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Broadband electroluminescence from reverse breakdown in individual suspended carbon nanotube pn-junctions

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Nano Research 2020年第10期13卷 2857-2861页

作者： Bo Wang Sisi Yang Yu Wang younghee kim Ragib Ahsan Rehan K.apadia Stephen KDoorn Han Htoon Stephen B.Cronin Department of Physics and Astronormy University of Southern CalforniaLos AngelesCA 90089USA Ming Hsieh Department of Electrical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Mork Farmily Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCA 90089USA Center for Integrated Nanotechnologies Materials Physics and Applications DivisionLos Alamos National LaboratoryLos AlamosNM 87545USA

There are various mechanisms of light emission in carbon nanotubes (CNTs), which give rise to a wide range of spectral emission characteristics that provide important information regarding the underlying physical processes that lead to photon emission. Here, we report spectra obtained from individual suspended CNT dual-gate field effect transistor (FET) devices under different gate and bias conditions. By applying opposite voltages to the gate electrodes (i.e., Vg1 = –Vg2), we are able to create a pn-junction within the suspended region of the CNT. Under forward bias conditions, the spectra exhibit a peak corresponding to E11 exciton emission via thermal (i.e., blackbody) emission occurring at electrical powers around 8 μW, which corresponds to a power density of approximately 0.5 MW/cm2. On the other hand, the spectra observed under reverse bias correspond to impact ionization and avalanche emission, which occurs at electrical powers of ~ 10 nW and exhibits a featureless flat spectrum extending from 1,600 nm to shorter wavelengths up to 600 nm. Here, the hot electrons generated by the high electric fields (~ 0.5 MV/cm) are able to produce high energy photons far above the E11 (ground state) energy. It is somewhat surprising that these devices do not exhibit light emission by the annihilation of electrons and holes under forward bias, as in a light emitting diode (LED). Possible reasons for this are discussed, including Auger recombination.

关键词： ballistic avalanche high-field band-to-band photoemission

Formation of ZSM-5 on Silicon Carbide Fibers for Catalytic Support

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材料科学与工程（中英文B版） 2016年第5期6卷 211-217页

作者： Yoon-joo Lee Dong-geun Shin younghee kim Woo-teck Kwon Soo-ryong kim Doh-hyung Riu Energy Materials Center Korea Institute of Ceramic Engineering and Technology 101 Soho-ro Jinju-si Gyeongsangnam-do52851 Korea Ceramic Fiber & Composite Center Korea Institute of Ceramic Engineering and Technology 101 Soho-ro Jinju-sLGyeongsangnam-do 52851 Korea Department of Materials Science and Engineering Seoul National University of Science and Technology 172 Gongreung 2-dongNowon-gu Seoul 139-743 Korea

Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1526-1534页

作者： Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara younghee kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion Jan M.Deussing Srinivas R.Sadda Bradley D.Gelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Aravind Eye Care System MaduraiIndia Departamento de Oftalmologia e Ciências Visuais Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloBrazil Center for Digital Image Evaluation CharlottesvilleVAUSA Doheny Eye Institute Los AngelesLos AngelesCAUSA Molecular Neurogenetics Department of Stress Neurobiology and NeurogeneticsMax Planck Institute of PsychiatryMunichGermany Department of Ophthalmology David Geffen School of MedicineUniversity of California–Los AngelesLos AngelesCAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global *** report that AβOs induce RPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMD that is currently *** demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that RPE expression of the purinergic ATP receptor P2RX7,an upstream mediator of NLRP3 inflammasome activation,is required for AβO-induced RPE *** classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NRTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE *** findings crystallize the importance of P2RX7 and NLRP3 in a disease-relevant model of AMD and identify inflammasome inhibitors as potential treatments for GA.

关键词： degeneration activation upstream

构建稳定S波接收函数及在韩国地震台网的应用

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构建稳定S波接收函数及在韩国地震台网的应用

Intravenous immune globulin suppresses angiogenesis in mice and humans

2017中国地球科学联合学术年会

作者：沈旭章 younghee kim Teh-Ru Alex Song 中国地震局兰州地震研究所 School of Earth and Environmental Sciences Seoul National University Seoul Department of Earth Sciences University College London

＜正＞远震S波接收函数是目前利用远震体波研究岩石圈-软流圈底界面（LAB）最为有效的地震学手段。和P波接收函数相比,S波接收函数中深部间断面的S-P转换波未受到来自浅部结构多次波的干扰,因此在探测LAB方面具有独特的优势。该方法近...

