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Acta Mathematica Sinica,English Series 2022年第5期38卷 937-952页

作者： Gang CAI Qiao Li dong yu PENG School of Mathematics Science Chongqing Normal UniversityChongqing 401331P.R.China College of Science Civil Aviation University of ChinaTianjin 300300P.R.China

In this paper,we investigate a new inertial viscosity extragradient algorithm for solving variational inequality problems for pseudo-monotone and Lipschitz continuous operator and fixed point problems for quasi-nonexpansive mappings in real Hilbert *** convergence theorems are obtained under some appropriate conditions on the ***,we give some numerical experiments to show the advantages of our proposed *** results obtained in this paper extend and improve some recent works in the literature.

关键词： Extragradient method variational inequality fixed point strong convergence quasi-nonexpansive mapping

An anchor-based spectral clustering method

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Frontiers of Information Technology & Electronic Engineering 2018年第11期19卷 1385-1396页

作者： Qin ZHANG Guo-qiang ZHONG Jun-yu dong Department of Computer Science and Technology Ocean University of China Science and Information College Qingdao Agricultural University

Spectral clustering is one of the most popular and important clustering methods in pattern recognition,machine learning, and data mining. However, its high computational complexity limits it in applications involving truly large-scale datasets. For a clustering problem with n samples, it needs to compute the eigenvectors of the graph Laplacian with O(n^3) time complexity. To address this problem, we propose a novel method called anchor-based spectral clustering(ASC) by employing anchor points of data. Specifically, m(m≤n) anchor points are selected from the dataset, which can basically maintain the intrinsic(manifold) structure of the original data. Then a mapping matrix between the original data and the anchors is constructed. More importantly, it is proved that this data-anchor mapping matrix essentially preserves the clustering structure of the data. Based on this mapping matrix, it is easy to approximate the spectral embedding of the original data. The proposed method scales linearly relative to the size of the data but with low degradation of the clustering performance. The proposed method, ASC,is compared to the classical spectral clustering and two state-of-the-art accelerating methods, i.e., power iteration clustering and landmark-based spectral clustering, on 10 real-world applications under three evaluation *** results show that ASC is consistently faster than the classical spectral clustering with comparable clustering performance, and at least comparable with or better than the state-of-the-art methods on both effectiveness and efficiency.

关键词： Clustering Spectral clustering Graph Laplacian Anchors

Optomechanical-organized multipulse dynamics in ultrafast fiber laser

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Chinese Physics B 2021年第11期30卷 338-342页

作者： Lin Huang yu-Sheng Zhang yu-dong Cui Ceyear Technologies Co. LtdQingdao 266555China Science and Technology on Electronic Test&Measurement Laboratory Qingdao 266555China School of Information Science and Engineering Shandong UniversityQingdao 266237China Hangzhou Institute of Advanced Studies Zhejiang Normal UniversityHangzhou 311231China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

A novel organized multipulse pattern and its birth dynamics under strong optomechanical effect in microfiber-assisted ultrafast fiber laser are investigated in this *** background pulses are observed to obviously exhibit selectively amplifying self-organized process of evolving into quasi-stable equidistant *** radio frequency spectrum of the multipulse pattern displays a harmonic mode-locking-like behavior with a repetition rate of 2.0138 GHz,corresponding to the frequency of torsional-radial(TR_(2m))acoustic mode in *** results show the evidence of optomechanical effect in dominating the birth dynamics and pattern of multipulse.

关键词： fiber lasers multipulse operation optomechanical effect

New Exact Travelling Wave Solutions for Zakharov-Kuznetsov Equation

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Communications in Theoretical Physics 2009年第4期51卷 609-612页

作者： MA Hong-Cai yu Yao-dong GE dong-Jie Department of Applied Mathematics College of Science Donghua University Shanghai 201620 China

In this paper, the nonlinear dispersive Zakharov- Kuznetsov equation is solved by using the generalized auxiliary equation method. As a result, new solitary pattern, solitary wave and singular solitary wave solutions ... 详细信息

关键词： Zakharov Kuznetsov equation auxiliary equation method exact solutions

MAP4K4 induces early blood-brain barrier damage in a murine subarachnoid hemorrhage model

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Neural Regeneration Research 2021年第2期16卷 325-332页

作者： Zheng Zou yu-Shu dong dong-dong Liu Gen Li Guang-Zhi Hao Xu Gao Peng-yu Pan Guo-Biao Liang Department of Neurosurgery General Hospital of Northern Theater Command(General Hospital of Shenyang Military Command)The Graduate Training Base of Liaoning Medical CollegeShenyangLiaoning ProvinceChina Department of Neurosurgery General Hospital of Northern Theater Command(General Hospital of Shenyang Military Command)ShenyangLiaoning ProvinceChina Dalian Medical University DalianLiaoning ProivnceChina

