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Epidemic Update and Risk Assessment of 2019 Novel Coronavirus--China, January 28, 2020

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China CDC weekly 2020年第6期2卷 83-86页

作者： Wenxiao tu Houlin Tang Fangfang Chen Yinong Wei Tingling Xu Kaiju Liao Nijian Xiang Guoqing Shi Qun Li Zijian Feng Public Health Emergency Center Chinese Center for Disease Control and Prevention(China CDC)BeijingChina National Center for AIDS/STD Control and Prevention China CDCBeijingChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Peking University Health Science Center BeijingChina.

On December 29,2019,the health authorities in Hubei Province and Wuhan City received a report of a cluster of pneumonia cases of unknown etiology from a local hospital,and all four patients were employees of the Wuhan Huanan Seafood Wholesale Market(HN market for short)(1).By January 8,2020,Chinese authorities had identified a new virus 2019 novel coronavirus(2019-nCoV)linked with the outbreak of disease,which has been named novel coronavirusinfected pneumonia(NCIP)(2).On 15 January,the National Health Commission(NHC)issued guidelines for the diagnosis,treatment,prevention,and control of *** guidelines directed case monitoring,reporting,diagnosis,treatment,management,close contact management,and laboratory testing.

关键词： diagnosis prevention authorities

A Case-control Study on Children with Guillain-barre Syndrome in North China

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Biomedical and Environmental Sciences 2003年第2期16卷 105-111页

作者： GAI-FEN LIU ZHENG-LAI WU HU-SHENG WU QUAN-YI WANG GE-tu ZHAO-RI CHUN-YONG WANG ZHI-XUE LIANG SHU-LAN CUI JIAN-DE ZHENG CorrespondenceshouldbeaddressedtoGai-FenLIU PekingUnionMedicalCollegeandChineseAcademyofMedicalSciencesBeijing100005China

To explore the risk factors for Guillain-barre syndrome. Methods Case-control study design was used in 51 cases of Guillain-barre syndrome,and 51 matched *** of the 51 cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C. jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using an ad hoc questionnaire, including his/her demographic information,onset of the illness, their personal hygiene and so on. Results The study showed that Guillain-barre syndrome was associated with a few factors, such as polio vaccine immunization before onset of illness (OR=7.27), no hand washing after defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with the illness (OR=9.5,P<0.001). Conclusion It is suggested that occurrence of Guillain-barre syndrome may correlate to infection of C. jejuni and poor personal hygiene in children.

关键词： Guillain-Barre syndrome (GBS) Case-control study Campylobacter jejuni

受高斯白噪声影响的有限化学反应体系的随机热力学──外噪声对化学反应体系影响的有效热力学量度

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高等学校化学学报 1998年第1期19卷 86-93页

作者：涂鹃罗久里四川大学化学系成都610064

通过分析噪声对跃迁概率的不同影响，借助Novikov定理及MSR理论，建立了受多源白噪声影响的有限化学反应体系的有效主方程及有效熵平衡方程，导出非平衡定态时这类噪声体系熵产生的一般表达式，揭示涨落熵产生的统计内涵及噪声贡献，并... 详细信息

通过分析噪声对跃迁概率的不同影响，借助Novikov定理及MSR理论，建立了受多源白噪声影响的有限化学反应体系的有效主方程及有效熵平衡方程，导出非平衡定态时这类噪声体系熵产生的一般表达式，揭示涨落熵产生的统计内涵及噪声贡献，并针对非宏观量级的外噪声，借助扰动按分布参数分离法及有效主方程的Kramers－Moyal展开，进一步对简单加合性噪声建立了非平衡定态宏观稳定性判据的随机模拟，论证了噪声对化学反应体系定态稳定性的弱化作用．

关键词：高斯白噪声外噪声化学反应有效熵平衡方程

Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2290-2293页

作者： Lei Fang tu-Shuai Li Jing-Zi Zhang Zhi-Honq Liu Jie Yang Bing-Hao Wang Yu-Meng Wang Jie Zhou Ling-Dong Kong The State Key Laboratory of Pharmaceutical Biotechnology Medical SchoolSchool of Life SciencesNanjing UniversityNanjingChina Chemistry and Biomedicine Innovation Center of Nanjing University NanjingChina

Dear Editor,The increasing consumption of dietary fructose has been proposed as a major contributor to metabolic syndrome,which promotes glomerular podocyte injury and proteinuria.1 Mitochondria are the key organelles for cellular bioenergetics to maintain energy homeostasis and gluconeogenesis.2 Mitochondrial damage may be linked to kidney diseases,in particular glomerular nephropathy.

