wide variety of *** this study,AMD3100,which was a prototype non-peptide antagonist of CXCR4 receptor,was labeled with;Tc.;Tc-AMD3100 was verified by thin layer radio chromatography（TLRC）.The tumor-localizing properties of;Tc-AMD3100 were evaluated and proved in mice bearing Hep-G2 tumor xenograft.;Tc-AMD3100 was a promising,novel receptor-specific radiopharmaceutical with potential application in the imaging of human tumors.

关键词： ^(99m)Tc Chemokine CXCR4 AMD3100 Tumor imaging

A new classification of duplex kidney based on kidney morphology and management

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Chinese Medical Journal 2013年第4期126卷 615-619页

作者： MA Rui WU Rong-de LIU Wei WANG Gang WANG Tao XU Zhuo-dong yu Qi-hai guo Zong-yuan Shandong Medical Imaging Research Institute Department of Pediatric Surgery Shandong Provincial Hospital Medical College of Shandong University Jinan Shangdong 250021 China

Background The initial classic classification of duplex kidney into complete （two ureters） and incomplete （＂Y＂ shaped ureter） types are based on the ureter status. At the meantime, the features of the upper and lower moieties of duplex kidney were very crucial for appropriate procedure of hemi-nephrectomy, which was most commonly used for addressing the issues caused by a duplex kidney; and recently more applications of laparoscopy were used. In this study, we aimed prudently to propose a new classification based on the features of the upper and lower moieties of duplex kidney. Methods Sixty-five children with 83 duplex kidneys were reviewed retrospectively. Based on kidney morphology found in CT urography and surgical findings, duplex kidney was classified into five types. Results The first was the appendant type （36/83） and its feature was that the mini upper moiety was located on top of the lower one, with a visualized shallow groove between them. The ureter was dilated with an ectopic orifice or ureterocele. The second was the embedded type （13/83）, the feature of which was that mini upper moiety located in the interior top of the lower one within the same capsule. The upper ureter was dilated with an ectopic orifice or ureterocele. The third was the hydronephrosis type （12/83）. The severe hydronephrotic upper moiety was almost as big as the lower moiety. The upper ureter was severely dilated and circuitous with an ectopic orifice. The forth was the dual-poor type （2/83）. The two moieties were all very small with ＂Y＂ shaped ureters and ectopic orifices. The last was the dual-well type （20/83）. The upper moiety was almost the same size as the lower one, without apparent dilation of ＂Y＂ shaped or double ureters. Conclusion Based on kidney morphology, duplex kidney can be mainly classified into five types which can be depicted by CT urography prior to management and can provide an aid in selecting a successful course of surgical correction.

关键词： kidney disease abnormalities classification computed tomography

Changes of Secondary Metabolites and Trace Elements in Gentiana macrophylla Flowers: A Potential Medicinal Plant Part

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Chinese Herbal Medicines 2014年第2期6卷 145-151页

作者： Xiao-xue Niu Xiao-wen Chen He Su A.Egrinya Eneji yu-hai guo Xue-hui Dong College of Agronomy and Biotechnology China Agricultural University Department of Soil Science University of Calabar

Objective To search for the potential medicinal plant part of Gentiana macrophyllabased on changes of secondary metabolites and trace elements in the flowers of *** HPLC was used to detect the changes of the active constituents（longanic acid,sweroside,gentiopicroside,and swertiamarin）and ICP-AES was used for mineral nutrients in *** during flower *** soluble sugar,starch,crude protein,hemicelluloses,cellulose,and lignin were *** Biomass of flower in full bloom（D2）phase was considerable during flower development,in which the contents of longanic acid and gentiopicroside were at the highest levels with 2.65 and 2.88 times higher than those recorded in Chinese Pharmacopoeia 2010,sweroside and swertiamarin in the flowers were reaching 6.06 and 1.25 times higher than those in *** is the most valuable stage during flower *** concentration of Fe,Mg,K,P,and B was higher in the flowers than that in *** accumulation of active constituents in the plant was influenced by the contents of metabolically linked carbon and nitrogen *** The secondary metabolites,mineral nutrients,and physicochemical indicators are tightly regulated by flower organ development,D2 is an important stage for both biomass and extraction of active constituents such as longanic *** flowers of *** could be used as a potential medicinal plant part for longanic acid at a high level.

