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Light-assisted rechargeable zinc-air battery:Mechanism,progress,and prospects

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Journal of Energy Chemistry 2024年第4期91卷 178-193页

作者： Jiangchang Chen Jinlong Luo Youlin Xiang Yingjian yu College of Physics Science and Technology Kunming UniversityKunming 650214YunnanChina

Exploring effective energy storage systems is critical to alleviate energy *** zinc-air batteries are promising energy storage ***,conventional rechargeable zinc-air battery systems face many challenges associated with electrolytes and electrodes,causing inferior electrochemistry *** light-assisted strategy represents a novel and innovative approach to conventional zinc-air battery technology that uses only electrical *** strategy effectively combines both light and electrical energy conversion/storage *** addition,light-assisted rechargeable zinc-air batteries can achieve photocharging with or without applied electrical bias by partially using solar energy and the acceleration of oxygen reduction/evolution reaction *** this paper,the working mechanism and structural design of the light-assisted rechargeable zinc-air batteries are introduced based on the theory of photoelectrochemistry and its ***,the latest advances in electrolyte and photocathode design strategies are discussed in *** performance enhancement of aqueous light-assisted rechargeable zinc-air batteries using photoelectric materials is ***,a summary and outlook on the further modification of properties of light-assisted rechargeable zinc-air batteries,especially the photovoltaic electrode catalyst design strategies,are *** review provides insights and guidance for the design of high-performance light-assisted rechargeable Zn-air batteries for next-generation energy storage devices.

关键词： Zn-air battery Light-assisted Electrolyte Catalyst Semiconductor

Azocalixarenes: a scaffold of universal excipients with high efficiency

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Science China Chemistry 2024年第5期67卷 1697-1706页

作者： yu-Xin yue Yi-Lin Lin Meng-Meng Chen Han-Wen Tian Rong Ma Ze-Han Wang Fang-yuan Chen yu-Chen Pan Dong-Sheng Guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China

Excipients are important components of pharmaceutical preparations that affect their quality, safety, and efficacy. Macrocyclic receptors are a family of supramolecular excipients with several advantages, including molecular-level protection, small sizes,fast kinetics of host-guest recognition, and modular construction. With the continuous advances in the medical field, personalized and precision medicine requires the development of excipients with low dosages, integrated modifying effects, universality,and controlled release. To meet these requirements, we have developed a new family of macrocyclic excipients based on calixarenes by integrating their covalent(broad chemical design space) and noncovalent(wide range of substrates) ***, azocalixarenes(Azo CAs) were designed, showing high binding affinities to a broad spectrum of active pharmaceutical ingredients(APIs), selectivity to interferents, and responsiveness to hypoxic microenvironments. Due to their highly efficient and controllable recognition, Azo CAs serve as low-dose excipients for 30 APIs. Molecular encapsulation by Azo CAs results in the integrated modification of the physicochemical properties of APIs, including solubility, stability, bioavailability,and biocompatibility. Moreover, Azo CAs can be reduced by azoreductases overexpressed in hypoxic microenvironments,leading to the controlled release of APIs. Collectively, Azo CA excipients have broad application prospects for a series of diseases such as enteritis, arthritis, stroke, cancer, bacterial infection and kidney injury, with diverse therapeutic modalities,including chemotherapy, photodynamic therapy, photothermal therapy, immunotherapy, boron neutron capture therapy, radiotherapy, fluorescence imaging, and their combinations.

关键词： supramolecular chemistry host-guest systems excipient calixarene molecular recognition

Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

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Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang Xiang-Cui Liu yu-Chao Wang Huan-Ran Zheng Jin-Xian Wang Jia-Yi Zheng Meng-Jie Liu Dan-Ni Deng yu Bai Ying-Bi Chen Tong Zhang Zhi-Ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

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World Journal of Clinical Oncology 2024年第3期15卷 391-410页

作者： Jin-yu Shi Xin Che Rui Wen Si-Jia Hou yu-Jia Xi Yi-Qian Feng Ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Department of Breast Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The Fifth Clinical Medical College Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Colorectal Surgery The Fifth Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Neurology The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Urology The Second Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Breast Surgery The First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Ferroptosis has recently been associated with multiple degenerative *** induction in cancer cells is a feasible method for treating neoplastic ***,the association of iron proliferation-related genes with prognosis in HER2+breast cancer(BC)patients is *** To identify and evaluate fresh ferroptosis-related biomarkers for HER2+*** First,we obtained the mRNA expression profiles and clinical information of HER2+BC patients from the TCGA and METABRIC public databases.A four gene prediction model comprising PROM2,SLC7A11,FANCD2,and fh was subsequently developed in the TCGA cohort and confirmed in the METABRIC *** were stratified into high-risk and low-risk groups based on their median risk score,an independent predictor of overall survival(OS).Based on these findings,immune infiltration,mutations,and medication sensitivity were analyzed in various risk ***,we assessed patient prognosis by combining the tumor mutation burden(TMB)with risk ***,we evaluated the expression of critical genes by analyzing single-cell RNA sequencing(scRNA-seq)data from malignant vs normal epithelial *** We found that the higher the risk score was,the worse the prognosis was(P fh was not,suggesting that these genes are expressed mainly in cancer epithelial cells(P<0.01).CONCLUSION Our model helps guide the prognosis of HER2+breast cancer pa

