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Advancing optothermal manipulation:decoupling temperature and flow fields in quasi-isothermal microscale streaming

Light(Science & Applications) 2023年第9期12卷 1713-1714页

作者： youngsun kim Yuebing Zheng Materials Science and Engineering Program and Texas Materials Institute The University of Texas at AustinAustinTX78712USA Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX78712USA

By decoupling temperature and flow fields through symmetry-correlated laser scan sequences,ISO-FLUCS enables quasi-isothermal optofluidic microscale *** technique offers precise control over fluid manipulation while m... 详细信息

关键词： thermal isothermal flow

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A clinical trial of submucosal saline injection in inverted colonic diverticula

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Chinese Medical Journal 2021年第12期134卷 1511-1512页

作者： Jeonghun Lee youngsun kim Department of Internal Medicine Ye HospitalAnyangKorea Department of Obstetrics and Gynecology Kyung Hee University HospitalKyung Hee University College of MedicineSeoulKorea

To the Editor:Colonic diverticulosis is a common colon disorder worldwide and is mostly observed in the right colon in Asian patients,unlike in western *** colonic diverticula(ICD)are less common and are observed in about 0.7%of colonoscopy *** ICD often resemble colon polyps,they are difficult to distinguish by ***,bowel perforation after biopsy or endoscopic resection may be a serious *** colonoscopy maneuvers described to help diagnose ICD include radiating pillow sign,the use of air insufflation and water jet,and reversion of the ICD with *** rings,most recently described as concentric pale rings surrounding the lesion,also can help to diagnose ICD without the need for *** present report describes the cases that underwent endoscopic maneuvers by submucosal saline *** results of this clinical trial may help to distinguish ICD from colon polyps.

关键词： injection colon colonic

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Sigmoid-sigmoid colon fistula caused by diverticulitis

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Chinese Medical Journal 2022年第4期135卷 491-492页

作者： Jeonghun Lee Young Joo Lee youngsun kim Department of Internal Medicine Ye HospitalAnyangRepublic of Korea Department of Obstetrics and Gynecology Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea

To the Editor:Diverticular disease is common worldwide and the incidence of this disease increases with *** diverticulitis is serious and includes abscess,fistula,obstruction,and ***,surgical treatment is recommended to the patients with symptomatic *** these,colocolic fistula caused by diverticulitis is rare findings and especially,sigmoid-sigmoid fistula is an extremely rare *** present report describes a case of sigmoid-sigmoid colon fistula caused by *** results of this case may help physicians to recognize that multidisciplinary management and surgery are needed for the treatment of complicated diverticulitis with fistula.

关键词： fistula colon obstruction

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Enhancing Hydrophilicity of Thick Electrodes for High Energy Density Aqueous Batteries

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Nano-Micro Letters 2023年第7期15卷 110-121页

作者： Jungeun Lee Hyeonsoo Lee Cheol Bak youngsun Hong Daeha Joung Jeong Beom Ko Yong Min Lee Chanhoon kim Sustainable Technology and Wellness R&D Group Korea Institute of Industrial Technology(KITECH)102 Jejudaehak-RoJeju-SiJeju-do 63243Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Physics Virginia Commonwealth UniversityRichmondVA 23284USA

Thick electrodes can substantially enhance the overall energy density of ***,insufficient wettability of aqueous electrolytes toward electrodes with conventional hydrophobic binders severely limits utilization of active materials with increasing the thickness of electrodes for aqueous batteries,resulting in battery performance deterioration with a reduced ***,we demonstrate that controlling the hydrophilicity of the thicker electrodes is critical to enhancing the overall energy density of *** binders are synthesized via a simple sulfonation process of conventional polyvinylidene fluoride binders,considering physicochemical properties such as mechanical properties and *** introduction of abundant sulfonate groups of binders(i)allows fast and sufficient electrolyte wetting,and(ii)improves ionic conduction in thick electrodes,enabling a significant increase in reversible capacities under various current ***,the sulfonated binder effectively inhibits the dissolution of cathode materials in reactive aqueous ***,our findings significantly enhance the energy density and contribute to the development of practical zinc-ion batteries.

