检索结果-南通市图书馆

Chinese medicine yu-Ping-feng-San attenuates allergic inflammation by regulating epithelial derived pro-allergic cytokines

引用

Chinese Journal of Natural Medicines 2019年第7期17卷 525-534页

作者： WANG Xiao-Tong LIU Hai-Liang yu Xi WANG Can GUI Li-Li WANG Xiao-yu HUA Yong-Qing ZHENG Jie HONG Min Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese Medicine

This study aimed to investigate the mechanisms of yu-Ping-feng-San(YPFS) on attenuating allergic inflammation in the initial stage of atopic dermatitis(AD). AD mouse model was established with fluorescein isothiocyanate(FITC) sensitization and elicitation. Epithelial barrier structure was observed with transmission electron microscope. The populations of dendritic cells(DCs)and group 2 innate lymphoid cells(ILC2 s) were detected by flow cytometry. Human immortalized keratinocyte(Ha Ca T) cells were stimulated with Poly(I:C)/TNF-α in vitro to assess thymic stromal lymphopoietin(TSLP), interleukin(IL)-33 and nuclear factor-κB(NF-κB) levels or expressions by immunofluorescence, enzyme linked immunosorbent assay(ELISA) and western blot. In the initial stage of AD, ear swelling and infiltration of inflammatory cells in ear tissues were markedly attenuated with YPFS treatments. The damaged structures of ear epithelium and the increased levels of Th2-cytokines induced by FITC were significantly rescued in YPFS-treated mice. The production of pro-allergic cytokines, TSLP and IL-33, as well as the cell populations of their target cells DCs and ILC2 s were decreased in AD model, respectively. Likewise, the levels of TSLP and IL-33 in Poly(I:C)/TNF-α-stimulated HaCaT cells showed the same results. Lower levels of p-NF-κB were detected with YPFS treatment, and the expressions of TSLP and IL-33 could be further decreased with inhibiting of NF-κB. Therefore, YPFS attenuates allergic inflammation in the initial stage of AD probably through regulating NF-κB-TSLP/IL-33 pathway, which may provide a novel effective target for the prevention and treatment of allergic diseases.

关键词： yu-Ping-feng-San Allergic inflammation TSLP IL-33 NF-κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

引用

World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-Fang feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

巴西龟代谢性骨病CT诊断病例报告

引用

动物医学进展 2025年第1期46卷 141-144页

作者：孙嘉徐甘靖宇江蓝刘波俞峰中国农业大学北京100193

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检... 详细信息

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检结果提示其肾脏、肝脏功能损害,钙磷代谢异常。CT扫查提示患龟全身组织大面积矿化、背甲凹陷,定量测量患龟背椎骨、神经骨和胸膜骨3处的骨骼密度远低于正常龟,诊断患龟有严重的MBD。治疗方案为对症治疗、改善饲养管理条件,同时对该龟补充维生素D 3。该病例报告系统陈述了龟鳖MBD的诊疗流程,同时表明了CT扫查可为龟鳖MBD精确诊断、治疗和预后提供新的参考。

关键词：龟代谢性骨病计算机断层扫描骨密度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of vacuum degree and aeration rate on sludge dewatering behavior with the aeration-vacuum method

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第9期11卷 638-655页

作者： yu-feng GAO Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai University Nanjing 210098 China Geotechnical Research Institute Hohai University Nanjing 210098 China The Science and Technology Division Hohai University Nanjing 210098 China

