检索结果-南通市图书馆

A double crosslinking MXene/cellulose nanofiber layered film for improving mechanical properties and stable electromagnetic interference shielding performance

引用

Journal of Materials Science & Technology 2022年第34期129卷 127-134页

作者： Shilu Luo Tiantian Xiang jingwen Dong Fengmei Su youxin ji Chuntai Liu Yuezhan Feng Key Laboratory of Materials Processing and Mold Ministry of Education National Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China

With the discovery of the two-dimensional(2D) MXene, it shows a great application potential in the field of electromagnetic interference(EMI) shielding, but the mechanical brittleness and easy oxidation of MXene limit its wide application. For this reason, a double crosslinking strategy is provided to solve the above problems in a nacre-like “brick-mortar” layered MXene/cellulose nanofiber(MXene/CNF) ***, the film was firstly suffered by dopamine modification, then was further reinforced by secondary Ca^(2+)bridging, so as to obtain excellent mechanical properties and antioxidative EMI shielding performance. Comparing with the single crosslinking, the double crosslinking strategy reveals a higher efficiency in improving the mechanical property. The mechanical strength and toughness of the double crosslinking MXene/CNF film can increase to 142.2 MPa and 9.48 MJ/m^(3), respectively. More importantly, while achieving good mechanical properties, the MXene composite film still holds a very stable EMI shielding performance of more than 44.6 dB when suffering from the oxidation treatment of hightemperature annealing, showing excellent anti-oxidation ability and environment tolerance. Therefore,this work provides a universal but effective double crosslinking strategy to solve the mechanical brittleness and easy oxidation of MXene-based composites, thus showing a huge potential in flexible EMI shielding applications.

关键词： Ti_(2)C_(3)T_(x)MXene Layered structure Double crosslinking Mechanical properties EMI shielding performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Primary resistance to crizotinib treatment in a non-small cell lung cancer patient with an EML4-ALK rearrangement:a case report

引用

Cancer Biology & Medicine 2018年第2期15卷 178-181页

作者： Ling Zhang Yunxia Li Shaohong Zhang Chen Gao Keke Nie youxin ji Department of Oncology Qingdao Cancer Hospital Department of Medicine Laixi Meihuashan Hospital Department of Oncology Affiliated Qingdao Central Hospital of Qingdao University

Crizotinib,a small molecular tyrosine kinase inhibitor,manifests dramatic responses in patients with non-small cell lung cancer with echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase(EML4-ALK)*** gene point mutation is the primary mechanism of acquired crizotinib resistance;however,the intrinsic mechanism is not fully ***,we report a patient with a low mutant allele fraction(MAF)of EML4-ALK rearrangement,who experienced primary resistance to crizotinib *** patient was a 66-year-old Chinese man,who had a history of metastatic lung cancer and was treated with first-and third-generation epidermal growth factor receptor tyrosine kinase inhibitors(EGFR TKIs).After 14 months of osimertinib treatment,his disease progressed,and next-generation sequencing was performed from a liquid biopsy of the patient’s *** EML4-ALK rearrangement was found and crizotinib was *** patient’s lung lesions continued to progress after one month of crizotinib treatment,and pemetrexed-bevacizumab was *** two cycles of chemotherapy,the metastatic cancers shrunk,and the patient maintained stable disease at his last ***4-ALK rearrangements can happen in patients with EGFR-positive NSCLC,after acquired resistance to EGFR TKI *** EGFR T790M and C797G mutations occur in cis is a critical mechanism of resistance to osimertinib *** MAF of EML4-ALK rearrangements in cancer cells might be a predictive factor for crizotinib treatment.

关键词： Non-small cell lung cancer EML4-ALK target therapy crizotinib

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polymer composites designed with 3D fibrous CNT“tracks”achieving excellent thermal conductivity and electromagnetic interference shielding efficiency

引用

Nano Research 2023年第8期16卷 11411-11421页

作者： Gui Yang Liangchun Zhou Mingjie Wang Tiantian Xiang Duo Pan jingzhan Zhu Fengmei Su youxin ji Chuntai Liu Changyu Shen National Engineering Research Center for Advanced Polymer Processing Technology The Key Laboratory of Material Processing and Mold of Ministry of EducationCollege of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450002China

The rapid improvement in the running speed,transmission efficiency,and power density of miniaturized devices means that multifunctional flexible composites with excellent thermal management capability and high electromagnetic interference(EMI)shielding performance are urgently ***,inspired by the fibrous pathways of the human nervous system,a“core–sheath”fibers structured strategy was proposed to prepare thermoplastic polyurethane/polydopamine/carbon nanotube(TPU/PDA/CNT)composites film with thermal management capability and EMI shielding ***,TPU@PDA@CNT fibers with CNT shell were prepared by a facile polydopamine-assisted coating on electrospun TPU ***,TPU/PDA/CNT composites with three-dimensional(3D)fibrous CNT“tracks”are obtained by a hot-pressing process,where CNTs distributed on adjacent fibers are compactly *** fabricated TPU/PDA/CNT composites exhibit a high in-plane thermal conductivity(TC)of 9.6 W/(m·K)at low CNT loading of 7.6 wt.%.In addition,it also presents excellent mechanical properties and excellent EMI shielding effectiveness of 48.3 dB as well as multi-source driven thermal management ***,this study provides a simple yet scalable technique to prepare composites with advanced thermal management and EMI shielding performance to develop new-generation wireless communication technologies and portable intelligent electronic devices.

