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Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

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20世纪日本的妇女解放斗争与法律发展

宝鸡文理学院学报（社会科学版） 2024年第1期44卷 57-63页

作者： [日本]渡边洋三宋海彬(译) 帝京大学法学部日本东京173-8605 西北政法大学国家安全学院中国陕西西安710122

妇女解放是包含男性在内的“人的解放”政治课题的一种特殊形态。资本主义条件下的男女不平等是资本主义阶级差别在妇女及其活动场域中的具体形式。割裂妇女解放斗争与工人解放运动的关系,将妇女解放曲解为针对男性的斗争,以及围绕职场... 详细信息

妇女解放是包含男性在内的“人的解放”政治课题的一种特殊形态。资本主义条件下的男女不平等是资本主义阶级差别在妇女及其活动场域中的具体形式。割裂妇女解放斗争与工人解放运动的关系,将妇女解放曲解为针对男性的斗争,以及围绕职场与家庭之间的所谓经验化论争,均无法为妇女解放提供真正的理论指导。由于日本资本主义的特殊形态及具体展开的历史过程,20世纪日本妇女解放运动艰辛曲折,发展缓慢。虽然经由二战后日本经济结构重组和社会民主化进程的带动,大众化的妇女解放运动和相应法律制度得以快速发展,但妇女的生活实际与既有法律之间存在巨大距离,妇女权益保护更表现出局域化、碎片化局面。立足妇女与工人阶级的内在联系,统摄妇女权益内部差别,构筑新的妇女解放的法学理论,推进妇女权益的社会实质平等,是日本马克思主义法学必须承担的时代课题。

关键词：妇女解放妇女法律地位实质平等日本马克思主义法学

Surface modification and characterization of F-Co doped spinel LiMn_2O_4

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Rare Metals 2006年第z1期25卷 33-38页

作者： watanabe Takayuki Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 Nagatsuta Yokomaha 226-8502 Japan

Spinel LiCo0.09Mn1.91O3.92F0.08 as cathode material was modified with LiCoO2 by the sol-gel method, and the crystal structure, morphology and electrochemical performance were characterized with XRD, SEM, EDS, AAS and charge-discharge test in this paper. The results show that a good clad coated on parent material can be synthesized by the sol-gel method, and the materials with modification have perfect spinel structure. LiCo0.09Mn1.91O3.92F0.08 materials coated by LiCoO2 improve the stability of crystal structure and decrease the dissolution of Mn into electrolyte. With the LiCoO2 content increasing, the specific capacity and cycle performance of samples are improved. The capacity loss is also suppressed distinctly even at 55 ℃.

关键词： lithium ion batteries spinel LiMn2O4 ion doping surface coating

The Theaflavin Monomers Inhibit the Cancer Cells Growth in Vitro

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 508-512页

作者： Naoharu watanabe Department of Applied Biological Chemistry 836 Ohya Shizuoka 422-8529 Shizuoka University Japan

The inhibition effects of tea theaflavins complex (TFs), theaflavin-3-3’-digallate (TFDG), theaflavin-3’-gallate (TF2B), and an unidentified compound (UC) on the growth of human liver cancer BEL-7402 cells, gastric cancer MKN-28 cells and acute promyelocytic leukemia LH-60 cells were investigated. TFs was obtained through the catalysis of catechins with immobilized polyphenols oxidase. TFDG, TF2B and UC were isolated from TFs with high speed countercurrent chromatography (HSCCC). The results showed that TF2B significantly inhibited the growth of all three kinds of cancer cells, TFs, TFDG and UC had some effect on BEL-7402 and MKN-28, but little activity on LH-60. The inhibition effects of TF2B, TFDG, and UC on BEL-7402 and MKN-28 were stronger than TFs. The relationship coefficients between monomer concentration and its inhibition rate against MKN-28 and BEL-7402 were 0.87 and 0.98 for TF2B, 0.96 and 0.98 for UC, respectively. The IC50 values of TFs, TF2B, and TFDG were 0.18, 0.11, and 0.16 mM on BEL-7402 cells, and 1.11, 0.22, and 0.25 mM on MKN-28 cells respectively.

关键词： theaflavin monomer separation cancer cells inhibition

Lattice Boltzmann simulations for multiple tidal turbines using actuator line model

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Journal of Hydrodynamics 2022年第3期34卷 372-381页

作者： Seiya watanabe Changhong Hu Research Institute for Applied Mechanics Kyushu UniversityFukuokaJapan

In numerical simulations of tidal current farms,large-scale computational fluid dynamic(CFD)simulations with a high-resolution grid are required to calculate the interactions between tidal *** this study,we develop a numerical simulation method for tidal current turbines using the lattice Boltzmann method(LBM),which is suitable for large-scale CFD *** turbines are modeled by using the actuator line(ACL)model,which represents each blade as a group of actuator points in a *** order to validate our LBM-ACL model,we perform simulations for two interacting tidal turbines,and results of turbine performance are compared with a water tank *** proposed model successfully reproduces the variation of the torque due to wave effects and mean turbine *** have demonstrated a large-scale simulation for ten tidal turbines using 8.55×10^(8) grid points and 16 GPUs of Tesla P100 and the simulation has been completed within 9 hours with the LBM performance of 392 MLUPS per GPU.

