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Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance

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Chinese Journal of Natural Medicines 2024年第4期22卷 341-355页

作者： WANG Hao GENG Xiaolong AI Fangbin yu zhilun ZHANG Yan ZHANG Beibei LV Cheng GAO Ruiyang yuE Bei DOU Wei The MOE Key Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicinesand the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese MedicineInstitute of Chinese Materia MedicaSchool of Traditional Chinese Materia MedicaShanghai University of Traditional Chinese Medicine(SHUTCM)Shanghai 201203China

Rheumatoid arthritis(RA)is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation,posing challenges in the development of effective ***,an alkaloid found in lotus leaf,has shown promising anti-inflammatory and anti-tumor effects,yet its efficacy in RA treatment remains *** study investigated the antiproliferative effects of nuciferine on the MH7A cell line,a human RA-derived fibroblast-like synoviocyte,revealing its ability to inhibit cell proliferation,promote apoptosis,induce apoptosis,and cause G1/S phase ***,nuciferine significantly reduced the migration and invasion capabilities of MH7A *** therapeutic potential of nuciferine was further evaluated in a collagen-induced arthritis(CIA)rat model,where it markedly alleviated joint swelling,synovial hyperplasia,cartilage injury,and inflammatory *** also improved collagen-induced bone erosion,decreased pro-inflammatory cytokines and serum immunoglobulins(IgG,IgG1,IgG2a),and restored the balance between T helper(Th)17 and regulatory T cells in the spleen of CIA *** results indicate that nuciferine may offer therapeutic advantages for RA by decreasing the proliferation and invasiveness of FLS cells and correcting the Th17/Treg cell imbalance in CIA rats.

关键词： Rheumatoid arthritis Collagen-induced arthritis Fibroblast-like synoviocyte Immune imbalance Nuciferine

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Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol

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Acta Pharmaceutica Sinica B 2024年第12期14卷 5286-5304页

作者： Gao, Ruiyang yue, Bei Lv, Cheng Geng, Xiaolong yu, zhilun Wang, Hao Zhang, Beibei Ai, Fangbin Wang, Zhengtao Liu, Donghui Chen, Kaixian Dou, Wei The MOE Key Laboratory of Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicines the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Centre for Chinese Herbal Medicine Drug Development Limited Hong Kong Baptist University Hong Kong SAR 999077 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China

Irinotecan (CPT11) chemotherapy-induced diarrhea affects a substantial cancer population due to β-glucuronidase (Gus) converting 10-O-glucuronyl-7-ethyl-10-hydroxycamptothecin (SN38G) to toxic 7-ethyl-10-hydroxycamptothecin (SN38). Existing interventions primarily address inflammation and Gus enzyme inhibition, neglecting epithelial repair and Gus-expressing bacteria. Herein, we discovered that dehydrodiisoeugenol (DDIE), isolated from nutmeg, alleviates CPT11-induced intestinal mucositis alongside a synergistic antitumor effect with CPT11 by improving weight loss, colon shortening, epithelial barrier dysfunction, goblet cells and intestinal stem cells (ISCs) loss, and wound-healing. The anti-mucositis effect of DDIE is gut microbiota-dependent. Analysis of microbiome profiling data from clinical patients and CPT11-induced mucositis mice reveals a strong correlation between CPT11 chemotoxicity and Gus-expressing bacteria, particularly Enterococcus faecalis (E. faecalis). DDIE counters CPT11-induced augmentation of E. faecalis, leading to decreased intestinal Gus and SN38 levels. The Partial Least Squares Path Model (PLS-PM) algorithm initially links E. faecalis to dysregulated epithelial renovation. This is further validated in a 3D intestinal organoid model, in which both SN38 and E. faecalis hinder the formation and differentiation of organoids. Interestingly, colonization of E. faecalis exacerbates CPT11-induced mucositis and disturbs epithelial differentiation. Our study unveils a microbiota-driven, epithelial reconstruction-mediated action of DDIE against mucositis, proposing the ‘Gus bacteria–host–irinotecan axis’ as a promising target for mitigating CPT11 chemotoxicity. © 2024 The Authors

关键词： Dehydrodiisoeugenol Enterococcus faecalis Epithelial regeneration Gus bacteria–host–irinotecan axis Intestinal mucositis Intestinal stem cells Irinotecan β-Glucuronidase

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论当代中国法治之路的不可逆转性

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法学杂志 2011年第3期32卷 51-55页

作者：朱力宇于之伦中国人民大学法学院北京100872

法学理论上一般将法治的内涵视为治国的基本方略,文明社会的基本原则,占主导地位的普遍观念或内在精神,严格有序的实际状态或社会秩序。实践中要建设成为"法治国家",至少需要五个条件健全完善的市场经济体制,高度民主的政治体制,全民具... 详细信息