关键词： composites three-dimensional(3D)fibrous carbon nanotube(CNT)“tracks” in-plane thermal conductivity(TC) electromagnetic interference(EMI)shielding multi-source driven thermal management

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Milk fat globule epithelial growth factorⅧ(MFG-E8)sustains survival of cancer cells by prompting tumor angiogenesis and suppressing host immunities

引用

Oncology and Translational Medicine 2017年第1期3卷 31-37页

作者： Keke Nie Shichao Liu Ling Zhang Zhongfa Zhang Xiao Zou youxin ji Oncology Department Qingdao Cancer HospitalQingdao 266042China Oncology Department Qingdao Central HospitalThe 2nd Affiliated Hospital of Qingdao UniversityQingdao 266042China

Milk fat globule epithelial growth factor VIII(MFG-E8) is a novel adhesion protein mainly produced by macrophages and dendritic cells; it is expressed in most of the human tissues and functions to prompt cancer progression and survival. MFG-E8 contains a signal sequence for secretion, two epidermal growth factor(EGF)-like domains at the NH2 terminus and two discoidin domains with blood-clotting factor V/factor Ⅷ(C1 and C2) at the COOH terminus. The second EGF domain contains an arginine-glycine-aspartic(RGD) integrin-binding motif that engages α_vβ_5 integrins to facilitate cell adhesion and induce integrinmediated signal transduction. Integrin α_vβ_3 associates with VEGF receptor 2, engagement of integrins can promote angiogenesis, which plays key roles in growth, proliferation, and survival of cancer cells. VEGF stimulates the expression of α_vβ_3 and α_vβ_5 integrins on angiogenic vasculature, thereby potentiating effects of VEGF receptor engagement. Mice expressing a mutant form of α_vβ_3 integrin are unable to undergo tyrosine phosphorylation, confirming the important role that this integrin plays in pathological angiogenesis and providing important mechanistic insights. The C-terminus discoidin-like domains promote binding to membrane phospholipids, functioning close to VEGF like angiogenesis. MFG-E8 is an opsonin for apoptotic cells, and it acts as a bridging protein between apoptotic cells and phagocytes. It also influences cell immunities by altering CD4^+ and/or CD8^+ cells. Antibody or small peptide works with MFG-E8 at different functional sites or interacts with EGF-like domains and/or discoidin-like domains may play an important role in anti-angiogenesis or immune restoration. Altering the structures and/or functions of MFG-E8 and/or its domains is promising for development of novel anti-cancer strategies.

关键词： milk fat globule epithelial growth factor Ⅷ(MFG-E8) carcinoma target therapy angiogenesis apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment of Skin Reaction Induced by Nivolumab Combined with Radiotherapy in Non-small Cell Lung Cancer:A Case Report

引用

Chinese Medical Sciences Journal 2018年第3期33卷 183-187页

作者： Zhimei Zhao Shichao Liu Xiajuan Xu Zhongfa Zhang Keke Nie youxin ji Department of Oncology Affiliated Qingdao Central Hospital of Qingdao UniversityQingdaoShandong 266042China Department of Oncology Qingdao Cancer HospitalQingdaoShandong 266042China

Skin reaction or dermatological toxicities induced by immunotherapy is *** usually manifests skin rash or erythema and can be cured by skin lotion or ***,a human IgG4 programmed cell death protein 1(PD-1)inhibitor,blocks T cells activation preventing signal and allows the immune system to clear cancer *** was approved in the second-line therapy in squamous cell lung cancer by FDA,with less than 10%unusual skin reaction,like sensory neuropathy,peeling skin,erythema multiforme,vitiligo,and *** could aggravate this skin reaction through inflammatory response and promotion of *** combined treatment of anti-PD-1 and radiotherapy represented a new promising therapeutic approach in many studies,but the risk of side effects may be *** reported a patient with advanced squamous cell lung cancer who suffered from serious skin immune-related adverse events when he was treated with nivolumab and *** immune overreaction of the treatment of anti-PD-1 treatment and radiotherapy might cause these serious skin adverse *** report warranted careful workup to reduce the risk of side effects by combinative therapy with anti-PD-1 and radiotherapy.

