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Current Medical Science 2020年第3期40卷 539-547页

作者： Hou-gang LI Peng-tao YOU yu XI yu CAI Yi-jun TU Meng-heng WANG Wan-ci SONG Tai-min QUAN Hui-ying REN Yan-wen LIU Han-xiong DAN Shi-qing XU Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineWuhan430065China College of Pharmacy Hubei University of Chinese MedicineWuhan430065China Wuhan Junan Pharmaceutical Co. Ltd.Wuhan430023China

yu gan Long(YGL)is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor(TGF-β)in the previous *** the mechanisms associated with platelet-derived growth factor(PDGF)-BB remain *** this study,we further investigated the mechanism of YGL reducing carbon tetrachloride(CCl4)-induced liver fibrosis in *** results showed that YGL suppressed CCl4-induced upregulation of collagen IV(Col IV),type HI precollagen(PCHI),hyaluronuc acid(HA)and laminin(LN),which are implicated in liver ***,YGL reduced theα-smooth muscle actin(α-SMA)expression,which acts as the indicator of liver ***,YGL decreased the serum levels of hepatic stellate cell(HSC)mitogen PDGF-BB and inflammation cytokines,including TNF-α,IL-1β,*** involved in liver fibrosis,such as Ras,p-Raf-1,p-ERK1/2,p-JNK,p-P38,p-PI3K,p-AKT,p-JAKl,p-STAT3 were downregulated significantly after treatment with *** results indicated that YGL ameliorated CCl4-induced liver fibrosis by reducing inflammation cytokines production,and suppressing Ras/ERK,PI3K/AKT,and JAK1/STAT3 signaling pathways,which provided further evidence towards elucidation of the anti-fibrotic mechanism of YGL.

关键词： yu gan Long traditional Chinese herbal therapy liver fibrosis Ras/ERK PI3K/AKT JAK1/STAT3

yu gan Long Inhibits Liver Fibrosis by Repressing TGF-β/Smad Signaling and Th17 differentiation

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Yu Gan Long Inhibits Liver Fibrosis by Repressing TGF-β/Sma...

New Splitting Algorithms for Multiplicative Noise Removal Based on Aubert-Aujol Model

第十二届全国免疫学学术大会

作者： Xia yu You Pengtao Wu Hezhen Zhai Ling Tu Yijun Ai Zhongzhu Yang Chunguang Li Hongwei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese Medicine School of Pharmacy Hubei University of Chinese Medicine

yu gan Long(YGL) is a traditional empirical formula in China which had been used for liver fibrosis treatment clinically for many years,but its anti-hepatofibrotic mechanisms remains incompletely *** this study,we investigated the anti-fibrotic effects of YGL and underlying mechanisms in CCl-treated *** rats were treated with YGL(0.25,0.5,1.0 g/kg/d,ig) for 12 weeks,then the serum and liver samples were *** biochemistry analyses was employed to assess liver *** liver fibrosis markers and inflammatory cytokines were measured by *** changes of liver tissues were evaluated by HE and Masson *** expression of liver fibrogenic proteins and signaling proteins were evaluated by *** with YGL significantly attenuated CCl-induced functional impairment,liver fibrosis and inflammation in a dosage-dependent manner by diminishing levels of AST,ALT and TBIL,decreasing levels of COL4、PC3、 HA、 LN and alpha smooth muscle actin(a-SMA) accumulation,down-regulating expressions of TGF-β,IL-6,PDGF-BB,IL-1β and TNF-α.Furthermore,the hepatoprotective effects of YGL on fibrosis were associated with downregulation of the phosphorylation of Smad2/3 in the livers of CC14-treated ***,YGL down-regulated the the phosphorylation of Stat3 and expression of IL17A with the downregulation of TGF-P and IL-6,which involved in the differentiation of *** results suggested that YGL exerts antifibrotic effects in CCl-treated rats via repressing TGF-B/Smad signaling and the differentiation of Th17 cells and that blocking this pathway and differentiation may be the central mechanisms by which YGL protects liver from injury.

关键词： YGL mechanisms liver fibrosis signaling Th17

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Numerical Mathematics(Theory,Methods and Applications) 2022年第2期15卷 415-441页

作者： yu gan Jie Zhang Huibin Chang School of Mathematical Sciences Tianjin Normal UniversityTianjinChina Department of Mathematics The University of Hong KongHong KongSARChina

In this paper,we propose new algorithms for multiplicative noise removal based on the Aubert-Aujol(AA)*** introducing a constraint from the forward model with an auxiliary variable for the noise,the NEMA(short for Noise Estimate based Multiplicative noise removal by alternating direction method of multipliers(ADMM))is firstly *** further reduce the computational cost,an additional proximal term is considered for the subproblem with regard to the original variable,the NEMA_(f)(short for a variant of NEMA with fully splitting form)is further *** conduct numerous experiments to show the convergence and performance of the proposed ***,the restoration results by the proposed algorithms are better in terms of SNRs for image deblurring than other compared methods including two popular algorithms for AA model and three algorithms of its convex variants.

