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Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, China

Biomedical and Environmental Sciences 2020年第5期33卷 306-314页

作者： DONG Shi Rui HAN Ya Jing wu Jing ZENG Cheng Li ZHU Ke Hui CHEN Xiao Jing LIU yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan WANG Yao HUANG Xiu Xia DU Xiu Ben HAO jian Lei WANG Huan yu GUO Shu JING Chun Xia YANG Guang Department of Pathogen Biology School of MedicineJinan UniversityGuangzhou 510632GuangdongChina Guangdong Key Laboratory of Environmental Pollution and Health Jinan UniversityGuangzhou 510632GuangdongChina Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655GuangdongChina Department of Epidemiology School of MedicineJinan UniversityGuangzhou 510632GuangdongChina Zhuhai Precision Medical Center Zhuhai People's Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai 519000GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou 510632GuangdongChina Department of Viral Encephalitis National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China The Key Laboratory for Virology of Guangzhou College of Life Science and TechnologyJinan UniversityGuangzhou 510632GuangdongChina

Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very *** study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in *** In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h *** 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput *** Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between Beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in *** In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics.

关键词： China. Guangzhou Particulate

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汽车油箱漏油的X射线成像分析方法

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失效分析与预防 2024年第4期19卷 258-263页

作者：郭兆丰刘玲玲敖波吴凌峰邹智健无损检测技术教育部重点实验室(南昌航空大学) 南昌330063 江铃汽车股份有限公司南昌330001

汽车金属油箱由薄不锈钢板经电阻焊工艺焊接而成,焊缝质量直接影响油箱的安全性和可靠性。本研究提出一种基于X射线成像的油箱焊缝漏油快速分析方法,即先采用微焦点射线数字成像(DR)对油箱焊缝漏油进行初步筛选,确定是否存在缺陷,再对... 详细信息

汽车金属油箱由薄不锈钢板经电阻焊工艺焊接而成,焊缝质量直接影响油箱的安全性和可靠性。本研究提出一种基于X射线成像的油箱焊缝漏油快速分析方法,即先采用微焦点射线数字成像(DR)对油箱焊缝漏油进行初步筛选,确定是否存在缺陷,再对含缺陷的焊缝进行显微计算机层析成像(CT),最后依据三维重建结果评估缺陷贯穿性。对2个汽车油箱电阻焊焊缝试样进行漏油分析,DR检测出2个焊缝试样分别含9、7处缺陷;显微CT的切片图像显示,试样缺陷中分别有6、1处贯穿型裂纹缺陷,这些裂纹均可能是油箱漏油点。对CT重建的缺陷进行三维分割和尺寸测量,试样缺陷尺寸分别为1.0~2.4、0.6~2.5 mm。对三维分割的缺陷进行内部可视化处理,结果与切片图像分析结果一致。本文所提方法可有效减少高精度CT检测资源的浪费,缩短漏油分析所需的时间,对于焊缝质量分析具有可靠性和安全性。

关键词：电阻焊射线数字成像显微计算机层析成像三维可视化

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基于DCT和维纳滤波的图像PRNU匿名算法

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刑事技术 2024年第4期49卷 350-358页

作者：李健赵欢欢马宾王春鹏吴晓明张晓波算力互联网与信息安全教育部重点实验室济南250300 济南250300

随着智能手机和社交媒体的普及,图像隐私引起的公共安全问题受到了广泛关注。犯罪分子可利用图像信息来侵犯他人隐私,从而进行恶意跟踪和诈骗勒索等活动。针对该问题,本研究从抑制图像源相机识别能力的角度提出了一种新的光响应非均匀性... 详细信息

随着智能手机和社交媒体的普及,图像隐私引起的公共安全问题受到了广泛关注。犯罪分子可利用图像信息来侵犯他人隐私,从而进行恶意跟踪和诈骗勒索等活动。针对该问题,本研究从抑制图像源相机识别能力的角度提出了一种新的光响应非均匀性(photo response non uniformity,PRNU)匿名算法,以降低图像被恶意使用的风险。算法首先对图像进行分块,并将离散余弦变换(discrete cosine transform,DCT)和维纳滤波相结合,对图像高频分量进行滤波处理。通过实验发现,迭代维纳滤波可以显著提高匿名算法的效率。将算法在MICHE-I数据集和UBIPR虹膜数据集中进行测试,结果表明,算法能够保证图像质量不受显著影响,并且视觉质量因子平均提高3 dB,有效地抑制了图像溯源能力,保留图像生物特征,并达到了较好的匿名效果,保证了大众隐私安全。

