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缺氧微环境对乳腺癌的影响及中药的干预作用

中国实验方剂学杂志 2024年第12期30卷 232-241页

作者：王馨楠胡文秀孙硕张文洁赵益孙有智江西中医药大学中医学院方证研究中心中医基础理论分化发展研究中心南昌330004

肿瘤微环境包括肿瘤病变部位和附近的血管、淋巴、神经、非恶性细胞及其代谢物等,肿瘤微环境与癌细胞相互作用,并促进癌症的进展。癌细胞快速增殖增加耗氧量或实体瘤内血管结构和功能的异常导致氧气供养量减少,形成缺氧微环境。缺氧微... 详细信息

肿瘤微环境包括肿瘤病变部位和附近的血管、淋巴、神经、非恶性细胞及其代谢物等,肿瘤微环境与癌细胞相互作用,并促进癌症的进展。癌细胞快速增殖增加耗氧量或实体瘤内血管结构和功能的异常导致氧气供养量减少,形成缺氧微环境。缺氧微环境的存在是局部晚期实体瘤的典型病理生理特征,广泛存在于人类各类恶性肿瘤中,是肿瘤微环境的标志,也是乳腺肿瘤微环境中重要而复杂的系统,其形成和发展与乳腺癌的生长密切相关,在乳腺癌的研究和治疗中占据重要地位。中药有效单体与复方以其多通路、多靶点的优势,可以较好地调节乳腺癌的缺氧微环境,通过抑制缺氧环境下乳腺癌细胞的增殖、侵袭和转移、并诱导凋亡、逆转其耐药性、干预缺氧环境下乳腺癌细胞代谢重编程和抑制其血管生成等,从而在一定程度上提高患者的生存质量,延长患者的生存周期。该文先总结并论述缺氧微环境通过对乳腺癌细胞增殖、侵袭、转移、耐药、免疫功能、代谢重编程、非编码RNA、铁死亡和自噬的作用,影响乳腺癌的发生与发展,并详细阐述了其背后的作用机制,再基于中药有效单体与中药复方这两种用药模式,阐释其靶向缺氧微环境的调控作用与机制,以期分析与提炼出中药在调控缺氧微环境上的不足与方向,为乳腺癌的有效治疗提供理论参考。

关键词：缺氧微环境乳腺癌中药有效单体中药复方综述

Acupuncture therapy on apoplectic aphasia rehabilitation

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Journal of Traditional Chinese Medicine 2012年第3期32卷 314-321页

作者： youzhi sun Steve An Xue Zhengyun Zuo The School of Chinese Medicine The Universityof Hong Kong Hong Kong China Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China Jiangxi University of Traditional ChineseMedicine Nanchang 330004 China IM International Health Management Ltd. Shenzhen 518000 China

OBJECTIVE:Acupuncture has often been used for aphasia rehabilitation in *** purpose of this paper was to:1) provide a historic overview of acupuncture for aphasia due to stroke;2) summarize the commonly used acupuncture approaches;and 3) objectively comment on the effectiveness of acupuncture for the rehabilitation of this type of ***:The Elsevier database and a Chinese database(CNKI) were searched through December,2010 with the key words "aphasia,acupuncture" in English and Chinese,*** reports,uncontrolled clinical observations and controlled clinical trials were all included if acupuncture was the sole treatment or the main component of complex intervention for the rehabilitation of aphasia caused by cerebrovascular ***:More than 100 relevant articles were *** analyzing these articles,we found that acupuncture for apoplectic aphasia most often included tongue,scalp,body and combination *** bleeding,deep insertion and strong stimulation were adopted by many *** ten most frequently used acupoints(or areas) were Lianquan(RN 23),Jinjin(EX-HN 12),Yuye(EX-HN 13),Tongli(HT 5),Fengchi(GB 20),Neiguan(PC 6),Baihui(DU 20),No.1,2 and 3 language sections,Sanyinjiao(SP 6) and Yamen(DU 15).CONCLUSIONS:Controlled clinical studies and a systematic literature review demonstrate that acupuncture has therapeutic effects on aphasia after stroke.

关键词： Acupuncture therapy Poststroke syndrome Anomia Rehabilitation

The theory development of traditional Chinese medicine constitution: a review

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Journal of Traditional Chinese Medical Sciences 2018年第1期5卷 16-28页

作者： youzhi sun Yi Zhao Steve An Xue Jianping Chen School of Chinese Medicine The University of Hong KongPokfulamHong Kong 999077China Jiangxi University of Traditional Chinese Medicine NanchangJiangxi 330004China Research Center for Differentiation and Development of TCM Basic Theory Jiangxi University of Traditional Chinese MedicineNanchangJiangxi 330004China Tian Shou Da Institute of Brain Science HangzhouZhejiang 310008China

Traditional Chinese medicine constitution (TCMC),as one of the most important parts of Chinese medicine theory,attracted the attention of more and more researchers and many research projects were conducted during past several decades in China's *** review provided a historic overview of TCMC theory and research progress in its classification,evaluation criteria and epidemiology,so as to give people through a different lens to understand human health.

关键词： Traditional Chinese medicine constitution (TCMC) Theory Classification Evaluation Epidemiology

Characteristics of TCM Constitutions of Adult Chinese Women in Hong Kong and Identification of Related Influencing Factors:A cross-sectional Survey

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Characteristics of TCM Constitutions of Adult Chinese Women ...

