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Multiple primary malignant neoplasms of three early cancer lesions： a case report

Chinese Medical Journal 2011年第8期124卷 1278-1280页

作者： ZHANG Wan-jun QIAN Xiao-ping SHI yu PAN Wen-sheng XU Xiang YE Zai-yuan WU Liang-qin Takeshi Terai Nobuhiro Sato Sumio watanabe Department of Gastroenterology the Second Affiliate-d Hospital Zhejiang University School ofMedicine Hangzhou Zhejiang 310009 China Department of Radiology the Second Affiliated Hospital Zhejiang University School ofMedicine Hangzhou Zhejiang 310009 China Department of Infectious Disease the First Affiliated Hospital ofZhejiang University School of Medicine Hangzhou Zhejiang310009 China Department of Pharmacy the Second Affiliated Hospital Zhejiang University School ofMedicine Hangzhou Zheiiang 310009 China Department of General Surgery Zhejiang Provincial People'sHospital Hangzhou Zhejiang 310014 China Terai Clinic Tokyo 101-0021 Japan Department of Gastroenterology Juntendo University School ofMedicine Tokyo 113-8431 Japan

Multiple primary malignant neoplasms （MPMNs） are rarely reported and it is important to give early diagnosis and proper therapy for these patients. Here reported a case of 62-year-old man with concomitant three early stage cancer lesions in upper gastrointestinal tract, all of which were detected by endoscopy. The first one was an llc-type lesion at angular part of stomach under endoscopy, which was histologically confirmed to be a mucosal well-differentiated *** patient underwent a standard radical gastrectomy for the lesion after the failure of endoscopic treatment. The other two neoplasms were observed during follow-up and were indicated as early stage lesions by synthesizing information from endoscopy, endoscopic ultrasonography, computed tomography and biopsy. One displayed as a hyperemic patch （3cm×4 cm in size） located at the part of esophagus 27 cm away from the incisor teeth and was proved to be moderately differentiated squamous cancer by histopathological examination. The other was an llc-type lesion （3.0 cm×3.5 cm in size） located at the part of esophagus 36 cm away from the incisor teeth, and the biopsy result showed a poorly differentiated squamous carcinoma. Both the two lesions were treated with radical radiation because the patient refused surgery management. No recurrence of former lesions or occurrence of novel lesions were observed during post-treatment follow-up, suggesting radical radiation might be effective for this patient.

关键词： multiple primary malignant neoplasms early cancer upper gastrointestinal tract

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优雅华贵进化版！采用筒状围裹式设计的礼服风格针织连衣裙

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国际服装技术 2007年第4期 26-37页

作者： Masako Kondo Jacky yu（翻译） Manabu Mizuta（摄影） Hideyuki watanabe

作为美人连衣裙的代名词，针织面料连衣裙的人气在今春仍然持续热潮！比起人气不断围裹款式，在衣袖、腰部以及裙摆处加入华贵元素的礼服风格针织连衣裙在今年同样引人注目。让我们一起感受其魅力所在！

关键词：针织面料连衣裙风格礼服进化优雅设计筒状

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Hemodynamic effects of ambrisentan-tadalafil combination therapy on progressive portopulmonary hypertension

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World Journal of Hepatology 2014年第11期6卷 825-829页

作者： yu Yamashita Ichizo Tsujino Takahiro Sato Asuka Yamada Taku watanabe Hiroshi Ohira Masaharu Nishimura First Department of Medicine Hokkaido University Hospital

Intravenous epoprostenol is recommended for World Health Organization functional class(WHO-FC) Ⅳ patients with pulmonary arterial hypertension(PAH) in the latest guidelines. However, in portopulmonary hypertension(PoP H) patients, advanced liver dysfunction and/or thrombocytopenia often makes the use of intravenous epoprostenol challenging. Here we report the cases of two WHO-FC Ⅳ PoP H patients who were successfully treated with a combination of two oral vasodilators used to treat PAH: ambrisentan and tadalafil. Oral vasodilator therapy using a combination of ambrisentan and tadalafil may be a safe and effective therapeutic option for WHO-FC Ⅳ PoP H patients and should be considered for selected patients with severe and rapidly progressing PoP H.