Sterile-20-like mitogen-activated protein kinase kinase kinase kinase 4(MAP4 K4)is expressed in endothelial cells and activates inflammatory vascular *** cells are important components of the blood-brain *** investigate whether MAP4 K4 plays a role in the pathophysiology of subarachnoid hemorrhage,we evaluated the time-course expression of MAP4 K4 after subarachnoid hemorrhage.A subarachnoid hemorrhage model was established using the intravascular perforation *** model mice were assigned to four groups:MAP4 K4 recombinant protein,scramble small interfering RNA,and MAP4 K4 small interfering RNA were delivered by intracerebroventricular injection,while PF-06260933,a small-molecule inhibitor of MAP4 K4,was administrated *** score assessments,brain water assessments,Evans blue extravasation,immunofluorescence,western blot assay,and gelatin zymography were performed to analyze neurological outcomes and mechanisms of vascular ***4 K4 expression was elevated in the cortex at 24 hours after subarachnoid hemorrhage,and colocalized with endothelial ***4 K4 recombinant protein aggravated neurological impairment,brain edema,and blood-brain barrier damage;upregulated the expression of phosphorylated nuclear factor kappa B(p-p65)and matrix metalloproteinase 9(MMP9);and degraded tight junction proteins(ZO-1 and claudin 5).Injection with MAP4 K4 small interfering RNA reversed these ***,administration of the MAP4 K4 inhibitor PF-06260933 reduced blood-brain barrier damage in mice,promoted the recovery of neurological function,and reduced p-p65 and MMP9 protein *** together,the results further illustrate that MAP4 K4 causes early blood-brain barrier damage after subarachnoid *** mechanism can be confirmed by inhibiting the MAP4 K4/NF-κB/MMP9 *** experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of General Hospital of Northern Theate

关键词： brain central nervous system injury pathways rat recovery regeneration repair

Ligustilide protects PC12 cells from oxygen-glucose deprivation/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway

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Neural Regeneration Research 2020年第3期15卷 473-481页

作者： Dan-Yang Zhao dong-dong yu Li Ren Guo-Rong Bi Shengjing Hospital of China Medical University ShenyangLiaoning ProvinceChina The First People’s Hospital of Shenyang ShenyangLiaoning ProvinceChina The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine ShenyangLiaoning ProvinceChina

Autophagy has been shown to have a protective effect against brain ***(LIG)is a bioactive substance isolated from Ligusticum chuanxiong,a traditional Chinese *** has a neuroprotective effect;however,it is unclear whether this neuroprotective effect involves *** this study,PC12 cells were treated with 1×10^-5–1×10^-9 M LIG for 0,3,12 or 24 hours,and cell proliferation was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium(MTS)*** with 1×10^-6 M LIG for 3 hours had the greatest effect on cell proliferation,and was therefore used for subsequent ***12 cells were pre-treated with 1×10^-6 M LIG for 3 hours,cultured in 95%N2/5%CO2 in Dulbecco’s modified Eagle’s medium without glucose or serum for 4 hours,and then cultured normally for 16 hours,to simulate oxygen-glucose deprivation/reoxygenation(OGD/R).Cell proliferation was assessed with the MTS *** was detected by flow *** expression levels of apoptosis-related proteins,Bcl-2 and Bax,autophagy-related proteins,Beclin 1 and microtubule-associated protein l light chain 3B(LC3-II),and liver kinase B1(LKB1)-5′-adenosine monophosphate-activated protein kinase(AMPK)-mammalian target of rapamycin(mTOR)signaling pathway-related proteins were assessed by western blot *** staining was used to detect LC3-II *** formation was observed by electron *** significantly decreased apoptosis,increased Bcl-2,Beclin 1 and LC3-II expression,decreased Bax expression,increased LC3-II immunoreactivity and the number of autophagosomes,and activated the LKB1-AMPK-mTOR signaling pathway in PC12 cells exposed to OGD/*** addition of the autophagy inhibitor 3-methyladenine or dorsomorphin before OGD/R attenuated the activation of the LKB1-AMPK-mTOR signaling pathway in cells treated with *** together,our findings show that LIG promotes autophagy and protects

关键词： AMPK apoptosis autophagy Bax Bcl-2 Beclin 1 LC3-II ligustilide mTOR PC12 cells

A network pharmacology study of Sendeng-4,a Mongolian medicine

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Chinese Journal of Natural Medicines 2015年第2期13卷 108-118页

作者： ZI Tian yu dong Department of Natural Medicinal Chemistry College of Pharmacy Inner Mongolia Medical University

We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from Drug Bank, SuperT arget, TTD(Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG(Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target- disease network using Cytoscape software, the analysis indicated that the chemical composition had at least nine different types of targets that acted together to exert effects on the diseases, suggesting a "multi-component, multi-target" feature of the traditional Mongolian medicine. We also employed the rat model of rheumatoid arthritis induced by Collgen Type II to validate the key targets of the chemical components of Sendeng-4, and three of the key targets were validated through laboratory experiments, further confirming the anti-inflammatory effects of Sendeng-4. In all, this study predicted the active ingredients and targets of Sendeng-4, and explored its mechanism of action, which provided new strategies and methods for further research and development of Sendeng-4 and other traditional Mongolian medicines as well.

