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Effect of two different doses of intravitreal bevacizumab with temporal retina-sparing laser photocoagulation for retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 166-169页

作者： A young choi Hochan Cho Yu Cheol Kim Department of Ophthalmology Keimyung University School of Medicine Dongsan Medical Center Department of Internal Medicine Keimyung University School of Medicine Dongsan Medical Center

This study aims to compare the efficacy and safety between two different doses of intravitreal bevacizumab（IVB） injection with temporal retina-sparing laser（TRSL） photocoagulation for retinopathy of prematurity（ROP）. We retrospectively evaluated 22 eyes of ROP infants who underwent IVB combined with partial TRSL for stage 3＋ zone I or posterior zone II ROP. Laser photocoagulation was applied on the avascular retina, sparing two-discdiameter width temporal avascular area anterior to ridge. A half dose（0.625 mg） or minimal dose（0.25 mg） of IVB was conducted. Four eyes in minimal dose group were retreated with IVB and laser photocoagulation on the spared retina. Of those 4 retreated eyes, three developed preretinal hemorrhage around the ridge after the first treatment, resulting in fibrotic macular dragging. A half dose of IVB may be more effective than a minimal dose with partial TRSL for ROP. Preretinal hemorrhage may be a harbinger of poor prognosis.

关键词： bevacizumab laser photocoagulation retinopathy of prematurity

Pilomatrixoma of the upper eyelid in a 10-month-old baby

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1510-1513页

作者： Jungyul Park Hyeshin Jeon Hee-young choi Department of Ophthalmology Pusan National University HospitalBusan 49241Korea Biomedical Research Institute Pusan National University HospitalBusan 49241Korea

Dear Editor,I am Dr. Jungyul Park from the Division of Oculoplasty,Department of Ophthalmology,Pusan National University Hospital, Busan, Korea. I am writing to present a case of pilomatrixoma of the upper eyelid in a... 详细信息

关键词： red Pilomatrixoma 10-month-old baby

iNID： An Analytical Framework for Identifying Network Models for Interplays among Developmental Signaling in Arabidopsis

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Molecular Plant 2014年第5期7卷 792-813页

作者： Daeseok choi Jaemyung choi Byeongsoo Kang Seungchul Lee young-hyun Cho Ildoo Hwang Daehee Hwang School of Interdisciplinary Bioscience and Bioengineering POSTECH 790-784 Pohang Republic of Korea Department of Life Sciences POSTECH 790-784 Pohang Republic of Korea Department of New Biology DGIST Daegu 711-873 Republic of Korea Division of Integrative Biosciences and Biotechnologies POSTECH 790-784 Pohang Republic of Korea Center for Systems Biology of Plant Senescence and-Life History Institute for BasicScience DGIST Daegu 711-873 Republic of Korea

Integration of internal and external cues into developmental programs is indispensable for growth and development of plants, which involve complex interplays among signaling pathways activated by the internal and external factors （IEFs）. However, decoding these complex interplays is still challenging. Here, we present a web-based platform that identifies key regulators and Network models delineating Interplays among Developmental signaling （iNID） in Arabidopsis. iNID provides a comprehensive resource of （1） transcriptomes previously collected under the conditions treated with a broad spectrum of IEFs and （2） protein and genetic interactome data in Arabidopsis. In addition, iNID provides an array of tools for identifying key regulators and network models related to interplays among IEFs using transcriptome and interactome data. To demonstrate the utility of iNID, we investigated the interplays of （1） phytohormones and light and （2） phytohormones and biotic stresses. The results revealed 34 potential regulators of the interplays, some of which have not been reported in association with the interplays, and also network models that delineate the involvement of the 34 regulators in the interplays, providing novel insights into the interplays collectively defined by phytohormones, light, and biotic stresses. We then experimentally verified that BME3 and TEM1, among the selected regulators, are involved in the auxin-brassinosteroid （BR）-blue light interplay. Therefore, iNID serves as a useful tool to provide a basis for understanding interplays among IEFs.

关键词： transcriptome analysis network analysis signal interplays development Arabidopsis.

A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly

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World Journal of Gastroenterology 2011年第5期17卷 651-656页

作者： Nam-Kyong choi Yoosoo Chang Sun-young Jung Yu-Kyong choi Joongyub Lee Jin-Ho Lee Ju-young Kim Byung-Joo Park Department of Preventive Medicine Seoul National University College of MedicineSeoul 110-799South Korea Medical Research Center Seoul National UniversitySeoul 110-799South Korea Department of Occupational Medicine Health Screening CenterKangbuk Samsung HospitalSungkyunkwan University College of MedicineSeoul 110-746South Korea National Evidence-Based Healthcare Collaborating Agency Seoul 110-450South Korea Department of Internal Medicine Gumi HospitalGumi 730-909South Korea Medical Research Collaborating Center Seoul National University Hospital Seoul National University College of Medicine Seoul 110-799South Korea Department of Internal Medicine Dongguk University Ilsan HospitalSchool of MedicineDongguk UniversityGoyang 410-733South Korea Department of Family Medicine Health Promotion CenterSeoul National University Bundang HospitalBundang 463-707South Korea

