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Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice

Signal Transduction and Targeted Therapy 2021年第1期6卷 131-143页

作者： Xuekun Fu Bo Zhou Qinnan Yan Chu Tao Lei Qin Xiaohao Wu Sixiong Lin Sheng Chen Yumei Lai Xuenong Zou Zengwu Shao Meiqing Wang Di Chen Wenfei Jin youqiang song Huiling Cao Ge Zhang Guozhi Xiao School of Medicine Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Researchand Shenzhen Key Laboratory of Cell MicroenvironmentSouthern University of Science and Technology1088 Xue Yuan Road518055 ShenzhenGuangdongChina Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist University999077 Hong KongSARChina Department of Biology Southern University of Science and Technology518055 ShenzhenChina School of Biomedical Sciences University of Hong Kong21 Sassoon RoadHong KongChina Department of Spine Surgery Orthopedic Research InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Orthopedics and Traumatology510080 GuangzhouChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and Technology430022 WuhanChina Department of Orthopedic Surgery Rush University Medical CenterChicagoIL 60612USA State Key Laboratory of Military Stomatology National Clinical Research Center for Oral DiseasesShanxi International Joint Research Center for Oral DiseasesDepartment of Oral Anatomy and Physiology and TMDSchool of Stomatologythe Fourth Military Medical University145 Changle West RoadXi’anChina Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences518055 ShenzhenChina

In vertebrates,the type 1 parathyroid hormone receptor(PTH1R)is a critical regulator of skeletal development and homeostasis;however,how it is modulated is incompletely *** we report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralizes the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult ***-cell profiling reveals that Kindlin-2 loss increases the proportion of osteoblasts,but not mesenchymal stem cells,chondrocytes and fibroblasts,in non-hematopoietic bone marrow cells,with concomitant depletion of osteoblasts on the bone surfaces,especially those stimulated by ***,haploinsufficiency of Kindlin-2 and Pth1r genes,but not that of either gene,in mice significantly decreases basal and,to a larger extent,PTH-stimulated bone mass,supporting the notion that both factors function in the same genetic ***,Kindlin-2 interacts with the C-terminal cytoplasmic domain of PTH1R via aa 474–475 and Gsα.Kindlin-2 loss suppresses PTH induction of cAMP production and CREB phosphorylation in cultured osteoblasts and in ***,PTH promotes Kindlin-2 expression in vitro and in vivo,thus creating a positive feedback regulatory ***,estrogen deficiency induced by ovariectomy drastically decreases expression of Kindlin-2 protein in osteocytes embedded in the bone matrix and Kindlin-2 loss essentially abolishes the PTH anabolic activity in bone in ovariectomized ***,we demonstrate that Kindlin-2 functions as an intrinsic component of the PTH1R signaling pathway in osteoblastic cells to regulate bone mass accrual and homeostasis.

关键词： homeostasis Kindlin skeletal

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基于Simulink的循环加热式热泵热水器动态仿真研究

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低温与超导 2018年第10期46卷 77-82页

作者：杨坤黄磊钱雪峰宋有强贾甲合肥通用机械研究院合肥230088

分别建立了压缩机、膨胀阀、换热器、水箱的数学模型,建立了循环加热式热泵热水器的Simulink动态仿真模型并进行了热水器运行过程的动态仿真。搭建了循环加热式热泵热水器试验系统,并对某品牌的循环加热式热泵热水器产品进行了试验测试... 详细信息

分别建立了压缩机、膨胀阀、换热器、水箱的数学模型,建立了循环加热式热泵热水器的Simulink动态仿真模型并进行了热水器运行过程的动态仿真。搭建了循环加热式热泵热水器试验系统,并对某品牌的循环加热式热泵热水器产品进行了试验测试。对比试验测试和仿真结果,优化了仿真模型,验证了仿真模型的准确性。

关键词：循环加热式热泵热水器 Simulink模型动态仿真试验研究

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Tectonic modes of mantle convection and their implications for Earth's tectonic evolution based on three-dimensional numerical simulations

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Science China Earth Sciences 2025年第1期68卷 270-296页

作者： song XIANG Jinshui HUANG Bingcheng WU School of Earth and Space Sciences University of Science and Technology of China CAS Center of Excellence in Comparative Planetary Studies

