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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu Yi-Sheng Chen yu-Chun xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Steady-state teleportation fidelity and Bell nonlocality in dissipative environments

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Communications in Theoretical Physics 2021年第7期73卷 75-80页

作者： yu-Xia xie School of Science Xi’an University of Posts and TelecommunicationsXi’an 710121China

We investigate quantum teleportation and Bell nonlocality for two channel qubits coupled via the Heisenberg interaction and subject to two independent dissipative *** with the case of two uncoupled qubits,it is shown that the interaction Hamiltonian is beneficial for enhancing the teleportation fidelity and Bell nonlocality,and remarkably,it can also be used to create nonclassical teleportation fidelity and Bell nonlocality even from the initial product ***,the interaction Hamiltonian guarantees the generation of steady-state nonclassical teleportation fidelity,which is independent of the initial state and therefore one can take any state as the initial channel state.

关键词： quantum teleportation Bell inequality decoherence

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Some New Results on Transition Probability

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Acta Mathematica Sinica,English Series 2008年第12期24卷 1965-1984页

作者： yu Quan xie School of Mathematics and Computational Science Xiangtan University Xiangtan 411105 P. R. China

In this paper, we study the basic properties of stationary transition probability of Markov processes on a general measurable space （E, δ）, such as the continuity, maximum probability, zero point, positive probability set,standardization, and obtain a series of important results such as Continuity Theorem, Representation Theorem, Levy Theorem and so on. These results are very useful for us to study stationary tri-point transition probability on a general measurable space （E, δ）. Our main tools such as Egoroff＇s Theorem, Vitali-Hahn-Saks＇s Theorem and the theory of atomic set and well- posedness of measure are also very interesting and fashionable.

关键词： Markov processes stationary transition probability maximum probability uniformly standard representation theorem

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Willmore Submanifolds in the Unit Sphere via Isoparametric Functions

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Acta Mathematica Sinica,English Series 2015年第12期31卷 1963-1969页

作者： yu Quan xie Department of Mathematics Hangzhou Normal University

In this paper,we show that both focal submanifolds of each isoparametric hypersurface in the sphere with six distinct principal curvatures are Willmore,hence all focal submanifolds of isoparametric hypersurfaces in th... 详细信息

关键词： Willmore submanifold isoparametric hypersurface focal submanifold

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Artemisia annua, artemisinin, and the Nobel Prize:beauty of natural products and educational significance

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Science Bulletin 2016年第1期61卷 42-44页

作者： De-yu xie Department of Plant and Microbial Biology North Carolina State University

In the beautiful evening on December 10,2015(local time in Sweden),the annual Nobel Prize ceremony was hosted by the Swedish Royal Family at Stockholm’s City Hall,Stockholm,*** to all ten new Nobel Prize Laureates and thanks them for using their brightest talents to make our world better!The 2015 Nobel Prize in Physiology or Medicine was awarded to Professors Youyou Tu,William ***,and Satoshi Omura

关键词：诺贝尔奖获得者青蒿素教育意义天然产品诺贝尔生理学或医学奖斯德哥尔摩颁奖典礼天然产物

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Constraint for the Existence of Ellipsoidal Vesicles

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Chinese Physics Letters 2000年第3期17卷 230-232页

作者： xie yu-Zhang Department of Physics Tsinghua UniversityBeijing 100084 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

Under the spontaneous curvature model of lipid bilayers,the constraints for the existence of equilibrium axisym-metric oblate and prolate ellipsoidal vesicles are obtained from the general shape *** degenerate either to the constraint for the existence of a spherical vesicle or to that of a circular cylindrical vesicle given by Ou-Yang and Helfrich[***.59(1987)2486;60(1988)120;***.A 39(1989)5280].

关键词： equation. curvature Existence

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Wound-Ribbon Helix Structure of Tilted Chiral Lipid Bilayers

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Chinese Physics Letters 1999年第3期16卷 229-231页

作者： xie yu-zhang Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080 Department of Modern Applied Physics Tsinghua UniversityBeijing 100084

With the equation of helicoid,it is found that for wound-ribbon helix of chiral lipid bilayers the edge line of the helix can only be parallel to the azimuthal direction of the *** clears the dilemma of the existence of both the parallel and the perpendicular case under the treatment of a chiral bilayer around a circular cylinder by Ou-Yang and Liu[***.65(1990)1679;***.A43(1991)6826].The present calculation also explains the self-transformation of the wound-ribbon helix into a prolate tube and the prolate tube into a multilayer soda straw structure.