关键词： Portopulmonary hypertension Ambrisentan Tadalafil Thrombocytopenia

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来自造型师南云佑子小姐的创意最强显瘦着装打造黄金线条

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国际服装技术 2007年第11期 52-62页

作者： Ayako Yonaga Jacky yu（翻译） Masaki Sone（摄影） Hideyuki watanabe（摄影）

线条感是女人永远的追求。同时对于缺乏品位的造型也会敬而远之!被称为线条感造型救世主的造型师南云小姐，将一一满足追求完美女性的愿望。充分发挥流行单品的独特效果，让我们一起来学习，时尚感与线条感兼备的，南云流神奇搭配技巧。

关键词：造型师线条创意黄金着装时尚搭配技巧

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以百搭度为标准精心挑选　随心所欲玩转盛装连衣裙

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国际服装技术 2007年第6期 116-123页

作者： Hitomi Takahasi Jacky yu（翻译） Fumi Kikuchi（摄影） Hideyuki watanabe（摄影）

让你为之痴心迷恋的盛装连衣裙。私藏的百搭秘籍，让你在平时也能享受到华美的时尚魅力。

关键词：连衣裙标准秘籍时尚

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来自造型师望月律子小姐的指南利用实力派小配件提升装扮效果

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国际服装技术 2007年第11期 68-73页

作者： Sayako ito Jacky yu（翻译） Hideyo Fukuda（摄影） Hideyuki watanabe（摄影）

为了令装扮即刻展现最新潮元素，推荐搭配合适的小配件。让我们跟着在小配件使用上颇有心得的造型师望月律子小姐，学习打造洗练感造型的小配件技巧!

关键词：造型师配件指南

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NB-3 signaling in axonal projection and plasticity

NB-3 signaling in axonal projection and plasticity

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中国神经科学学会第十届全国学术会议

作者： Zhenhui Huang yuhui Sun Yang yu Yarong Gao Chao Zhang yue Ying Yasushi Shimoda Kazutada watanabe Yaobo Liu Institute of Neuroscience Soochow University Institute of Biophysics Chinese Academy of Sciences The Medical School of Lanzhou University Department of Bioengineering Nagaoka University of Technology

Neural recognition molecules of the immunoglobulin（Ig） superfamily play important roles not only in the formation of axon trajectories and synaptic connections during development but also in synaptic plasticity and memory in ***-3 is a member of the contactin subgroup of the immunoglobulin superfamily,which contains six Ig-lite domains and four fibronectin type in like domains with a glycosylphosphatidyl inositol moiety at the COOH *** our previous study,we found that the temporal expression of NB-3 in the deep layers of the motor cortex in mice was coincident with the development of the corticospinal tract（CST）,meanwhile NB-3 was expressed specifically in the projecting CST *** tracing of CST axons in NB-3"’’ mice at different developmental stages revealed that the descending of CST and the branching of CST axons into spinal gray matter were obviously delayed in NB-3"’" mice compared with wild-type（WT） mice from the embryonic to postnatal *** adult mice,we found that NB-3 was induced coincidently in the distal end of injured axons and in the reactive cells of lesion area after spinal cord *** anterograde and retrograde tracing in NB-3"’" mice after spinal cord injury,we observed the enhancement of axonal sprouting out and regeneration in lesion area of the spinal ***,we also observed some of NB-3"’"mice exhibited locomotion recovery after spinal cord ***,we speculate that injury-induced NB-3 in both axons and reactive cells mediated a contact-inhibit effect on axon regeneration after spinal cord *** data suggest that NB-3 signaling pathway is involved in the projection,branching of developing CST axons and the axonal plasticity after spinal cord injury.

