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Anti-aging based on stem cell therapy:A scoping review

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World Journal of Experimental Medicine 2024年第3期14卷 57-63页

作者： Nassar El Assaad Alain Chebly Rawad Salame Robert Achkar Nour Bou Atme Khalil Akouch Paul Rafoul Colette Hanna Samer Abou zeid Marwan Ghosn Charbel Khalil Faculty of Medicine Saint Joseph UniversityBeirut 961Lebanon Centre Jacques Loiselet for Medical Genetics and Genomics(CGGM) Faculty of MedicineSaint Joseph UniversityBeirut 961Lebanon Higher Institute of Public Health Saint Joseph UniversityBeirut 961Lebanon Stem Cell Therapy Lab Reviva Regenerative Medicine CenterBeirut 961Lebanon Poz Pozan University of Medical Sciences Pozan 034Poland Department of Epidemiology and Biostatistics Faculty of Public HealthLebanese UniversityBeirut 961Lebanon School of Medicine Lebanese American UniversityBeirut 961Lebanon Bone Marrow Transplant Unit Burjeel Medical CityAbu Dhabi 999041United Arab Emirates

Stem cells are present in the tissues and organs and remain in a quiescent and undifferentiated state until it is physiologically necessary to produce new descendant *** to their multipotency property,mesenchymal stem cells have attracted considerable attention worldwide due to their immunomodulation and therapeutic function in tissue *** cells secrete components such as paracrine factors,extracellular vesicles,and exosomes which have been shown to have anti-inflammatory,anti-aging,reconstruction and wound healing potentials in many in vitro and in vivo *** pluripotency and immunomodulatory features of stem cells could potentially be an effective tool in cell therapy and tissue *** affects the capacity for self-renewal and differentiation of stem cells,decreasing the potential for regeneration and the loss of optimal functions in organisms over *** progress in the field of cellular therapy and regenerative medicine has facilitated the evolution of particular guidelines and quality control approaches,which eventually lead to clinical *** therapy could potentially be one of the most promising therapies to control aging due to the fact that single stem cell transplantation can regenerate or substitute the injured *** understand the involvement of stem cells not only in tissue maintenance and disease but also in the control of aging it is important to know and identify their properties,functions,and regulation in vivo,which are addressed in this review.

关键词： Mesenchymal stem cell Anti-aging Telomerase Regenerative medicine Stem cell therapy

Tailored pancreatic reconstruction after pancreaticoduodenectomy: a single-center experience of 892 cases

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 528-536页

作者： Ayman El Nakeeb Ahmad M Sultan Ehab Atef Ali Salem Mostaffa abu zeid Ahmed abu El Eneen Gamal El Ebidy Mohamed Abdel Wahab Gastroenterology Surgical Center Mansoura UniversityMansoura 35516 Egypt

BACKGROUND: Pancreatic reconstruction following pancreaticoduodenectomy(PD) is still debatable even for pancreatic surgeons. Ideally, pancreatic reconstruction after PD should reduce the risk of postoperative pancreatic fistula(POPF) and its severity if developed with preservation of both exocrine and endocrine pancreatic functions. It must be tailored to control the morbidity linked to the type of *** study was to show the best type of pancreatic reconstruction according to the characters of pancreatic stump. METHODS: We studied all patients who underwent PD in our center from January 1993 to December 2015. Patients were categorized into three groups depending on the presence of risk factors of postoperative complications: low-risk group(absent risk factor), moderate-risk group(presence of one risk factor) and high-risk group(presence of two or more risk factors). RESULTS: A total of 892 patients underwent PD for resection of periampullary tumor. BMI >25 kg/m~2, cirrhotic liver, soft pancreas, pancreatic duct diameter <3 mm, and pancreatic duct location from posterior edge <3 mm are risk variables for development of postoperative complications. POPF developed in 128(14.3%) patients. Delayed gastric emptying occurred in 164(18.4%) patients, biliary leakage developed in 65(7.3%) and pancreatitis presented in 20(2.2%). POPF in low-, moderate-and high-risk groups were 26(8.3%), 65(15.7%) and 37(22.7%) patients, respectively. Postoperative morbidity and mortality were significantly lower with pancreaticogastrostomy(PG) in high-risk group, while pancreaticojejunostomy(PJ) decreases incidence of postoperative steatorrhea in all groups. CONCLUSIONS: Selection of proper pancreatic reconstruction according to the risk factors of patients may reduce POPF and postoperative complications and mortality. PG is superior to PJ as regards short-term outcomes in high-risk group but PJ provides better pancreatic function in all groups and therefore, PJ is superior in l

关键词： periampullary tumor pancreaticogastrostomy pancreaticojejunostomy pancreaticoduodenectomy postoperative pancreatic fistula

