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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang Yunhong Zhang hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Global Talent Cultivation Against the Backdrop of International Cooperation for Education

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学术界 2017年第1期 285-290页

作者： Jiang youwei School of Foreign Languages Chongqing University of Technology Chongqing 400054

With a continuously rising economic and political status on the global market,China has been witnessing increasingly more frequent exchanges with many countries and regions in the *** to this,globally-minded talents who are highly competent in cross-cultural communications are now in heavy ***,a host of challenges are to be confronted with in the process of cooperation with overseas higher educational *** response to meeting the country's rising demands for internationally competitive talents,higher institutions should spare no efforts to make specific plans to cultivate students with a global vision and a good command of knowledge of international business via taking various measures to upgrade their overall plan for education,putting the cultivation of new generation of globally-minded talents on their top agenda and it is argued that the academic English should be introduced to students with care and without delay.

关键词：人才培养国际教育合作高等教育机构跨文化交际国际竞争力全球市场国际商务

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Intelligent Silent Zone for Source-Location Privacy Based on Context-Awareness in WSNs

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 203-218页

作者： Zhou Qian Qin Xiaolin Ding youwei College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106P.R.China Jiangsu Key Laboratory of Internet of Things and Control Technology Nanjing 211106P.R.China

In many wireless sensor networks(WSNs)applications,the preservation of source-location privacy plays a critical role in concealing context information,otherwise the monitored entities or subjects may be put in *** traditional solutions have been proposed based on the creation of random routes,such as random walk and fake sources approach,which will lead to serious packet delay and high energy *** of applying the routing in a blind way,this article proposes a novel solution for source location privacy in WSNs by utilizing sensor ability of perceiving the presence a mobile attacker nearby,for patient attackers in particular to increase the safety period and decrease the data delivery *** proposed strategy forms an intelligent silent zone(ISZ)by sacrificing only a minority of sensor nodes to entice patient attackers away from real packet routing *** analysis and simulation results show that the proposed scheme,besides providing source location privacy energy efficiently,can significantly reduce real event reporting latency compared with the existing approaches.

关键词： source location privacy wireless sensor networks energy-efficiency context-aware

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Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng Wei Yu-Qing Huang Cheng-hong Yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke

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Room temperature synthesis of single-crystal Te nanorods from Na_2TeO_4

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Rare Metals 2008年第6期27卷 608-611页

作者： MIAO Chunyan YAO youwei WAN Junxi TANG Guoyi Institute of Advanced Materials Graduate School of Shenzhen Tsinghua University Shenzhen 518055 China

Single-crystalline tellurium nanorods were synthesized through the reduction of Na2TeO4 by hydrazine monohydrate, in the absence of surfactants, in an aqueous ammonia solution at room temperature. X-ray diffraction （XRD）, transmission electron microscopy （TEM）, and selected area electron diffraction （SAED） were used to characterize the composition and morphology of the products. The concentration of the OH ion has a significant influence on the morphology of the products and is found to be responsible for tailoring the crystal growth dynamically： the concentration of Te blocking in the solution is reduced via increasing the concentration of the OH^- ion, and subsequently the nucleation rate of Te is suppressed and Te nanorods gradually grow because of the inherently anisotropic structure of Te. New generation tellurium atoms add to the surface of the particles during the long period of reaction.

关键词： nanorods tellurium room temperature synthesis single crystal sodium tellurate

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Primal-dual algorithms for total variation based image restoration under Poisson noise Dedicated to Professor Lin Qun on the Occasion of his 80th Birthday

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Science China Mathematics 2016年第1期59卷 141-160页

作者： WEN youwei CHAN Raymond Honfu ZENG TieYong Faculty of Science Kunming University of Science and TechnologyKunming 650093China Department of Mathematics The Chinese University of Hong KongShatinHong KongChina Department of Mathematics Hong Kong Baptist UniversityKowloonHong KongChina

We consider the problem of restoring images corrupted by Poisson noise. Under the framework of maximum a posteriori estimator, the problem can be converted into a minimization problem where the objective function is composed of a Kullback-Leibler(KL)-divergence term for the Poisson noise and a total variation(TV) regularization term. Due to the logarithm function in the KL-divergence term, the non-differentiability of TV term and the positivity constraint on the images, it is not easy to design stable and efficiency algorithm for the problem. Recently, many researchers proposed to solve the problem by alternating direction method of multipliers(ADMM). Since the approach introduces some auxiliary variables and requires the solution of some linear systems, the iterative procedure can be complicated. Here we formulate the problem as two new constrained minimax problems and solve them by Chambolle-Pock's first order primal-dual approach. The convergence of our approach is guaranteed by their theory. Comparing with ADMM approaches, our approach requires about half of the auxiliary variables and is matrix-inversion free. Numerical results show that our proposed algorithms are efficient and outperform the ADMM approach.

关键词： image restoration Poisson noise total variation (TV) alternating direction method of multipliers (ADMM) primal-dual minimax problem

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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou hongdong Zhao Ye hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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Solid–liquid equilibrium of dimethyl terephthalate(DMT), dimethyl isophthalate(DMI) and dimethyl phthalate(DMP) in melt crystallization process

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Chinese Journal of Chemical Engineering 2017年第12期25卷 1735-1739页

作者： Chunyuan Wu youwei Cheng Lijun Wang Xi Li Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China

The binary solid-liquid equilibrium of Dimethyl Terephthalate （DMT）, Dimethyl lsophthalate （DMI） and Dimeth- yl Phthalate （DMP） was investigated by experiment and differential scanning calorimetry （DSC）. The result demonstrated DMT/DMI and DMT/DMP systems are eutectic while DMI/DMP is a solid-solution system. The eutectic temperature of DMT/DMI system is 336.7 K and that of DMT/DMP is 271.1 K. Furthermore, a classical solid-liquid phase equilibrium model was used to fit the experimental data of the eutectic systems of DMT/DMI and DMT/ DMP and the theoretical model could describe the eutectic solid-liquid phase diagrams properly.

关键词： Solid-liquid equilibrium Differential scanning calorimetry Eutectic Solid-solution Phase equilibrium model

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A Total Variation Based Method for Multivariate Time Series Segmentation

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Advances in Applied Mathematics and Mechanics 2023年第2期15卷 300-321页

作者： Min Li Yumei Huang youwei Wen School of Mathematics and Statistics Center for Data ScienceLanzhou UniversityLanzhouGansu 730000China School of Mathematics and Statistics Hunan Normal UniversityChangshaHunan 410081China and Key Laboratory of Computing and Stochastic Mathematics(LCSM)Ministry of Education of China

Multivariate time series segmentation is an important problem in data mining and it has arisen in more and more practical applications in recent *** task of time series segmentation is to partition a time series into segments by detecting the abrupt changes or anomalies in the time *** time series segmentation can provide meaningful information for further data analysis,prediction and policy decision.A time series can be considered as a piecewise continuous function,it is natural to take its total variation norm as a prior information of this time *** this paper,by minimizing the negative log-likelihood function of a time series,we propose a total variation based model for multivariate time series *** iterative process is applied to solve the proposed model and a search combined the dynamic programming method is designed to determine the *** experimental results show that the proposed method is efficient for multivariate time series segmentation and it is competitive to the existing methods for multivariate time series segmentation.

关键词： Multivariate time series segmentation total variation dynamic programming

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