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Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma

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Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 157-174页

作者： Piao Luo Qian Zhang Shuo Shen Yehai An Lixia yuan Yin-Kwan Wong Sizhe Huang Shaohui Huang Jingnan Huang Guangqing Cheng Jiahang Tian yu chena Xiaoyong Zhang Weiguang Li Songqi He Jigang Wang Qingfeng Du School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Department of Nephrology Shenzhen key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong 100872China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China

Hepatocellular carcinoma(HCC)is one of most common and deadliest ***(Cel),a natural product derived from the Tripterygium wilfordii plant,has been extensively researched for its potential effectiveness in fighting ***,its clinical application has been hindered by the unclear mechanism of ***,we used chemical proteomics to identify the direct targets of Cel and enhanced its targetability and antitumor capacity by developing a Cel-based liposomes in *** demonstrated that Cel selectively targets the voltage-dependent anion channel 2(VDAC2).Cel directly binds to the cysteine residues of VDAC2,and induces cytochrome C release via dysregulating VDAC2-mediated mitochondrial permeability transition pore(mPTP)*** further found that Cel induces ROS-mediated ferroptosis and apoptosis in HCC ***,coencapsulation of Cel into alkyl glucoside-modified liposomes(AGCL)improved its antitumor efficacy and minimized its side *** has been shown to effectively suppress the proliferation of tumor *** a xenograft nude mice experiment,AGCL significantly inhibited tumor growth and promoted *** findings reveal that Cel directly targets VDAC2 to induce mitochondria-dependent cell death,while the Cel liposomes enhance its targetability and reduces side ***,Cel shows promise as a therapeutic agent for HCC.

关键词： Celastrol VDAC2 Ferroptosis Apoptosis Hepatocellular carcinoma Liposomes

Erosion-control mechanism of sediment check dams on the Loess Plateau

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International Journal of Sediment Research 2021年第5期36卷 668-677页

作者： Zhaoyin Wang Zuyu chena Shu yu Qiang Zhang yu Wang Jianwei Hao State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower Research

Severe soil erosion occurs on the Loess Plateau in China, which makes the Yellow River the most sediment-laden river in the world. Construction of about 60,000 sediment check dams has remarkably controlled soil erosion on the Loess Plateau and reduced the sediment load of the middle and lower Yellow River. Nonetheless, little is known about the mechanism of erosion control and vegetation development of sediment check dams. The function of a single check dam mainly is trapping sediment,while the function of a train of check dams comprising dozens of or over hundreds of check dams in a gully encompasses controlling bed incision and reducing erosion energy. A formula was proposed to calculate the potential energy of bank failure and slope failure in a gully, which essentially constitutes the erosion energy. The erosion energy increases when gully incision occurs, which is induced by the incision of the Yellow River and its tributaries on the Loess Plateau. Sediment deposition in many gullies due to construction of check dams reduces the erosion energy to almost zero, which in turn greatly reduces soil erosion and sediment yield. Construction of check dams promotes vegetation development. The vegetation-erosion dynamics model was used to study the effect of check dams on vegetation development. Simulation results show that reforestation without check dam construction might result in an increase of vegetation cover in the first ten years and then a drop of vegetation cover to less than 10% in the later years. The check dams provide a foundation for vegetation development.

关键词： Loess plateau Check dam Energy of soil erosion Vegetation-erosion dynamics Gully incision

IncR26319/miR-2834/EndophilinA axis regulates oogenesis of the silkworm,Bombyx mori

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Insect Science 2023年第1期30卷 65-80页

作者： Yi Wang yu Fu Hao chena Chenyue Zhao Qunxia Huang Meiling Chang Wujie Qiu Yawen Shen Dandan Li Henan Key Laboratory of Insect Biology in Funiu Mountain Henan International Joint Laboratory of Insect BiologyCollege of Life Science and Agricultural EngineeringNanyang Normal UniversityNanyangHenan ProvinceChina

Oocyte maturation is critical for insect ***,the timely production and uptake of vitellogenin(Vg),is crucial for female *** is synthesized in fat body and absorbed by the oocytes through endocytosis during insect *** the silkworm,Bombyx mori,we discovered that a nucleus-enriched long-noncoding RNA(lncRNA)lncR26319 regulates Endophilin A(EndoA)-a member of the endophilin family of endocytic proteins-through competitive binding to *** lncR26319-miR-2834-EndoA axis was required for Vg endocytosis in the silkworm;loss of EndoA or overexpression ofmiR-2834significantlyreduced eggnumbers ***,accumulation of miR-2834 resulted in pupal and adult deformation and reduced fecundity in *** expression of Vg,30-kDa(30K)protein,and egg-specific protein(Esp)decreased after knockdown of EndoA or overexpression of miR-2834,while knockdown of miR-2834 had an opposite effect on the expression of Vg,30K protein gene,and *** results suggest that the lncR26319-miR-2834-EndoA axis contributes to the endocytic activity in theVguptake and leads to the normal progression of oogenesis in the ***,miR-2834 and EndoA are crucial for female reproduction and could be potential targets for new pest management strategies in lepidopterans.

