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Adjuvant chemotherapy with paclitaxel and cisplatin in lymph node-positive thoracic esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2017年第2期29卷 149-155页

作者： Liangze Zhang Weiwei Li Xiao Lyu Yan Song yousheng mao Shaoming Wang Jing Huang Department of Thoracic Surgical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China Department of Medical Oncology the First Affiliated Hospital of Xinxiang Medical University Xinxiang 453100 China Department of Medical Oncology Central Hospital of Zibo Zibo 255036 China Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China Department of Cancer Epidemiology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China

Objective： No standard postoperative adjuvant chemotherapy has ever been established in node-positive esophageal squamous cell carcinoma （ESCC）. This is a study to explore the effect of postoperative paelitaxel （PTX） and cisplatin （DDP） in lymph node-positive, completely resected thoracic ESCC patients. Methods： We conducted a prospective phase II trial. Patients had pathologically node-positive thoracic ESCC with negative margins. Outcomes of disease-free survival （DFS） and overall survival （OS） were compared with a matched historical control cohort. The postoperative chemotherapy regimen consisted of 4 to 6 cycles of PTX 150 mg/m2 administered intravenously on d 1 followed by DDP 50 mg/m2 on d 2 every 14 d. Results： Forty-three patients were accrued from December 2007 to May 2012 at Cancer Hospital of Chinese Academy of Medical Sciences for adjuvant chemotherapy. The historical control group consisted of 80 patients who received complete resection but no adjuvant chemotherapy during the same period of time. Of the 43 patients with adjuvant chemotherapy, 37 （86.0%） patients completed 4 to 6 cycles of chemotherapy. The 3-year DFS rates were 56.3% in the adjuvant group and 34.6% in the control group （P=0.006）. The 3-year OS rates were 55.0% in the adjuvant group and 37.5% in the control group （P=0.013）. Multivariate analysis revealed that postoperative chemotherapy was the significant predictor for improved OS （P=0.005）. Conclusions： Biweekly adjuvant PTX and DDP might improve 3-year DFS and OS in lymph node-positive, curatively resected thoracic ESCC patients. These conclusions warrant further study in randomized phase III clinical trials.

关键词： Esophageal cancer adjuvant chemotherapy surgery paclitaxel cisplatin

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Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from Lung Cancer Patients

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Genomics, Proteomics & Bioinformatics 2019年第3期17卷 287-296页

作者： Xiang Wang Botao Zhang Yikun Yang Jiawei Zhu Shujun Cheng yousheng mao Lin Feng Ting Xiao State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College

T cells and T cell receptors(TCRs)play pivotal roles in adaptive immune responses against *** development of next-generation sequencing technologies has enabled the analysis of the TCRb repertoire *** the scarce investigations on the TCR repertoire in lung cancer tissues,in this study,we analyzed TCRb repertoires in lung cancer tissues and the matched distant non-tumor lung tissues(normal lung tissues)from 15 lung cancer *** on our results,the general distribution of T cell clones was similar between cancer tissues and normal lung tissues;however,the proportion of highly expanded clones was significantly higher in normal lung tissues than in cancer tissues(0.021%±0.002%vs.0.016%±0.001%,P=0.0054,Wilcoxon signed rank test).In addition,a significantly higher TCR diversity was observed in cancer tissues than in normal lung tissues(431.37±305.96 vs.166.20±101.58,P=0.0075,Mann-Whitney U test).Moreover,younger patients had a significantly higher TCR diversity than older patients(640.7±295.3 vs.291.8±233.6,P=0.036,Mann-Whitney U test),and the higher TCR diversity in tumors was significantly associated with worse cancer ***,we provided a comprehensive comparison of the TCR repertoires between cancer tissues and matched normal lung tissues and demonstrated the presence of distinct T cell immune microenvironments in lung cancer patients.