法学理论上一般将法治的内涵视为治国的基本方略,文明社会的基本原则,占主导地位的普遍观念或内在精神,严格有序的实际状态或社会秩序。实践中要建设成为"法治国家",至少需要五个条件健全完善的市场经济体制,高度民主的政治体制,全民具有较高的法律文化素质,人民和谐相处的社会环境,改革开放导致的社会转型和国家融入世界。当一个国家基本上或大体上具备了上述法治内涵和实现条件时,其成为法治国家的趋势就是不可逆转的。以这些内涵和条件评价近现代中国对法治之路探索的是非曲直和经验教训后,得出的结论是当代中国的法治之路已经不可逆转。

关键词：法治实现条件破立不可逆转

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我看生本教育

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现代教育论丛 2007年第3期 10-13页

作者：余志伦湖南省汨罗市教研室

生本教育是以学生自主学习为主要形式的教育。它因极大程度地尊重了人的生命自然,而备受人们推崇。本文用大量生动鲜活的事例进一步证明生本教育的无比优越性。

关键词：生本教育自主学习

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西式饮食与炎症性肠病相关性的研究进展

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胃肠病学 2019年第6期24卷 373-376页

作者：岳备任怡静于之伦罗晓平张婧任君宇窦薇上海中医药大学中药研究所中药标准化教育部重点实验室暨上海市复方中药重点实验室

炎症性肠病(IBD)包括溃疡性结肠炎和克罗恩病,是一种病因不明的慢性复发性消化道炎性病变。近年IBD发病率呈逐年递增的态势,流行病学显示IBD的发生与西式饮食存在一定关联。西式饮食可能通过破坏菌群结构、损伤黏膜屏障、激发黏膜固有... 详细信息

炎症性肠病(IBD)包括溃疡性结肠炎和克罗恩病,是一种病因不明的慢性复发性消化道炎性病变。近年IBD发病率呈逐年递增的态势,流行病学显示IBD的发生与西式饮食存在一定关联。西式饮食可能通过破坏菌群结构、损伤黏膜屏障、激发黏膜固有免疫反应等方式增加IBD的易感性。本文就西式饮食与IBD发病率、发病机制的关系以及IBD的饮食干预作一综述。

关键词：炎症性肠病西式饮食发病机制

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土木香内酯药理作用研究进展

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上海中医药大学学报 2019年第6期33卷 82-87页

作者：任怡静岳备于之伦罗晓平张靖任君宇窦薇上海中医药大学中药研究所中药标准化教育部重点实验室上海市复方中药重点实验室

总结国内外文献,综述土木香内酯(alantolactone,ATL)的药理作用及相关机制。ATL是一种倍半萜内酯类化合物,是中药土木香的主要活性成分之一。近年来,国内外研究发现其具有多种药理作用,包括抗肿瘤、抗菌、抗炎、保肝等,其抗肿瘤活性显著... 详细信息

总结国内外文献,综述土木香内酯(alantolactone,ATL)的药理作用及相关机制。ATL是一种倍半萜内酯类化合物,是中药土木香的主要活性成分之一。近年来,国内外研究发现其具有多种药理作用,包括抗肿瘤、抗菌、抗炎、保肝等,其抗肿瘤活性显著,对结直肠癌、肺癌、乳腺癌、宫颈癌、骨髓瘤、胶质母细胞瘤等均具有抑制作用,显示出良好的临床应用前景。

关键词：土木香内酯药理作用抗肿瘤综述

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Effect of SrO Content on Structure,Thermal Properties and Chemical Stability of Bi2O3-B2O3-ZnO-SrO Low-melting Glass for Si-Al Alloy Package

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Journal of Wuhan University of Technology(Materials Science) 2020年第2期35卷 368-376页

作者： WU zhilun ZHANG Ming ZHANG Chunyan MENG Fancheng LIN Huixing College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China Key Laboratory of Inorganic Functional Materials and Devices Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201800China

The 40Bi2O3-30B2O3-(30-x)ZnO-xSrO (x=0-15mol%,BBZSr) glass system was prepared by the conventional melt quenching *** effect of SrO addition on structure,thermal properties,chemical stability and sealing performance of BBZSr glass were investigated *** experimental results show that the total proportions of [BO3] group and [BO4] group decrease and the vibrations of [BiO3] group and [BiO6] group become weaker with the increase of SrO addition content,suggesting the glass network structure is strengthened owing to the SrO ***,both the thermal and chemical stability were significantly improved as the SrO content was *** the SrO content increased from 0 to 15mol%,the glass transition temperature and softening temperature slightly increased from 380 to 388 ℃ and from 392.7 to 402.2 ℃,respectively,meanwhile the coefficient of thermal expansion also increased from 10.49×10^-6 to 11.16×10^-6/℃ (30-300 ℃).The BBZSr glass with 15mol% SrO exhibited excellent comprehensive properties with low glass transition temperature(384.9 ℃),low softening temperature(400.3 ℃),high coefficient of thermal expansion (11.14×10^-6 ℃,30-300 ℃),good thermal and chemical ***,the glass had the good wetting behavior and sealing performance for Al-50%Si alloy.