关键词： Network pharmacology Mongolian medicine Sendeng-4 Drug targeting Disease pathway networks Rheumatoid arthritis In vivo evaluation

Transmissive-detected laser speckle contrast imaging for blood flow monitoring in thick tissue: from Monte Carlo simulation to experimental demonstration

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Light(Science & Applications) 2021年第12期10卷 2492-2506页

作者： dong-yu Li Qing Xia Ting-Ting yu Jing-Tan Zhu Dan Zhu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology430074 WuhanHubeiChina MoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology430074 WuhanHubeiChina

Laser speckle contrast imaging(LSCI)is a powerful tool to monitor blood flow distribution and has been widely used in studies of microcirculation,both for animal and clinical ***,LSCI usually works on reflectivedetected ***,it could provide promising temporal and spatial resolution for in vivo applications only with the assistance of various tissue windows,otherwise,the overlarge superficial static speckle would extremely limit its contrast and ***,we systematically investigated the capability of transmissive-detected LSCI(TR-LSCI)for blood flow monitoring in thick *** Monte Carlo simulation,we theoretically compared the performance of transmissive and reflective *** was found that the reflective-detected mode was better when the target layer was at the very surface,but the imaging quality would rapidly decrease with imaging depth,while the transmissivedetected mode could obtain a much stronger signal-to-background ratio(SBR)for thick *** further proved by tissue phantom,animal,and human experiments that in a certain thickness of tissue,TR-LSCI showed remarkably better performance for thick-tissue imaging,and the imaging quality would be further improved if the use of longer wavelengths of near-infrared ***,both theoretical and experimental results demonstrate that TR-LSCI is capable of obtaining thick-tissue blood flow information and holds great potential in the field of microcirculation research.

关键词： reflective thick speckle

End-to-side neurorrhaphy repairs peripheral nerve injury：sensory nerve induces motor nerve regeneration

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Neural Regeneration Research 2017年第10期12卷 1703-1707页

作者： Qing yu She-hong Zhang Tao Wang Feng Peng dong Han yu-dong Gu Department of Hand Surgery Huashan Hospital of Fudan UniversityKey Laboratory of Hand Reconstructionthe Ministry of HealthKey Laboratory of Peripheral Nerve and MicrosurgeryShanghaiChina Department of Rehabilitation Medicine Huashan Hospital of Fudan UniversityShanghaiChina

End-to-side neurorrhaphy is an option in the treatment of the long segment defects of a *** involves suturing the distal stump of the disconnected nerve（recipient nerve） to the side of the intimate adjacent nerve（donor nerve）.However,the motor-sensory specificity after end-to-side neurorrhaphy remains *** study sought to evaluate whether cutaneous sensory nerve regeneration induces motor nerves after end-to-side *** rats were randomized into three groups：（1） end-to-side neurorrhaphy using the ulnar nerve（mixed sensory and motor） as the donor nerve and the cutaneous antebrachii medialis nerve as the recipient nerve;（2） the sham group：ulnar nerve and cutaneous antebrachii medialis nerve were just exposed;and（3） the transected nerve group：cutaneous antebrachii medialis nerve was transected and the stumps were turned over and *** 5 months,acetylcholinesterase staining results showed that 34% ± 16% of the myelinated axons were stained in the end-to-side group,and none of the myelinated axons were stained in either the sham or transected nerve *** fluorescent tracing of spinal motor neurons and dorsal root ganglion showed the proportion of motor neurons from the cutaneous antebrachii medialis nerve of the end-to-side group was 21% ± 5%.In contrast,no motor neurons from the cutaneous antebrachii medialis nerve of the sham group and transected nerve group were found in the spinal cord *** results confirmed that motor neuron regeneration occurred after cutaneous nerve end-to-side neurorrhaphy.

关键词： nerve regeneration peripheral nerve injury end-to-side neurorrhaphy motor-sensory specificity rat dorsal root ganglion motor neuron axon cutaneous antebrachii medialis nerve ulnar nerve acetylcholinesterase staining retrograde neuron tracing neural regeneration

A novel cerrobend block in the radiation therapy

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Science China(Technological Sciences) 2012年第1期55卷 22-27页

作者： CHANG ShuQuan ZHANG yu dong yu ZHANG HongXu DAI Yaodong College of Material Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

This study was carried out to look for the substitute products of lead cerrobend block and determine whether the products can give more radiation dose to the tumor in the skin and superficial tumors in radiotherapy treatment. Five kinds of PbO/ Er203/Epoxy（E-51） samples used as the cerrobend block in the electron beam radiotherapy treatment were prepared success- fully by a solidified forming approach. The central axis depth dose and off-axis dose profiles in the water phantom were calcu- lated using BEAMnrc/DOSEXYZnrc user codes. The results revealed that there were more energy deposition events induced by low energy electron beams in the surface of the water phantom. These electron beams were attributed to Compton scattering and photoemission between photons and erbium, plumbum elements. The maximum dose （Dm） and the depth at the maximum dose （Rm） were linearly dependent on the mass fraction of erbium and plumbum element in the sample. The max dose and its depth varied depending on the combined actions of new electrons and transmission electrons.

关键词： cerrobend block epoxy radiotherapy