关键词： Adaptive immune response T cell receptor repertoire Lung cancer High-throughput sequencing TCR diversity

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Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3551-3566页

作者： Quanyou Wu Lin Feng Yaru Wang yousheng mao Xuebing Di Kaitai Zhang Shujun Cheng Ting Xiao State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China Department of Thoracic Surgery National Cancer Center/National Clinical Research Centerfor Cancer/CancerHospitalChinese Academyof Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Alternative RNA splicing is one of the most important mechanisms of posttranscriptional gene regulation,which contributes to protein diversity in *** is well known that RNA splicing dysregulation is a critical mechanism in tumor pathogenesis and the rationale for the promising splice-switching therapeutics for cancer *** we have a comprehensive understanding of DNA mutations,abnormal gene expression profiles,epigenomics,and proteomics in lung adenocarcinoma(LUAD),little is known about its aberrant alternative splicing ***,based on the multi-omics data generated from over 1000 samples,we systematically studied the RNA splicing alterations in LUAD and revealed their biological and clinical *** identifed 3688 aberrant alternative splicing events(AASEs)in LUAD,most of which were alternative promoter and exon *** specific regulatory roles of RNA binding proteins,somatic mutations,and DNA methylations on AASEs were comprehensively *** dissected the functional implications of AASEs and concluded that AASEs mainly affected biological processes related to tumor proliferation and *** also found that one subtype of LUAD with a particular AASEs pattern was immunogenic and had a better prognosis and response rate to *** findings revealed novel events related to tumorigenesis and tumor immune microenvironment and laid the foundation for the development of splice-switching therapies forLUAD.

关键词： alterations adenocarcinoma clinical

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Network Structure and Variability of Recurrence Fear in Early-Stage Non-Small Cell Lung Cancer:A Symptom Network Analysis

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Psycho-Oncologie 2024年第4期18卷 317-328页

作者： Lu Liu Zhuoheng Lv yousheng mao Yan Liu Man Liu Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China

Background:Lung cancer,one of the most prevalent and deadly malignancies worldwide,not only poses a significant physical burden but also a profound psychological challenge to *** these psychological challenges,the fear of recurrence stands out as a particularly distressing *** fear,often rooted in the patients’past experiences with the disease and its treatment,can significantly impact their quality of life,mental health,and even compliance with follow-up ***,this fear can be exacerbated by the lack of understanding and support from healthcare professionals and family members,further isolating patients and compounding their psychological ***,understanding and addressing the fear of recurrence in lung cancer patients is crucial for improving their overall well-being and ***:This study aims to develop a symptom network model for fear of recurrence in early-stage lung cancer patients,analyzing symptom correlations to enhance healthcare providers’understanding and management of these symptoms,thereby improving patient outcomes and quality of ***:A cross-sectional study design was ***:We employed convenience sampling to recruit 551 lung cancer patients from the Thoracic Surgery Department of a tertiary hospital in Beijing between January 2023 and December 2023.A cross-sectional study was conducted using the General Information Questionnaire,Fear of Disease Progression Scale,and Level of Hope *** analysis was performed with JASP 0.***.3.0 using the EBICglasso method,and centrality metrics including Betweenness,Closeness,Degree centrality,and Expected influence were ***:Symptom network analysis identified fear of family impact and future work disruption as central to recurrence fear in these ***-based analysis revealed‘fear of being unable to continue work’as central in males,while‘fear of affecting family members’was central in *** adolescents,concerns about fu

关键词： Symptom network recurrence fear early-stage non-small cell lung cancer

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Elevated expression of lung development-related protein HSP9O0 indicates poor prognosis in non-small cell lung cancer through affecting the cell cycle and apoptosis

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Signal Transduction and Targeted Therapy 2021年第3期6卷 611-613页

作者： Xiang Wang Yaru Wang Lin Feng Minghui Wang Kaitai Zhang yousheng mao Ting Xiao Shujun Cheng State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Concer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Thoracic Surgery National CancerCenter/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Dear Editor,Oncogenesis was considered to be similar to the early embryonic development process in a variety of ways.1 Using normal development samples as research models will help us understand tumors and identify potential ***-shock protein 90 beta(HSP90P,HSP90AB1)is one of the major isoforms of HSP90 and is involved in embryonic development,signal transduction,and cellular adaptability.