第十四届全国中药和天然药物学术研讨会

作者： sun youzhi Pie liu Jianping Chen The University of Hong Kong

＜正＞Background Traditional Chinese Medicine Constitution（TCMC）refers to an integrated,metastable and natural specialty of individual in morphosis,physiological functions and psychological *** is formed on the basis of innate and acquired endowments in the human life process,which can be divided into normal constitution and unbalanced *** aim of this

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2008年北京奥运经济、社会效益研究探析

生产力研究 2007年第3期 3-4页

作者：孙有智喻坚湖州师范学院体育学院浙江湖州313000

文章采用文献资料、逻辑分析等方法,对2008年北京奥运会经济、社会效益研究的现状与存在的某些不足进行了探讨和分析。并提出了今后研究的主要内容、基本思路、方法以及几点建议。

关键词： 2008年北京奥运会经济效益社会效益

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学生评教中的博弈与变革

高教发展与评估 2020年第5期36卷 47-56,I0004页

作者：孙鳌孙由之南方医科大学经济学系广东广州510507 中国矿业大学(北京)英语系北京100083

在教师的利益与学生评教分数捆绑的政策下,师生间博弈将导致学生评教分数与课程分数同时膨胀。高校间博弈将导致各校容忍自己的教师讨好学生。高校与监管者的博弈将会鼓励高校坚持学生评教政策。克服学生评教失灵的根本的解决办法是,在... 详细信息

在教师的利益与学生评教分数捆绑的政策下,师生间博弈将导致学生评教分数与课程分数同时膨胀。高校间博弈将导致各校容忍自己的教师讨好学生。高校与监管者的博弈将会鼓励高校坚持学生评教政策。克服学生评教失灵的根本的解决办法是,在高校中实现从评教到教的咨询的变革。教的咨询是企业管理咨询在高校中的对应物,其本质是咨询专家向教师提供的旨在改进教师绩效的咨询服务,也是诊断、考核和发展教师绩效的持续过程,其三个基本阶段是诊断教师的绩效问题、制定和执行教师绩效改进策略,其核心是咨询专家向教师提供的咨询性反馈。建立和有效实施教的咨询制度的前提是,放弃把教师的利益与学生评教分数捆绑的政策,对咨询专家实行效率工资,为教的咨询重新设计学生评教表。

关键词：学生评教分数膨胀教师绩效教的咨询

Genome-wide association study of seedling nitrogen-use efficiency-associated traits in common wheat(Triticum aestivum L.)

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The Crop Journal 2024年第1期12卷 222-231页

作者： Huawei Shi Weichong Wang Lifeng Gao Jirong Wu Chengmei Hu Huishu Yan Yugang Shi Ning Li youzhi Ma Yongbin Zhou Zhaoshi Xu Jun Chen Wensi Tang Kai Chen Daizhen sun Yuxiang Wu Ming Chen College of Agriculture Shanxi Agricultural UniversityJinzhong 030801ShanxiChina National Key Facility for Crop Gene Resources and Genetic Improvement Key Laboratory of Biology and Genetic Improvement of Triticeae CropsMinistry of AgricultureInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Nitrogen(N)fertilizer application is essential for crop-plant growth and *** genetic loci associated with N-use efficiency(NUE)could increase wheat yields and reduce environmental pollution caused by *** subjected a panel of 389 wheat accessions to N and chlorate(a nitrate analog)treatments to identify quantitative trait loci(QTL)controlling NUE-associated traits at the wheat seedling *** the panel with a 660K single-nucleotide polymorphism(SNP)array,we identified 397 SNPs associated with N-sensitivity index and chlorate inhibition *** SNPs were merged into 49 QTL,of which eight were multi-environment stable QTL and 27 were located near previously reported QTL.A set of 135 candidate genes near the 49 QTL included TaBOX(F-box family protein)and TaERF(ethylene-responsive transcription factor).A Tabox mutant was more sensitive to low-N stress than the wild-type *** developed two functional markers for Hap 1,the favorable allele of TaBOX.

关键词： Wheat NUE Genome-wide association study Nitrogen sensitive index Chlorate inhibition rate

The Efficacy of Guolin-Qigong on Body-mind Health of Chinese Women with Breast Cancer:Study Protocol for a Randomized Controlled Trial

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The Efficacy of Guolin-Qigong on Body-mind Health of Chinese...

第十四届全国中药和天然药物学术研讨会

作者： Jieshu You Pei Liu youzhi sun Jie Yang Wing-hang Tsang Ava Kwong Jianping Chen The University of Hong Kong

＜正＞Background Breast cancer（BC）is the most prevalent malignancy among women *** the mortality of BC patients has been falling by early diagnosis,surgery,chemotheropy and radiotherapy in recent years,these methods are very limited in relieving unpleasant *** Qigong（GLQG）,as a unique form of Qigong specifically designed for

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湿润烧伤膏治疗烧烫伤的止痛效果观察

中国继续医学教育 2017年第30期9卷 120-121页

作者：孙有志吉林省辽源矿业(集团)公司总医院烧伤科吉林辽源136201

目的探讨湿润烧伤膏治疗烧烫伤的止痛效果。方法随机选取2016年2月—2017年2月在我科治疗烧烫伤的120例患者作为研究对象,随机分为对照组和观察组各60例。对照组采取磺胺嘧啶银悬浊液治疗,观察组采取湿润烧伤膏治疗。比较两组的治疗效... 详细信息

目的探讨湿润烧伤膏治疗烧烫伤的止痛效果。方法随机选取2016年2月—2017年2月在我科治疗烧烫伤的120例患者作为研究对象,随机分为对照组和观察组各60例。对照组采取磺胺嘧啶银悬浊液治疗,观察组采取湿润烧伤膏治疗。比较两组的治疗效果。结果观察组患者的疼痛评分低于对照组,观察组患者的止痛效果优于对照组,观察组患者的创面愈合时间短于对照组(P<0.05)。结论湿润烧伤膏治疗烧烫伤,可以使创面愈合时间缩短,有效的减轻患者的疼痛感。

关键词：湿润烧伤膏烧烫伤止痛效果