Five tectonic modes of mantle convection are obtained and analyzed with three-dimensional numerical models in a spherical shell domain. The five tectonic convective modes are non-plate mobile-lid, plate-like mobile-lid, episodic plate-like mobile-lid, episodic stagnant-lid, and stagnant-lid convective modes, respectively. The typical characteristics of these five tectonic modes and their numerical classification criteria based on plateness, mobility, and their standard deviations are presented and discussed. The results show that the yield stress of the lithosphere has profound effects on the tectonic convective *** the gradual increase of yield stress, the tectonic mode of mantle convection changes from one to another sequentially through the aforementioned five modes. Additionally, as the Rayleigh number increases, the range of yield stress for the platelike mobile-lid convective mode decreases, and the dimensionless transition stress between different tectonic modes ***, the dimensional transition stress between the non-plate mobile-lid convective mode and plate-like mobile-lid convective mode increases with the increase of Rayleigh number, but decreases between other tectonic modes. Furthermore, we find that the transition stress between different tectonic modes is inversely proportional to the internal heating rate, with the transition stress decreasing as the internal heating rate increases. The fitting analysis of the transition stress between tectonic modes shows that Earth's current plate tectonics correspond to a lithospheric yield stress of 150–250 MPa, which aligns with the strength of serpentinized mantle rock determined by experimental petrography. If the Archean mantle was 300°C warmer than it is today, then the Earth was in an episodic stagnant-lid convective mode. The tectonic evolution of the Earth's surface is closely related to the lithospheric strength and the process of thermal evolution. If the lithospheric strength w

关键词： Tectonic mode of mantle convection Plate-like mobile-lid convection Episodic plate-like mobile-lid convection Episodic stagnant-lid convection Plate tectonics and tectonic evolution of the Earth

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R32、R290滚动转子式压缩机的热力性能对比研究

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低温与超导 2018年第2期46卷 75-80页

作者：袁旭东胡继孙宋有强贾甲合肥通用机械研究院有限公司合肥230031 合肥通用环境控制技术有限责任公司合肥230088

建立了滚动转子式压缩机热力学稳态仿真模型,在相同理论容积输气量的条件下,分析了吸气过热度、蒸发温度、冷凝温度对以R22、R32和R290为制冷工质的滚动转子式压缩机热力性能的影响规律。对比研究表明:在相同工况下,R22的性能系数COP最... 详细信息

建立了滚动转子式压缩机热力学稳态仿真模型,在相同理论容积输气量的条件下,分析了吸气过热度、蒸发温度、冷凝温度对以R22、R32和R290为制冷工质的滚动转子式压缩机热力性能的影响规律。对比研究表明:在相同工况下,R22的性能系数COP最大但与R32接近,R290的COP最小;若压缩机高低压比降低,COP增加明显;当仅增加吸气过热度时,R32、R22的COP变化很小,而R290的COP增加较为明显,并逐渐接近R32和R22;吸气过热度仅对排气温度有较大影响,而对质量流量、功率、制冷量、COP的影响很小,蒸发温度、冷凝温度对热力性能的影响更显著。

关键词：滚动转子式压缩机热力学稳态仿真吸气过热度 1132 11290

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一种冷热联供一体机的实验研究

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低温与超导 2017年第9期45卷 66-71页

作者：宋有强贾甲黄磊戴琳孔晓明合肥通用环境控制技术有限责任公司合肥230088

搭建了基于自行复叠循环的冷热联供实验平台。采用二元混合制冷剂R744/R600a作为运行工质,在加注一定的比例并对不断对成分比例和充注量进行调整后,实验系统最终在冷凝侧产生55.1℃生活热水的同时,蒸发侧箱体内获得了平均温度为-30.5℃... 详细信息

搭建了基于自行复叠循环的冷热联供实验平台。采用二元混合制冷剂R744/R600a作为运行工质,在加注一定的比例并对不断对成分比例和充注量进行调整后,实验系统最终在冷凝侧产生55.1℃生活热水的同时,蒸发侧箱体内获得了平均温度为-30.5℃的实验结果。装置通过多次开机以及长时间的实验研究。结果表明:压缩机压比不大于6,排气温度不高于81℃,系统运行安全稳定。

关键词：冷热联供 R744/R600a 混合制冷剂实验研究

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Molecular dynamics simulations of helium transport through inorganic mineral nanopores

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Science China Earth Sciences 2025年第1期68卷 237-252页

作者： Dandan song Ping GUAN Chi ZHANG Jiahao REN School of Earth and Space Sciences Peking University