关键词： HSP90 lung prognosis

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Recent advances in the mechanisms of development and the early diagnosis and treatment of esophageal cancer

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Holistic Integrative Oncology 2023年第1期2卷 323-329页

作者： Donghui Jin yousheng mao Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The occurrence and development of esophageal cancer(EC)is a multi-stage process involving from inflammation to invasive ***,this process is very complex,and so far there are few relevant studies to reveal this *** diagnosis and treatment of EC is the focus of the early diagnosis and treatment of malignant tumors project in *** to screen EC in a lower cost and more efficient way deserves to be ***,we reviewed the recent advances in the mechanisms of the occurrence and development,and early diagnosis and treatment of EC.

关键词： Esophageal premalignant lesion Esophageal cancer Biomarkers Pathogenesis Early diagnosis Endoscopic treatment

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Surgical Treatment and Prognosis of Synchronous Double Primary Lung Cancer： a Report of 31 Cases

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Chinese Journal of Clinical Oncology 2005年第5期2卷 824-828页

作者： Feiyue Feng Dechao Zhang Xiangyang Liu Yonggang Wang yousheng mao Department of Thoracic Surgery Cancer Hospital/Institute Chinese Academy of Medical Sciences＆Peking Union Medical College Beijing 100021 China.

OBJECTIVE The concept of double primary lung cancer （DPLC） has been generally accepted. Recently, an increasing incidence of synchronous DPLC has been reported, while the diagnostic standard and treatment strategies remain to be improved. This study was conducted to investigate effective surgical treatment and prognosis of synchronous DPLC. METHODS From January 1983 to April 2004, 31 patients with synchronous DPLC were operated in our department. Clinical data, such as surgical pattern, postoperative complications, and survival status, of all these patients were reviewed retrospectively. RESULTS The 31 patients with synchronous DPLC accounted for 0.67% of all the 4,649 patients operated for primary lung cancer in our department during the same period. Both tumors of the synchronous DPLC were resected with Iobectomy or pneumonectomy in 12 patients, while among the other 19 patients at least 1 tumor was treated with partial pulmonary resection. The postoperative morbidity was 29%（9/31）, including 1 case of respiratory insufficiency, 3 cases of atelectasis, 2 cases of atrial fibrillation, 1 case of haemoptysis, 1 case of pleural effusion, and 1 case of wound fat necrosis. No deaths occurred during the operations or within 30 days postoperatively. The postoperative 1 -, 3-, and 5-year survival rates were 52%, 29%, and 20%, respectively. CONCLUSION The incidence of synchronous DPLC is low. An aggressive and reasonable surgical approach can achieve a satisfactory outcome in patients with synchronous DPLC. The postoperative morbidity is low. Some patients might achieve long-term survival.

关键词： synchronous double primary lung cancer surgery prognosis.

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食管肿瘤微创外科治疗进展

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中华胃肠外科杂志 2018年第1期21卷 112-117页

作者：赵越毛友生北京协和医学院国家癌症中心中国医学科学院肿瘤医院胸外科 100021

食管癌是我国常见恶性消化道肿瘤之一，有着较高的发病率和死亡率。手术治疗目前仍是食管癌综合治疗中最重要的一部分。食管癌常规开放手术创伤大，并发症发生率高。近年来，随着手术器械以及技术的进步，食管癌的微创治疗越来越多地应... 详细信息

食管癌是我国常见恶性消化道肿瘤之一，有着较高的发病率和死亡率。手术治疗目前仍是食管癌综合治疗中最重要的一部分。食管癌常规开放手术创伤大，并发症发生率高。近年来，随着手术器械以及技术的进步，食管癌的微创治疗越来越多地应用于临床。与传统的开放手术相比，微创手术优势何在，临床医生应当如何选择？本文将微创食管癌手术的发展历程及目前常见的术式进行概括，并总结国内外相关研究的大量文献报道。从围手术期各项指标和术后康复情况、淋巴结清扫结果及长期生存3个方面对食管癌微创手术和开放手术进行比较，结果显示：微创手术术中出血、术后肺部并发症发生率、住院时间及ICU住院时间均显著少于开放手术的患者；术后吻合口瘘、围手术期病死率、R0切除率及清扫淋巴结阳性数目方面未见明显差异：而在手术时间、喉返神经损伤、淋巴结清扫数目及长期生存方面尚未得出明确结果。这仍有赖于大规模的前瞻性临床观察或随机对照研究结果来进一步明确微创手术是否优于常规开放手术。此外，本文还对机器人技术在微创食管癌手术中的应用和发展进行综述，介绍了当前机器人技术在微创食管癌手术中的使用现状，并对机器人技术的前景加以展望。目前限制机器人技术推广普及的重要原因，主要包括费用问题以及手术适应证的把控．希望在未来几年能够得到妥善的解决。

