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Fe+Cr及Si含量对Zr-4合金耐腐蚀性能的影响

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核动力工程 2024年第3期45卷 146-153页

作者：岳慧芳庞华高博高士鑫罗倩倩赵艳丽蒋有荣中国核动力研究设计院核反应堆系统设计技术重点实验室成都610213 国核宝钛锆业股份公司陕西省核级锆材重点实验室陕西宝鸡721013

为了优化国产Zr-4合金的耐腐蚀性能,在420℃、10.3.MPa的高温高压水蒸气加速腐蚀条件下,研究了合金元素Fe+Cr以及杂质元素Si对国产Zr-4合金耐腐蚀性能的影响。结果表明:在美国材料实验学会(ASTM)规定的Fe+Cr含量范围内(0.28 wt%~0.3. wt... 详细信息

为了优化国产Zr-4合金的耐腐蚀性能,在420℃、10.3.MPa的高温高压水蒸气加速腐蚀条件下,研究了合金元素Fe+Cr以及杂质元素Si对国产Zr-4合金耐腐蚀性能的影响。结果表明:在美国材料实验学会(ASTM)规定的Fe+Cr含量范围内(0.28 wt%~0.3. wt%,wt%表示质量分数),Fe+Cr含量越高,析出的第二相数目越多、尺寸越大,越有利于材料耐腐蚀性能提升。在420℃水蒸气中腐蚀126 d后,当Fe+Cr含量从0.28 wt%增加到0.3. wt%时,Zr-4合金的腐蚀增重降低约3.%。Zr-4合金在1100℃淬火时,当Si含量低至10 mg/kg时,形成粗大的平行板条结构;而增加Si含量到100 mg/kg后,析出的细小Zr_(3.Si为α相提供形核位置,使得组织中出现网篮结构和细小的平行板条结构。网篮结构能促使组织中第二相分布更均匀弥散,因此,高Si含量的Zr-4合金表现出更优良的耐腐蚀性能。

关键词： Zr-4合金 Fe+Cr含量 Si含量耐腐蚀性能

益肾固疏方干预老年性骨质疏松症患者骨代谢标志物的变化及临床疗效

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中国组织工程研究 2024年第8期28卷 1155-1160页

作者：章晓云刘桦柴源陈锋曾浩高振罡黄有荣广西中医药大学附属瑞康医院广西壮族自治区南宁市530011

背景:随着疾病治疗模式的改变及近年来对老年性骨质疏松症研究的深入,越来越多的研究证实中医药在防治老年性骨质疏松症方面的效果显著。目的:探讨益肾固疏方对肾虚血瘀型老年性骨质疏松症患者骨代谢标志物的影响。方法:选择2020年7月至... 详细信息

背景:随着疾病治疗模式的改变及近年来对老年性骨质疏松症研究的深入,越来越多的研究证实中医药在防治老年性骨质疏松症方面的效果显著。目的:探讨益肾固疏方对肾虚血瘀型老年性骨质疏松症患者骨代谢标志物的影响。方法:选择2020年7月至2022年3.广西中医药大学附属瑞康医院收治的肾虚血瘀型老年性骨质疏松症患者102例,其中男3.例,女70例,年龄71-93.。采用随机数字表法将102例患者分为试验组及对照组,每组51例,对照组给予碳酸钙D3.粒+阿仑磷酸钠片治疗,治疗组给予碳酸钙D3.粒+阿仑磷酸钠片+益肾固疏方治疗,连续治疗3.月。治疗前及治疗3.月后,检测两组患者L_(1-4)椎体与左侧股骨颈骨密度,评估目测类比评分,检测血清骨钙素、骨桥素、Ⅰ型胶原交联C-末端肽及抗酒石酸酸性磷酸酶水平,评估中医证候积分与治疗有效率。结果与结论:①两组治疗3.月后的L1-4椎体与左侧股骨颈骨密度均高于治疗前(P3.月后的L1-4椎体与左侧股骨颈骨密度均高于对照组(P3.月后的目测类比评分均低于治疗前(P3.月后的目测类比评分低于对照组(P3.月后的血清骨钙素、骨桥素、Ⅰ型胶原交联C-末端肽及抗酒石酸酸性磷酸酶水平均较治疗前明显改善(P3.月后的血清骨钙素、骨桥素水平高于对照组(P3.月后的中医证候总评分均低于治疗前,试验组治疗3.月后的中医证候总评分低于对照组;治疗3.月后,两组均未发生明显不良反应,试验组于对照组治疗总有效率分别为88.2%,70.6%,组间比较差异有显著性意义(P<0.05);⑤结果显示,益肾固疏方联合抗骨质疏松药物可通过调节骨代谢、提高骨密度、减轻患者病痛来显著改善肾虚血瘀型老年性骨质疏松症患者的临床症状,阻止疾病的进一步发展。