关键词： structure chiral cylinder

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Literature overview of basic characteristics and flotation laws of flocs

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 943-958页

作者： Wanzhong Yin yu xie Zhanglei Zhu School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China College of Chemistry and Chemical Engineering Xi’an University of Science and TechnologyXi’an 710054China

Flocculation flotation is the most efficient method for recovering fine-grained minerals,and its essence lies in flotation and recovery of *** physical characteristics of flocs are mainly determined by their apparent particle size and structure(density and morphology).Substantial researches have been conducted regarding the effect of floc characteristics on particle settling and water ***,the influence of floc characteristics on flotation has not been widely *** on the floc formation and flocculation flotation,this study reviews the fundamental physical characteristics of flocs from the perspectives of floc particle size and structure,summarizing the interaction between floc particle size and ***,it thoroughly discusses the effect of floc particle size and structure on floc floatability,further revealing the influence of floc characteristics on bubble collision and adhesion and elucidating the mechanisms of interaction between flocs and ***,it is observed that floc particle size is not the only factor influencing flocculation *** the appropriate apparent particle size range,flocs with a compact structure exhibit higher efficiency in bubble collision and adhesion during flotation,thereby resulting in enhanced flotation *** study aims to provide a reference for flocculation flotation,targeting the development of more efficient and refined flocculation flotation processes in the future.

关键词： flocs basic characteristics particle size and structure flotation laws bubbles

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Lateral-profile planning:Three-dimensional-profile-based optimal trajectory generation

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Science China(Technological Sciences) 2022年第12期65卷 3057-3068页

作者： ZHANG yuanLong xie yu BAO WeiMin College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China Science and Technology Committee of China Aerospace Science and Technology Corporation Beijing 100048China

The conventional re-entry guidance method considerably limits the maneuverability of hypersonic glide vehicles under pre-given angle-of-attack *** address this issue,based on a previous three-dimensional(3D)profile guidance method,we propose a lateral-profile-first 3D profile optimization design strategy to solve the trajectory generation problem under complex conditions involving multiple *** the traditional method,which prioritizes the design of the longitudinal drag acceleration profiles,our method first converted the re-entry flight constraints into a lateral flight corridor,generated the initial lateral profile via parameterization,and solved the 3D profile using the coupling relationship between the longitudinal and lateral *** design of the 3D profile requires simultaneous consideration of waypoints,no-fly zones,and altitude profiles;hence,a new 3D profile optimization design model was constructed,and a customized sequential quadratic programming algorithm was employed to solve *** advantages of the proposed method were demonstrated based on landing footprint results obtained using the lateral profile-first ***,simulation results based on the common aero vehicle-high-performance model verified the feasibility and effectiveness of the strategy.

关键词： hypersonic glide vehicle three-dimensional profile lateral profile-first planning optimal trajectory footprint

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Studies on sensitivity to tension and gating pathway of MscL by molecular dynamic simulation

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Acta Mechanica Sinica 2013年第2期29卷 256-266页

作者： Jun-yu xie Guang-Hong Ding Mechanics and Engineering Science Fudan University Shanghai Research Center of Acupuncture and Maridians

Mechanosensitive（MS） ion channels play an important role in various physiological *** the determination of the structure of mechanosensitive channel of large conductance（MscL） makes the simulation study possible,it has not so far been possible to directly simulate the gating mechanism of MscL in atomic *** this article,MscL has been studied via molecular dynamic（MD） simulations to gain a detailed description of the sensitivity to lateral tension and the gating *** undergoes conformational rearrangement in sustaining lateral tension,and the open state is obtained when 2.0 MPa lateral tension is directly applied on the pure *** the opening process,Loop region responds to tension first,and the mechanical sensitivity is followed by S1 ***（TM） bundle is the key position for channel opening,and the motion of TM1 helices finally realizes the significant expansion of the constricted gating pore.C-terminus domain presents expansion later during the TM *** our study,return of the whole protein to the initial closed state is achieved only in the early opening *** the relaxation from the open state,the TM helices are the most mobile domain,which is different from the opening process.

关键词： Molecular dynamic simulation·MscL·Lateral tension·Sensitivity·Gating pathway

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