关键词： Bombyx mori endophilin lncRNA miRNA oogenesis

Amorphous molybdenum sulfide mediated EDTA with multiple active sites to boost heavy metal ions removal

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Chinese Chemical Letters 2021年第9期32卷 2797-2802页

作者： Qi Huang Yizhong Zhang Wei Zhou Xiang Huang Yiliang chena Xin Tan Tao yu School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China School of Science Tibet UniversityLhasa 850000China School of Science Tianjin UniversityTianjin 300350China Research Center of Environmental Pollution Control Engineering Technology Chinese Research Academy of Environmental SciencesBeijing 100012China

The rational design of strong affinity adsorbents for heavy metal ions removal remains a critical challenge for water *** this study,amorphous molybdenum sulfide composites(EDTA-MoSx(x=2,3))were fabricated via a facile hydrothermal method mediated by EDTA,which was applied to heavy metal ions(Cu^(2+),Cd^(2+),Pb^(2+),Zn^(2+)and Ni^(2+))removal from aqueous solutions.A case study for Cu^(2+)ions showed that the adsorption capacity of EDTA-MoSx(x=2,3)was superior to crystalline phase MoS2 at pH 6.0 with an initial concentration of 200 mg/*** mechanisms of different sulfide groups and—COOH of EDTA-MoSx(x=2,3)were verified systematically via a series of experiments,characterizations,and density functional theory(DFT)*** bridging S_(2)^(2-)and—COOH covalently bonded with Cu^(2+)ions were ascribed to the critical factors for this enhanced removal efficiency on the surface of EDTA-MoSx(x=2,3).This work offers a new method to enhance the adsorption performance of molybdenum sulfide-based materials by controlling crystallinity mediated with an organic complex small molecule.

关键词： Amorphous phase MoS_(2) MoS_(3) Adsorption Heavy metal ions DFT calculations

Enabling ultrafast lithium-ion conductivity of Li_(2)ZrCl_(6) by indium doping

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Chinese Chemical Letters 2022年第10期33卷 4635-4639页

作者： Shuai chena Chuang yu Shaoqing Chen Linfeng Peng Cong Liao Chaochao Wei Zhongkai Wu Shijie Cheng Jia Xie State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Solid-state batteries with high energy density and safety are promising next-generation battery ***,lithium oxide and lithium sulfide electrolytes suffer low ionic conductivity and poor electrochemical stability,*** halide solid electrolyte shows high conductivity and good compatibility with the pristine high-voltage cathode but limited applications due to the high price of rare ***-based lithium halides with low cost and high stability possess great ***,a small amount of In^(3+)is introduced in Li_(2)ZrCl_(6) to synthesize Li_(2.25)Zr_(0.75)In_(0.25)Cl_(6) electrolytes with a high room temperature Li-ion conductivity of 1.08 mS/***-state batteries using Li_(2.25)Zr_(0.75)In_(0.25)Cl_(6)/Li_(5.5)PS_(4.5)Cl_(1.5) bilayer solid electrolytes combined with Li-In anode and pristine LiNi_(0.7)Mn_(0.2)Co_(0.1)O_(2) cathode deliver high initial discharge capacities under different cut-off *** work provides an effective strategy for enhancing the conductivity of Li2ZrCl6 electrolytes,promoting their applications in solid-state batteries.

关键词： Solid electrolyte Li_(2)ZrCl_(6) Li-ion conductivity In-doping Solid-state battery

Boosting Li-ion storage in Li2MnO_(3) by unequal-valent Ti4+-substitution and interlayer Li vacancies building

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Chinese Chemical Letters 2023年第4期34卷 564-569页

作者： yu Tian yuling Zhao Fanqi Meng Kaicheng Zhang Yanyuan Qi yujie Zeng Congcong Cai yuli Xiong Zelang Jian Yang Sun Lin Gu Wen chena School of Materials Science and Engineering Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China C Innovation Laboratory Contemporary Amperex Technology Ltd.(CATL)Ningde 352100China Institute of Physics Chinese Academy of SciencesBeijing 100190China Sanya Science and Education Innovation Park of Wuhan University of Technology Wuhan 430070China

Lithium rich layered oxide(LRLO) has been considered as one of the promising cathodes for lithium-ion batteries(LIBs). The high voltage and large capacity of LRLO depend on Li2MnO_(3)phase. To ameliorate the electrochemical performance of Li2MnO_(3), also written as Li(Li1/3Mn2/3)O_(2), we propose a strategy to substitute Mn4+and Li+in Mn/Li transition metal layer with Ti4+, which can stabilize the structure of Li2MnO_(3)by inhibiting the excessive oxidation of O_(2)-above 4.5 V. More significantly, the unequal-valent substitution brings about the emergence of interlayer Li vacancies, which can promote the Li-ion diffusion based on the enlarged interlayer and increase the capacity by activating the Mn3+/4+redox. We designed Li0.7[Li1/3Mn2/3]0.7Ti0.3O_(2)with high interlayer Li vacancies, which presents a high capacity(290 m Ah/g at 10 m A/g) and stable cycling performance(84% over 60 cycles at 50 m A/g). We predict that this strategy will be helpful to further improve the electrochemical performance of LRLOs.

