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Risk factors and classifications of hilar cholangiocarcinoma

World Journal of Gastrointestinal Oncology 2013年第7期5卷 132-138页

作者： Miguel Angel Suarez-Munoz Jose Luis Fernandez-Aguilar Belinda Sanchez-Perez Jose Antonio Perez-Daga Beatriz Garcia-Albiach ysabel pulido-roa Naiara Marin-Camero Julio Santoyo-Santoyo General Digestive and Transplantation Surgery Service HPB and Liver Transplant UnitUniversity Hospital Carlos Haya29010 MalagaSpain

Cholangiocarcinoma is the second most common primary malignant tumor of the *** cholangiocarcinoma or Klatskin tumor represents more than 50% of all biliary tract cholangiocarcinomas.A wide range of risk factors have been identified among patients with Perihilar cholangiocarcinoma including advanced age,male gender,primary sclerosing cholangitis,choledochal cysts,cholelithiasis,cholecystitis,parasitic infection(Opisthorchis viverrini and Clonorchis sinensis),inflammatory bowel disease,alcoholic cirrhosis,nonalcoholic cirrhosis,chronic pancreatitis and metabolic *** classifications have been used to describe the pathologic and radiologic appearance of *** three systems most commonly used to evaluate Perihilar cholangiocarcinoma are the Bismuth-Corlette(BC) system,the Memorial Sloan-Kettering Cancer Center and the TNM *** BC classification provides preoperative assessment of local *** Memorial Sloan-Kettering cancer center proposes a staging system according to three factors related to local tumor extent:the location and extent of bile duct involvement,the presence or absence of portal venous invasion,and the presence or absence of hepatic lobar *** TNM classification,besides the usual descriptors,tumor,node and metastases,provides additional information concerning the possibility for the residual tumor(R) and the histological grade(G).Recently,in 2011,a new consensus classification for the Perihilar cholangiocarcinoma had been *** consensus was organised by the European Hepato-PancreatoBiliary Association which identified the need for a new staging system for this type of *** classification includes information concerning biliary or vascular(portal or arterial) involvement,lymph node status or metastases,but also other essential aspects related to the surgical risk,such as remnant hepatic volume or the possibility of underlying disease.

关键词： Hilar cholangiocarcinoma Klatskin tumor Perihilar cholangiocarcinoma Bile duct cancer

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Fast-track program in laparoscopic liver surgery:Theory or fact?

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World Journal of Gastrointestinal Surgery 2012年第11期4卷 246-250页

作者： Belinda Sánchez-Pérez José Manuel Aranda-Narváez Miguel Angel Suárez-Muoz Moises elAdel-delFresno José Luis Fernández-Aguilar Jose Antonio Pérez-Daga ysabel pulido-roa Julio Santoyo-Santoyo Department of General Digestive and Transplantation SurgeryUniversity Regional Hospital Carlos Haya29010 MálagaSpain

AIM:To analyze our results after the introduction of a fast-track(FT) program after laparoscopic liver surgery in our Hepatobiliarypancreatic ***:All patients(43) undergoing laparoscopic liver surgery between March 2004 and March 2010 were included and divided into two consecutive groups:Control group(CG) from March 2004 until December 2006 with traditional perioperative cares(17 patients) and fast-track group(FTG) from January 2007 until March 2010 with FT program cares(26 patients).Primary endpoint was the influence of the program on the postoperative stay,the amount of re-admissions,morbidity and *** we considered duration of surgery,use of drains,conversion to open surgery,intensive cares needs and ***:Both groups were homogeneous in age and *** differences in technique,time of surgery or conversion to open surgery were found,but more malignant diseases were operated in the FTG,and then transfusions were higher in *** and morbidity were similar in both groups,without *** stay was similar,with a median of 3 for CG vs 2.5 for ***,the 80.8% of patients from FTG left the hospital within the first 3 d after surgery(58.8% for CG).CONCLUSION:The introduction of a FT program after laparoscopic liver surgery improves the recovery of patients without increasing complications or re-admissions,which leads to a reduction of the stay and costs.

关键词： Liver surgery Laparoscopy Fast-track

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Extra dimensions and atomic transition frequencies

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Chinese Physics B 2008年第1期17卷 70-75页

作者：李志刚倪维斗 Antonio pulido Patón Center for Gravitation and Cosmology Purple Mountain ObservatoryChinese Academy of Sciences

New unification theories predict large extra dimensions （LEDs）. If that is the case, gravity would be stronger at short ranges than what Newtonian gravity predicts. LEDs could also have effects at atomic level. In this paper we propose a new method to constrain the size of ‘gravity-only’ LEDs by analysing how these LEDs modify the energy of the atomic transitions 1s-2s and 2s-2p （Lamb shift）, in the particular case of the hydrogen and muonium atoms. We estimate these effects by using Bethe＇s non-relativistic treatment of Lamb shift. In the particular case of three LEDs, which may be a candidate to explain the interaction mechanism of dark matter particles, we have found that current knowledge in atomic spectroscopy could constrain their sizes to less than 10 μm. Although our contributions do not reach the sensitivity given by SN1987a, they are still slightly better than recent constraints given by Inverse Square Law tests of the Eoet-Wash group at Washington University, which gave R3 〈 36.6 μm.

