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一氧化碳参与的过渡金属催化的插羰环加成反应研究进展

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有机化学 2024年第4期44卷 1045-1068页

作者：李晨龙余志祥北京大学化学与分子工程学院、北京分子科学国家研究中心、生物有机与分子工程教育部重点实验室北京100871

作为一种高效构建环状分子的方法,环加成反应一直以来备受合成化学家的青睐.一氧化碳(CO)气体是一种商业易得且廉价的原料,常作为“一碳”组分参与各种过渡金属催化的环加成反应.近几十年来,得益于金属有机化学的深入研究,CO气体参与的... 详细信息

作为一种高效构建环状分子的方法,环加成反应一直以来备受合成化学家的青睐.一氧化碳(CO)气体是一种商业易得且廉价的原料,常作为“一碳”组分参与各种过渡金属催化的环加成反应.近几十年来,得益于金属有机化学的深入研究,CO气体参与的过渡金属催化的环加成反应得到了迅速发展.此类插羰环加成反应之所以成为有机化学的研究前沿,是因为它们不仅可以用于构建复杂的环状骨架,还可以引入具有广泛衍生化能力的羰基官能团.这篇文章旨在详细介绍CO气体参与的过渡金属催化的插羰环加成反应,并按照不同反应类型进行梳理和总结.

关键词：环状分子一氧化碳(CO)气体过渡金属催化插羰反应环加成反应

Intratumoural microorganism can affect the progression of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4232-4243页

作者： Bao-Qun Liu Yi Bai Da-Peng Chen Ya-Min Zhang Tian-Ze Wang Jing-Rui Chen xiang-yu Liu Bin Zheng Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Tianjin First Central Hospital Clinic Institute School of MedicineNankai UniversityTianjin 300192China School of Medicine Tianjin UniversityTianjin 300072China

BACKGROUND Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma(HCC);however,their role in tumor progression remains ***,there is a need for further research on the role of intratumoural microorganisms in *** To investigate the changes in intratumoural microorganisms in HCC and the effect of Propionibacterium on HCC *** HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization(FISH).After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two *** was cocultured with HCC cells in *** in cell proliferation and migration capacity were *** expression of NF-κB pathway related proteins in tumor cells was *** orthotopic liver implantation model and the subcutaneous xenograft model were *** tissues and subcutaneous tumors were collected 2 weeks *** FISH demonstrated the presence of microorganisms in HCC and normal liver tissues.16S rRNA sequencing revealed an abundance of Lysobacter,Lachnospiraceae,Pseudomonas,and Lactobacillus in HCC *** distribution and abundance of Propionibacterium showed differences between HCC and peritumoral tissues(P<0.05).In vitro studies demonstrated that Propionibacterium and its metabolite propionic acid(PA)inhibited the proliferation and migration of HCC cells(P<0.05).The expression of the proteins in NF-κB signaling pathway also decreased in HCC cells(P<0.05).CONCLUSION Microorganisms in HCC and normal liver tissues displayed significant *** PA-producing bacterium Propionibacterium in HCC exerts an effect on the NF-κB pathway,thereby affecting the biological behavior of HCC.

关键词： Hepatocellular carcinoma Intratumoural microbiome 16S rRNA sequencing Propionibacterium

Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

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Neuroscience Bulletin 2024年第8期40卷 1104-1114页

作者： Man Chen yun‑Hui Chu Wen‑xiang yu yun‑Fan You yue Tang Xiao‑Wei Pang Hang Zhang Ke Shang Gang Deng Luo‑Qi Zhou Sheng Yang Wei Wang Jun Xiao Dai‑Shi Tian Chuan Qin Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)*** in microglial lipid metabolism is believed to be closely associated with the neuropathology of ***,there is limited evidence on the functional relevance of circulating lipids in CNS demyelination,cellular metabolism,and microglial ***,we found that serum low-density lipoprotein(LDL)was positively correlated with markers of neurological damage in NMOSD *** addition,we demonstrated in a mouse model of NMOSD that LDL penetrates the CNS through the leaky BBB,directly activating *** activation leads to excessive phagocytosis of myelin debris,inhibition of lipid metabolism,and increased glycolysis,ultimately exacerbating myelin *** also found that therapeutic interventions aimed at reducing circulating LDL effectively reversed the lipid metabolic dysfunction in microglia and mitigated the demyelinating injury in *** findings shed light on the molecular and cellular mechanisms underlying the positive correlation between serum LDL and neurological damage,highlighting the potential therapeutic target for lowering circulating lipids to alleviate the acute demyelinating injury in NMOSD.