Helium transport through nanoscale inorganic mineral pores and pore throats is essential for its overall migration. To elucidate helium's transport dynamics within nanopores, we employed equilibrium and non-equilibrium molecular dynamics simulations to investigate helium's static self-diffusion and pressure-driven flow in quartz slit-shaped nanopores. We also introduced water and various gases, including hydrogen, methane, ethane, nitrogen, and carbon dioxide, into the nanopores to assess their influence on helium transport. Our findings indicate minimal helium adsorption on quartz pore surfaces. Under conditions where the pore size is less than 5 nm and the pressure under 10 MPa, environmental factors markedly influence helium diffusion. Large pore sizes, high temperatures, and low gas pressures enhance helium desorption and facilitate faster diffusion. We observed a positive correlation between helium flow velocity and factors such as pore size, pressure gradient, and surface smoothness of the pores. Notably, the presence of pore water and carrier gases in quartz nanopores, which diffuse more slowly than helium, tends to reduce helium surface adsorption and slow its diffusion. Among the carrier gases studied, nitrogen showed similar adsorption capacity, diffusivity, and stability to helium, while carbon dioxide displayed the highest adsorption capacity and the slowest diffusion rate, markedly differing from helium. Based on the simulation results, we concluded that water and carrier gases primarily function as transport mediums in helium migration, moving together with helium. Nitrogen, which shares similar properties with helium, effectively assists in this co-migration process. Conversely, carbon dioxide, due to its high adsorption capacity and slow diffusion, tends to be lost during co-migration. As a result, gas reservoirs with high nitrogen levels and low carbon dioxide levels are more likely to have higher helium concentrations. Additionally, the smaller por

关键词： Helium transport Slit nanopores Molecular dynamics simulations Diffusion Flow carriers

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R717与R22在开启式螺杆压缩机中的性能对比试验研究

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低温与超导 2015年第5期43卷 62-64,75页

作者：宋有强樊海彬许敬德王晓光合肥通用环境控制技术有限责任公司合肥230088

依据国标GB/T5773-2004《容积式制冷剂压缩机性能试验方法》,以吸气管路流量计法和气体冷却器法为试验方法,搭建了开启式螺杆压缩机的性能测试平台。分别以R717和R22为制冷工质在冷凝温度为30℃和40℃,蒸发温度从-35℃～5℃范围内进行... 详细信息

依据国标GB/T5773-2004《容积式制冷剂压缩机性能试验方法》,以吸气管路流量计法和气体冷却器法为试验方法,搭建了开启式螺杆压缩机的性能测试平台。分别以R717和R22为制冷工质在冷凝温度为30℃和40℃,蒸发温度从-35℃～5℃范围内进行了试验研究。结果表明,在测试工况条件下,R717工质的容积效率比R22高3%左右,轴功率高6%左右,COP高6%～10%。

关键词： R717 R22 试验研究开启式螺杆压缩机

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基于GUM法的压缩机性能测试不确定度分析

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流体机械 2023年第4期51卷 86-90页

作者：屈博艺贾磊宋有强赵盼盼孙云合肥通用机械研究院有限公司压缩机技术国家重点实验室合肥230031 合肥通用环境控制技术有限责任公司合肥230031

因在压缩机性能测试过程中直接测量得到的各项参数及其不确定度均会对最终结果产生不同程度的影响,为了找到影响结果的主要因素并合理改善这种情况,本文依据GB/T 5773-2016对某涡旋式压缩机进行了性能测试,并基于GUM法对测量结果进行了... 详细信息

因在压缩机性能测试过程中直接测量得到的各项参数及其不确定度均会对最终结果产生不同程度的影响,为了找到影响结果的主要因素并合理改善这种情况,本文依据GB/T 5773-2016对某涡旋式压缩机进行了性能测试,并基于GUM法对测量结果进行了不确定度分析和敏感度分析。结果表明:压缩机的制冷量测试结果为108.26 kW,合成标准不确定度为0.58 kW,扩展不确定度的相对值为1.07%;对测量结果不确定度产生最大影响的因素是温度仪器的精度,精度提高1倍,可使测量结果的不确定度降低21.15%。

关键词：压缩机性能测试不确定度 GUM法

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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA song HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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PR状态方程的二元混合制冷剂热力性质计算

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低温与超导 2013年第8期41卷 72-77页

作者：宋有强张秀平贾磊许敬德夏玲周全合肥通用机械研究院制冷与环境研究所合肥230088

基于PR状态方程法和剩余函数法建立了混合制冷剂在过冷区、两相区以及过热区的热力学参数计算模型,将混合制冷剂R410A的计算结果与NIST数据库进行比对以验证模型精度。在此基础上,对二元混合制冷剂CO2/R600a(33.546/66.454,mass%)在不... 详细信息

基于PR状态方程法和剩余函数法建立了混合制冷剂在过冷区、两相区以及过热区的热力学参数计算模型,将混合制冷剂R410A的计算结果与NIST数据库进行比对以验证模型精度。在此基础上,对二元混合制冷剂CO2/R600a(33.546/66.454,mass%)在不同相区的热力性质进行了推算,其计算结果可以用于以CO2/R600a为制冷剂的制冷系统的热力计算分析和性能优化。

关键词：混合制冷剂 PR状态方程剩余函数法热力学性质理论推算

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