关键词： Lithium-ion batteries Li2MnO_(3) Unequal-valent Ti4+-substitution Interlayer Li vacancies Activated Mn3+/4+redox

Computer Assisted Assignments of Rotationally Resolved Molecular Spectra

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Chinese Journal of Chemical Physics 2006年第1期19卷 39-42页

作者： Ling Wu Li-juan Zheng Xiao-hua Yang yu-yan Liu Yang-qin chena Key Laboratory of Optical and MaEnetic Resonance Spectroscopy Ministry of Education and De-partment of Physics East China Normal University ShanEhai 200062 China School of Science Hangzhou Dianzi University Hangzhou 310018 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Science Wuhan 430071 China

A graphically oriented interactive program for assignments of rotationally resolved molecular spectra has been devised. The program functions by grouping spectral lines in term of the second difference principle. and graphing spectral intensity versus frequency in a bar graph of the selected groups, distinguished by color and/or line-type. This allows for easy detection of regular patterns buried in the observed spectrum. Furthermore, it includes a Loomis-Wood view for assisting in spectral assignments. As an example, the program was applied in assigning the molecular spectrum of the production in the discharge of PCl3 buffered by helium gas, which may belong to several species. The results suggest that the program is highly efficient and quite useful in the assignment and the analysis of molecular spectra, especially those of symmetric top, slightly asymmetric top and linear molecules. The accuracy and efficiency of this program will likely ensure its wide application in the processing of molecular spectra.

关键词： Assignment Rotationally resolved Molecular spectra Computer assisted

A reliable and rapid pharmacokinetic study of pueraria isoflavones using pueraria reference extractive substance in beagle plasma:Application to study of yufeng Ningxin Tablets

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Chinese Herbal Medicines 2020年第1期12卷 88-94页

作者： Qin Zha Sha chena Jun Zhang Xiang-yu Zhang Pei-jun Ruan Heba MAmer An Liu Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Bijie Institute of Traditional Chinese Medicine Bijie 551700China Medicinal and Aromatic Plants Researches Department National Research CentreEl Buhouth St.DokkiCairo 11435Egypt

Objective:In order to evaluate the reliability and feasibility of pueraria reference extractive substance(RES)used in biological sample,the pharmacokinetics of 3–hydroxy puerarin(3-HP),puerarin,3–methoxy puerarin(3-MP),and daidzein-8-C-apiosyl-(1-6)-glucoside(DAG)in beagle plasma following oral administration of yufeng Ningxin Tablet were ***:A reliable and sensitive high-performance liquid chromatography-tandem triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method developed with chromatographic separation was operated on a Merck C18 column,and acetonitrile-5 mmol/L ammonium was used as mobile phase in gradient *** plasma samples were deproteinized by acetone,detected by triple quadrupole mass spectrometry with an electrospray ionization interface,and quantified using selected ion monitoring *** pharmacokinetic parameters were calculated by Winnonlin ***:The calibration curves of the reference extractive substance and standard substance methods were linear over the ranges 0.0417–11.3309μg/m L and 0.0394–10.0000μg/m *** intra-day and interday precision of the two methods at three concentrations were less than 13.63%,and the average recoveries of 3-HP,puerarin,3-MP,and DAG were more than 70.67%.The RSD of the mean plasma concentrations of the analytes calculated by the two methods was less than 5%,and cos(?)==*** the analytes,puerarin showed the highest blood concentration[(940±185)ng/m L]and the longest retention time[(5±1)h]in the dog’s ***:Pueraria reference extractive substance can be seen as an alternative to the standard substance to overcome the scarcity of standard substance for the analysis of biological samples.

关键词： beagle plasma pharmacokinetic pueraria isoflavones reference extractive substance standard substance

X-MOL: large-scale pre-training for molecular understanding and diverse molecular analysis

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Science Bulletin 2022年第9期67卷 899-902,M0003页

作者： Dongyu Xue Han Zhang Xiaohan chena Dongling Xiao yu kang Gonga Guohui Chuai yu Sun Hao Tian Hua Wu yukun Li Qi Liu These authors contributed equally to this work.a Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China Department of Natural Language Processing Baidu Inc.Beijing 100085China

In silico modeling and analysis of small molecules substantially accelerates the process of drug development. Representing and understanding molecules is the fundamental step for various in silico molecular analysis t... 详细信息

关键词： accelerate analysis development