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Therapeutic benefit of repetitive transcranial magnetic stimulation for severe mirror movements A case report

Neural Regeneration Research 2013年第6期8卷 569-574页

作者： Han Sun Kim Sung Ho Jang Zee-Ihn Lee Mi young Lee Yun woo Cho Migyoung Kweon Su Min son Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University Department of Pediatrics College of MedicineYeungnam University Department of Physical Medicine and Rehabilitation Daegu Fatima Hospital Department of Physical therapy College of Health and TherapyDaegu Haany University

Congenital mirror movements retard typical hand functions, but no definite therapeutic modality is available to treat such movements. We report an 8-year-old boy with severe mirror movements of both hands. His mirror movements were assessed using the woods and Teuber grading scale and his fine motor skills were also evaluated by the Purdue Pegboard Test. A 2-week regimen of repetitive transcranial magnetic stimulation produced markedly diminished mirror movement symptoms and increased the fine motor skills of both hands. Two weeks after the completion of the regimen, mirror movement grades had improved from grade 4 to 1 in both hands and the Purdue Pegboard Test results of the right and left hands also improved from 12 to 14 or 13. These improvements were maintained for 1 month after the 2-week repetitive transcranial magnetic stimulation regimen. After 18 months, the mirror movement grade was maintained and the Purdue Pegboard test score had improved to 15 for the right hand while the left hand score was maintained at 13. This occurred without any additional repetitive transcranial magnetic stimulation or other treatment. These findings suggest that repetitive transcranial magnetic stimulation for this patient had a therapeutic and long-term effect on mirror movements.

关键词： neural regeneration neurorehabilitation clinical practice mirror movements Purdue Pegboard test hand transcranial magnetic stimulation hand function cortex suppression corticospinal tract grants-supported paper neuroregeneration

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Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2447-2450页

作者： Hye Seong Bo Kyu Choi young-Hee Han Jun Hyoung Kim Jeong-An Gim Sooyeon Lim Ji Yun Noh Hee Jin Cheong woo Joo Kim Joon young song Department of Internal Medicine Korea University College of MedicineSeoulRepublic of Korea Asia Pacific Influenza Institute Korea University College of MedicineSeoulRepublic of Korea Vaccine Innovation Center Korea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Department of Food and Nutrition Chungbuk National UniversityCheongjuRepublic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongjuRepublic of Korea Medical Science Research Center Korea University College of MedicineSeoulRepublic of Korea

Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global *** vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics.

关键词： vaccines respiratory acute

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A facile synthesis of hierarchical Sn3O4 nanostructures in an acidic aqueous solution and their strong visible- light-driven photocatalytic activity

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Nano Research 2015年第11期8卷 3553-3561页

作者： Hui song Su-young son Seul Ki Kim Gun young Jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju 500-712 Republic of Korea Carbon Convergence Materials Research Center Institute of Advanced Composite Materials Korea Institute of Science and Technology (KIST) Jeollabuk-do 565-905 Republic of Korea

层次锡(III ) 氧化物， Sn 3 O 4, nanospheres 在强烈酸的周围的条件下面经由热水的反应被综合。Sn 3 O 4 与减少的 pH 变化了。多刺的 Sn 3 O 4 nanospheres 变成了 Sn 3 被有高度的单人赛水晶的 nanoplates 盖住的 O 4 nanospheres ... 详细信息

层次锡(III ) 氧化物， Sn 3 O 4, nanospheres 在强烈酸的周围的条件下面经由热水的反应被综合。Sn 3 O 4 与减少的 pH 变化了。多刺的 Sn 3 O 4 nanospheres 变成了 Sn 3 被有高度的单人赛水晶的 nanoplates 盖住的 O 4 nanospheres 赌了 ca 的表面区域。55.05 m 2

关键词：光催化活性酸性水溶液纳米微球简便合成结构层比表面积纳米结构光催化剂

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Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1167-1175页

作者： Yeon Ji Chae Hwon Heo Chul-woong woo Sang-Tae Kim Jae-Im Kwon Monica young Choi Yu Sub Sung Kyung Won Kim Jeong Kon Kim Yoonseok Choi Dong-Cheol woo Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Center Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Center Asan Medical CenterSeoulRepublic of Korea Department of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Institute Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal *** study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in *** analysis was conducted to assess compare the monitoring of liver function by MRI and ***-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week *** images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY ***:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control *** the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA ***,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin *** correlations between either AUCtmax or T_(2)*values and the serological biomarkers were ***:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development.