关键词： Tidal current turbine lattice Boltzmann method(LBM) actuator line model numerical water tank multi-turbine interaction

Decomposition of Glycerine by Water Plasmas at Atmospheric Pressure

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Plasma Science and Technology 2013年第4期15卷 357-361页

作者： Takayuki watanabe NARENGERILE Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259 NagatsutaYokohama 226-8502 Japan

High concentration of aqueous glycerine was decomposed using a direct current （DC） plasma torch at atmospheric pressure. The torch can generate the plasma with water as the plasma-supporting gas in the absence of any additionM gas supply system and cooling devices. The results indicated that 5 mol% glycerine was completely decomposed by water plasmas at arc powers of 0.55~1.05 kW. The major products in the effluent gas were H2 （68.9%~71.1%）, CO2 （18.9%~23.0%）, and CO （0.2%~0.6%）. However, trace levels of formic acid （HCOOH） and formaldehyde （HCHO） were observed in the liquid effluent. The results indicated that the water plasma waste treatment process is capable of being an alternative green technology for organic waste decomposition.

关键词： thermal plasma water plasma glycerine decomposition

Comparative assessment of primary and secondary infection risks in a norovirus outbreak using a household model simulation

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Journal of Environmental Sciences 2016年第12期28卷 13-20页

作者： Fuminari Miura Toru watanabe Kozo watanabe Kazuhiko Takemoto Kensuke Fukushi Department of Urban Engineering Graduate School of Engineering the University of Tokyo Department of Food Life and Environmental Sciences Faculty of Agriculture Yamagata University Department of Civil and Environmental Engineering Ehime University Institute for the Advanced Study of Sustainability the United Nations University Todai Institutes for Advanced Study(TODIAS) Integrated Research System for Sustainability Science(IR3S) The University of Tokyo

Diarrheal diseases can be transmitted via both primary infection due to exposures to contaminated materials from the environment and secondary infection due to person- to-person contacts. Usually, the importance of secondary infection is empirically assessed by fitting mathematical models to the epidemic curves. However, these empirical models may not be applicable to other epidemic cases because they are developed only for the target epidemics and they don＇t consider the detail routes of infection. In our previous study, we developed a theoretical model taking into account the various routes of infection that commonly occur in households （e.g., shaking hands, food handling, and changing diapers）. This model was made flexible and applicable to any epidemics by means of adjusting model parameters. In this study, we proposed a new index ＂Vulnerability indicator to secondary infection （VISI）＂, which expressed a ratio of secondary infection to primary infection risks and calculated this index in a simulated norouirus （NOV） epidemic that involved I0,000 households. The results demonstrated that households composed of more than three members including infant（s） had much higher levels of VlSl （5-45） than two-member-households with VlSI （0.1-4）. These results concluded that the infants were likely to be a hub of secondary infections in highly dense families and therefore careful handling of diapers was deemed indispensible in such families to effectively control the secondary infections.

关键词： Norovirus Quantitative microbial riskassessment Secondary infection

Evaluation of Important Factors Affecting Quench Distortion of Carburized Hypoid Gear with Shaft by Using Computer Simulation Methods

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材料热处理学报 2004年第5期25卷 480-485页

作者： Tsuyoshi Sugimoto Youichi watanabe Nissan Motor Co. Ltd. 6-1 Daikoku-cho Tsurumi Yokohama JapanNissan Motor Co. Ltd. 6-1 Daikoku-cho Tsurumi Yokohama Japan

To minimize quenching distortion and dispersion, carburizing and quenching process conditions must be optimized; this includes the parts racking design used for quenching. We investigated some factors affecting carburized quenching distortion with an experiment using a hypoid gear having a shaft and with numerical simulation methods. The experimental results and those obtained from simulation were generally in agreement. Focusing on the surface temperature distribution in the gear, we studied quenching distortion characteristics in terms of changes in tooth profile and helix deviation. In our experiments, distortions occur during quenching in 373 K oil after austenitized temperature treatments conducted with various attitudes. We calculated the distortions by simulating the carburized oil-quenching process for the hypoid gear. Our results show large differences between the cooling rates of the tooth toe, middle section, and heel edges, and these greatly influence the change in tooth profile and helix deviation. We found that reducing the differences in temperatures on the gear surfaces during quenching is most important for minimizing the quench distortion of the hypoid gear.

关键词：淬火变形螺旋偏差外形偏差冷却曲线传热系数准双曲面齿轮

Relapse of prostate cancer from the viewpoint of total gland volume kinetics theory

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Asian Journal of Andrology 2015年第6期17卷 904-907页

作者： Hiroki watanabe Director Watanabe Memorial Choumei ResearchLaboratory Shiga Japan Honorary Professor KyotoPrefectural University of Medicine and Meiji Universityof Integrated Medicine Kyoto Japan.

In many cases of prostate cancer, changes of prostate volume were measured very frequently after castration by means of transrectal ultrasound. For short-term observations, a factor called as ＂reduction time （tau [τ]）,＂ which means the time required for the volume of ＂effective portion＂（volume responded to castration） to be reduced to one-tenth of its original value, correlated very well with patients＇ prognosis. For long-term observations for relapse, changes of prostate volume could be divided clearly into two types, namely, ＂metastatic progressive type＂ with metastasis without volume increase and ＂local progressive type＂ with remarkable volume increase without metastasis. ＂τ＂ in the ＂local progressive type＂ was far shorter than that in the ＂metastatic progressive type.＂ Much longer survival was obtained when the patient belonged to the ＂local progressive type＂ than to the ＂metastatic progressive type.＂ Thus, ＂τ＂ was the most important and the most reliable factor to predict the prognosis. Based upon these observations, a schematic analysis of prostate cancer relapse was shown.

关键词： Relapse prostate theory