Autunite-Group Minerals and Their Paragenesis from the Sheared Granite of Gabal El Sela, South Eastern Desert, Egypt

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Open Journal of Geology 2020年第6期10卷 703-725页

作者： Ehab K. abu zeid Nuclear Material Authority Cairo Egypt

G. El Sela is located in the Southern Eastern Desert of Egypt cropping as two parts, occupied by monzogranites that were categorized as biotite granite, muscovite granite and two mica granites. The northern part is more significant according its high concentrations of uranium that controlled by complicated structure regime;faulting, infrastructures and shearing are the most common structural criteria of this part. The Egyptian Nuclear Materials Authority (NMA) mined this part to produce the uranium ore. The previous mineralogical studies indicated that this granite was dominated by primary uranium minerals (pitchblende and coffinite) and secondary minerals belong to the autunite group (autunite, metautunite, phurcalite) in addition to uranophane. In the present work, petrographic and mineralogical studies are applied for the granites using the polarized and stereo microscopes and followed by electron microscope and XRD. The result of the microscopic examinations revealed the tectonic regime controlling the radioactivity and recognized the sodic autunite (meta-natroautunite) beside the pre-mentioned autunite group minerals completing the paragenetic sequrnce of these minerals. In this study, it is concluded that the sheared biotite granite is monzogranite originated during the episode of the continental plate collision (syncollision). The study finished to presence of two main types of the alteration corresponding to the two high levels of radioactivity (moderate and anomalous). The first is the thermal alteration (saussiritization, sericitization, kaolinization, silicification and hematization) and the second is the chemical transformation (oxidation, dehydration, ion substitutions and confusion) responsible for formation of the secondary uranium minerals. The temperature needed for the thermal alteration is sourced by the hydrothermal solutions, while the temperature needed for the uranium minerals transformation may be generated during the episode of the continent

关键词： Autunite-Group Paragenesis Thermal Alteration Chemical Alteration Confusion

Petrology, geochemistry, radioactivity, and M–W type rare earth element tetrads of El Sela altered granites, south eastern desert,Egypt

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Acta Geochimica 2019年第1期38卷 95-119页

作者： A.M.El Mezayen M.A.Heikal M.G.El-Feky H.A.Shahin I.K.abu zeid S.R.Lasheen Geology Department Faculty of Science Al Azhar University Nuclear Material Authority

The southern part of the Eastern Desert of Egypt—about 30 km southwest of abu-Ramad city—is mainly covered by ophiolitic rocks(Sul Hamed), island arc assemblage, younger granites(muscovite granites of Qash Amer and two mica granites of El Sela), and various acidic and basic dikes. Field, petrological, and geochemical studies indicate that the El Sela shear zone has been subject to hydrothermal and supergene alteration such as kaolinization, albitization, sericitization, and hematitization. It is invaded by quartz ENE–WSW veins associated with hydrothermal alteration accompanied by radioactive mineralization. The investigated younger granitic rocks had very low contents of compatible elements, such as Cr, Ni,and Co; and high contents of incompatible elements, such as Zr, and large ion lithophiles, such as Sr, especially in the El Sela shear zone. Major oxide and trace element analyses revealed calc-alkaline affinity and peraluminous *** highly differentiated granitic rocks' lower Zr/Hf and higher Y/Ho than the normal ratio are consistent with hydrothermal alteration. Most samples had rare earth element(REE)-patterns with an M-type tetrad effect in the first and fourth segments and a W-type tetrad in the third segment. The average ∑REE in the studied granites was lower than the world granite average; the ratio of light to heavy REEs greater. The main radioactive, uranium-bearing, and uraniferous Fe and Mn minerals are uranothorite,autunite, uranophane and autunite as compounds, kasolite,columbite, xenotime, uranophane-bearing zircon and jarosite, silver-bearing pyrite, hematite, and autunite-bearing pyrolusite.

关键词： Geochemistry REE-tetrad effect Radioactive minerals Radiometric measurements Qash Amer El Sela

Geochemistry, mineralogy, and radioactivity of the abu Furad Area, Central Eastern Desert, Egypt

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Acta Geochimica 2019年第2期38卷 307-326页