关键词：光响应非均匀性匿名离散余弦变换(DCT) 维纳滤波

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原发性肾病综合征儿童血清Apelin-13 FOXO1表达水平及其临床意义

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山西医药杂志 2024年第11期53卷 813-818页

作者：陆彩霞钟余楷刘健吴亲芳何欢刘兴元上海市杨浦区控江医院儿科上海200093 同济大学附属同济医院儿科

目的探究原发性肾病综合征儿童血清Apelin-13、FOXO1表达水平及其临床意义。方法选取2019年1月至2022年12月在本院收治的183例原发性肾病综合征儿童作为研究组。另选取同时期在本院体检的185名体检健康的儿童作为对照组,苏木精-伊红(ELI... 详细信息

目的探究原发性肾病综合征儿童血清Apelin-13、FOXO1表达水平及其临床意义。方法选取2019年1月至2022年12月在本院收治的183例原发性肾病综合征儿童作为研究组。另选取同时期在本院体检的185名体检健康的儿童作为对照组,苏木精-伊红(ELISA)法检测血清Apelin-13、FOX-O1水平;采用Pearson法分析Apelin-13、FOXO1水平与血脂指标的关系;使用受试者工作特征(ROC)曲线分析Apelin-13、FOXO1对原发性肾病综合征的诊断价值;多因素Logistic回归分析影响原发性肾病综合征发生的危险因素。结果与对照组比较,研究组患儿血清Apelin-13水平降低,甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(apo)B、FOXO1水平升高(P<0.05);与研究组治疗前比较,治疗后血清Apelin-13水平升高,TG、TC、LDL-C、apoB、FOXO1水平降低(P<0.05);Pearson相关性分析表明,原发性肾病综合征患儿血清Apelin-13与TG、TC、LDL-C、apoB均呈负相关,FOXO1与TG、TC、LDL-C、apoB均呈正相关(P<0.05);ROC曲线分析表明,Apelin-13、FOXO1诊断原发性肾病综合征发生的曲线下面积(AUC)为0.795、0.734,二者联合诊断的AUC为0.920;多因素Logistic回归分析显示,Apelin-13与FOX-O1是影响原发性肾病综合征发生的危险因素。结论原发性肾病综合征儿童血清Apelin-13呈低表达、FOXO1呈高表达,二者与血脂水平有关,并且对原发性肾病综合征具有一定的诊断价值。

关键词：原发性肾病综合征 Apelin-13 叉头框转录因子O亚族1 血脂

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TOD宽间隔混沌调制跳变图案设计

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北京邮电大学学报 2009年第6期32卷 77-82页

作者：邰能建吴德伟吴杰于丽娜空军工程大学电讯工程学院西安710077 海军航空工程学院电子与信息工程系山东烟台264001

为增强调制跳变技术的抗截获性能,提出一种基于时间信息(TOD)的宽间隔混沌调制跳变图案设计方法.针对周期抽取法构造的混沌跳变序列在均衡性方面的缺陷,提出采用改进的周期抽取与多比特抽取结合的方法产生迭代式TOD混沌跳变序列,并分析... 详细信息

为增强调制跳变技术的抗截获性能,提出一种基于时间信息(TOD)的宽间隔混沌调制跳变图案设计方法.针对周期抽取法构造的混沌跳变序列在均衡性方面的缺陷,提出采用改进的周期抽取与多比特抽取结合的方法产生迭代式TOD混沌跳变序列,并分析验证了该方法良好的均衡性.为进一步完善抗截获性能,采用对偶法和随机平移替代法对跳变图案进行宽间隔处理.仿真结果表明,对偶法在长周期条件下的性能优于随机平移法,适用于产生正常通信使用的调制跳变图案;随机平移法在最大有效周期长度范围内具有很好的均衡性,适用于短周期突发通信.

