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Synthesis and Evaluation of Novel N-（4＇-Arylpyrimidin-2＇-yl） Sulfonylurea Derivatives as Potential Antifungal Agents

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Chemical Research in Chinese Universities 2015年第2期31卷 218-223页

作者： chen Wei LI Yuxin SHI Yanxia WEI Wei chen youwei LI Yonghong LIU Jingbo LI Baoju LI Zhengmmg State Key Laboratory of Elemento-Organie Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai University Tianjin 300071 P. R. China Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Beijing 100081 P. R. China

Sulfonylureas（SUs） are potent and selective inhibitors of acetohydroxyacid synthase and has been used as herbicides. Some SUs also displayed other biological activities. In order to discuss the antifungal activity of SUs, a series of novel SUs containing aryl-substituted pyrimidine moieties was designed and synthesized. The preliminary bioassay showed that the title compounds exhibited moderate to favorable fungicidal activities in vivo. Especially, compound 9b exhibited more efficacy than the controls against five fungi at 25 mg/L. These promising results indicate that an aryl group on pyrimidine ring is favorable for antifungal activity and SUs are potential inhibitors for some phytopathogenic fungi.

关键词： Acetohydroxyacid synthase Sulfonylurea Fungicidal activity Substituted pyrimidine

Synthesis and Biological Activities of Novel Methyl Xanthine Derivatives

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Chemical Research in Chinese Universities 2014年第1期30卷 98-102页

作者： chen youwei WANG Baolei GUO Yanjun ZHOU Yunyun PAN Li XIONG Lixia YU Shujing LI Zhengming State Key Laboratory of Elemento-organic Chemistry Research Institute of Elemento-organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai University Tianjin 300071 P. R. China

Caffeine is one of methyl xanthine compounds,which has the similar mode of action as ryanodine receptor *** order to find novel and efficient insecticide,structural modification of certain methyl xanthine compounds was made by introducing some common pesticidal active moieties into the structure of *** novel methyl xanthine compounds were synthesized and characterized by 1H nuclear magnetic resonance（1H NMR）,elemental analylsis or high-resolution mass spectrometry（HRMS）.According to the biological activity results,it was found that these new compounds show moderate activity towards Mythimna separata Walker and Culex pipiens *** example,compound 2d shows a lethality rate of 40％ at 200 mg/L towards Mythimna separata Walker,compounds 2i and 2f show 56.7％ and 53.3％ lethality rates at 2 mg/L towards Culex pipiens pallens,which are all better than *** addition,some compounds of them show moderate antifungal activity to some plant pathogenous fungi.

关键词： Caffeine Xanthine Insecticidal activity Antifungal activity

Design, Synthesis, Antifungal Activities and SARs of （R）-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acid Derivatives

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Chinese Journal of Chemistry 2015年第11期33卷 1269-1275页

作者： Jingbo Liu Yuxin Li youwei chen Xuewen Hua Yingying Wan Wei Wei Haibin Song Shujing Yu Xiao Zhang Zhengming Li State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science DQG Engineering ( Tianjin) Nankai University Tianjin 300071 China

Based on the structure of natural product 2-aryl-4,5-dihydrothiazole-4-carboxylic acid, a series of novel （R）-2-aryl-4,5-dihydrothiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were characterized by ^1H NMR, ^13C NMR and HRMS. The single crystal structure of compound 9b was determined by X-ray diffraction analysis. The antifungal activities were evaluated for the first time. The bioassay results indicated that most compounds exhibited moderate to good antifungal activities. The antifungal activities of compound 13a （against Cercospora arachidicola Hori）, 13d （against Alternaria solani）, and 16e （against Cercospora arachidieola Hori） were 61.9%, 67.3% and 61.9%, respectively, which are higher than those of the commercial fungicides chlorothalonil and carbendazim. Moreover, compound 13d exhibited excellent antifungal activities against 7 kinds of the fungi tested （66.7%, 77.3%, 63.0%, 87.9%, 70.0%, 70.0% and 80.0% at 50 μg/mL）. Therefore, 13d can be used as a new lead structure for the development of antifungal agents.