AIM:To evaluate the possibility of an association between polyethylene glycol(PEG) and acute renal failure(ARF) in elderly patients using a health insurance claims ***:We conducted a population-based casecrossover study using information obtained from Korean Health Insurance Review and Assessment Service(HIRA) claims from January 1,2005 to December 31,2005(Seoul,Korea).The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1,2005 to December 31,*** each patient,one case and two control periods were *** use in a 2-or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2-or 4-wk control window *** logistic regression analysis was used to estimate odds ratios(ORs) and 95% CI,adjusting for concomitant uses of diuretics,angiotensin converting enzyme inhibitors,non-steroidal anti-inflammatory drugs,antibiotics,anti-cancer drugs,and contrast ***:Within the HIRA database which contained 1 093 262 elderly patients,1156 hospitalized ARF cases were *** these cases,PEG was prescribed to 17(1.5%) patients before *** adjusted ORs when applying the 2-and 4-wk window periods were 0.4(95% CI:0.03-5.24) and 2.1(95% CI:0.16-27.78),***:No increased risk of ARF was found in elderly PEG ***,based on the limited number of study subjects,further analysis should be performed to confirm these results.

关键词： Polyethylene glycol Acute renal failure Adverse drug reaction Health insurance claims data-base Case-crossover

Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma

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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho choi Hyo Won Lee Kyung Yul Hur Jae Joon Kim Gyeong-Sin Park Si-Hyong Jang young Soo Song Ki-seok Jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

Prediction of mechanical properties of Al alloys with change of cooling rate

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China Foundry 2012年第4期9卷 381-386页

作者： Quan-Zhi Dong young-Sire choi Jun-Ho Hong Ho-young Hwang Dept.of Virtual Engineering University of Science and TechnologyIncheon 406-840Korea e-Design Center Korea Institute of Industrial TechnologyIncheon 406-840Korea

The solidification process significantly affects the mechanical properties and there are lots of factors that affect the solidification *** progress has been made in the research on the effect of solidification on mechanical *** them,the PF(Phase Field) model and CA(Cellular Automata) model are widely used as simulation methods which can predict nucleation and its growth,and the size and morphology of the grains during *** they can give accurate calculation results,it needs too much computational memory and calculation *** it is difficult to apply the simulation to the real production *** this study,a more practical simulation approach which can predict the mechanical properties of real aluminum alloys is proposed,by identifying through experiment the relationship between cooling rate and SDAS(Secondary Dendrite Arm Spacing) and mechanical *** experimentally measured values and the values predicted by simulation have relatively small differences and the mechanical properties of a variety of Al alloys are expected to be predicted before casting through use of the simulation.

关键词： mechanical properties dendrite structure aluminum alloy cooling rate solidification castingsimulation

Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park Sun Bok choi Won-seok Jung Su-young Jung Jung-Hee Cho Mee-Ok choi Ho-Joon Song Sung-Joo Park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea Hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 *** also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis High-mobility group box protein-1

Do we have enough evidence for expanding the indications of ESD for EGC?

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World Journal of Gastroenterology 2011年第21期17卷 2597-2601页

作者： Hang Lak Lee Chang Hwan choi Dae young Cheung Department of Internal Medicine Hanyang University College of Medicine Department of Internal Medicine ChungAng University College of Medicine Division of Gastroenterology Department of Internal MedicineYeouido St.Mary's Hospitalthe Catholic University of Korea College of Medicine

Endoscopic submucosal dissection(ESD) is the most advanced and representative technique in the field of therapeutic endoscopy and has been used for the treatment of gastrointestinal neoplasms,including early gastric *** major difference and advantage of ESD compared to existing endoscopic resection techniques,such as endoscopic mucosal resection(EMR) and polypectomy,are the width and depth of the *** developed cutting devices,distal attachable endoscopic accessories,and an advanced electrosurgical unit have helped to overcome the limitations of therapeutic endoscopy in terms of lesion size,location,presence of fibrotic scarring,and accompanying *** a result,the indications for ESD have been expanded from the classical indication for EMR and polypectomy,and there is now support for a further expansion of ESD *** present,the most critical factor to consider in the decision of whether to perform ESD is the probability of unexpected lymph node *** guidelines for ESD are continually being updated and *** this review,we discuss the strengths and weaknesses of the expanded guidelines,based on evidence found in the literature.

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Early gastric cancer Indications

Case Report:Congenital atresia of the left main coronary artery in an infant

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 539-541页

作者： Su Ye SOHN Gi young JANG Byung Min choi Department of Pediatrics Korea University Hospital

Congenital atresia of the left main coronary artery is a rare occurrence, and surgical revascularizationbypass graft is required. We here report a rare case of congenital coronary anomaly in an infant. A lO-month-old male infant was admitted to the hospital with heart failure symptoms. Echocardiographic examinations revealed mitral valve regurgitation and ischemic changes of the anterolateral atresia of the left main coronary artery with a severe papillary muscle and chordae. Coronary angiography showed hypoplastic left anterior descending artery and a circumflex coronary artery. Unfortunately, sudden cardiac arrest occurred after catheterization and the infant did not recover despite of immediate cardiopulmonary resuscitation. Further studies are needed to find a newer diagnostic method to detect coronary anomaly in an infant, and coronary angiography, if necessary, has to be performed very carefully.

关键词： Conqenital heart disease Anomalous coronaries Infant