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Bioactives and extracts affect the physico-chemical properties of concentrated whey protein isolate dispersions

Food Production, Processing and Nutrition 2022年第1期4卷 25-40页

作者： Mackenzie M.hansen Richard W.hartel yrjöh.roos Food Technology School of Food and Nutritional SciencesUniversity College CorkCorkIreland Department of Food Science College of Agricultural and Life SciencesUniversity of WisconsinOffice A11Babcock Hall1605 Linden DriveMadisonWI53706USA

Non-covalent complexation interactions are known to occur between bioactive compounds and proteins. While formulating with these components can have positive outcomes such as stabilization of colors and actives, it can also result in changes to the structures and physical properties of proteins, affecting product functionality and sensory attributes. Previous experiments reported measurable changes in the physico-chemical properties of whey protein isolate (WPI) dispersions upon formulation with Aronia berry extract, ascribing changes to protein-polyphenol (PP) interactions in the systems. Pure gallotannin, beet extract, and cranberry extract, providing a diverse variety structures and sizes, were selected for further experimentation and comparison with the effects of Aronia extract. Concentrated dispersions with varying WPI:sucrose ratios, formulated with several bioactives contents from multiple different sources were analyzed to identify the effects of different bioactives on physico-chemical properties of dispersions. Dispersions formulated with cranberry extract demonstrated the largest increases in surface tensions, viscosities, and particle sizes, while those formulated with beet extract were the least affected by the presence of bioactives, suggesting that different bioactives and extracts had varying propensities for complexation interactions with WPI, despite their relatively low levels of addition (0, 0.5, and 1%).

关键词： Whey protein Concentrated dispersions Polyphenols Extracts Physico-chemical properties

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Effects of Aronia polyphenols on the physico-chemical properties of whey,soy,and pea protein isolate dispersions

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Food Production, Processing and Nutrition 2021年第1期3卷 391-405页

作者： Mackenzie M.hansen Richard W.hartel yrjö h.roos Food Technology School of Food and Nutritional SciencesUniversity College CorkCorkIreland Department of Food Science College of Agricultural and Life SciencesUniversity of WisconsinOffice A11Babcock Hall1605 Linden DriveMadisonWI 53706USA

Bioactive compounds including polyphenols(PP)have been observed to naturally form non-covalent complexation interactions with proteins under mild ph and temperature conditions,affecting protein structures and ***,addition of Aronia berry PP to liquid dispersions containing whey protein isolate(WPI)and sucrose was found to alter characteristics including viscosity,surface tension,and particle sizes,with changes being attributed to protein-PP *** this study we aimed to investigate whether Aronia PP would interact with soy and pea protein isolates(SPI and PPI,respectively)to a similar extent as with WPI in liquid protein-sucrose-PP *** hypothesized that formulations containing PPI(comprised of larger proteins)and hydrolyzed SPI(containing more carboxyl groups)may exhibit increased viscosities and decreased aggregate sizes due to enhanced protein-PP *** liquid dispersions of varied ratios of protein to sucrose contents,containing different protein isolates(WPI,SPI,and PPI),and varied Aronia PP concentrations were formulated,and physical properties were evaluated to elucidate the effects of PP *** addition altered physical characteristics differently depending on the protein isolate used,with changes attributed to protein-PP *** and PPI appeared to have higher propensities for PP interactions and exhibited more extensive shifts in physical properties than WPI *** findings may be useful for practical applications such as formulating products containing fruit and proteins to obtain desirable sensory attributes.

关键词： Whey protein Soy protein Pea protein Polyphenols Concentrated dispersions Physico-chemical properties

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César h.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray Marc hanauer Kristina hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIhR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public health Methodology&Digital HealthAmsterdamThe Netherlands health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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Importance of genetic data from type specimens:The questionable type locality of southern white-cheeked gibbon,Nomascus siki(Delacour,1951)

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Zoological Research 2022年第4期43卷 666-670页

作者： Christian roos Roberto Portela Miguez Dietmar Zinner Tilo Nadler Van Ngoc Thinh Gene Bank of Primates German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Natural history Museum London SW7 BDUK Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany Department of Primate Cognition Georg-August-UniversityGoettingen 37083Germany Three Monkeys Wildlife Conservancy Cuc Phuong CommuneNho Quan DistrictNinh Binh ProvinceVietnam World Wide Fund for Nature(WWF)Vietnam Nam Tu Liem DistrictHanoiVietnam

DEAR EDITOR,Many historical descriptions of new species have included vague or inaccurate information about the type *** can lead to confusion in the study of the species and their geographic distributions,thereby hindering conservation *** such example is the southern white-cheeked gibbon(Nomascus siki(Delacour,1951)).The type locality is given as Thua Luu in central Vietnam,which is located within the range of another crested gibbon species(***)and more than 200 km south of the known range of *** investigate the problematic type locality of ***,we sequenced the mitochondrial genome of the holotype and compared its cytochrome b gene sequence to those of other georeferenced crested gibbon samples.