关键词： Alternating direction method of multipliers image denoising and deblurring multiplicative noise total variation

Prediction of thermoelectric performance for layered IV-V-VI semiconductors by high-throughput ab initio calculations and machine learning

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npj Computational Materials 2021年第1期7卷 1609-1618页

作者： yu gan Guanjie Wang Jian Zhou Zhimei Sun School of Materials Science and Engineering Beihang UniversityBeijing 100191China Center for Integrated Computational Materials Engineering International Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing 100191China

Layered IV-V-VI semiconductors have immense potential for thermoelectric(TE)applications due to their intrinsically ultralow lattice thermal ***,it is extremely difficult to assess their TE performance via experimental trial-and-error ***,we present a machine-learning-based approach to accelerate the discovery of promising thermoelectric candidates in this chalcogenide *** on a dataset generated from high-throughput ab initio calculations,we develop two highly accurateand-efficient neural network models to predict the maximum ZT(ZT_(max))and corresponding doping type,*** top candidate,n-type Pb_(2)Sb_(2)S_(5),is successfully identified,with the ZT_(max) over 1.0 at 650 K,owing to its ultralow thermal conductivity and decent power ***,we find that n-type Te-based compounds exhibit a combination of high Seebeck coefficient and electrical conductivity,thereby leading to better TE performance under electron doping than hole *** p-type TE performance of Se-based semiconductors is superior to n-type,resulting from large Seebeck coefficient induced by high density-ofstates near valence band edges.

关键词： performance doping semiconductors

Morphology and multifractal features of a guyot in specific topographic vicinity in the Caroline Ridge,West Pacific

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Journal of Oceanology and Limnology 2021年第5期39卷 1591-1604页

作者： yu gan Xiaochuan MA Zhendong LUAN Jun YAN CAS Key Laboratory of Marine Geology and Environment Institute ofOceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Pilot National Laboratory for MarineScience and Technology(Qingdao)Qingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao266071China

Massive seamounts have been surveyed and documented in the last ***,the morphologies of seamounts are usually described in qualitative manners,yet few quantitative detections have been carried ***,based on the high-re solution multi-beam bathymetric data,we report a recentlysurveyed guy ot on the Caroline Ridge in the West Pacific,and the large-scale volcanic structures and smallscale erosive-depositional landforms in the guyot area have been *** multifractal features of the guyot are characterized for the first time by applying multifractal detrended fluctuation analysis on the surveyed bathymetric *** results indicate that the multifractal spectrum parameters of the seafloor have strong spatial dependency on the fluctuations of local *** small-and large-scale components contribute to the degree of asymmetry of the multifractal spectrum(B),while the fluctuations of B are mostly attributed to the changes in small-scale *** maximum singularity strength(α0)correlates well with the roughness of large-scale landforms and likely reflects the large-scale topographic *** to traditional roughness parameters or monofractal exponents,multifractal spectra are able to depict not only the multiscale characteristics of submarine landforms,but also the spatial variations of scaling *** more comparative works are required for various seamounts,we hope this study,as a case of quantifying geomorphological characters and multiscale behaviors of seamounts,can encourage further studies on seamounts concerning geomorphological processes,ocean bottom circulations,and seamount ecosystems.

关键词： guyot morphology multifractal detrended fluctuation analysis(MFDFA) Caroline Ridge West Pacific Ocean

A new species of the genus Amolops(Anura:Ranidae)from yunnan,China

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Zoological Research 2020年第2期41卷 188-193页

作者： yu-Lu gan Guo-Hua yu Zheng-Jun Wu Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Guangxi Normal University) Ministry of EducationGuilinGuangxi 541004China Guangxi Key Laboratory of Rare and Endangered Animal Ecology College of Life ScienceGuangxi Normal UniversityGuilinGuangxi 541004China

DEAR EDITOR,A new species of the genus Amolops,Amolops tuanjieensis ***.,is described from yunnan,*** new species can be distinguished by the following characters:dorsolateral folds present;dorsal and ventral surfaces smooth;top of head and dorsum brown-red with irregular gray and dark spots;flank green;side of head black,from tip of snout,diffusing posteriorly to axilla,continuing as black streak below edge of dorsolateral fold;SVL 39.5-40.4 mm in males,56.8-60.7 mm in females;tympanum distinct;supratympanic fold indistinct;vomerine teeth in two oblique rows between choanae,closer to each other than choanae;vocal sacs present;nuptial pads present;outer metatarsal tubercle absent,supernumerary tubercles absent;all fingertips expanded into discs;limbs dorsally brown with dark brown bars and irregular dark brown blotches.