关键词： (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acid synthesis antifungal activity structure-activity relationship

Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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Journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： Ziyi Lin Xiaolong Fan Gaojie chen youwei Hong Mengren Li Lingling Xu Baoye Hu chen Yang Yanting chen Zhiqian Shao Jinsheng chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,*** concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and *** on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping *** to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace *** the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain *** risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source

Design, Synthesis and Biological Activities of Novel Anthranilic Diamides Containing Dihydroisoxazoline and Isoxazole

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Chemical Research in Chinese Universities 2016年第1期32卷 41-48页

作者： LIU Jingbo LI Yuxin chen youwei WU Changchun WAN Yingying WEI Wei XIONG Lixia ZHANG Xiao YU Shujing LI Zhengming State Key Laboratory of Elemento-organie Chemistry Institute of Elemento-organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai University Tianjin 300071 P. R. China

Anthranilic diamides are one of the most important classes of modern agrochemical insecticides. To discover new structures with higher activity, lower toxicity and lower residue, a series of novel anthranilic diamides containing dihydroisoxazoline and isoxazole was designed and synthesized. Their structures were characterized by means of melting points, proton nuclear magnetic resonance（IH NMR）, 13C NMR and high resolution mass spectrometry（HRMS）. According to the bioassay data, it was found that some of the title compounds exhibit moderate insecticidal activity and good antifungal activity. In particularly, compound 15b with a concentration of 50 mg/L shows a lethality rate of 60.0% against Mythimna separata Walker and a lethality rate of 50.0% against Culex pipiens pallens with a concentration of 1 mg/L. Moreover, compound 15b showed good antifungal activities（58.8%, 77.1%, 70.7%, 55.3%, 60.7%, 65.4%） when against all the tested fungi（Cercospora araehidicola tIori, Physalospora piricola, Rhizoctonia cerealis, Bipolaris maydis, Watermelon anthracnose, Fusarium moniliforme）. The effects of compounds 14h, 14j and 15b on the concentration of intracellular calcium ion（[Ca2＋]i） in the central neurons of Mythimna separate Walker were well investigated via calcium imaging technique. The results demonstrate that the novel compounds can elevate the calcium concentration in the neurons, denoting that some new structures are potential modulators of the insect ryanodine receptor（RyR）.

关键词： Anthranilic diamide Dihydroisoxazoline Isoxazole Biological activity Calcium channel

媒体融合背景下的大型公立医院对外宣传策略及思考

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中国社会医学杂志 2024年第3期41卷 266-268页

作者：聂文闻王继亮孙晖熊婉婷彭锦弦陈有为华中科技大学同济医学院附属协和医院湖北武汉430022

在媒体融合不断深化的背景下,大型公立医院必须明确对外宣传对象、平台、内容,精准宣传功能定位,走高质量发展道路。对外宣传工作作为医院品牌形象输出的重要窗口,已经从主要依赖传统媒体逐步迈入深度互融的媒体融合新时代。在健康中国... 详细信息

在媒体融合不断深化的背景下,大型公立医院必须明确对外宣传对象、平台、内容,精准宣传功能定位,走高质量发展道路。对外宣传工作作为医院品牌形象输出的重要窗口,已经从主要依赖传统媒体逐步迈入深度互融的媒体融合新时代。在健康中国战略的引领下,如何适应新形势、积极开展对外宣传工作,是广大医疗机构卫生新闻宣传工作人员面临的困境和问题。文章对国内有关公立医院媒体融合发展状况的相关文献进行分析和研究,结合综合性大型公立医院创新实践,提出了公立医院对外宣传工作的新发展路径。

关键词：媒体融合对外宣传公立医院高质量发展

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Atmospheric oxidation capacity and O_(3) formation in a coastal city of southeast China:Results from simulation based on four-season observation

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Journal of Environmental Sciences 2024年第2期136卷 68-80页

作者： Gaojie chen Taotao Liu Jinsheng chen Lingling Xu Baoye Hu chen Yang Xiaolong Fan Mengren Li youwei Hong Xiaoting Ji Jinfang chen Fuwang Zhang Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China College of Harbour and Coastal Engineering Jimei UniversityXiamen 361021China Environmental Monitoring Center of Fujian Fuzhou 350013China