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Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

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Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： yuya Nagasawa yu Takahashi Wataru Itani Hitoshi watanabe Yusuke Hidaka Shotaro Morita Kei Suzuki Kouichi watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama Motohiro Horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi Hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein

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Order parameter analysis of synchronization transitions on star networks

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Frontiers of physics 2017年第6期12卷 11-20页

作者： Hong-Bin Chen yu-Ting Sun Jian Gao Can Xu Zhi-Gang Zheng Institute of Systems Science Huaqiao University Xiamen 361021 China CoUege of Information Science and Engineering Huaqiao University Xiamen 361021 China Department of Physics and the Beijing-Hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Beijing) Beijing Normal University Beijing 100875 China

The collective behaviors of populations of coupled oscillators have attracted significant attention in recent years. In this paper, an order parameter approach is proposed to study the low-dimensional dynamical mechanism of collective synchronizations, by adopting the star-topology of coupled oscil- lators as a prototype system. The order parameter equation of star-linked phase oscillators can be obtained in terms of the watanabe--Strogatz transformation, Ott--Antonsen ansatz, and the ensem- ble order parameter approach. Different solutions of the order parameter equation correspond to the diverse collective states, and different bifurcations reveal various transitions among these collective states. The properties of various transitions in the star-network model are revealed by using tools of nonlinear dynamics such as time reversibility analysis and linear stability analysis.

关键词： Kuramoto model synchronization order parameter Ott-Antonsen ansatz star network

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大鼠降结肠上皮γ-氨基丁酸及谷氨酸脱羧酶的表达特征

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世界华人消化杂志 2005年第24期13卷 2833-2837页

作者：汪芳裕 Maemura Kentaro 朱人敏 Hirata Ichiro Katsu Ken-ichi watanabe Masahito 中国人民解放军南京军区南京总医院消化内科江苏省南京市210002 大阪医科大学解剖学教研室日本大阪医科大学第二内科学教研室

目的:检测γ-氨基丁酸(gamma-aminobutyricacid,GABA)和谷氨酸脱羧酶(glutamicaciddecarboxylase,GAD)在大鼠降结肠上皮的表达及分布特征,并探讨GABA与上皮细胞分化增殖的关系.方法:用免疫荧光及激光共聚焦显微扫描技术,检测GABA、GAD65... 详细信息

目的:检测γ-氨基丁酸(gamma-aminobutyricacid,GABA)和谷氨酸脱羧酶(glutamicaciddecarboxylase,GAD)在大鼠降结肠上皮的表达及分布特征,并探讨GABA与上皮细胞分化增殖的关系.方法:用免疫荧光及激光共聚焦显微扫描技术,检测GABA、GAD65及GAD67在大鼠降结肠上皮中的表达,并以麦芽凝聚素组织化学染色与免疫荧光结合的双重染色显示GABA和GAD65表达细胞的分布特征.同时,用RT-PCR和原位分子杂交方法检测GADmRNA的表达.此外,用3H-胸腺嘧啶放射自显影法显示降结肠上皮的增殖带.结果:RT-PCR显示降结肠黏膜中GAD65及GAD67mRNA均阳性,原位杂交显示阳性杂交信号主要分布在上皮细胞的隐窝和腔面,且GAD65信号较GAD67强.GABA及GAD65免疫反应阳性细胞主要分布在降结肠的腔面和隐窝的上1/3上皮细胞的胞质,而GAD67阳性细胞仅分布腔面,此外,GABA及GAD65阳性染色也见于黏膜固有层.双重染色显示杯状细胞中GABA及GAD65均阴性.3H-胸腺嘧啶标记阳性细胞主要在隐窝的中下段.结论:GABA及GAD65分布在大鼠降结肠上皮的成熟带及功能带,GABA系统可能参与上皮细胞的分化与增殖的调节.

关键词： γ-氨基丁酸谷氨酸脱羧酶结肠上皮大鼠

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