关键词： black closer brown

Bioleaching of vanadium from barren stone coal and its effect on the transition of vanadium speciation and mineral phase

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International Journal of Minerals,Metallurgy and Materials 2018年第3期25卷 253-261页

作者： Xin Wang Hai Lin Ying-bo Dong gan-yu Li School of Civil and Resource Engineering University of Science and Technology Beijing Beijing 100083 China School of Energy and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083 China

This study determined the optimal conditions required to obtain maximum vanadium extraction and examined the transition of mineral phases and vanadium speciation during the bioleaching process. Parameters including the initial p H value, initial Fe^(2+) concentration, solid load, and inoculum quantity were examined. The results revealed that 48.92 wt% of the vanadium was extracted through bioleaching under optimal conditions. Comparatively, the chemical leaching yield(H_2SO_4, pH 2.0) showed a slower and milder increase in vanadium yield. The vanadium bioleaching yield was 35.11 wt% greater than the chemical leaching yield. The Community Bureau of Reference(BCR) sequential extraction results revealed that 88.62 wt% of vanadium existed in the residual fraction. The bacteria substantially changed the distribution of the vanadium speciation during the leaching process, and the residual fraction decreased to 48.44 wt%. The X-ray diffraction(XRD) and Fourier transform infrared(FTIR) results provided evidence that the crystal lattice structure of muscovite was destroyed by the bacteria.

关键词： bioleaching stone coal BCR-sequential extraction vanadium speciation mineral phase

A Comprehensive Study on the Consequences of Gap-Graded Sands Considering the Loss of Fine Particles

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Journal of Earth Science 2024年第2期35卷 597-612页

作者： Weiping Liu yu gan yunwei Cui Faming Huang Lina Hu School of Civil Engineering and Architecture Nanchang UniversityNanchang330031China

Water and sand leakage disasters are likely to occur during construction in water-rich sand layer areas,resulting in ground *** stress-strain action characteristics of discontinuous graded sand under different internal erosion degrees,and the evolution mechanism of water and sand leakage disasters caused by the internal erosion need to be further ***,this paper takes the discontinuous graded sand in a water rich sand layer area in Nanchang City of China as the research *** the influence of different fine particle losses(0,10%,20%and 30%)under the internal erosion of sand,the salt solution method is used to realize the specified loss of fine particles in the internal *** stress-strain behavior after the loss of fine particles due to internal erosion is studied by triaxial shear ***,the physical model test and PFC-CFD method are both used to study the evolution rules of water and sand leakage disaster considered the influence of internal erosion *** show that:(1)under the same confining pressure,the peak failure strength of sand samples decreases along with the increase of fine particle loss.(2)In the water and sand leakage test of saturated sand,a natural filter channel is formed above the observed soil *** greater the loss of fine particles,the steeper and wider the collapse settlement area.(3)The relationship between the cumulative amount of water and sand leakage and time is *** total mass loss of sand increases along with the increase of internal erosion degree.(4)After the soil arch is formed around the damaged opening,the sand continues to converge above the soil arch under the action of water flow,resulting in the dense convergence of contact force chains.

关键词： sandy soil internal erosion stress and strain water and sand leakage PFC3D engineering geology

Temperature Dependence of In-plane Resistivity and Inverse Hall Angle in NLED Holographic Model

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Communications in Theoretical Physics 2019年第5期71卷 577-589页

作者： Qing-yu gan Peng Wang Hai-Tang Yang Center for Theoretical Physics Sichuan UniversityChengdu 610064China

In the strange metal phase of the high-Tc cuprates, it is challenging to explain the linear temperature dependence of the in-plane resistivity and the quadratic temperature dependence of the inverse Hall angle. In this paper, we investigate the temperature dependence of the in-plane resistivity and inverse Hall angle in the nonlinear electrodynamics holographic model developed in our recent work. Maxwell electrodynamics and Born-Infeld electrodynamics are considered. Both cases support a wide spectrum of temperature scalings in parameter space. For Maxwell electrodynamics, the T-linear in-plane resistivity generally dominates at low temperatures and survives into higher temperatures in a narrow strip-like manner. Meanwhile, the T-quadratic inverse Hall angle dominates at high temperatures and extends down to lower temperatures. The overlap between the T-linear in-plane resistivity and the T-quadratic inverse Hall angle, if occurs, would generally present in the intermediate temperate regime. The Born-Infeld case with a > 0 is quite similar to the Maxwell case. For the Born-Infeld case with a < 0, there can be a constraint on the charge density and magnetic field. Moreover, the overlap can occur for strong charge density.

关键词： high-Tccuprates DC conductivity NLED holographic model

Fresh Frozen Plasma for the Treatment of a Chinese Patient with Hereditary Angioedema

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Chinese Medical Sciences Journal 2009年第4期24卷 246-247页

作者： Rui Tang Hong-yu Zhang Jia gan Department of Allergy Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

HEREDITARY angioedema （HAE） is an autosomal dominant inherited condition which was initially described by Osier in 1888.1 Patients with HAE can develop rapid subcutaneous or submucosal edema involving the hands, feet, limbs, face, intestinal tract, even larynx and trachea. The mortality of an acute attack of HAE without treatment was reported as high as 30%.2 HAE is caused by the deficiency of Cl esterase inhibitor （CIINH） which results in episodes of edema in parts of the human body,

关键词： fresh frozen plasma hereditary angioedema treatment