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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-young kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Preparation of AZ91D Slurries for Semi-Solid Forming Using Al8 ( Mn, Fe) 5 Precipitates

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Journal of Rare Earths 2004年第Z2期22卷 42-46页

作者： Ji young Byun Soon Il kwon Jeong man Doh Heon Phil Ha Metal Processing Research Center Division of MaterialsKorea Institute of Science and Technology# 39-1 Haweolgok-DongSungbuk-KuSeoul 136-791Republic of Korea

During the solidification of the AZ91D-alloys, the Al8(Mn, Fe)5 phase is generally precipitated in the melt in advance of the precipitation of the primary α-Mg. The basic principle for manufacturing AZ91D-alloy slurries for semi solid forming is to use the Al8(Mn, Fe)5 precipitates as the heterogeneous nucleation sites for primary α-Mg phases. Microscopic analysis for the location of the Al8(Mn, Fe)5 precipitate explains that the Al8(Mn, Fe)5 precipitate is the effective heterogeneous nucleation site for the primary α-Mg phase. It was also observed that increase of the Mn content in the melt and the cooling rate below to the solid/liquid two-phase region resulted in smaller and more globular primary α-Mg due to the increase of heterogeneous nucleation sites. It was found that the average α-Mg diameter grew as a function of t0.278, where t is the holding time at the solid/liquid two-phase region. This would be attributed to the Ostwald type ripening and coalescence between primary α-Mg phases. The cooling rate below to the solid/liquid two-phase region, Mn content in AZ91D alloy, and the holding time and temperature affected on the quality of slurry.

关键词： AZ91D alloy semi-solid forming solidification heterogeneous nucleation

Robust fault detection of piecewise affine ARX systems

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Journal of Control and Decision 2020年第3期7卷 276-285页

作者： young-man Kim School of Engineering Liberty University1971 University Blvd.LynchburgVAUSA

In this paper,l1 regularisation-based robust fault detection technique for PWARX(PieceWise affine Auto Regressive eXogenous)systems is *** problem is formulated in convex optimisation form using l1 regularisation hence,global solution can be *** regularisation constant plays a key role for finding the number of *** MSE(mean square error)value between actual system and its model under no fault is used as a threshold for tracking dynamics change and detecting *** simplicity of turning only one parameter(regularisation constant)outstands this approach from *** proposed algorithm also shows the capability of separating the dynamics change from additive fault under *** illustration concludes this proposal by demonstrating its effectiveness.

关键词： Piecewise affine ARX fault detection regularisation convex optimisation sparsity

Effect of asymmetrical channel chirping on field intensity patterns of supermodes and modal discrimination in index guided laser arrays

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Journal of Central South University 2014年第9期21卷 3513-3517页

作者： Kee-young kwon College of Engineering Kongju National University

The effect of channel-width chirping on near- and far-field intensity patterns of the six supermodes was investigated. The supermode discrimination was evaluated in various channel-chirped index guided laser arrays. The results show that the linearly channel-chirped laser array has very good supermode discrimination which is better than that of a uniform laser array, the V channel-chirped laser array has the smallest radiation angle of the fundamental supermode among the calculated arrays, and the asymmetrically V channel-chirped array has a very small radiation angle of the fundamental supermode, which is smaller than that of the uniform array and also allows for very good fundamental supermode discrimination against the higher-order supermodes, which is better than that of the V channel-chirped laser array.

关键词： laser array channel-width chirping field pattern modal gain

Enhancement of Performance by Blade Optimization in Two-Stage Ring Blower

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Journal of Thermal Science 2010年第5期19卷 383-389页

作者： Choon-man Jang Gi-young Han Plant Research Division Korea Institute of Construction Technology dh-m co. ltd.626-5Bulmo-dongSeo-guIncheon404-270Korea

This paper describes the shape optimization of an impeller used for two-stage high pressure ring *** shape variables,which are used to define an impeller shape,are introduced to increase the blower *** pressure of a blower is selected as an object function,and the blade optimization is performed by a response surface ***-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of object function for the training *** good agreement between experimental measurements and numerical simulation is obtained in the present *** the shape optimization,it is found that a hub height is effective to increase pressure in the ring *** pressure rise for the optimal two-stage ring blower is successfully increased up to 1.86% compared with that of reference at the design flow *** recirculation flow having low velocity is formed in both sides of the impeller outlet by different flow direction of the inlet and outlet of the *** flow field inside the ring blower is also analyzed and discussed.