关键词： Liver fibrosis Magnetic resonance imaging Silymarin T1-weight-ed dynamic contrast-enhanced T_(2)*

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A 360-Degree Panoramic Image Inpainting Network Using a Cube Map

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Computers, Materials & Continua 2021年第1期66卷 213-228页

作者： Seo woo Han Doug young Suh Department of Electronic Engineering Kyung Hee UniversityYoungin17104South Korea

Inpainting has been continuously studied in the field of computer *** artificial intelligence technology developed,deep learning technology was introduced in inpainting research,helping to improve ***,the input target of an inpainting algorithm using deep learning has been studied from a single image to a ***,deep learning-based inpainting technology for panoramic images has not been actively *** propose a 360-degree panoramic image inpainting method using generative adversarial networks(GANs).The proposed network inputs a 360-degree equirectangular format panoramic image converts it into a cube map format,which has relatively little distortion and uses it as a training *** the cube map format is used,the correlation of the six sides of the cube map should be ***,all faces of the cube map are used as input for the whole discriminative network,and each face of the cube map is used as input for the slice discriminative network to determine the authenticity of the generated *** proposed network performed qualitatively better than existing single-image inpainting algorithms and baseline algorithms.

关键词： Panoramic image image inpainting cube map generative adversarial networks

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Pathologic etiology and predictors of malignancy in children with cervical lymphadenopathy

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World Journal of Pediatrics 2023年第3期19卷 283-287页

作者： Jee woo Kim Jee Yeon Baek Ji young Lee Sung Min Lim Ji-Man Kang Won Kee Ahn Seung Min Hahn Jung woo Han Chuh Joo Lyu Jong Gyun Ahn Department of Pediatrics Severance Children's HospitalYonsei University College of Medicine50-1 Yonsei-RoSeodaemun-guSeoul 03722South Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Pediatric Hematology and Oncology Department of PediatricsYonsei University College of MedicineYonsei University Health SystemSeoulSouth Korea Department of Pediatric Hemato-Oncology Yonsei Cancer CenterYonsei University Health SystemSeoulSouth Korea

Cervical lymphadenopathy in children is a common disease entity that is accompanied by a variety of processes,ranging from benign disease to *** the cause of cer-vical lymphadenopathy in children is often benign[1-4],the presence of enlarged lymph nodes can cause anxiety to parents because of its association with *** should be considered for the histologic diagnosis of persistent or unex-plained cervical lymphadenopathy in ***,biopsy is an invasive examination method,and it is difficult to clinically determine whether biopsy is needed in children with unexplained cervical ***,clini-cians should be aware of the differential diagnosis of lymph node enlargement in children and should identify situations in which malignancy may be *** this study,we aimed to identify the etiology of pediatric cervical lymphadenopathy using biopsy and to analyze the risk factors associated with malignancy in children with cervical lymphadenopathy.

关键词： malignancy cervical diagnosis

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Fast ethylamine gas sensing based on intermolecular charge-transfer complexation

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Chinese Chemical Letters 2012年第4期23卷 484-487页

作者： Eun Mi Lee Seon young Gwon young A son Sung Hoon Kim BK21 FTIT Department of Advanced Organic Materials and Textile System EngineeringChungnam National UniversityDaejeon 305-764Republic of Korea Department of Textile System Engineering Kyungpook National UniversityDaegu 702-701 Republic of Korea School of Chemistry Science & Technology Zhanjiang Normal UniversityZhanjiang 524048China

We have investigated the fast ethylamine gas sensing of 2-chloro-3,5-dinitrobenzotrifluoride（CDBF） loaded poly（acrylonitrile） nanofiber based on an intermolecular charge-transfer *** response and recovery were ach... 详细信息