关键词： low-melting sealing lead-free glass Bi2O3-B2O3-ZnO-SrO glass silicon-aluminium alloy thermal expansion

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Super-resolution vibrational microscopy by stimulated Raman excited fluorescence

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Light(Science & Applications) 2021年第5期10卷 906-915页

作者： Hanqing Xiong Naixin Qian yupeng Miao zhilun Zhao Chen Chen&Wei Min Department of Chemistry Columbia UniversityNew YorkNY10027USA

Inspired by the revolutionary impact of super-resolution fluorescence microscopy,super-resolution Raman imaging has been long pursued because of its much higher chemical specificity than the fluorescence ***,vibrational contrasts are intrinsically less sensitive compared with fluorescence,resulting in only mild resolution enhancement beyond the diffraction limit even with strong laser excitation *** such,it is still a great challenge to achieve biocompatible super-resolution vibrational imaging in the optical *** 2019 Stimulated Raman Excited Fluorescence(SREF)was discovered as an ultrasensitive vibrational spectroscopy that combines the high chemical specificity of Raman scattering and the superb sensitivity of fluorescence *** we developed a novel super-resolution vibrational imaging method by harnessing SREF as the contrast *** first identified the undesired role of anti-Stokes fluorescence background in preventing direct adoption of super-resolution fluorescence *** then devised a frequency-modulation(FM)strategy to remove the broadband backgrounds and achieved high-contrast SREF *** by newly synthesized SREF dyes,we realized multicolor FM-SREF imaging with nanometer spectral ***,by integrating stimulated emission depletion(STED)with background-free FM-SREF,we accomplished high-contrast super-resolution vibrational imaging with STED-FM-SREF whose spatial resolution is only determined by the signal-to-noise *** our proof-of-principle demonstration,more than two times of resolution improvement is achieved in biological systems with moderate laser excitation power,which shall be further refined with optimized instrumentation and imaging *** its super resolution,high sensitivity,vibrational contrast,and mild laser excitation power,STED-FM-SREF microscopy is envisioned to aid a wide variety of applications.

关键词： field. vibrational resolution

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Treating temperature effect on bandgap in polymer opal photonic crystals

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Chinese Science Bulletin 2002年第11期47卷 960-962页

作者： Bo Li Ji Zhou Wei Hu Longtu Li zhilun Gui Tsing Hua Univ State Key Lab New Ceram & Fine Proc Dept Mat Sci & Engn Beijing 100084 Peoples R China

The optical reflective spectra and microstruc-tures of polystyrene opal photonic crystals treated with different temperatures have been investigated. With temperature increasing, the polystyrene spheres in opal structure transform to dodecahedrons, and the peak of reflective spectrum moves to shorter wavelength. The experiment result testifies the effect of the effective refractive index and the filling ratio to the bandgap position, and it corresponds to the theoretical simulative result.

关键词： photonic crystals opal temperature self-assemble.

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Parameterization, sensitivity, and uncertainty of 1-D thermodynamic thin-ice thickness retrieval

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Acta Oceanologica Sinica 2024年第7期43卷 93-111页

作者： Tianyu Zhang Mohammed Shokr Zhida Zhang Fengming Hui Xiao Cheng zhilun Zhang Jiechen Zhao Chunlei Mi School of Geospatial Engineering and Science Sun Yat-Sen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-Sen University) Ministry of EducationZhuhai 519082China State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China Science and Technology Branch Environment and Climate Change CanadaToronto M3H5T4Canada Qingdao Innovation and Development Base(Centre) Harbin Engineering UniversityQingdao 266500China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Retrieval of Thin-Ice Thickness(TIT)using thermodynamic modeling is sensitive to the parameterization of the independent variables(coded in the model)and the uncertainty of the measured input *** article examines the deviation of the classical model’s TIT output when using different parameterization schemes and the sensitivity of the output to the ice ***,it estimates the uncertainty of the output in response to the uncertainties of the input *** parameterized independent variables include atmospheric longwave emissivity,air density,specific heat of air,latent heat of ice,conductivity of ice,snow depth,and snow *** input parameters include air temperature,ice surface temperature,and wind *** the independent variables,the results show that the highest deviation is caused by adjusting the parameterization of snow conductivity and depth,followed ice *** sensitivity of the output TIT to ice thickness is highest when using parameterization of ice conductivity,atmospheric emissivity,and snow conductivity and *** retrieved TIT obtained using each parameterization scheme is validated using in situ measurements and satellite-retrieved *** in situ measurements,the uncertainties of the measured air temperature and surface temperature are found to be *** resulting uncertainties of TIT are evaluated using perturbations of the input data selected based on the probability distribution of the measurement *** results show that the overall uncertainty of TIT to air temperature,surface temperature,and wind speed uncertainty is around 0.09 m,0.049 m,and−0.005 m,respectively.

关键词： Arctic sea ice 1-D thermodynamic ice model thin-ice thickness sea ice parameterization

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