关键词： thereby hinder locality

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Superconvergence of a Galerkin FEM for higher-Order Elements in Convection-Diffusion Problems

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Numerical Mathematics(Theory,Methods and Applications) 2014年第3期7卷 356-373页

作者： Sebastian Franz h.-G.roos Institut für Numerische Mathematik Technische Universit¨at Dresden01062 DresdenGermany

In this paper we present a first supercloseness analysis for higher-order Galerkin FEM applied to a singularly perturbed convection-diffusion *** a solution decomposition and a special representation of our finite element space,we are able to prove a supercloseness property of p+1/4 in the energy norm where the polynomial order p≥3 is odd.

关键词： Singular perturbation layer-adapted meshes superconvergence postprocessing

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Weighted Bergman kernels and virtual Bergman kernels

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Science China Mathematics 2005年第Z1期48卷 225-237页

作者： Guy roos Nevski Prospekt 113/4-53 191024 St Petersburg Russian Federation

We introduce the notion of virtual Bergman kernel and study some of its applications.

关键词： Bergman kernel, weighted Bergman kernel, virtual Bergman kernel.

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New classes of domains with explicit Bergman kernel

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Science China Mathematics 2004年第3期47卷 352-371页

作者： roos GUY henan University Kaifeng 475001 China Nevski Prospekt 113/4-53 191024 St Petersburg Russian Federation

We introduce two classes of egg type domains, built on general boundedsymmetric domains, for which we obtain the Bergman kernel inexplicit formulas. As an auxiliary tool, we compute the integralof complex powers of the generic norm on a bounded symmetricdomains using the well-known integral of Selberg. Thisgeneralizes matrix integrals of hua and leads to a specialpolynomial with integer or half-integer coefficients attached toeach irreducible bounded symmetric domain.

关键词： Cartan domain, Bergman kernel, holomorphic automorphism group, boundedsymmetric domain, hua integral.

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STABILIZED FEM FOR CONVECTION-DIFFUSION PROBLEMS ON LAYER-ADAPTED MEShES

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Journal of Computational Mathematics 2009年第2期27卷 266-279页

作者： hans-Grg roos TU Dresden Germany

The application of a standard Galerkin finite element method for convection-diffusion problems leads to oscillations in the discrete solution, therefore stabilization seems to be necessary. We discuss several recent stabilization methods, especially its combination with a Galerkin method on layer-adapted meshes. Supercloseness results obtained allow an improvement of the discrete solution using recovery techniques.

关键词： Singular perturbations Convection-diffusion Finite element method Stabi-lization Layer-adapted mesh Superconvergenee Recovery

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Genes & Diseases 2022年第6期9卷 1506-1520页

作者： Jon Christiansen Anne-Katrin Guttsches Ulrike Schara-Schmidt Matthias Vorgerd Christoph heute Corinna Preusse Werner Stenzel Andreas roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e Universitatsmedizin Berlin Freie Universitat Berlin10117 BerlinGermany humboldt-Universitat zu Berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s hospital of Eastern Ontario Research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MRI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LGMDR12 MMD3 Muscle inflammation Muscle MRI

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GRADED MEShES FOR hIGhER ORDER FEM

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Journal of Computational Mathematics 2015年第1期33卷 1-16页

作者： hans-Gorg roos Ljiljana Teofanov Zorica Uzelac Institute of Numerical Mathematics Technical University of Dresden Dresden D-01062 Germany Department for Fundamental Disciplines Faculty of Technical Sciences University of Novi Sad Trg D. Obradovida 6 21000 Novi Sad Serbia

A singularly perturbed one-dimensional convection-diffusion problem is solved numeri- cMly by the finite element method based on higher order polynomials. Numerical solutions are obtained using S-type meshes with special emphasis on meshes which are graded （based on a mesh generating function） in the fine mesh region. Error estimates in the s-weighted energy norm are proved. We derive an ＇optimal＇ mesh generating function in order to min- imize the constant in the error estimate. Two layer-adapted meshes defined by a recursive formulae in the fine mesh region are also considered and a new technique for proving er- ror estimates for these meshes is presented. The aim of the paper is to emphasize the importance of using optimal meshes for higher order finite element methods. Numerical experiments support all theoretical results.

关键词： Singular perturbation Boundary value problem Layer-adapted meshes Gradedmeshes Finite element method.

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