The pollution of atmospheric ozone in China shows an obvious upward trend in the past ***,the studies on the atmospheric oxidation capacity and O_(3)formation in four seasons in the southeastern coastal region of China with the rapid urbanization remain ***,a four-season field observation was carried out in a coastal city of southeast China,using an observation-based model combining with the Master Chemical Mechanism,to explore the atmospheric oxidation capacity(AOC),radical chemistry,O_(3)formation pathways and *** results showed that the average net O_(3)production rate(14.55 ppbv/hr)in summer was the strongest,but the average O_(3)concentrations in autumn was *** AOC and ROx levels presented an obvious seasonal pattern with the maximum value in summer,while the OH reactivity in winter was the highest with an average value of 22.75 sec^(-1).The OH reactivity was dominated by oxygenated VOCs(OVOCs)(30.6%-42.8%),CO(23.2%-26.8%),NO_(2)(13.6%-22.0%),and alkenes(8.4%-12.5%)in different *** photolysis dominated OH primary source on daytime in winter,while in other seasons,HONO photolysis in the morning and ozone photolysis in the afternoon contributed *** analysis indicated that O_(3)production was controlled by VOCs in spring,autumn and winter,but a VOC-limited and NOx-limited regime in summer,and alkene and aromatic species were the major controlling factors to O_(3)***,the study characterized the atmospheric oxidation capacity and elucidated the controlling factors for O_(3)production in the coastal area with the rapid urbanization in China.

关键词： Atmospheric oxidation capacity Radical chemistry Ozone production Sensitivity analysis

2D hierarchical lattices' imperfection sensitivity to missing bars defect

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Theoretical & Applied Mechanics Letters 2015年第4期5卷 141-145页

作者： Bo Wang Yunfeng Shi Rui Li youwei chen Yihua Mo State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Beijing Institute of Astronautical Systems Engineering

Commercially available lattices contain various kinds of morphological imperfections which result in great degradation in lattices＇ mechanical properties, therefore, to obtain imperfection insensitive lattice structure is obviously a practical research subject. Hierarchical structure materials were found to be a class of promising anti-defect materials, This paper builds hierarchical lattice by adding soft adhesion to lattice＇s cell edges and numerical results show that its imperfection sensitivity to missing bars is minor compared with the classic lattice. Soft adhesion with appropriate properties reinforce cell edge＇s bending stiffness and thus reduce the bending deformation in lattice caused by missing bars defect, which is confirmed by statistical analysis of normalized node displacements of imperfect lattices under hydrostatic compression and shear loads.

关键词： Hierarchical structures Lattices Imperfection sensitivity Elastic properties Missing bars

混合三端直流输电系统受端交流故障穿越协调控制策略

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电力科学与工程 2024年第4期40卷 31-43页

作者：王成磊濮永现黄力文唐岚陈有为胡红文魏可佳昆明理工大学电力工程学院云南昆明650051 中国电建集团昆明勘测设计研究院有限公司云南昆明650051 云南电网责任有限公司曲靖供电局云南曲靖655100

以乌东德电站送电广东广西特高压多端柔性直流示范工程为研究对象,考虑混合三端柔性直流输电系统因受端不同位置交流故障所致的直流过电压,提出相应的故障穿越协调控制策略。在受端主站发生网侧交流瞬时故障的情形下,通过设计混合型模... 详细信息

以乌东德电站送电广东广西特高压多端柔性直流示范工程为研究对象,考虑混合三端柔性直流输电系统因受端不同位置交流故障所致的直流过电压,提出相应的故障穿越协调控制策略。在受端主站发生网侧交流瞬时故障的情形下,通过设计混合型模块化多电平电压源换流器全桥子模块自适应负投入策略,实现了利用子模块电容短时过电压储能的能力来快速补偿站间直流电压的上升;短暂时延后,送端电网换相换流器通过定量调整电流指令值策略来减小子模块的不平衡充电功率。在受端主站发生阀侧交流故障的情形下,优先利用输电健全极的功率转代裕度来消纳故障极的部分不平衡功率;同时,故障极从站跟随主站半压运行,相应的高低压阀组切换至定电流及定电压模式,最终实现抑制站间过电流及减小盈余功率。仿真结果表明,2种故障条件下,所提的协调控制策略均可较快实现故障期间的功率平衡,有效抑制仅配备稳态基本协调控制策略下系统所出现的直流过电压现象,同时也基本维持了送端的总体有功传输容量。

关键词：特高压直流输电多端柔性直流输电受端交流故障穿越直流过电压抑制站间协调控制策略