关键词： skin reaction nivolumab immunotherapy radiotherapy non-small cell lung cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

运动饮料瓶盖注塑模计算机辅助设计

引用

塑料科技 2010年第6期38卷 70-73页

作者：张晓黎王松杰薛敏杰纪又新郑州大学材料科学与工程学院河南郑州450001 郑州大学橡塑模具国家工程研究中心河南郑州450002

介绍了运动饮料瓶盖的计算机辅助注塑模具设计,根据制品结构和使用要求,为了保证模具开启后制品留在动模侧,设计时采用了双脱模机构,即定模侧使用推杆顶出,动模侧采用推管和推杆顶出。设计过程中还结合Mold?ow进行模流分析,确定最佳进... 详细信息

介绍了运动饮料瓶盖的计算机辅助注塑模具设计,根据制品结构和使用要求,为了保证模具开启后制品留在动模侧,设计时采用了双脱模机构,即定模侧使用推杆顶出,动模侧采用推管和推杆顶出。设计过程中还结合Mold?ow进行模流分析,确定最佳进浇点和选择合适的成型工艺条件,保证有效提高成型制品的质量。

关键词：运动饮料瓶盖注塑模双脱模机构计算机辅助设计

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Severe acute interstitial lung disease induced by crizotinib therapy in a patient with c-Met amplification non-small cell lung cancer

引用

Chinese Medical Journal 2014年第8期127卷 1600-1600页

作者： ji youxin Zhang Zhongfa Nie Keke Lan Ketao Geng Chuanxin Liu Shichao Zhang Ling Zhang Zongchun Sun Lei Zou Xiao Qingdao Univ Dept Oncol Qingdao Cent Hosp Affiliated Hosp 2 Qingdao 266042 Shandong Peoples R China

To the editor： Severe acute interstitial lung disease is not uncommon during and after irradiation of the lung, but is very rare during crizotinib treatment. We reported here one case of severe acute interstitial lun...

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brain age estimation:premise,promise,and problems

引用

Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

“迷你”设备在理论教学和实验教学中的一机两用实践初探--以郑州大学高分子成型与模具专业为例

引用

广东化工 2020年第19期47卷 238-239页

作者：郑国强潘亚敏纪又新郑州大学材料科学与工程学院河南郑州450001

高分子制品已经渗透到我们日常生活和工业领域的各个方面。高分子科学已经发展成为一门独立的学科,与其他传统学科不同,它既是一门基础学科也是一门应用学科。目前,国内近200所高校开设了高分子材料科学与工程专业,“聚合物成型加工原... 详细信息

高分子制品已经渗透到我们日常生活和工业领域的各个方面。高分子科学已经发展成为一门独立的学科,与其他传统学科不同,它既是一门基础学科也是一门应用学科。目前,国内近200所高校开设了高分子材料科学与工程专业,“聚合物成型加工原理”理论课和“聚合物成型加工原理”实验课是该专业的主干课程,在高分子材料专业人才培养中发挥着至关重要的作用。笔者作为担任此课程的主讲教师,具有十余年的教学经验,在理论和实验教学过程发现“聚合物成型加工原理”理论课中涉及到的实验的内容不能够有效支撑理论教学,“聚合物成型加工原理”实验课也没有和理论教学内容相关联等问题。这不仅不利于学生对“聚合物成型加工原理”所涉及到专业理论知识的理解和掌握,而且会导致学生对后续专业课程学习失去兴趣,甚至可能影响到学生的动手创新能和科研能力的培养。鉴于此,本文提出从“迷你”聚合物成型加工仪器研发的角度来解决理论教学和实验教学不能相互支撑的问题,以期为国内高校在“聚合物成型加工原理”理论课和实验课的建设提供借鉴。

关键词： “迷你”仪器高分子材料聚合物成型加工教学改革

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

非小细胞肺癌靶向治疗中不良反应的护理

引用

中西医结合护理（中英文） 2015年第4期1卷 114-115页

作者：孙雷刘改丽张玲季有信山东省青岛市肿瘤医院肿瘤综合科山东青岛266042

目的总结非小细胞肺癌靶向治疗中不良反应的护理措施。方法回顾性分析46例非小细胞肺癌患者靶向治疗后不良反应的预防及护理。结果 46例患者中,出现皮肤反应28例,腹泻17例,肝功能异常3例,间质性肺炎1例。护理对策包括针对皮疹和腹泻患... 详细信息

目的总结非小细胞肺癌靶向治疗中不良反应的护理措施。方法回顾性分析46例非小细胞肺癌患者靶向治疗后不良反应的预防及护理。结果 46例患者中,出现皮肤反应28例,腹泻17例,肝功能异常3例,间质性肺炎1例。护理对策包括针对皮疹和腹泻患者合理使用药物,积极监测肝功能异常患者各项肝功能指标,保持室内空气清新等。结论非小细胞肺癌靶向治疗中应严密观察患者皮肤、胃肠道等方面的不良反应。

关键词：非小细胞肺癌靶向治疗不良反应护理干预

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：