关键词： homeostasis glomerular dietary

Comprehensive Treatment Uncertainty Analysis and PTV Margin Estimation for Fiducial Tracking in Robotic Liver Stereotactic Body Radiation Therapy

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当代医学科学(英文) 2023年第3期43卷 572-578页

作者： Zhi-wen LIANG Meng-lan ZHAI Biao tu Xin NIE Xiao-hui ZHU Jun-ping CHENG Guo-quan LI Dan-dan YU Tao ZHANG Sheng ZHANG Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective This study aims to quantify the uncertainties of CyberKnife Synchrony fiducial tracking for liver stereotactic body radiation therapy(SBRT)cases,and evaluate the required planning target volume(PTV)*** A total of 11 liver tumor patients with a total of 57 fractions,who underwent SBRT with synchronous fiducial tracking,were enrolled for the present *** correlation/prediction model error,geometric error,and beam targeting error were quantified to determine the patient-level and fraction-level individual composite treatment *** composite uncertainties and multiple margin recipes were compared for scenarios with and without rotation correction during *** The correlation model error-related uncertainty was 4.3±1.8,1.4±0.5 and 1.8±0.7 mm in the superior-inferior(SI),left-right,and anterior-posterior directions,*** were the primary contributors among all uncertainty *** geometric error significantly increased for treatments without rotation *** fraction-level composite uncertainties had a long tail ***,the generally used 5-mm isotropic margin covered all uncertainties in the left-right and anterior-posterior directions,and only 75%of uncertainties in the SI *** order to cover 90%of uncertainties in the SI direction,an 8-mm margin would be *** scenarios without rotation correction,additional safety margins should be added,especially in the superior-inferior and anterior-posterior *** The present study revealed that the correlation model error contributes to most of the uncertainties in the *** patients/fractions can be covered by a 5-mm *** with large treatment uncertainties might need a patient-specific margin.

关键词： CyberKnife fiducial tracking liver cancer stereotactic body radiation therapy margin expansion

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结合异常样本检测的汽油族组成拉曼光谱分析

光谱学与光谱分析 2010年第4期30卷 979-983页

作者：淡图南戴连奎浙江大学工业控制技术国家重点实验室浙江杭州310027

汽油族组成不仅决定了汽油品质,同时直接关系到燃烧尾气对环境的影响。文章成功地将拉曼光谱分析技术应用于汽油族组成的定量分析。通过对校正集进行异常样本检测,剔除个别异常样本,有效地提高了偏最小二乘的模型精度,得到了较好的预测... 详细信息

汽油族组成不仅决定了汽油品质,同时直接关系到燃烧尾气对环境的影响。文章成功地将拉曼光谱分析技术应用于汽油族组成的定量分析。通过对校正集进行异常样本检测,剔除个别异常样本,有效地提高了偏最小二乘的模型精度,得到了较好的预测效果。芳烃含量、烯烃含量和氧含量的标准预测误差分别达到了0.23,0.52和0.143,其预测复相关系数分别达到了0.987,0.927和0.971。实验结果表明:采用拉曼光谱分析技术可以有效的解决汽油族组成的定量分析问题,其分析精度显著高于近红外光谱法与多维气相色谱法;同时也适用于汽油生产过程中的在线分析。

关键词：拉曼光谱汽油族组成定量分析异常检测

Medication Regularities of Traditional Chinese Medicine for treating COVID-19: A data mining-based literature analysis

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Journal of Hainan Medical University 2020年第19期26卷 15-19页

作者： Wen-Han Zhao Xiao-tu Xi Lin Lin Guangzhou University of Chinese Medicine Guangzhou510006China The Second Affiliated Hospital of Chinese Medicine Guangzhou University of Chinese MedicineGuangzhou510120China

