检索结果-南通市图书馆

Requirement and Functional Redundancy of Ib Subgroup bHLH Proteins for Iron Deficiency Responses and Uptake in Arabidopsis thaliana

引用

Molecular Plant 2013年第2期6卷 503-513页

作者： Ning Wang Yan Cui Yi Liu Huajie Fan Juan Du Zongan Huang youxi yuan Huilan Wu Hong-Qing Ling State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences No. 1West Beichen Road Chaoyang District Beijing 100101 China Graduate School of theChinese Academy of Sciences Yuquan Road Shijingshan District Beijing 100049 China Present address: Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Present address: Institute of Vegetable Crops Wenzhou Academy of Agricultural Sciences Wenzhou Vocation College of Science and TechnologyWenzhou 325014 China

The Ib subgroup of the bHLH gene family in Arabidopsis contains four members （AtbHLH38, AtbHLH39, AtbHLHIO0, and AtbHLH101）. AtbHLH38 and AtbHLH39 were previously confirmed to interact with FER-like iron deft-ciency induced transcription factor （FIT）, directly functioning in activation of the expression of ferric-chelate reductase FRO2 and high-affinity ferrous iron transporter IRT1. In this work, we characterized the functions of AtbHLH100 and AtbHLH101 in the regulation of the iron-deficiency responses and uptake. Yeast two-hybrid analysis and bimolecular fluorescence complementation assay demonstrated that both AtbHLH100 and AtbHLH101 could interact with FIT. Dual expression of either AtbHLH100 or AtbHLH101 with FIT in yeast cells activated the GUS expression driven by promoters of FRO2 and IRT1. The plants overexpressing FIT together with AtbHLHI01 showed constitutive expression of FRO2 and IRT1 in roots, and accumulated more iron in shoots. Further, the single, double, and triple knockout mutants of AtbHLH38, AtbHLH39, AtbHLH100, and AtbHLH101 were generated and characterized. The FRO2 and IRT1 expression in roots and the iron content in shoots were more drastically decreased in the triple knockout mutant of AtbHLH39, AtbHLH100, and AtbHLH101 than that of the other available double and triple mutants of the four genes. Comparison of the physiological responses as well as the expression of FRO2 and IRT1 in the multiple knockout mutants under iron deficiency revealed that AtbHLH100, AtbHLH38, AtbHLH101, and AtbHLH39 played the gradually increased important role in the iron-deficiency responses and uptake. Taken all together, we conclude that the four Ib subgroup bHLH proteins are required and possess redundant functions with differential significance for activation of iron-deficiency responses and uptake in Arabidopsis.

关键词： transcription factor bHLH protein iron homeostasis FIT.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular regulation mechanism of iron uptake in arabidopsis and tomato

Molecular regulation mechanism of iron uptake in arabidopsis...

引用

International Symposium on Green Technology and Ecosystem Health

作者： Hongqing Ling youxi yuan and Huilan Wu Ning Wang The State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences Datun Load Chaoyang District Beijing 100101 China

＜正＞Iron is an essential nutrition element for all organisms. It functions as a component of many important enzymes and proteins involved in fundamentally biochemical processes. Iron deficiency causes anaemia afflic... 详细信息

关键词： arabidopsis iron molecular mechanism uptake tomato

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Double Penalized Quantile Regression for the Linear Mixed Effects Model

引用

Journal of Systems Science & Complexity 2020年第6期33卷 2080-2102页

作者： LI Hanfang LIU yuan LUO youxi School of Science Hubei University of TechnologyWuhan 430068China School of Mathematics and Statistics Central China Normal UniversityWuhan 430079China Rollins School of Public Health Emory UniversityAtlanta 30322USA

This paper proposes a double penalized quantile regression for linear mixed effects model,which can select fixed and random effects *** of using two tuning parameters,the proposed iterative algorithm enables only one optimal tuning parameter in each step and is more *** authors establish asymptotic normality for the proposed estimators of quantile regression *** studies show that the new method is robust to a variety of error distributions at different *** outperforms the traditional regression models under a wide array of simulated data models and is flexible enough to accommodate changes in fixed and random *** the high dimensional data scenarios,the new method still can correctly select important variables and exclude noise variables with high probability.A case study based on a hierarchical education data illustrates a practical utility of the proposed approach.