＜正＞远震S波接收函数是目前利用远震体波研究岩石圈-软流圈底界面（LAB）最为有效的地震学手段。和P波接收函数相比,S波接收函数中深部间断面的S-P转换波未受到来自浅部结构多次波的干扰,因此在探测LAB方面具有独特的优势。该方法近年来已被广泛应用于全球及不同区域岩石圈结构的研究,并取得了很多较为重要的结果。但目前在S波接收函数计算和结果解释中,仍有不少问题需

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco younghee kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich younghee kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies

Effect of preparation method of noble metal supported catalyts on formaldehyde oxidation at room temperature: Gas or liquid phase reduction

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Journal of Environmental Sciences 2022年第12期34卷 201-216页

作者： younghee Jang Ye Hwan Lee Hanki Eom Sang Moon Lee Sung Su kim Department of Environmental Energy Envineering Graduate School of kyonggi UniversityGyeonggi-do 16227Korea Department of Environmental Energy Engineeing Kyonggi UniversityGyonggi-do 16227Korea

Formaldehyde(HCHO) is toxic to the human body and is one of the main threats to the indoor air quality(IAQ). As such, the removal of HCHO is imperative to improving the IAQ,whereby the most useful method to effectively remove HCHO at room temperature is catalytic oxidation. This review discusses catalysts for HCHO room-temperature oxidation,which are categorized according to their preparation methods, i.e., gas-phase reduction and liquid-phase reduction methods. The HCHO oxidation performances, structural features,and reaction mechanisms of the different catalysts are discussed, and directions for future research on catalytic oxidation are reviewed.

关键词： Formaldehyde Indoor air quality Catalyst Prepared method

Monitoring the Hepatitis A Virus in Oyster from Korea

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Advances in Microbiology 2015年第13期5卷 825-831页

作者： Sanghun Park Hyowon Jeong Jihun Jung Kyungsik kim Sungkyu Park Musang kim Yeonsun kim younghee Oh Kweon Jung Infectious Disease Research Division Seoul Metropolitan Government Research Institute of Public Health and Environment Gwacheon-si Korea Department of Public Health Graduate School Dankook University Seoul Korea

Hepatitis A virus (HAV) causes many cases of oyster- or clam-associated gastroenteritis in various countries. HAV was detected on oyster by RT-PCR in 19.6% (11/56) in Korea. The percentages of HAV-positive samples in 2011 and 2012 were 27.6% and 11.1%, respectively. Phylogenetic analysis revealed that several nucleotide sequences highly similar to those of HAVs isolated in this study. Phylogenetic analysis of the coding regions of the viral protein VP4/VP2 revealed that all amplicons were classi?ed into IA genogroup. It will provide useful data that aids in our understanding circulating HAVs and may contribute to future control.

关键词： HAV Oyster IA Genogroup

Human Rhinoviruses in Korean with Acute Low Respiratory Tract Infections

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Open Journal of Medical Microbiology 2015年第4期5卷 237-245页

作者： Sanghun Park Sungsun Choi Jungim Jang Eunjeung kim Seokju Cho Jihun Jung Kyungsik kim Sungkyu Park Musang kim Yeonsun kim younghee Oh Kweon Jung Seoul Metropolitan Government Research Institute of Public Health and Environment Infectious Disease Research Division Gwacheon-si Korea Department of Public Health Graduate School Dankook University Seoul Korea

Human rhinovirus (HRV) must be viewed as a significant etiological agent of acute low respiratory tract infections (ALRIs) in infants and young children. The present study has been carried out to investigate the prevalence of recently identified respiratory viruses and determine the phylogenetic composition of HRV strains. In total, 923 nasopharyngeal aspirates (NPAs) collected from hospitalized patients with ALRIs between January and December 2010 (453 females and 470 males) at five referral hospitals in Seoul were tested for respiratory viruses. Viruses were detected by RT-PCR (Reverse transcription polymerase chain reaction) in 501 (54.3%) of the 923 positive samples obtained. Overall, HRV was detected in 7.9%, ADV in 10.2%, IFV in 21.9%, RSV in 3.6%, hMPV in 2.7%, HCoV in 2.5%, HEV in 1.6%, HBoV in 1.6%, and PIV in 2.4% of the samples. HRV infections occurred throughout the year, with peaks in January, May, July, and November of 2010. Phylogenetic analyses using the VP4/VP2 cording region showed that among the 27 isolates with HRV, 14 (52%) were infected with species A, 2 (7%) were infected with species B, and 11 (41%) were infected with the strains from HRV-C. HRV-C sequences are genetically distinct, sharing only 32% to 33% of their amino acids with HRV-A and HRV-B, while retaining 46% to 100% identity with each other. HRV-A, B, and C were co-circulating in children hospitalized with ALRIs in Korea in 2010. These findings indicated that HRV-C was the important causative agent of HRV associated with ALRIs.

关键词： NPAs ALRIs Human Rhinovirus