关键词： Neuromyelitis optica spectrum disorder Low-density lipoprotein Microglia

Magnesium cantharidate suppresses PP2A and ERK1/2 pathway to inhibit hepatocellular carcinoma cells

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Toxicology Advances 2024年第1期6卷 16-27页

作者： Ze Wang yu-Xi Huang Tian-Mu He xiang-yu Tan Xiao-Fei Li yun Liu Rong Yan School of Pharmacy Zunyi Medical UniversityZunyi 563000China School of Basic Medicine Zunyi Medical UniversityZunyi 563000China Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi Medical UniversityZunyi 563000China

Background:Magnesium cantharidate(MC)is a protein phosphatase 2A(PP2A)inhibitor antitumor ***,its antitumor mechanism in hepatocellular carcinoma cell(HCC)remains ***:PP2A lentiviral vector over expression strategy was utilized both in vivo and in vitro to explore the antitumor effect in MC and okadaic acid(OA).Tumor weight was detected in mice after MC and OA *** proliferation,cell cycle,apoptosis rate,and western blotting were detected to explore the effects on MC and OA in human hepatocarcinoma SMMC-7721 ***:In vivo results demonstrated that MC inhibited HCC progression while OA promoted tumor *** vitro results demonstrated that MC effectively inhibited the growth of SMMC-7721 cells by arresting the cell cycle at the G2/M phase with inhibiting Cdc25C and activating the phosphorylation of the Cdc2 *** cytometry results further showed that MC increased ***,the expression of phosphorylated ERK1/2 was lower in the MC group but higher in the OA *** docking results showed that MC docked well with ERK1/***:MC inhibited HCC progression by suppressing the growth and activating the apoptosis of cancer cells and suppressing the expression of PP2A and ERK1/2.

关键词： magnesium cantharidate ERK1/2 HCC PP2A

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发现磁性氧化物异质结中的超导条纹相

科学通报 2024年第22期69卷 3199-3201页

作者：华翔宇项子霁陈仙辉中国科学技术大学微尺度物质科学国家研究中心合肥230026 合肥国家实验室合肥230088 中国科学技术大学物理系合肥230026

非常规超导电性是凝聚态物理学领域重要的研究方向,目前学术界普遍认为非常规超导配对的形成与磁性密切相关.在铜氧化物和铁基高温超导体中,超导电性在相图中都发生在磁有序态附近,而超导与磁性的相互作用则会导致更为奇特的演生现象或... 详细信息

非常规超导电性是凝聚态物理学领域重要的研究方向,目前学术界普遍认为非常规超导配对的形成与磁性密切相关.在铜氧化物和铁基高温超导体中,超导电性在相图中都发生在磁有序态附近,而超导与磁性的相互作用则会导致更为奇特的演生现象或物态.

关键词：凝聚态物理学超导电性非常规超导铜氧化物铁基高温超导体磁有序异质结磁性氧化物

基于RSM-BBD的多源煤基固废胶结体配比及性能研究

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材料导报 2024年第9期38卷 149-155页

作者：赵新元杨科何祥魏祯于祥张继强安徽理工大学深部煤矿采动响应与灾害防控国家重点实验室安徽淮南232001 安徽理工大学矿业工程学院安徽淮南232001 合肥综合性国家科学中心能源研究院(安徽省能源实验室) 合肥230000

本工作采用响应面法(RSM)Box-Behnken Design(BBD)模式对脱硫石膏、气化细渣和炉底渣等多源煤基固废进行配比优选,并研究了最优配比胶结体的力学性能、孔隙结构、热稳定性、微观结构等特性。结果表明:(1)气化细渣掺量对胶结体的1 d强度... 详细信息

本工作采用响应面法(RSM)Box-Behnken Design(BBD)模式对脱硫石膏、气化细渣和炉底渣等多源煤基固废进行配比优选,并研究了最优配比胶结体的力学性能、孔隙结构、热稳定性、微观结构等特性。结果表明:(1)气化细渣掺量对胶结体的1 d强度影响最大,脱硫石膏掺量对胶结体3 d和7 d强度影响最大,两种固废的交互作用对胶结体早期强度影响最显著,表现为负效应;在粉煤灰与矸石质量比为0.4∶1和质量浓度为80%的条件下,获得脱硫石膏、气化细渣和炉底渣的最优质量比为0.2∶0.1∶0.1,并分析了最优配比胶结体的压缩变形和破坏特征。(2)研究了胶结体的微观特性:胶结体内存在密集细颈型封闭孔隙,孔直径范围在5~3.7×10^(5) nm,微孔较少,以中、大孔为主;胶结体在55~65℃和90~120℃区间出现游离水和结晶水的吸热脱水反应,在600~700℃区间出现结构水、羟基水的脱除和水化产物的分解,在800℃累计失重约8%。(3)煤基固废胶结体的水化反应以水泥为主,固废之间未发生化学反应,水化产物为少量短杆状钙矾石相和薄层绒状C-S-H凝胶;钙矾石中少量Al^(3+)被Si^(4+)取代,少量SO_(4)^(2-)被CO_(3)^(2-)取代。

关键词：煤基固废胶结充填体响应面法配比优化微观特性

A promising solution for highly reversible zinc metal anode chemistry:Functional gradient interphase

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Nano Research Energy 2024年第2期3卷 3-6页