关键词：食管肿瘤微创食管癌切除术开放食管癌切除术

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胸段食管鳞癌淋巴结转移规律及淋巴结清扫方式的选择

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中华胃肠外科杂志 2018年第9期21卷 987-994页

作者：赵越毛友生北京协和医学院国家癌症中心中国医学科学院肿瘤医院胸外科 100021

食管癌是一种具有高发病率和病死率的恶性肿瘤。目前手术治疗仍是食管癌综合治疗中最为重要的一部分。淋巴结转移数目对食管癌预后有着重要的影响．因此手术当中淋巴结清扫的彻底与否是影响预后的重要因素，而食管癌手术中对淋巴结清扫... 详细信息

食管癌是一种具有高发病率和病死率的恶性肿瘤。目前手术治疗仍是食管癌综合治疗中最为重要的一部分。淋巴结转移数目对食管癌预后有着重要的影响．因此手术当中淋巴结清扫的彻底与否是影响预后的重要因素，而食管癌手术中对淋巴结清扫方式的选择一直以来都是一个存在争议的话题。本文结合国内外相关文献，对胸段食管鳞癌的淋巴结转移规律进行总结，发现食管黏膜下层的纵向淋巴管网及固有肌层的横向淋巴通路是食管癌淋巴结转移的解剖学基础。本文还从阳性淋巴结数目、远处淋巴结转移、淋巴结转移度、孤立性淋巴结转移、淋巴结微转移以及结外侵犯等六个方面分析了淋巴结转移对食管癌预后的影响。在食管癌手术当中，究竟应该选择二野还是三野淋巴结清扫？本文就两种淋巴结清扫方式的临床效果进行对比分析，结果显示．三野淋巴结清扫术后部分亚组的食管癌患者5年生存率要显著高于二野淋巴结清扫术后的患者：三野淋巴结清扫的手术时间要显著长于二野清扫；清扫淋巴结数目也更多。并发症方面，有研究指出，三野淋巴结清扫术后患者出现吻合口漏、喉返神经麻痹以及气管缺血等并发症的概率要显著高于二野清扫术。文章最后介绍了前哨淋巴结在食管癌手术当中的应用，以及喉返神经旁淋巴结作为颈部淋巴结转移的预测标志的相关研究证据。

关键词：食管肿瘤淋巴结转移淋巴结清扫术

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肺癌胸腔镜术后并发症的防治策略

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中国肺癌杂志 2018年第3期21卷 230-233页

作者：毛友生赫捷国家癌症中心/中国医学科学院北京协和医学院肿瘤医院胸外科

肺癌目前已经成为国内发病率和死亡率最高的恶性肿瘤，严重威胁着人们的健康。外科手术作为肺癌综合治疗中最主要的一环，近年来发展迅速，尤其是胸腔镜技术的应用和普及起到了重要的作用。胸腔镜手术与传统的开胸手术相比，有着创伤少... 详细信息

肺癌目前已经成为国内发病率和死亡率最高的恶性肿瘤，严重威胁着人们的健康。外科手术作为肺癌综合治疗中最主要的一环，近年来发展迅速，尤其是胸腔镜技术的应用和普及起到了重要的作用。胸腔镜手术与传统的开胸手术相比，有着创伤少、疼痛轻、术后康复快等优势，但术后并发症的发生，无疑会延长患者住院时间并抵消胸腔镜的优势。

关键词：胸腔镜技术术后并发症肺癌防治胸腔镜手术恶性肿瘤综合治疗外科手术

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