关键词：骨质疏松症骨代谢标志物益肾固疏方中医药临床疗效随机对照试验

绝经后骨质疏松症动物模型研究现状及趋势的文献计量可视化分析

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中国组织工程研究 2025年第14期29卷 3070-3080页

作者：章晓云李坤健莫坚柴源黄有荣广西中医药大学附属瑞康医院骨科广西壮族自治区南宁市530011 广西中医药大学广西壮族自治区南宁市530001

背景:近年来,绝经后骨质疏松症受到社会的广泛关注,随着动物模型研究的逐渐深入,动物模型已然成为现代中医药研究的重要手段以及实验基础,因此了解动物模型的研究现状、热点及发展趋势尤为重要。目的:分析国内外绝经后骨质疏松症动物模... 详细信息

背景:近年来,绝经后骨质疏松症受到社会的广泛关注,随着动物模型研究的逐渐深入,动物模型已然成为现代中医药研究的重要手段以及实验基础,因此了解动物模型的研究现状、热点及发展趋势尤为重要。目的:分析国内外绝经后骨质疏松症动物模型的研究现状、热点及发展趋势,为后续研究提供一定的理论基础及参考依据。方法:以“主题词=绝经后骨质疏松AND主题词=鼠+兔+犬+猪+羊+猴+鱼+实验动物+动物实验”为检索式,对1999-01-01/2023.10-01在中国知网、万方数据库中的文章进行主题词检索;同时以“TS=(Postmenopausal osteoporosis)AND TS=(mouse OR mice OR rat OR rabbit OR dog OR swine OR pig OR sheep OR monkey OR fish or flies OR“laboratory animal”OR“experiment animal”)”为检索式,对1999-01-01/2023.10-01在Web of Science核心合集数据库中的文章进行主题词检索。应用Citespace软件对文献作者、机构、国家、关键词以及文献共被引量进行可视化分析。结果与结论:①分析后筛选中国知网及万方数据库共纳入123.篇文献,Web of Science核心合集数据库共纳入3.19篇文献。自1999年来,该领域发文量总体呈上升趋势,研究中心性最高的是美国,发文量最高的是中国,研究中心性最高的机构为美国加利福尼亚大学。②去除与文章主题直接相关的关键词,综合共现频率及中心性,“生物力学”“左归丸”“阿仑膦酸盐”“乳腺癌”“生化指标”处于该研究领域较为核心的地位。③通过文献共被引分析,被引频次前10位的文献中有5篇文献与绝经后骨质疏松症治疗措施与临床疗效有关。④综合关键词与共被引文献分析显示,探究成骨细胞的形成以及骨形成的机制、代谢组学的作用机制、中药复方的治疗、信号通路、甲状旁腺激素治疗及硬骨素抗体治疗等方面是当下的研究热点也是未来的研究趋势。

关键词：绝经后骨质疏松症动物模型文献计量学可视化分析 CiteSpace 成骨分化代谢组学中药复方研究热点

Steady thermal-solutal capillary convection in a shallow annular pool with the radial temperature and concentration gradients

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Science China(Technological Sciences) 2012年第8期55卷 2176-2183页

作者： LI yourong GONG ZhenXing WU ChunMei WU ShuangYing Key Laboratory of Low-grade Energy Utilization Technologies and Systems of Ministry of Education College of Power EngineeringChongqing UniversityChongqing 400044China

Using asymptotical analysis,we investigate the characteristics of the coupled thermal and solutal capillary convection with the radial temperature and solute concentration gradients in a shallow annular pool with the free *** pool is heated from the outer cylinder with high solutal concentration and cooled at the inner cylinder with low solutal *** asymptotic solution is obtained in the core region in the limit as the aspect ratio,which is defined as the ratio of the depth to the width of the pool,goes to *** comparison with the previous work certifies that the asymptotic solution is right and *** influences of the solutal capillary force,the buoyant force,the Soret effect and the geometric parameters on the fluid flow are analyzed.

关键词： coupled thermal and solutal capillary convection asymptotic solution buoyancy Soret effect

Two-dimensional numerical simulation of thermocapillary convection in detached solidification

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Science China(Technological Sciences) 2012年第2期55卷 527-536页

作者： PENG Lan FAN JuYan LI yourong MENG HaiYong Key Laboratory of Low-grade Energy Utilization Technologies and Systems of Ministry of Education(Chongqing University) Chongqing 400044China

Numerical simulations of flow in the melt(CdZnTe) with different conditions are conducted using the finite-difference *** the top surface of the melt is solid wall under microgravity condition,the thermocapillary convection is caused in the melt by the surface tension gradient on the free *** the Marangoni number is small,the flow is steady thermocapillary *** the Marangoni number exceeds the critical value,the steady flow transits into unstable thermocapillary *** the top surface of the melt is free surface under microgravity,two roll cells are observed in the melt,which are driven by both the surface tension gradients on the upper and lower free *** the top surface of the melt is free surface under gravity condition,the effect of the buoyancy on the flow is little as the Marangoni number is *** the Marangoni number increasing,the effect of the buoyancy increases,which makes the upper roll cell weaken and the lower roll cell strengthen.