关键词： large extra dimensions Lamb shift atomic spectroscopy

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comIntraspecific variation in heritable secondary metabolites and defensive strategies in a relict tree

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Journal of Plant Ecology 2018年第2期11卷 256-265页

作者： Adara Pardo Yonatan Cáceres Fernando pulido Institute for Dehesa Research(INDEHESA) University of ExtremaduraPlasenciaSpain

Aims Key herbivory interaction traits such as plant defensive compounds may differ among populations of a single species due to the spatial variation in herbivore feeding guilds and the strength of the ***,the genealogy of population lineages could represent an additional source of variation interacting with the predominant eco-clinal *** tested for the existence of genetically based intraspecific variation in chemical defence profiles across the range of the relict tree Prunus lusitanica ***,we investigated geographical variation in defence inducibility and tested for the exist-ence of a trade-off between qualitative and quantitative *** We conducted a greenhouse experiment where 210 plants were grown under a common environment,comprising 10 different pop-ulations throughout the distribution range of the species and span-ning three separate regions:iberia,Morocco and *** test for the inducibility of defences,we artificially defoliated *** treatments were established within each population:undam-aged,defoliated and sampled after 2 h,and defoliated and sampled after 72 *** concentration of cyanogenic glycosides(prunasin)and phenolics was determined in leaf samples for all *** findings Basal levels of cyanogenics and phenolics significantly differed among populations and regions across the range of ***,with this variation having a heritable ***(pruna-sin)were significantly higher in ancient Macaronesian populations,while phenolic concentrations were larger in *** higher cyanogenic levels found in Macaronesia could be a consequence of the known stronger herbivory pressure in the islands than in iberia or the likely longer coevolutionary history with herbivores in this *** findings indicate that the geographical variation of key ecological traits such plant chemical defences can be imprinted by phylogeographical signals,particularly in relict spe

关键词： herbivory intraspecific variation phylogeography plant defences relict flora

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Robust Disturbance Rejection Based Control with Extended-state Resonant Observer for Sway Reduction in Uncertain Tower-cranes

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International Journal of Automation and computing 2019年第6期16卷 812-827页

作者： Horacio Coral-Enriquez Santiago pulido-Guerrero John Cortés-Romero Programa de Ingeniería Mecatrónica Facultad de IngenieríaUniversidad de San Buenaventura sede BogotáCra.8H No 172-20 Edif.DBBogotáOf204Colombia Departamento de Ingeniería Eléctrica y Electrónica Facultad de IngenieríaUniversidad Nacional de Colombia sede BogotáCra.30 No 45-03 Edif.453BogotáOf222Colombia

In this paper, the problem of load transportation and robust mitigation of payload oscillations in uncertain tower-cranes is addressed. This problem is tackled through a control scheme based on the philosophy of active-disturbance-rejection. Here, a general disturbance model built with two dominant components: polynomial and harmonic, is stated. Then, a disturbance observer is formulated through state-vector augmentation of the tower-crane model. Thus, better performance of estimations for system states and disturbances is achieved. The control law is then formulated to actively reject the disturbances but also to accommodate the closed-loop system dynamics even under system uncertainty. The proposed control schema is validated via experimentation using a small-scale tower-crane,and compared with other relevant active disturbance rejection control(ADRC)-based techniques. The experimental results show that the proposed control scheme is robust under parametric uncertainty of the system, and provides improved attenuation of payload oscillations even under system uncertainty.

关键词： Active disturbance rejection control(ADRC) extended state observer(ESO) tower-crane control resonant observer disturbance observer linear matrix inequality

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Comparative Analysis of Different Evaluation Functions for Protein Structure Prediction Under the HP Model

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Journal of Computer Science & Technology 2013年第5期28卷 868-889页

作者： Mario Garza-Fabre Eduardo Rodriguez-Tello Gregorio Toscano-pulido Information Technology Laboratory CINVESTAV-Tamaulipas Km.5.5 Carretera Ciudad Victoria-Soto La Marina 87130 Ciudad Victoria Tamaulipas México

The HP model for protein structure prediction abstracts the fact that hydrophobicity is a dominant force in the protein folding process. This challenging combinatorial optimization problem has been widely addressed through metaheuristics. The evaluation function is a key component for the success of metaheuristics; the poor discrimination of the conventional evaluation function of the HP model has motivated the proposal of alternative formulations for this component. This comparative analysis inquires into the effectiveness of seven different evaluation functions for the HP model. The degree of discrimination provided by each of the studied functions, their capability to preserve a rank ordering among potential solutions which is consistent with the original objective of the HP model, as well as their effect on the performance of local search methods are analyzed. The obtained results indicate that studying alternative evaluation schemes for the HP model represents a highly valuable direction which merits more attention.