作者： A.M.El Mezayen E.K.abu zeid W.S.Hosny M.G.El-Feky S.M.Omar S.A.Taalab Geology Department Faculty of Science Al Azhar University Nuclear Material Authority Cairo Egypt

abu Furad is in the Central Eastern Desert,Egypt. It comprises metasediments, metavolcanics,metagabbros, syn-to late-orogenic granites, and post-orogenic granites, in addition to numerous dykes and veins of different shapes and composition invading all the older rocks cropping out in the study area. Field, petrographic,mineralogical, and chemical investigations led to the classification of abu Furad granites as quartz diorite, tonalite,granodiorite, and *** oxide and trace element data revealed that the syn-to late-orogenic granites and post-orogenic granites are peraluminous. Syn-to lateorogenic granites originated from calc-alkaline volcanic arc–related magma; while the post-orogenic granites(syenogranite) are highly fractionated, calc-alkaline granite from a within plate regime. Radiometrically, the studied quartz diorite, tonalite, and granodiorite had lower uranium and thorium contents and higher eU/eTh ratios than the syenogranites. This may indicate that the syn-to late-orogenic rocks originated from sources depleted in these elements. The average e Th/eU ratio of syenogranites was higher than that of average continental crust, suggesting that the syenogranites are relatively depleted in U. The studied altered syenogranites were strongly enriched in U and Th compared to the Earth's crust. On the other hand, the average of e U in pegmatites is lower than the global average for uraniferous pegmatites. The most recorded accessory minerals in the altered syenogranites were thorite, fergusonite, samarskite, columbite, zircon, monazite, xenotime,apatite, fluorite, sphene, atacamite, and malachite, in addition to chromium and nickel inclusions.

关键词： Hydrothermal alterations Major oxide and trace elements Radiometry Mineralogy Geochemistry Altered syenogranites Egypt

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阿斯旺高坝的环境影响

地理译报 1990年第4期9卷 20-25页

作者： Mahmoud abu zeid 丁登山水研究中心

阿斯旺高坝的建造,可以认为是充分利用尼罗河水的一场灌溉革命。该坝在20年前竣工时,成了大规模发展计划引起的全球性环境和社会问题的象征。科学和公众传播媒介所刊载的一系列论文和文章,很快使得这座高坝成为世界上最广为人知的环境... 详细信息

阿斯旺高坝的建造,可以认为是充分利用尼罗河水的一场灌溉革命。该坝在20年前竣工时,成了大规模发展计划引起的全球性环境和社会问题的象征。科学和公众传播媒介所刊载的一系列论文和文章,很快使得这座高坝成为世界上最广为人知的环境问题。高坝业已修建了20年。

关键词：坝环境影响

Dosimetric study of field junction in adjacent beams using asymmetric collimators and MLC

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The Chinese-German Journal of Clinical Oncology 2014年第9期13卷 435-438页

作者： Ahmed Zaki Hosnya abu-zeid Hada Ashry Khaled EL Shahat Department of Radiation Oncology El Gala Military Hospital Department of Physics Women College for Arts Science and Education Ain sham University National Center for Radiaion Research and Technology AEA Department of Clinical Oncology and Nuclear medicine Faculty of Medicine Alazahr University

Adjacent treatment fields are commonly employed in external beam radiation therapy, such as the mantle and inverted-Y fields for the treatment of Hodgkin's disease. In some cases, the adjacent fields are orthogonal, such as the craniospinal fields used in the treatment of medulloblastoma. Another example is the irradiation of head and neck tumors when the lateral neck fields are placed adjacent to the anterior supraclavicular field. In each of these situations, there is a possibility of introducing very large dosage errors across the junction. Consequently, this region is at risk for tumor recurrence if it is underdosed or severe complications if it is overdosed. Four millimeter overlap and gap resulted in an unacceptable dose in homogeneity in the junction. As a result of this study, the magnitudes of hot and cold spots might be clinically acceptable for 3 mm gap between photon fields.

关键词： field junctions linear accelerator dosimetric study

Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases

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World Journal of Gastroenterology 2017年第38期23卷 7025-7036页

作者： ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab gastroenterology surgical center mansoura university

AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary *** This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the *** Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%.

关键词： Pancreaticoduodenectomy Pancreaticogastrostomy Pancreaticojejunostomy Postoperative pancreatic fistula Periampullary tumor

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水因素与缺血性心脏病死亡率的关系

环境卫生学杂志 1980年第6期 335-337页

作者： abu-zeid HAH 姚志麒

Kobayashi 1957年首先在日本证明脑出血死亡率与河水化学成分有关。美国、瑞典和英国的报告表明,水硬度与心血管和脑血管疾病、冠心病、高血压等死亡率呈负相关。英国的大量研究几乎一直支持心血管疾病死亡率与“水因素”有关的假设。Gr... 详细信息

Kobayashi 1957年首先在日本证明脑出血死亡率与河水化学成分有关。美国、瑞典和英国的报告表明,水硬度与心血管和脑血管疾病、冠心病、高血压等死亡率呈负相关。英国的大量研究几乎一直支持心血管疾病死亡率与“水因素”有关的假设。Grawford 报导,水硬度在三十年内增高的某些地区心血管疾病死亡率下

关键词：标准化死亡率心血管疾病硬水显著相关标化死亡率 IHD 水硬度