关键词： Ring blower Blower performance Numerical simulation Blade optimization Response surface method

A Study of the Influence of Air-knife Tilting on Coating Thickness in Hot-dip Galvanizing

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Journal of Thermal Science 2009年第3期18卷 262-267页

作者： Tae-Seok CHO young-Doo kwon Soon-Bum kwon School of Mechanical Engineering Kyungpook National University

Gas wiping is a decisive operation in hot-dip galvanizing process. In special, it has a crucial influence on the thickness and uniformity in coating film, but may be subsequently responsible for the problem of splashing. The progress of industry demands continuously the reduction of production costs which may relate directly with the increase of coating speed, and the speed up of coating results in the increase of stagnation pressure in gas wiping system in final. It is known that the increase of stagnation pressure may accompany a harmful problem of splashing in general. Together with these, also, from the view point of energy consumption, it is necessary to design a nozzle optimally. And there is known that the downward tilting of nozzle using in air knife system is effective to prevent in somewhat the harmful problem of splashing. In these connections, first, we design a nozzle with constant expansion rate. Next, for the case of actual coating conditions in field, the effects of tilting of the constant expansion rate nozzle are investigated by numerical analysis. Under the present numerical conditions, it was turned out that the nozzle of constant expansion rate of p = having a downward jet angle of 5^0 is the most effective to diminish the onset of splashing, while the influence of small tilting of the nozzle on impinging wall pres- sure itself is not so large.

关键词： Air-knife Constant expansion rate nozzle Impinging pressure Wall shear stress Hot-dip galvanizing Coating thickness Splashing

Experimental and Computational Studies on Coanda Nozzle Flow for the Air Knife Application

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Journal of Thermal Science 2007年第2期16卷 164-169页

作者： Soon-Bum kwon Dong-Won LEE young-Doo kwon School of Mechanical Engineering Kyungpook National University1370Sankyuk-dongDaegu 702-701Korea

To control the film thickness of zinc in the process of continuous hot-dip galvanizing, it is known from the early days that the gas wiping through an air knife is the most effective one. The gas wiping using in galvanizing process brings about a problem of splashing from the strip edge for a certain high speed of coating. So, in the present study, the effects of the deflection angle of Coanda nozzle on jet structure and the distribution of impinging pres- sure at the plate surface are investigated numerically and experimentally. In numerical analysis, the governing equations consisted of three-dimensional time dependent full Navier-Stokes equations, standard k-ε turbulence model to solve turbulent stTess and so on are employed. In experiment, 16 channel pressure scanning valve and 3-axis auto traversing unit are used to measure the impinging pressure at the strip surface. As a result, it is found that the smaller the deflection angle for the same nozzle slit of air knife is, the larger the impinging pressure is. To reduce the size of separation bubble and to enhance the cutting ability, it is recommendable to use an air knife with the Coanda nozzle.

关键词： Air knife Coanda effect edge splashing gas wiping hot-dip galvanizing impinging jet

Effect of polyethylene glycol on electrochemically deposited trivalent chromium layers

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中国有色金属学会会刊：英文版 2009年第4期19卷 819-823页

作者： Joo-Yul LEE man KI M Sik-Chol kwon Department of Surface Technology Korea Institute of Materials Science

The structural characteristics of the trivalent chromium deposits and their interfacial behavior in the plating solution with and without polyethylene glycol molecules were observed by using various electrochemical methods such as cyclic voltammetry,open circuit potential transition,electrochemical impedance spectroscopy,scanning electron microscopy and X-ray photoelectron *** is shown that the polyethylene glycol molecules make the reductive current density lower in the trivalent chromium plating system and promote a hydrogen evolution reaction through their adsorption on the electrode *** the trivalent chromium layer formed from the polyethylene glycol-containing solution has somewhat higher density of cracks on its surface and results in a lower film resistance,lower polarization resistance,and higher capacitance in a corrosive *** is also revealed that the formation of chromium carbide layer is facilitated in the presence of polyethylene glycol,which means easier electrochemical codeposition of chromium and carbon,not single chromium deposition.

关键词：聚乙二醇电沉积层三价铬扫描电子显微镜电化学阻抗谱电极表面电化学方法乙二醇溶液

Decomposing Composite Changes for Code Review and Regression Test Selection in Evolving Software

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Journal of Computer Science & Technology 2019年第2期34卷 416-436页

作者： Bo Guo young-Woo kwon Myoungkyu Song Department of Global Operations PayPal Omaha Nebraska 68128 U.S.A. School of Computer Science and Engineering Kyungpook National University Daegu 702-701 South Korea Department of Computer Science University of Nebraska at Omaha Omaha 68128 U.S.A.

Inspecting and testing code changes typically require a significant amount of developer *** a system evolves,developers often create composite changes by mixing multiple development issues,as opposed to addressing one independent issue—an atomic *** composite changes often becomes time-consuming and *** test unrelated edits on composite changes,rerunning all regression tests may require excessive *** address the problem,we present an interactive technique for change decomposition to support code reviews and regression test selection,called *** a developer specifies code change within a diff patch,ChgCutter partitions composite changes into a set of related atomic changes,which is more cohesive and self-contained regarding the issue being *** composite change inspection,it generates an intermediate program version that only includes a related change subset using program dependence *** cost reduction during regression testing,it safely selects only affected tests responsible for changes to an intermediate *** the evaluation,we apply ChgCutter to 28 composite changes in four open source *** partitions these changes with 95.7% accuracy,while selecting affected tests with 89.0% *** conduct a user study with professional software engineers at PayPal and find that ChgCutter is helpful in understanding and validating composite changes,scaling to industry projects.

关键词： software maintenance and evolution code review test selection program slicing