关键词： HER2+breast cancer Ferroptosis Tumor mutation burden Single-cell RNA sequencing Prognosis

Uhrf1基因重组腺病毒载体构建及其在小鼠心肌细胞DNA损伤修复中的作用研究

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中国病理生理杂志 2024年第2期40卷 238-243页

作者：江南王驰寅聂宇王珏温州医科大学第一临床医学院浙江温州325000 温州医科大学附属第一医院心脏外科浙江温州325000 中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管疾病国家重点实验室北京100037

目的:构建携带小鼠泛素样同源域和环指结构域1(Uhrf1)基因的重组腺病毒载体,验证Uhrf1基因在原代乳鼠心肌细胞中的表达情况,并探究其在过氧化氢(H_(2)O2)诱导的心肌细胞DNA损伤中的作用。方法:利用PCR扩增小鼠Uhrf1基因的编码序列,将其... 详细信息

目的:构建携带小鼠泛素样同源域和环指结构域1(Uhrf1)基因的重组腺病毒载体,验证Uhrf1基因在原代乳鼠心肌细胞中的表达情况,并探究其在过氧化氢(H_(2)O2)诱导的心肌细胞DNA损伤中的作用。方法:利用PCR扩增小鼠Uhrf1基因的编码序列,将其酶切后插入pADM-CMV-C-fh载体,获得重组腺病毒质粒ADM-Uhrf1。将该质粒转染至HEK293T细胞包装成重组腺病毒颗粒,数代扩增后进行腺病毒的纯化及滴度检测。分离25只1日龄ICR小鼠原代心肌细胞,分为两组,以感染复数(MOI)为50的比例分别感染ADM-Uhrf1及ADM-control(ADMCtrl),通过Western blot及免疫荧光染色验证重组腺病毒介导的UHRF1蛋白的表达,并利用H_(2)O2诱导心肌细胞DNA损伤,进而探究Uhrf1在DNA损伤修复过程中的作用。结果:通过壳蛋白免疫法检测得到的ADM-Uhrf1病毒滴度为1.8×10^(13) pfu/L。Western blot验证显示UHRF1蛋白表达水平显著升高(P<0.05),免疫荧光染色显示UHRF1主要表达在细胞核内,且Uhrf1的过表达能够显著抑制DNA损伤标志物磷酸化组蛋白H_(2)A变异体(γH_(2)AX)蛋白的表达(P<0.01)。结论:成功构建了携带小鼠Uhrf1基因的重组过表达腺病毒载体,并通过腺病毒递送系统在心肌细胞中实现了Uhrf1的过表达,且Uhrf1的过表达有效减轻了H_(2)O2诱导的心肌细胞DNA损伤。

关键词： Uhrf1基因腺病毒载体质粒心肌细胞 DNA损伤

不同品种烟草患黑胫病根际土壤真菌群落结构研究

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西南农业学报 2024年第7期37卷 1494-1503页

作者：程凌寒张裕棠方宇刘玲玲蔡永占刘冬梅韩小女余磊齐颖刘佳妮昆明学院/云南省都市特色农业工程技术研究中心昆明650214 合肥高尔生命健康科学研究院有限公司合肥230088 云南省烟草公司曲靖市公司云南曲靖655002 云南省宣威市农业技术推广中心云南宣威655499

[目的]揭示不同品种患病根际土壤真菌中的差异显著物种,探讨根际土壤真菌与不同品种烟草互作关系,为品种抗性机理研究以及生物防治提供参考。[方法]采用Illumina MiSeq高通量测序技术,分析云南省8个主栽烟草品种的患病植株根际土壤真菌... 详细信息

[目的]揭示不同品种患病根际土壤真菌中的差异显著物种,探讨根际土壤真菌与不同品种烟草互作关系,为品种抗性机理研究以及生物防治提供参考。[方法]采用Illumina MiSeq高通量测序技术,分析云南省8个主栽烟草品种的患病植株根际土壤真菌的群落结构组成与多样性。[结果]8个品种的患病根际土壤真菌OTU丰度值分布在822~1126,各品种间根际土壤真菌多样性与丰富度指数存在显著差异,其中品种K326、云105、云87和云99显著高于其他品种。在门水平上,各品种患病根际土壤真菌主要以子囊菌门(Ascomycota)、被孢霉门(Mortierellomycota)和担子菌门(Basidiomycota)为优势菌门。在属水平上,各处理组主要以Microidium属、镰孢菌属(Fusarium)、腐质霉属(Humicola)、被孢霉属(Mortierella)和链格孢属(Alternaria)等为优势菌属。LEFSe显著差异分析表明:腐质霉属、假丝酵母属(Candida)、小不整球壳属(Plectosphaerella)、链格孢属、丝葚霉属(Papulaspora)、镰孢菌属、Boeremia属、被孢霉属、赤霉菌属(Gibberella)是不同品种烟草患病根际土壤的重要差异显著物种。[结论]不同品种烟草的患病根际土壤真菌群落结构与多样性存在显著差异,且显著差异物种的分布与品种抗性存在一定联系。对黑胫病具有较高抗性的品种(云97、K326、云100和云87)中以有益菌属为主,而在感病和中抗品种(红大、云105、云116和云99)中则聚集了部分病原菌。