Objective:Traditional Chinese Medicine(TCM)has been widely used as an approach *** explore distribution regularities of the nature,flavor,and meridian entry of Chinese Medicines(CMs)for treating Corona Virus Disease 2019(COVID-19)by data mining in the relevant literature to provide basis for clinical ***:The database was established by collecting and analyzing the prescriptions for COVID-19 in regional schemes of CMs for COVID-19 announced by National health Commission and Administration of TCM of the provinces,municipalities and autonomous *** frequencies and the distribution regularities of the nature and flavor of these Chinese medicines were statistically analyzed by SPSS ***:CMs with bitter,xin,sweet flavors were widely used in treating COVID-19,most of them entered lung,stomach,spleen,and heart meridian entries,with warm,cold,flat *** property CMs were used most in coastal areas such as Liaoning,Hebei,Tianjin,Shandong,Jiangsu,Shanghai,Zhejiang,Guangxi and inland areas such as Ningxia,Shanxi,Hubei,and Sichuan,and Guizhou,while cold property CMs were used most in coastal areas such as Heilongjiang,Jilin,Fujian,Guangdong,Hainan and inland areas such as Inner Mongolia,Xinjiang,Beijing,Shanxi,Jiangxi,and ***:The medication regularities of nature and flavor of CMs might reflect the pathogenesis of *** were used variously according ro the region,reflected the dialectical characteristics of TCM,patients were treated in accordance with seasonal conditions,local conditions and the patient's individuality.

关键词： Data mining Novel coronavirus pneumonia Nature and flavor Meridian entry

2-phenyl-3,4-thiadiazole [3,2-α]-pyrimidine-7-one inhibits cell proliferation by changing the cell cycle and inducing endogenous and exogenous apoptosis in HeLa cells

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中国药理学与毒理学杂志 2019年第10期 890-891页

作者： YANY Yan WANG Min-jie BAI tu-ya LYU Xiao-li FAN Lei CHANG Fu-hou Colege of Pharmacy Inner Mongolia Medical University School of Basic Medical Sciences The Center for Drug Screening Center for New Drug Safety Evaluation and Research Inner Mongolia Medical University

OBJECTIVE To investigate the effects and mechanism of a new chemical synthetic drug TPh on the proliferation and apoptosis of Hela cel s. METHODS MTT assay was performed to detect the effect of TPh on the proliferation of He La cel s at different times. The impact of each dose on the cycle of Hela cells was analyzed by flow cytometry; Annexin-Ⅴ FITC/PI staining was used to detect the effect of TPh on the apoptosis of He La cells;JC-1 staining was made to observe the effect of TPh on the mitochondrial membrane potential of Hela cell. The levels of apoptosis-related protein caspase-3, caspase-8,caspase-9 were evaluated in TPh-treated cel s by Western blotting. RESULTS TPh could inhibit the proliferation of Hela cells within a certain concentration range, and the effect is proportional to time and concentration. Comparing with the blank control group, the proportion of cells in the G0/G1 phase gradually increased and the proportion of cells in the G2/M phase decreased in all of the groups with TPh. Besides, apoptotic He La cells increased in a dose-dependent manner after treated with different concentrations of TPh, mitochondrial membrane potential reduced in different degrees, the protein expression of caspase-3,caspase-8 and caspase-9 were increased in a dose-dependent manner under TPh treatment. CONCLUSION TPh could inhibit the proliferation of He La cel s in a dose-dependent manner; it blocks He La cells in the G0/G1 phase and inhibits the conversion of Hela cells in the G0/G1 phase to S and G2/M phase. Besides, it could induces apoptosis of He La cells by reducing the mitochondrial membrane potential and promoting the expression of caspase-3, caspase-8, caspase-9.

关键词： TPh Hela cell proliferation cycle apoptosis

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对涡旋流影响压气机转子性能和稳定性的研究

推进技术 2016年第4期37卷 640-645页

作者：屠宝锋胡骏张凯南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室江苏南京210016 先进航空发动机协同创新中心北京100191

为研究对涡旋流影响跨声速轴流压气机性能和稳定性的机理,设计了一种叶片式旋流发生器,并对旋流发生器和跨声速单转子进行了联合数值模拟研究。计算结果表明旋流发生器叶片数越少,对涡强度越低;对涡旋流导致压气机总压比、峰值效率、稳... 详细信息

为研究对涡旋流影响跨声速轴流压气机性能和稳定性的机理,设计了一种叶片式旋流发生器,并对旋流发生器和跨声速单转子进行了联合数值模拟研究。计算结果表明旋流发生器叶片数越少,对涡强度越低;对涡旋流导致压气机总压比、峰值效率、稳定工作范围和堵塞边界流量减小,失速边界流量增大,对涡强度等于60°时峰值效率和堵塞边界流量分别降低1.11%和2.12%,失速边界流量增加4.17%;对涡中的同向涡导致叶尖进口攻角增加,进口相对马赫数减小;反向涡使叶尖进口攻角降低,进口相对马赫数增大;对涡前缘的轴向速度偏低,造成叶尖进口攻角大幅增加,叶尖泄漏流堵塞严重;由于叶尖泄漏流在叶片前缘溢流导致失稳。

关键词：压气机跨声速对涡效率稳定性