作者： Xiaofeng He xiang-yu Kong Liping Wen CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Rechargeable zinc(Zn)metal batteries have long been plagued by dendrite growth and parasitic reactions due to the absence of a stable Zn-ion conductive solid-electrolyte interphase(SEI).Although the current strategies assist in suppressing dendritic Zn growth,it is still a challenge to obtain the operation-stability of Zn anode with high Coulombic efficiency(CE)required to implement a sustainable and long-cycling life of Zn metal *** this perspective,we summarize the advantages of the functional gradient interphase(FGI)and try to fundamentally understand the transport behaviors of Zn ions,based on recently an article understanding Zn *** correlation between the function-orientated design of gradient interphase and key challenges of Zn metal anodes in accelerating Zn2+transport kinetics,improving electrode reversibility,and inhibiting Zn dendrite growth and side reactions was particularly ***,the rational design and innovative directions are provided for the development and application of functional gradient interphase in rechargeable Zn metal battery systems.

关键词： zinc metal battery dendrite gradient solid-electrolyte interphase energy storage

分布式电驱动汽车原地转向机理与控制方法研究

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中国公路学报 2024年第3期37卷 231-244页

作者：吕皓玉王翔宇谢斌李全通中国农业大学现代农业装备优化设计北京市重点实验室北京100083 清华大学汽车安全与节能国家重点实验室北京100084

分布式电驱动汽车能够通过原地转向功能提高车辆的机动性。原地转向下车辆的4个车轮均处于滑移状态,极易发生车身偏移甚至失控。为了实现稳定精准的原地转向控制,分析了原地转向的动力学机理,并提出横摆角速度与滑转率协同的控制策略。... 详细信息

分布式电驱动汽车能够通过原地转向功能提高车辆的机动性。原地转向下车辆的4个车轮均处于滑移状态,极易发生车身偏移甚至失控。为了实现稳定精准的原地转向控制,分析了原地转向的动力学机理,并提出横摆角速度与滑转率协同的控制策略。基于纵向动力学设计路面附着估计算法,完成原地转向前的路面状况判断;采用了分层式控制架构,上层控制器基于车辆状态协调转矩控制策略,下层控制设计横摆角速度决策框架,根据油门开度计算原地转向的名义横摆角速度,基于二次性能指标的单神经元自适应PID控制算法计算四轮驱动转矩,以实现横摆角速度的跟踪控制,并引入模糊逻辑推理得到四轮期望滑转率,通过PID算法计算驱动转矩调节量,配合横摆角速度转矩控制以抑制转向中心的偏移。仿真测试和实车试验表明:在附着系数一定的情况下,稳态原地转向的轮胎视为刚体,侧偏角与地面侧向反作用力基本不变,试验结果符合所推断的原地转向动力学机理;并验证横摆角速度跟踪控制算法在不同附着系数下具有理想的跟踪效果和鲁棒性,响应速度相比于PID提高46%,最大超调量减小24.0%,平均调节时间缩短1.3 s,平均稳态误差均在0.01 (°)·s^(-1);横摆角速度与滑转率协同控制减小横、纵坐标偏移量2.94、1.69 m,对转向中心偏移起到了抑制作用。

关键词：汽车工程原地转向协同控制分布式驱动汽车单神经元自适应PID

Landscape of urine biomarkers for bladder cancer:molecular function,cell-of-origin,and bibliometric trend

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Oncology and Translational Medicine 2024年第3期10卷 132-142页

作者： Min Liu Shuo Li yuan Rong Fei Long Wu-Shi Zhao yu-Xuan Qin Ting Wang Fu-Bing Wang xiang-yu Meng Department of Laboratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Single-Cell Omics and Tumor Liquid Biopsy Zhongnan Hospital of Wuhan UniversityWuhan 430071China School of Information Management Wuhan UniversityWuhan 430000China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China Health Science Center Hubei Minzu UniversityEnshi 445000China

Background:The effective management of bladder cancer(BCa)depends on the early diagnosis and *** studies have explored numerous urinary molecules as potential biomarkers of ***,the molecular functions and cell-of-origin profiles of these biomarkers are yet to be *** this study,we aimed to provide a comprehensive overview of the landscape of urinary biomarker genes for ***:We conducted an exhaustive literature search in PubMed,through which 555 biomarker genes were *** then analyzed the BCa single-cell atlas to infer the cellular origin of these BCa urine biomarker genes and performed functional enrichment analysis to gain insights into the functional molecular implications of these ***:These genes are involved in tumor proliferation,angiogenesis,cellmigration,and cell death and are predominantly expressed in epithelial and stromal ***,our analysis ofmultiomics tumor data revealed a discordance between tissue and urine in terms of differential methylation and RNA expression,suggesting that biomarker discovery for liquid biopsies should ideally begin with the analysis of bodily fluids rather than relying interest and that test strategies incorporating multiple molecular markers represent an ongoing ***:Collectively,our study has built a landscape of BCa urine biomarker genes,uncovered molecular insights into these biomarkers,and revealed the bibliometric trends in this field,which will contribute to the discovery of novel biomarkers in the future.

关键词： Bladder cancer Urine biomarker Molecular function Cell-of-origin Bibliometric