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Novel non-invasive biological predictive index for liver fibrosis in hepatitis C virus genotype 4 patients

World Journal of Hepatology 2016年第32期8卷 1392-1401页

作者： Mahmoud Khattab Mohamed Amin Sakr Mohamed Abdel Fattah youssef mousa.elwy solima. Ashraf Breedy Mona Fathi Salwa Gaber Ahmed Altaweil Ashraf Osman Ahmed Hassouna Ibrahim Motawea Department of Internal Medicine Minia University Department of Tropical Medicine Ain Shams University Department of Clinical Pathology Ain Shams University Department of Pathology Minia University Department of Pathology Ain Shams University Department of Clinical Pathology Minia University Department of Cardiothoracic Surgery Ain Shams University

AIMTo investigate the diagnostic ability of a non-invasive biological marker to predict liver fibrosis in hepatitis C genotype 4 patients with high accuracy. METHODSA cohort of 332 patients infected with hepatitis C genotype 4 was included in this cross-sectional study. Fasting plasma glucose, insulin, C-peptide, and angiotensin-converting enzyme serum levels were measured. Insulin resistance was mathematically calculated using the homeostasis model of insulin resistance (HOMA-IR). RESULTSFibrosis stages were distributed based on Metavir score as follows: F0 = 43, F1 = 136, F2 = 64, F3 = 45 and F4 = 44. Statistical analysis relied upon reclassification of fibrosis stages into mild fibrosis (F0-F) = 179, moderate fibrosis (F2) = 64, and advanced fibrosis (F3-F4) = 89. Univariate analysis indicated that age, log aspartate amino transaminase, log HOMA-IR and log platelet count were independent predictors of liver fibrosis stage (P CONCLUSIONOur predictive model is easily available and reproducible, and predicted liver fibrosis with acceptable accuracy.

关键词： Liver fibrosis Insulin resistance Aspartate amino transaminase Platelets Age

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Mixes of Carrot Juice and Some Fermented Dairy Products: Potentiality as Novel Functional Beverages

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Food and Nutrition Sciences 2012年第2期3卷 233-239页

作者： Amany E. El-Abasy Hany A. Abou-Gharbia Hamida M. mousa Mohammed M. youssef Food Science and Technology Department Faculty of Agriculture Alexandria University Alexandria Egypt.

The present study aimed to formulate and evaluate yoghurt and Rayeb (Traditional Egyptian natural fermented milk) mixes with red and yellow carrot juices. Out of 16 different mixing ratios (Eight for yoghurt and eight for Rayeb), data indicated that the most significantly acceptable mixes as judged by panelists were: yoghurt-red carrot juice (3:1 v/v), yoghurt-yellow carrot juice (2:1 v/v), Rayeb-red carrot juice (2:1 v/v) and Rayeb-yellow carrot juice (4:1 v/v). The aforementioned mixes were further investigated versus their counterpart controls (yoghurt and Rayeb). It was obvious that the formulated mixes contained considerably higher concentrations of the bioactive components mainly, ascorbic acid and anthocyanins (red-carrot mixes) and β-carotene (yellow-carrot mixes) along with antioxidant activity (DMPD Radical Scavenging Activity) and higher counts of probiotic LAB, as compared to the controls.

关键词： Yoghurt Rayeb Probiotics Anthocyanins β-Carotene Antioxidants

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