关键词： Thick electrodes Hydrophilic binder Sulfonation Aqueous zinc-ion batteries High areal capacity

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Microsphere-assisted hyperspectral imaging:super-resolution,non-destructive metrology for semiconductor devices

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Light(Science & Applications) 2024年第6期13卷 1098-1111页

作者： Jangryul Park youngsun Choi Soonyang Kwon Youngjun Lee Jiwoong kim Jae-joon kim Jihye Lee Jeongho Ahn Hidong Kwak Yusin Yang Taeyong Jo Myungjun Lee Kwangrak kim Metrology and Inspection Equipment R&D Team Mechatronics ResearchSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department DRAM Process Development TeamSemiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department Semiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea

As semiconductor devices shrink and their manufacturing processes advance,accurately measuring in-cell critical dimensions(CD)becomes increasingly *** test element group(TEG)measurements are becoming inadequate for representing the fine,repetitive patterns in cell *** non-destructive metrology technologies like optical critical dimension(OCD)are limited due to their large spot diameter of approximately 25μm,which impedes their efficacy for detailed in-cell structural ***,there is a pressing need for small-spot and non-destructive metrology *** address this limitation,we demonstrate a microsphere-assisted hyperspectral imaging(MAHSI)system,specifically designed for small spot optical metrology with *** microsphere-assisted super-resolution imaging,this system achieves an optical resolution of 66 nm within a field of view of 5.6μm×5.6μ*** approach effectively breaks the diffraction limit,significantly enhancing the magnification of the *** MAHSI system incorporating hyperspectral imaging with a wavelength range of 400–790 nm,enables the capture of the reflection spectrum at each camera *** achieved pixel resolution,which is equivalent to the measuring spot size,is 14.4 nm/pixel and the magnification is *** MAHSI system enables measurement of local uniformity in critical areas like corners and edges of DRAM cell blocks,areas previously challenging to inspect with conventional OCD *** our knowledge,this approach represents the first global implementation of microsphere-assisted hyperspectral imaging to address the metrology challenges in complex 3D structures of semiconductor devices.

关键词： metrology resolution enable

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HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer

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World Journal of Gastroenterology 2016年第41期22卷 9141-9153页

作者： Yiseul Choi Young San Ko Jinju Park youngsun Choi Younghoon kim Jung-Soo Pyo Bo Gun Jang Douk Ho Hwang Woo Ho kim Byung Lan Lee Department of Tumor Biology Cancer Research Institute Seoul National Universit College of Medicine Department of Anatomy Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Pathology Eulji University Hospital Eulji University College of Medicine Department of Pathology Jeju National University Hospital Ischemic/Hypoxic Disease Institute Medical Research Center Seoul National University College of Medicine

AIM To investigated the relationships between HER2, c-Jun N-terminal kinase(JNK) and protein kinase B(AKT) with respect to metastatic potential of HER2-positive gastric cancer(GC) *** Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively. Transwell assay, Western blot, semi-quantitative reverse transcriptionpolymerase chain reaction and immunofluorescence staining were used in cell culture experiments. RESULTS In GC specimens, HER2, JNK, and AKT activations were positively correlated with each other. In vitro analysis revealed a positive regulatory feedback loop between HER2 and JNK in GC cell lines and the role of JNK as a downstream effector of AKT in the HER2/AKT signaling pathway. JNK inhibition suppressed migratory capacity through reversing EMT and dual inhibition of JNK and AKT induced a more profound effect on cancer cell *** HER2, JNK and AKT in human GC specimens are positively associated with each other. JNK and AKT, downstream effectors of HER2, co-operatively contribute to the metastatic potential of HER2-positive GC cells. Thus, targeting of these two molecules in combination with HER2 downregulation may be a good approach to combat HER2-positive GC.

关键词： Gastric cancer HER2 c-Jun N-terminal kinase Protein kinase B Metastatic potential

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