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Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv Shu-Meng Han Li-yun He Zi-Yi Li yu-cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-yue Shang Ying Chen Meng Tian cheng-yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Translocation of Heterogeneous Flexible Polymers Assisted by Binding Particles

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Chinese Journal of Polymer Science 2020年第7期38卷 784-790,I0008页

作者： Wan-cheng yu Department of Physics School of PhysicsBeihang UniversityBeijing 100191China

A polymer chain usually contains two or more types of monomeric species from the perspective of polymer chemistry,which poses achallenge to the understanding of structure-property *** is of course true in the field of polymer *** the present work,Iinvestigate the translocation dynamics of heterogeneous flexible polymers composed of two types of monomers labeled A and B through ananopore assisted by binding particles(BPs)by using the coarse-grained Langevin dynamics simulations in two-dimensional ***,multiblock copolymers with different block lengths and monomeric components are considered.I critically examine how thetranslocation dynamics responds to the variations in the block length and the monomeric ***,it is found that the periodicstructure of a multiblock copolymer causes an obvious fingerprint feature in the residence time of individual monomers in which the number ofpeaks is exactly equal to the number of *** findings provide a basic understanding about the sequence-dynamics relationship for theBPs-assisted translocation of heterogeneous flexible polymers.

关键词： Polymer translocation Multiblock copolymer Binding particles Langevin dynamics simulations

Improved concept models for straight thin-walled columns with box cross section

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1473-1479页

作者： yu-cheng LIU Department of Mechanical Engineering University of Louisville Louisville KY40292 USA

This paper focuses on developing improved concept models for straight thin-walled box sectional columns which can better predict the peak crushing force that occurs during crashworthiness analyses. We develop a nonlinear translational spring based on previous research and apply such a spring element to build the enhanced concept models. The work presented in this article is developed on the basis of the publication of the author (Liu and Day, 2006b) and has been applied in a crashworthiness design issue, which is presented by the author in another paper (Liu, 2008).

关键词： Concept model Peak crushing force Box section Nonlinear translational springs Crashworthiness analysis Thin-walled column

Spectroscopy of X-Ray-Boosted Photoionization with an Intense Laser Pulse

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Chinese Physics Letters 2013年第8期30卷 50-53页

作者： GE yu-cheng School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871

The present study shows that x-ray photoionization in the presence of an intense laser pulse has interesting energetic and statistical properties due to field modulation and interference between *** spectral cut-off energies,integral,and double integral reflect the strength,time,and interference of the laser field *** methods are proposed for precise intense-laser-pulse measurement in *** methods have the advantages of accuracy,simplicity,speed,and large dynamic ranges.

关键词： laser pulse intense

The Commutant of Analytic Toeplitz Operators on Bergman Space

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Acta Mathematica Sinica,English Series 2008年第10期24卷 1737-1750页

作者： yu cheng LI Department of Mathematics Hebei Normal University Shijiazhuang 050016 P. R. China

In this paper, using the matrix skills and operator theory techniques we characterize the commutant of analytic Toeplitz operators on Bergman space. For f（z） = z^ng（z）（n ≥1）, g（z） = b0 ＋ b1z^p1 ＋b2z^p2 ＋.. , bk ≠ 0 （k = 0, 1, 2,...）, our main result is =A′（Mf） = A′（Mzn）∩A′（Mg） = A′（Mz^s）, where s = g.c.d.（n,p1,p2,...）. In the last section, we study the relation between strongly irreducible curve and the winding number W（f,f（α））, α ∈ D.

关键词： Bergman space analytic Toeplitz operator commutant strong irreducibility

Effect of acupressure on postpartum low back pain, salivary cortisol, physical limitations, and depression: a randomized controlled pilot study

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Journal of Traditional Chinese Medicine 2020年第1期40卷 128-136页

作者： cheng Hsuesh-yu Carol Shieh Wu Bei-yu cheng yu-Fen Department of Nursing Kaohsiung Chang Gung Memorial HospitalKaohsiung 80830Taiwan China Department of Community and Health Systems Indiana University School of NursingIndiana 600USA Department of Chinese Medicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 80830Taiwan China