关键词： Double penalized fixed effects quantile regression random effects variable selection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于SB-DInSAR时间序列探测地震形变过程的研究

引用

大地测量与地球动力学 2011年第6期31卷 15-19页

作者：罗三明杨国华董运洪韩月萍李陶袁油新中国地震局第一监测中心天津300180 武汉大学卫星导航定位技术研究中心武汉430079

对2009年4月6日意大利拉奎拉6.3级地震9景ENVISAT重轨单视复数据采用双轨模式进行小基线(SB)干涉处理,获得了此次地震的SB-DInSAR时间序列干涉图、位移场以及位移速度场。结果表明:1)地震位移场形变过程为由震前的缓慢变化到震后的加速... 详细信息

对2009年4月6日意大利拉奎拉6.3级地震9景ENVISAT重轨单视复数据采用双轨模式进行小基线(SB)干涉处理,获得了此次地震的SB-DInSAR时间序列干涉图、位移场以及位移速度场。结果表明:1)地震位移场形变过程为由震前的缓慢变化到震后的加速运动,速度明显由慢到快;2)震中以西为大面积隆起区,最大隆起量为140 mm;震中以东为大面积下沉区域,但形变集中在破裂区,主要在发震过程及震后形成,最大沉降量达185mm;3)地震产生的破裂主要沿震中的东南方向传播,集中在约13.4 km×7.6 km、方向约135°的椭圆形区域内。

关键词： SB-DInSAR 时间序列拉奎拉地震雷达干涉形变过程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

机械零件淬火质量缺陷及控制方法

引用

煤矿机电 2014年第3期35卷 117-119页

作者：程占北赵永丽袁有西河南万合机械有限公司河南新密452371

针对机械零件淬火后易产生的缺陷,通过对零件淬火产生畸变的类型、减少畸变的途径和方法、如何校正畸变、淬火开裂的原因、硬度不足产生的原因、软点以及表面麻点产生的原因及措施进行了分析,以期对提高零件的淬火质量、减少淬火缺陷的... 详细信息

针对机械零件淬火后易产生的缺陷,通过对零件淬火产生畸变的类型、减少畸变的途径和方法、如何校正畸变、淬火开裂的原因、硬度不足产生的原因、软点以及表面麻点产生的原因及措施进行了分析,以期对提高零件的淬火质量、减少淬火缺陷的产生,有一定的参考价值。

关键词：热处理淬火工艺缺陷及控制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

引用

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The dopaminergic system and Alzheimer's disease

引用

Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sex differences in aging and injured brain

引用

Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EMCCD冷指温度控制系统

引用

天文研究与技术 2013年第3期10卷 293-300页

作者：袁尤西李彬华程向明金建辉昆明理工大学信息工程与自动化学院云南昆明650500 中国科学院云南天文台云南昆明650011

为了对EMCCD冷指温度进行精确的控制,介绍了一种新的温度检测与控制系统的设计方案。该系统采用铂电阻Pt1000作为温度敏感元件,AD7705作为模数转换模块,以单片机STC89C52为核心实现数据采集与加热控制功能。温度数据可以在系统的液晶屏... 详细信息

为了对EMCCD冷指温度进行精确的控制,介绍了一种新的温度检测与控制系统的设计方案。该系统采用铂电阻Pt1000作为温度敏感元件,AD7705作为模数转换模块,以单片机STC89C52为核心实现数据采集与加热控制功能。温度数据可以在系统的液晶屏上实时显示,也可通过RS232串口传至上位机进行显示、存储。系统测试时,分别采用了20 V和18.5 V的电源电压对EMCCD冷指进行加热。测试数据的统计分析表明,该系统能将EMCCD冷指温度控制在一个设定低温值(如-100℃)附近,系统误差在0.006 8℃以内。

关键词： CCD 制冷温度检测单片机统计分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

引用

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：