关键词： detached solidification thermocapillary convection buoyancy CdZnTe numerical simulation

Hot Deformation and Modeling of Flow Stress for a Ti-containing HSLA Steel

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Journal of Materials Science & Technology 1998年第5期14卷 419-424页

作者： Xu, yourong Hou, Dahua Wang, Deying Xu, W-Ping Shanghai Univ Sci & Technol Sch Mat Sci & Engn Shanghai 201800 Peoples R China

Single stage and double-stage interrupted hot compression tests for simulating hot rolling have been carried out for a Ti-containing HSLA steel (10Ti). Physical simulation of hot rolling was in progress utilizing a Thermecmastor-Z simulator in 850-1150 degree C and strain rate of 0.1-60 s** minus **1. A model for residual strain ratio lambda was designed, and a model of flow stress considering residual strain has been obtained. The hot deformation behavior at various strain rate has also been studied. (Edited author abstract) 13.Refs.

关键词： Steel

Channel Estimation for Full-Duplex Relay Transmission in Cloud Radio Access Networks

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China Communications 2015年第11期12卷 35-42页

作者： HU Chunjing LI Jian MAO Zhendong BAN yourong Key Laboratory of Universal Wireless Communication Ministry of EducationBeijing University of Posts and Telecommunications Department of Electrical Engineering University of Arkansas

Relay in full-duplex(FD) mode can achieve higher spectrum efficiency than that in half-duplex mode,while it is crucial to suppress relay self-interference to ensure transmission quality which requires instantaneous channel state information(CSI). In this paper,the channel estimation issue in FD amplify-andforward relay networks is considered,where the training-based estimation technique is adopted. Firstly,the least square(LS) estimation is implemented to obtain composite channel coefficients of source-relay-destination(SRD) channel and relay loop-interference(LI) channel in order to assist destination in performing data detection. Secondly,both LS and maximum likelihood estimation methods are utilized to perform individual channel estimation aiming at supporting successive interference cancelation at destination. Finally,simulation results demonstrate the effectiveness of both composite and individual channel estimation,and the presented ML method can achieve lower MSEs than LS solution.

关键词： channel estimation full-duplex cloud radio access networks

Semi-Blind Pilot-Aided Channel Estimation in Uplink Cloud Radio Access Networks

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China Communications 2016年第9期13卷 72-79页

作者： yourong Ban Qiang Hu Zhendong Mao Zhongyuan Zhao Key Laboratory of Universal Wireless Communications Ministry of EducationBeijing University of Posts & Telecommunications

In this paper, a quasi-Newton method fbr semi-blind estimation is derived for channel estimation in uplink cloud radio access networks （C-RANs）. Different from traditional pilot-aided estimation, semiblind estimation utilizes the unknown data symbols in addition to the known pilot symbols to estimate the channel. An initial channel state information （CSI） obtained by least-squared （LS） estimation is needed in semi-blind estimation. BFGS （Brayben, Fletcher, Goldfarb and Shanno） algorithm, which employs data as well as pilot symbols, estimates the CSI though solving the problem provided by maximum-likelihood （ML） principle. In addition, mean-square-error （MSE） used to evaluate the estimation performance can be further minimized with an optimal pilot design. Simulation results show that the semi-blind estimation achieves a significant improvement in terms of MSE performance over the conventional LS estimation by utilizing data symbols instead of increasing the number of pilot symbols, which demonstrates the estimation accuracy and spectral efficiency are both improved by semiblind estimation for C-RANs.

关键词： cloud radio access networks semi-blind channel estimation

Cutting the root:the next generation of T cells engagers against cancer stem cells to overcome drug resistance in triple-negative breast cancer

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Cancer Biology & Medicine 2023年第3期20卷 169-173页

作者： Jiali Zhang Bin Liu Minchao Lyu yourong Duan State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China

Triple-negative breast cancer(TNBC)is the most difficult type of breast cancer to *** is defined by the lack of expression of three receptors:estrogen receptor(ER);progesterone receptor(PR);and human epidermal growth factor receptor 2(HER2).Chemotherapy is currently first-line treatment for TNBC;however,due to the high heterogeneity of TNBC,most patients eventually develop chemotherapy resistance,which is associated with a poor *** immune checkpoint blockade(ICB)therapies have been shown to have promising therapeutic efficacy in treating solid tumors.A phase III clinical trial reported that the combination of ICB and chemotherapy lengthened progression-free survival in patients with metastatic PD-L1+TNBC3.however,most patients had primary resistance or acquired resistance to ***,the intrinsic mechanisms underlying ICB resistance are still under investigation4.

关键词： chemotherapy breast resistance