关键词：烟草黑胫病品种根际土壤真菌群落

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芦荟的化学成分研究

化学研究与应用 2024年第5期36卷 1101-1106页

作者：余榕林志达何健民拱北海关技术中心广东珠海5519075 保山学院资源环境学院云南保山678000

采用硅胶、Sephadex LH-20凝胶柱色谱方法等对阿福花科(Asphodelaceae)植物芦荟Aloe vera(L.)Burm.f.的化学成分进行分离纯化,并通过核磁共振波谱学技术对所分离化合物进行结构鉴定。从芦荟中分离鉴定了12个化合物,包括3个色原酮:5-(S-2... 详细信息

采用硅胶、Sephadex LH-20凝胶柱色谱方法等对阿福花科(Asphodelaceae)植物芦荟Aloe vera(L.)Burm.f.的化学成分进行分离纯化,并通过核磁共振波谱学技术对所分离化合物进行结构鉴定。从芦荟中分离鉴定了12个化合物,包括3个色原酮:5-(S-2’-oxo-4’-hydroxypentyl)-2-hydroxymethylchromone(1)、5-(4E-2’-oxopentenyl)-2-hydroxymethylchromone(2)、5-(2-oxopentyl)-2-hydroxymethylchromone(3),1个酚酸:咖啡酸(4),6个蒽醌:大黄素(5)、大黄酚(6)、芦荟大黄素(7)、大黄素-8-β-D-吡喃葡萄糖苷(8)、芦荟苷A和B(9和10),1个香豆素:好望角芦荟内酯(11)和1个氧杂苯并吡喃类成分:8-hydroxy-2-(2-hydroxypropyl)-7-acetyl-1-oxaphenalene(12)。其中,咖啡酸(4)和氧杂苯并吡喃类成分(12)首次从芦荟属植物中发现。

关键词：芦荟阿福花科色原酮蒽醌氧杂苯并吡喃

626例耐药肺结核临床特征及其耐药基因突变分布

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中华医院感染学杂志 2024年第8期34卷 1130-1133页

作者：方珂李丹汤中文余娇程芳武汉市金银潭医院手术室湖北武汉430000 武汉市金银潭医院麻醉科湖北武汉430000 武汉市金银潭医院结核外科湖北武汉430000 武汉市金银潭医院护理部湖北武汉430000

目的分析626例耐药肺结核患者的临床特征及其耐药基因突变特征。方法纳入2018年6月-2022年12月武汉市金银潭医院收治的肺结核患者626例进行研究,根据其结核分枝杆菌耐药情况,分别纳入耐药组(189例)、非耐药组(437例)。分析肺结核患者耐... 详细信息

目的分析626例耐药肺结核患者的临床特征及其耐药基因突变特征。方法纳入2018年6月-2022年12月武汉市金银潭医院收治的肺结核患者626例进行研究,根据其结核分枝杆菌耐药情况,分别纳入耐药组(189例)、非耐药组(437例)。分析肺结核患者耐药情况,分析肺结核患者耐药临床特征,分析肺结核患者耐药基因突变特征。结果626例肺结核患者分离626株结核分枝杆菌,其中耐药189例,耐药率为30.19%,耐多药87例,异烟肼、链霉素、利福平耐药率较高;临床特征分析结果显示,耐药组年龄、病历类型复治高于非耐药组(P<0.05);肺结核患者耐药基因突变主要为katG基因突变(315位Ser替代为Thr,突变率为38.10%),rpoB基因突变(521位Ser替代为Leu,突变率为28.04%),rpsL基因突变(43位Lys替代为Arg,突变率为26.98%)。结论肺结核患者耐药情况不容乐观,耐药临床特征包括年龄≥60岁、病历类型复治等,分析其临床特征及耐药基因突变特征,可为预防措施的制定提供依据。

关键词：肺结核耐药结核分枝杆菌基因突变临床特征

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Preliminary studies on form, structure and function of androgenic gland in Penaeus chinensis

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Chinese Science Bulletin 1997年第6期42卷 499-503页

作者： Li, fh Xiang, JH Institute of Oceanology Chinese Academy of Sciences Qingdao China

SCIENTISTS have paid much attention to sex control of animals. Sex control of shrimp is a noticeable topic in the field of high technology in aquaculture. Increasing the proportion of female shrimps in a rearing population is undoubtedly a very effective path to obtain higher aquacultural production of Penaeus chinensis. But up to date, the mechanism of sex differentiation and determination in shrimp is not clear. In recent years, we have done some work on

关键词： Penaeus chinensis androgenic gland function.