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Relationship between treatment types and blood–brain barrier disruption in patients with acute ischemic stroke:Two case reports

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World Journal of Clinical Cases 2022年第7期10卷 2351-2356页

作者： youngbeom seo Jonghoon Kim Min Cheol Chang Hyungkyu Huh Eun-Hee Lee Department of Neurosurgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Rehabilitation Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea Medical Interdisciplinary Team Medical Device Development CenterDaegu-Gyeongbuk Medical Innovation FoundationDaegu 41061South Korea

BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic ***,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are ***,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different *** SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was *** a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be *** Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.

关键词： Blood-brain barrier Ischemic stroke Dynamic contrast-enhanced magnetic resonance imaging Thrombectomy Penumbra Case report

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