Due to large-scale dredging operations, a large amount of sludge is inevitably produced. Large areas of land are occupied when the dredged sludge is discarded in the disposal site as waste material. The sludge dewatering with aeration-vacuum (SDAV) method is suit for treating the sludge with high water content and high clay content in the disposal site. The water in the sludge can be discharged out. The volume of the sludge can be reduced quickly, and the recycling of the land can be accelerated by this method. Most importantly, this technique is an efficient way to deal with clogging problems when pumping water from high water content, high clay content dredged sludge. Vacuum degree range tests, the aeration rate range tests, and the influencing factors of sludge dewatering behavior tests were conducted with a self-developed SDAV model test device. Sludge samples were taken from the South-to-North Water Diversion East Line Project in Huai’an White-Horse Lake disposal site, Jiangsu Province, China. The optimal range of vacuum degree and aeration rate were obtained through the test results, and the mechanisms for how the two factors work and how they affect the sludge dewatering behavior were analyzed. The suitable vacuum degree range in SDAV is below 50 kPa, and the suitable aeration rate is about 1.0 m3/h. The low-vacuum degree contributes to reduce the ad-sorption effect of micro-channels on soil particles in filter material and to maintain the arch structures. Aeration has the effects of expansion, disturbance, changing Reynolds number, and dynamic sieve separating. The pump quantity of water per meter of filter tube (m) has different change rules as the vacuum degree changes under different aeration rates. The reason is that the formed arch structures’ conformation and permeability differ greatly under different combined-conditions of vacuum degree and aeration rate. The optimal combined-condition for dewatering the sludge is 35 kPa with 1.0 m3/h.

关键词： High water content dredged sludge Sludge dewatering with aeration-vacuum (SDAV) Vacuum degree Aeration rate Arch structures

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ion channelopathy and hyperphosphorylation contributing to cardiac arrhythmias~1

引用

Acta Pharmacologica Sinica 2005年第8期26卷 918-925页

作者： feng yu Research Division of Pharmacology China Pharmaceutical University Nanjing 210009 China

The occurrence of cardiac an-hythmias is related to the abnormality of ion chan-nels not only in sarcolemma but also in the sarcoplasmic reticulum, which regu-lates the process of calcium release and up-take intracellularly. Patterns of ion channelopathy in the sarcolemma can be divided into single channel disorder from gene mutations and multiple channels disorder in a diseased hypertrophied heart. Abnormal RyR2, FKBP12.6, SERCA2a, and PLB are also involved in the initiation of cardiac arrhythmias. Maladjustment by hyperphosphorylation on the ion channels in the sarcolemma and RyR2-FKBP12.6 and SERCA2a-PLB is discussed. Hyperphosphorylation, which is the main abnormality upstream to ion channels, can be targeted for suppressing the deterioration of ion channelopathy in terms of new drug discovery in the treatment and prevention of malignant cardiac arrhythmias.

关键词： ion channels arrhythmia ryanodine receptor calcium release channel FKBP12.6 sarco-plasmic reticulum, phospholamban phos-phorylation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Character Formulas for a Class of Simple Restricted Modules over the Simple Lie Superalgebras of Witt Type

引用

Chinese Annals of Mathematics,Series B 2020年第1期41卷 49-60页

作者： yu-feng YAO Department of Mathematics Shanghai Maritime UniversityShanghai 201306China

Let F be an algebraically closed field of prime characteristic, and W(m, n, 1) be the simple restricted Lie superalgebra of Witt type over F, which is the Lie superalgebra of superderivations of the superalgebra ■(m;1) ■∧(n), where ■(m;1) is the truncated polynomial algebra with m indeterminants and ∧(n) is the Grassmann algebra with n indeterminants. In this paper, the author determines the character formulas for a class of simple restricted modules of W(m, n, 1) with atypical weights of type Ⅰ.

关键词： Restricted Lie superalgebra Witt type Lie superalgebra Restricted representation Typical(atypical) weight Character formula

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Macroscopic Regulation of Hierarchical Nanostructures in Liquid-crystalline Block Copolymers towards Functional Materials

引用

Chinese Journal of Polymer Science 2021年第4期39卷 397-416,I0004页

作者： feng Cai yu-Xuan Chen Wen-Zhong Wang Hai-feng yu Department of Materials Science and Engineering and Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of EngineeringPeking UniversityBeijing 100871China