关键词：抗截获通信调制跳变调制跳变图案混沌宽间隔

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Downregulation of NADPH-cytochrome P450 reductase via RNA interference increases the susceptibility of Acyrthosiphon pisum to desiccation and insecticides

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Insect Science 2022年第4期29卷 1105-1119页

作者： jian-Wen Qiao Yong-Liang Fan Bing-Jin wu Tian-Tian Bai Ying-Hao Wang Zhan-Feng Zhang Dun Wang Tong-Xian Liu State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYanglingShaanxi ProvinceChina Key Lab of Integrated Crop Pest Management of Shandong Province College of Plant Health and MedicineQingdao Agricultural UniversityQingdaoShandong ProvinceChina

Nicotinamide adenine dinucleotide phosphate(NADPH)-cytochrome P450 reductase(CPR)is involved in the metabolism of endogenous and exogenous substances,and detoxification of *** interference(RNAi)of CPR in certain insects causes developmental defects and enhanced susceptibility to ***,the CPR of Acyrthosiphon pisum has not been characterized,and its function is still not *** this study,we investigated the biochemical functions of *** CPR(ApCPR).ApCPR was found to be transcribed in all developmental stages and was abundant in the embryo stage,and in the gut,head,and abdominal *** optimizing the dose and silencing duration of RNAi for downregulating ApCPR,we found that ApCPR suppression resulted in a significant decrease in the production of cuticular and internal hydrocarbon contents,and of cuticular waxy *** in cuticular hydrocarbons(CHCs)decreased the survival rate of *** under desiccation stress and increased its susceptibility to contact ***,desiccation stress induced a significant increase in ApCPR mRNA *** further confirmed that ApCPR participates in CHC *** results indicate that ApCPR modulates CHC production,desiccation tolerance,and insecticide susceptibility in ***,and presents a novel target for pest control.

关键词： Acyrthosiphon pisum desiccation tolerance lhydrocarbon insecticide sus-ceptibility NADPH-cytochrome P450 reductase

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Magnetic brain stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice

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Zoological Research 2020年第4期41卷 381-394页

作者： Qing-Bo Lu jian-Fei Sun Qu-Yang Yang Wen-Wen Cai Meng-Qin Xia Fang-Fang wu Ning Gu Zhi-Jun Zhang Department of Neurology Affiliated Zhongda HospitalSchool of MedicineInstitution of NeuropsychiatrySoutheast UniversityNanjingJiangsu 210009China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210009China

Magnetic brain stimulation has greatly contributed to the advancement of ***,challenges remain in the power of penetration and precision of magnetic stimulation,especially in small ***,a novel combined magnetic stimulation system(c-MSS)was established for brain stimulation in *** c-MSS uses a mild magnetic pulse sequence and injection of superparamagnetic iron oxide(SPIO)nanodrugs to elevate local cortical *** imaging of the SPIO nanoparticles in the left prelimbic(Pr L)cortex in mice,we determined their safety and physical ***-like behavior was established in mice using a chronic unpredictable mild stress(CUMS)*** nanodrugs were then delivered precisely to the left Pr L cortex using in situ injection.A 0.1 T magnetic field(adjustable frequency)was used for magnetic stimulation(5 min/session,two sessions daily).Biomarkers representing therapeutic effects were measured before and after c-MSS *** showed that c-MSS rapidly improved depressive-like symptoms in CUMS mice after stimulation with a 10 Hz field for 5 d,combined with increased brainderived neurotrophic factor(BDNF)and inactivation of hypothalamic-pituitary-adrenal(HPA)axis function,which enhanced neuronal activity due to SPIO nanoparticle-mediated *** c-MSS was safe and effective,representing a novel approach in the selective stimulation of arbitrary cortical targets in small animals,playing a bioelectric role in neural circuit regulation,including antidepressant effects in CUMS *** expands the potential applications of magnetic stimulation and progresses brain research towards clinical application.