关键词： Ethylamine gas Fast gas sensing 2-Chloro-3 5-dinitrobenzotrifluoride(CDBF) Electrospinning PAN nanofiber Intermolecular charge-transfer(CT) complexation

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Uniform assembly of gold nanoparticles on S-doped g-C3N4 nanocomposite for effective conversion of 4-nitrophenol by catalytic reduction

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Journal of Materials Science & Technology 2020年第5期40卷 176-184页

作者： Vellaichamy Balakumar Hyungjoo Kim Ji Won Ryu Ramalingam Manivannan young-A son Department of Advanced Organic Materials Engineering Chungnam National University220 Gung-dongYuseong-guDaejeon305-764South Korea

In this work,a simple synthesis of sulfur doped graphitic carbon nitride(S-g-C3N4)act as a support cum stabilizers for gold nanoparticles(Au)and its was characterized by UV–vis and XRD to measure the absorbance and crystallinity,*** functional group and morphology of the samples were identified using FT-IR and ***,the Au@S-g-C3N4 nanocatalyst exhibits good catalytic performance and stability in the reduction of hazardous 4-nitrophenol(NP)compared to S-g-C3N4 using Na ***,the Au@S-g-C3N4 nanocomposite holds a good catalytic efficiency(near 100%)achieved by within 5 *** highest catalytic reduction of NP is due to the synergistic effect of Au nanoparticles decorated on *** fast electron transfer reduction mechanism was elucidated and *** reusability and stability of the developed nanocomposites were also observed in consecutive reduction *** filtering and catalyzing device was used for the direct conversion of NP polluted *** method can open a new avenue for the metal nanoparticles based carbon materials heterogeneous catalyst and its reduction of toxic contaminants.

关键词： Gold nanoparticles S-doped g-C3N4 Catalytic reduction 4-nitrophenol

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A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi Seong wook Seo Hyuk woo Lee Chong Hak Chae woo-Kyu Park Hyun young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

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Approaching 18% efficiency of ternary organic photovoltaics with wide bandgap polymer donor and well compatible Y6 : Y6-1O as acceptor

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National Science Review 2021年第8期8卷 20-29页

作者： Xiaoling Ma Anping Zeng Jinhua Gao Zhenghao Hu Chunyu Xu Jae Hoon son Sang young Jeong Caixia Zhang Mengyang Li Kai Wang He Yan Zaifei Ma Yongsheng Wang Han young woo Fujun Zhang Key Laboratory of Luminescence and Optical Information Ministry of EducationBeijing Jiaotong University Organic Optoelectronic Materials Laboratory Department of ChemistryCollege of ScienceKorea University Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology Department of Chemistry The Hong Kong University of Science and Technology Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua University

A series of ternary organic photovoltaics(OPVs) are fabricated with one wide bandgap polymer D18-Cl as donor, and well compatible Y6 and Y6-1O as acceptor. The open-circuit-voltage(V)of ternary OPVs is monotonously increased along with the incorporation of Y6-1O, indicating that the alloy state should be formed between Y6 and Y6-1O due to their excellent compatibility. The energy loss can be minimized by incorporating Y6-1 O, leading to the VOC improvement of ternary OPVs. By finely adjusting the Y6-1O content, a power conversion efficiency of 17.91% is achieved in the optimal ternary OPVs with 30 wt% Y6-1O in acceptors, resulting from synchronously improved short-circuit-current density(JSC) of 25.87 mA cm, fill factor(FF) of 76.92% and VOC of 0.900 V in comparison with those of D18-Cl : Y6 binary OPVs. The JSC and FF improvement of ternary OPVs should be ascribed to comprehensively optimal photon harvesting, exciton dissociation and charge transport in ternary active layers. The more efficient charge separation and transport process in ternary active layers can be confirmed by the magnetophotocurrent and impedance spectroscopy experimental results, respectively. This work provides new insight into constructing highly efficient ternary OPVs with well compatible Y6 and its derivative as acceptor.

关键词： organic photovoltaics power conversion efficiency ternary strategy photon harvesting morphology regulation

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