The great potential of liquid-crystalline block copolymers(LCBCs)containing photoresponsive mesogens toward novel applications in photonics and nanotechnology has been attracting increasing attention,due to the combination of the inherent property of microphase separation of block copolymers and the hierarchically-assembled structures of liquid-crystalline polymers(LCPs).The periodically ordered nanostructures in bulk film of LCBCs can be acquired by supramolecular cooperative motion,derived from the interaction between liquid-crystalline elastic deformation and microphase separation,which are able to improve physical properties of polymer film toward advanced functional ***,various micro/nano-patterned structures have been fabricated via light manipulation of photoresponsive LCBCs with good reproducibility and mass *** to recent developments in synthesis and polymerization techniques,diverse azobenzene-containing LCBCs have been designed,resulting in the creation of a wide variety of novel *** review illustrates recent progresses in macroscopic regulation of hierarchical nanostructures in LCBCs towards functional *** existing challenges are also discussed,showing perspectives for future studies.

关键词： Liquid-crystalline block copolymers Microphase separation Hierarchical nanostructures Functional materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Complex Higher-Dimensional Lie Algebra with Real and Imaginary Structure Constants as Well as Its Decomposition

引用

Communications in Theoretical Physics 2008年第11期50卷 1021-1026页

作者： ZHANG yu-feng Mathematical School Liaoning Normal University Dalian 116029 China

A new Lie algebra G of the Lie algebra sl（2） is constructed with complex entries whose structure constants are real and imaginary numbers. A loop algebra G corresponding to the Lie algebra G is constructed, for which it is devoted to generating a soliton hierarchy of evolution equations under the framework of generalized zero curvature equation which is derived from the compatibility of the isospectral problems expressed by Hirota operators. Finally, we decompose the Lie algebra G to obtain the subalgebras G1 and G2. Using the G2 and its one type of loop algebra G2, a Liouville integrable soliton hierarchy is obtained, furthermore, we obtain its bi-Hamiltonian structure by employing the quadratic-form identity.

关键词： complex Lie algebra structure constant loop algebra bi-Hamiltonian structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Super and Weak Poincare Inequalities for Hypoelliptic Operators

引用

Acta Mathematicae Applicatae Sinica 2009年第4期25卷 617-630页

作者： feng-yu Wangt School of Mathematical Sciences and Lab. Math. Com. Sys. Beijing Normal University Beijing 100875 China Department of Mathematics Swansea University Singleton Park SA2 8PP Swansea UK

Sufficient conditions are presented for super/weak Poincare inequalities to hold for a class of hypoelliptic operators on noncompact manifolds. As applications, the essential spectrum and the convergence rate of the associated Markov semigroup are described for Gruschin type operators on R2 and Kohn-Laplacian type operators on the Heisenberg group.

关键词： Hypoelliptic operator super Poincare inequality essential spectrum weak Poincar~ inequality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Derivative formulas and Poincaré inequality for Kohn-Laplacian type semigroups

引用

Science China Mathematics 2016年第2期59卷 261-280页

作者： WANG feng-yu School of Mathematical Sciences Beijing Normal University Department of Mathematics Swansea University

As a generalization to the heat semigroup on the Heisenberg group, the diffusion semigroup generated by the subelliptic operator L :=1/2 sum from i=1 to m X_i^2 on R^(m+d):= R^m× R^d is investigated, where X_i(x, y) = sum (σki?xk) from k=1 to m+sum (((A_lx)_i?_(yl)) from t=1 to d,(x, y) ∈ R^(m+d), 1 ≤ i ≤ m for σ an invertible m × m-matrix and {A_l}_1 ≤ l ≤d some m × m-matrices such that the Hrmander condition *** first establish Bismut-type and Driver-type derivative formulas with applications on gradient estimates and the coupling/Liouville properties, which are new even for the heat semigroup on the Heisenberg group; then extend some recent results derived for the heat semigroup on the Heisenberg group.

关键词： Kohn-Laplacian type operator derivative formula Poincare inequality reverse Poincare inequality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：