OBJECTIVE:To investigate the effect of acupressure on postpartum low back pain(LBP),salivary cortisol,physical limitations,and postpartum ***:Participants were 70 postpartum women who were randomly assigned to either an intervention(n=35)or a control(n=35)*** intervention group received 10 acupressure sessions(1 session per day,5 d per week).The control group received 10 sham acupressure *** were assessed using a visual analogue scale(LBP intensity),salivary cortisol values(LBP biomarker),and Chinese versions of the Roland-Morris Disability Questionnaire(daily activity limitations),Oswes-try Disability Index(physical activity limitations),and the Edinburgh Postnatal Depression Scale(postpartum depression).RESULTS:Participants in the intervention group had significantly lower levels of LBP intensity,daily activity limitations,physical activity limitations,and postpartum depression than those in the control *** was no significant between-group difference in salivary ***:Acupressure may reduce postpartum LBP intensity and limitations in daily and physical activity,and alleviate postpartum depressive *** should be offered in postpartum care settings as an alternative treatment for postpartum women with LBP.

关键词： Acupressure Low back pain Postpartum period Depression Randomized controlled trial Pilot projects

The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury

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Neural Regeneration Research 2023年第11期18卷 2482-2488页

作者： Zhengran yu Xing cheng Wenxu Pan cheng yu Yang Duan Department of Spine Surgery Orthopedics Center of Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Gastroenterology Guangzhou Women and Children’s Medical CenterJinan UniversityGuangzhouGuangdong ProvinceChina Department of Spine Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Chronic compressive spinal cord injury in compressive cervical myelopathy conditions can lead to rapid neurological deterioration in the early phase,followed by partial self-recovery,and ultimately an equilibrium state of neurological *** is a crucial pathological process in many neurodegenerative diseases;however,its role in chro nic compressive spinal cord injury remains *** this study,we established a chronic compressive spinal cord injury rat model,which displayed its most severe behavioral and electrophysiological dysfunction at 4 wee ks and partial recovery at 8 weeks after *** RNA sequencing data identified enriched functional pathways,including ferroptosis,presynapse,and postsynaptic membrane activity at both 4 and 8 wee ks following chro nic compressive spinal co rd *** nsmission electron microscopy and malondialdehyde quantification assay confirmed that ferroptosis activity peaked at 4 weeks and was attenuated at 8 weeks after chronic *** ptosis activity was negatively correlated with behavioral ***,quantitative polymerase chain reaction,and western blotting showed that expression of the anti-ferroptosis molecules,glutathione peroxidase 4(GPX4) and MAF BZIP transcription factor G(MafG),in neuro ns was suppressed at 4 weeks and upregulated at 8 weeks following spinal co rd *** was a positive correlation between the expression of these two molecules,suggesting that they may work together to contribute to functional recovery following chronic compressive spinal cord *** conclusion,our study determined the genome-wide expression profile and fe rroptosis activity of a consistently compressed spinal cord at different time *** results showed that anti-fe rroptosis genes,specifically GPX4 and MafG,may be involved in spontaneous neurological recovery at 8 weeks of chronic compressive spinal cord *** findings contribute to a better understanding of t

关键词： chronic spinal cord compression compressive cervical myelopathy ferroptosis genome-wide transcriptome glutathione peroxidase 4(GPX4) MAF BZIP transcription factor G(MafG) neurological function

NUMERICAL SI MULATION OF MOVING SCOUR BOUNDARY AND TURBULENCE FLOWAROUND SUBMARINE PIPELINES

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Journal of Hydrodynamics 2005年第4期17卷 404-411页

作者： LI yu-cheng LU Lin State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

A two dimensional vertical mathematical model is proposed in this paper for simulating the equilibrium profile of local scour around submarine pipelines. The current model is composed of a new k-ε turbulence model, fitting moving boundary with pre-meshed grid lines and incipient criterion of shear stress for sediments. Employing the proposed model, an instance is carried out numerically and compared with experiments. The calculation results agree well with the experiments. It shows that the improved two equation turbulence model, adopted in this paper is appropriate to simulating the turbulent flow ficld around submarine pipelines, fitting moving boundary with pre-mcshed grid lines method is efficient for moving boundary problems in a multiply connected domain and the stability evaluation method for seabed with critical shear stress based on log-wall law is a reliable choice.

关键词： numerical simulation submarine pipeline local scour moving boundary turbulence model