关键词： oxide injection drugs

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装备战场抢修的任意随机Petri网建模及仿真

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系统仿真学报 2007年第24期19卷 5651-5653,5658页

作者：刘勇武昌林健曾玉君空军工程大学电讯工程学院陕西西安710077

基于任意分布随机Petri网(ASPN),建立了装备战场抢修系统的ASPN模型。利用ARENA通用仿真平台,对装备战场抢修系统的ASPN模型进行仿真,得出了一些有价值的结论。仿真的结果与实际情况吻合,充分验证了模型的正确性。仿真的结论可为装备战... 详细信息

基于任意分布随机Petri网(ASPN),建立了装备战场抢修系统的ASPN模型。利用ARENA通用仿真平台,对装备战场抢修系统的ASPN模型进行仿真,得出了一些有价值的结论。仿真的结果与实际情况吻合,充分验证了模型的正确性。仿真的结论可为装备战场抢修的决策阶层提供决策支持,对提高我军装备维修保障能力,实现经济型维修保障,具有重要的意义。

关键词：随机Petri网任意分布战场抢修仿真

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Trends of Oral Cancer Mortality in China from 1990 to 2019 and a 15-Year Predictive Analysis Based on a Bayesian Age-Period-Cohort Model

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Biomedical and Environmental Sciences 2023年第6期36卷 553-556页

作者： GU jian Chang SONG Ji wu LIU yun WANG Xiao Lan XU Shuang Shuang ZHANG Liang Liang LIU yun Xia DING Gang School of Stomatology Weifang Medical UniversityWeifang 261053ShandongChina Department of Stomatology Weifang People’s HospitalFirst Affiliated Hospital of Weifang Medical UniversityWeifang 261053ShandongChina Department of Dentistry Affiliated Hospital of Weifang Medical UniversityWeifang 261035ShandongChina

Oral cancer is the most common malignant tumor of the head and *** is characterized by high rates of recurrence and distant metastasis and usually has a poor *** advances in cancer diagnosis and treatment,the overall ... 详细信息

关键词： diagnosis cancer Cancer

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A national report from China Liver Transplant Registry: steroid avoidance after liver transplantation for hepatocellular carcinoma

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Chinese Journal of Cancer Research 2017年第5期29卷 426-437页

作者： Qiang Wei Feng Gao Runzhou Zhuang Qi Ling Qinghong Ke jian wu Tian Shen Mangli Zhang Min Zhang Xiao Xu Shusen Zheng Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Division of Hepatobiliary and Pancreatic Surgery Department of Surgery the First Affiliated Hospital Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

Objective：We aimed to evaluate the efficacy and safety of steroid-free immunosuppression after liver transplantation（LT）for hepatocellular carcinoma（HCC）.Methods：We retrospectively analyzed HCC recipients without steroids after LT（SF group,n=368）based on the China Liver Transplant Registry（CLTR）*** recipients were matched 1：2 with patients using steroids（S group,n=736）for the same period after LT for HCC,according to propensity ***：Multivariate analysis indicates that recipients with younger age[odds ratio（OR）,1.053;P=0.011],preoperative hepatitis B virus（HBV）DNA≥1,000 copies/mL（OR,2.597;P=0.004）and beyond Milan criteria（OR,4.255;P〈0.001）were identified as the risk factors associated with tumor recurrence in steroid avoidance recipients after *** patients fulfilling the Milan criteria in the SF group presented higher overall and tumor-free survival rates than those in the S group（P〈0.05）.Multivariate analysis revealed that recipient beyond Milan criteria was an independent prognostic factor for overall survival（OR,1.690;P〈0.001）and tumor-free survival（OR,2.066;P〈0.001）.The incidences of new-onset diabetes mellitus（21.20% vs.33.29%,P〈0.001）,new-onset hypertension（10.05%vs.18.61%,P〈0.001）and hyperlipidemia（4.08% vs.7.20%,P=0.042）were significantly lower in the SF ***：Steroid-free immunosuppression could be safe and feasible for HBV-related HCC patients in ***,HBV DNA level and Milan criteria maybe risk factors associated with tumor recurrence in steroid avoidance *** beyond Milan criteria was an independent prognostic factor and recipient fulfilling Milan criteria can benefit the most from steroid-free immunosuppression.

关键词： Steroid liver transplantation hepatocellular carcinoma

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