关键词： flower development Gentiana macrophylla Gentianaceae gentiopicroside longanic acid trace elements

Down-regulation of C-type natriuretic peptide receptor by vasonatrin peptide in cardiac myocytes and fibroblasts

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Acta Pharmacologica Sinica 2004年第4期25卷 26-32页

作者： Shun-yan Lü, Miao-zhang ZHU2, Dian-shi WANG3, Jun yu, hai-tao guo, yu-zhen HU, Qi-ming WEI4 Department of Physiology, Departmentof Anatomy, Fourth Military Medical University, Xi-an 710032, China 4Cardiorenal 3 Molecular Laboratory, University of Maryland School of Medicine, Baltimore21201, USA Department of Physiology Fourth Military Medical University Xi-an 710032 China

AIM: To investigate the regulatory effects of vasonatrin peptide (VNP) on the expression of C-type natriuretic peptide receptor (NPR-C) in cultured neonatal rat cardiac myocytes and fibroblasts. METHODS: Quantitative RT- PCR was undertaken to evaluate the levels of NPR-C mRNA and radioimmunoassay was used to determine the formation of intracellular cGMP. RESULTS: Twenty-four hours hypoxic exposure increased the level of NPR-C mRNA in cardiomyocytes, while did not alter the expression of NPR-C in cardiac fibroblasts. VNP (1×10-8-1×10-6 mol/L) reduced the levels of NPR-C mRNA in cardiac myocytes induced by hypoxia in a concentration-dependent manner, and with high concentration (1×10-6mol/L) also decreased the expression of NPR-C in cardiac fibroblasts and air-control cardiac myocytes. The inhibitory effects of VNP on the expression of NPR-C was mimicked by 8- bromo-cGMP 1×10-6 mol/L (a membrane permeable analog of cGMP). VNP (1×10-8-1×10-6mol/L) increased the formation of intracellular guanosine-3',5'-cyclic monophosphate (cGMP) in both cardiac myocytes and fibroblasts. HS-142-1, the particulate guanylyl cyclase-coupled receptor antagonist, partially abrogated the above effects of VNP. CONCLUSION: Hypoxic exposure for 24 h up-regulated the expression of NPR-C in cultured neonatal rat cardiac myocytes. VNP decreased the expression of NPR-C in cardiac myocytes and fibroblasts under both air- control and hypoxic condition, which was at least partially mediated by guanylate cyclase linked natriuretic peptide receptors through increasing the intracellular cGMP.

关键词： C-type natriuretic peptide myocardium fibroblasts hypoxia

双相钢DP600塑性率相关效应试验及本构模型

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上海交通大学学报 2009年第10期43卷 1672-1675,1680页

作者：余海东郭永进上海交通大学机械与动力工程学院上海200240

考虑汽车在碰撞过程中具有明显的高应变率特性,对双相钢DP600在应变率10-4~103s-1进行拉伸试验,讨论不同应变率下材料塑性特性与应变率之间的关系.基于试验结果,对John-son-Cook模型进行讨论和修正,建立了适用于双相钢材料的塑性特性的... 详细信息

考虑汽车在碰撞过程中具有明显的高应变率特性,对双相钢DP600在应变率10-4~103s-1进行拉伸试验,讨论不同应变率下材料塑性特性与应变率之间的关系.基于试验结果,对John-son-Cook模型进行讨论和修正,建立了适用于双相钢材料的塑性特性的本构模型,并给出参数确定方法;通过用户子程序VUMAT与商用软件接口,验证模型的有效性.结果表明,建立的本构模型可以准确地描述材料的塑性率相关特性,能够应用于汽车的碰撞安全数值仿真分析.

关键词：双相钢率相关塑性硬化率本构模型

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吉林省鸟类新纪录——沙丘鹤

东北师大学报（自然科学版） 2011年第1期43卷 159-160页

作者：于国海王海涛孙鹏杨萍吉林莫莫格国家级自然保护区管理局吉林镇赉137316 东北师范大学生命科学学院吉林长春130024

报道了吉林省鸟类新纪录———沙丘鹤,由此吉林省的鹤类由6种增至7种.

关键词：沙丘鹤鸟类新纪录