关键词： evaluation function protein structure prediction metaheuristics combinatorial optimization bioinformatics

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Influence of local and landscape environmental factors on alpha and beta diversity of macroinvertebrates in Andean rivers

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Journal of Mountain Science 2023年第9期20卷 2487-2501页

作者： DIAZ-ROJAS Camila A PEDROZA-RAMOS Adriana X BARRERA-HERRERA July A roa-FUENTES Camilo A Ecology Unit in Aquatic Systems Research Group Pedagogical and Technological University of ColombiaUPTCAvenida Central del Norte 39-115TunjaBoyacáColombia

Research on macroinvertebrate community structure in Andean rivers has been oriented towards describing patterns of alpha and gamma diversity by taking into account environmental predictors at local spatial scales(e.g.,micro-and mesohabitats).However,the patterns of beta diversity and the importance of landscape-scale variables have been evaluated to a lesser *** objective of this study was to describe the patterns of alpha and beta diversity of benthic macroinvertebrates in the Andean rivers of the Orinoco basin and their relationship with local and landscape environmental variation.A stratified random sampling of macroinvertebrates was carried out at 40 sites(comprising an altitudinal range of between 500 and 2900 m.a.s.l.),local and landscape variables were *** results showed that the variation of alpha diversity was influenced by local and landscape variables,which are directly and indirectly related to the contribution of sediments,substrate composition and flow velocity,providing a heterogeneity of *** beta diversity was explained by the combined effect of local and landscape *** the beta diversity phenomena,turnover was predominant while nestedness presented a minor contribution and both were explained in greater proportion by local descriptors and some landscape variables,specifically those of a geomorphological *** results concur with the view of an environmental and spatial hierarchy within the river habitat and highlight the influence of multiple scales on macroinvertebrate *** above suggests that both local and landscape scales must necessarily be considered for environmental management and the conservation of Andean lotic ecosystems.

关键词： Andean lotic systems Andean agroecosystems Instream habitat Landcover Turnover Nestedness

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Recovering information in probabilistic quantum teleportation

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Frontiers of physics 2019年第6期14卷 9-13页

作者： Luis roa Andrea Espinoza Ariana Munoz Maria L·Ladron de Guevara Departamento de Física Universidad de ConcepciónCasilla 160-CConcepciónChile Departamento de Física Universidad Católica del NorteAngamos 0610AntofagastaChile Facultad de Ingeniería Universidad Autónoma de Chile5 Poniente 1670TalcaChile

In this paper we redesign the probabilistic teleportation scheme considered in ***.A 61,034301(2000)by Wan-Li Li et al.,where the optimal state extraction protocol complements the basic teleportation process with a partially entangled pure state channel,in order to transfer the unknown state with fidelity *** that scheme,where the information of the unknown state is lost if the state extraction fails,our proposal teleports exactly and optimally an unknown state,and allows to recover faithfully that state when the process has not *** order to study the resilience of the scheme,we apply it to the teleportation problem through a quantum channel in a mixed state with pure *** find that a successful process transfers an unfaithful state,namely,the outcome state acquires the decoherence of the channel,but the unknown state is recovered by the sender with fidelity 1 if the teleportation *** addition,in this case,the fidelity of the teleported state has quantum features only if the channel has an amount of entanglement different from zero.

关键词： quantum information teleportation

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AN OPTIMAL CONTROL PROBLEM FOR A LOTKA-VOLTERRA COMPETITION MODEL WITH CHEMO-REPULSION

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Acta Mathematica Scientia 2024年第2期44卷 721-751页

作者： Diana I.HERNÁNDEZ Diego A.RUEDA-GOMEZ Élder J.VILLAMIZAR-roa Universidad Industrial de Santander Escuela de MatemáticasA.A.678BucaramangaColombia

In this paper we study a bilinear optimal control problem for a diffusive Lotka-Volterra competition model with chemo-repulsion in a bounded domain of ℝ^(ℕ),N=2,*** model describes the competition of two species in which one of them avoid encounters with rivals through a chemo-repulsion *** prove the existence and uniqueness of weak-strong solutions,and then we analyze the existence of a global optimal solution for a related bilinear optimal control problem,where the control is acting on the chemical ***,we derive first-order optimality conditions for local optimal solutions using the Lagrange multipliers ***,we propose a discrete approximation scheme of the optimality system based on the gradient method,which is validated with some computational experiments.

关键词： Lotka-Volterra chemo-repulsion optimal control optimality conditions

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Periodic Solutions in Unbounded Domains for the Boussinesq System

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Acta Mathematica Sinica,English Series 2010年第5期26卷 837-862页

作者： Elder Jesús VILLAMIZAR-roa María ngeles RODRíGUEZ-BELLIDO Marko Antonio ROJAS-MEDAR Escuela de Matemáticas Universidad Nacional de Colombia Dpto. Ecuaciones Diferenciales y Análisis Numérico Universidad de Sevilla Aptdo Dpto. de Ciencias Básicas Facultad de Ciencias Universidad del Bío BíoCampus Fernando May

Assuming that the external forces of the system are small enough, the reference temperature being a periodic function, we study the existence, the uniqueness and the regularity of time-periodic solutions for the Boussinesq equations in several classes of unbounded domains of Rn. Our analysis is based on the framework of weak-Lp spaces.

关键词： Boussinesq equations strong periodic solutions unbounded domains

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