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Engineering 2022年第4期8卷 27-41页

作者： Ahsan Noor Khan young-ok cha Henry Giddens Yang Hao School of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

The integration of electronics and biology has spawned bioelectronics and opened exciting opportunities to fulfill the unmet needs of therapeutic *** developments in nanoelectronics and soft and biocompatible materials have shown potential applicability to clinical practices,including physiological sensing,drug delivery,cardiovascular monitoring,and brain *** date,most bioelectronic devices require wired connections for electrical control,making their implantation complicated and inconvenient for *** an alternative,wireless technology is proliferating to create bioelectronics that offer noninvasive control,biotelemetry,and wireless power transfer(WPT).This review paper provides a comprehensive overview of wireless bioelectronics and ongoing developments in their applications for organ-specific treatments,including disorders and *** main emphasis is on delineating the key features of antennas,namely their radiation characteristics,materials,integration with rest of the electronics,and experimental *** the recent progress in wireless mediated bioelectronics is expected to enhance the control of its functionalities,there are still numerous challenges that need to be addressed for commercialization,as well as to address everexpanding and evolving future therapeutic targets.

关键词： Bioelectronics Neural implants Drug delivery Antennas Wireless power

Active control of highway bridges subject to a variety of earthquake loads

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Earthquake Engineering and Engineering Vibration 2015年第2期14卷 253-263页

作者： Ryan Mitchell young-Jin cha Yeesock Kim Aniket Anil Mahajan Department of Civil and Environmental Engineering Worcester Polytechnic Institute (WPI) Worcester MA 01609-2280 USAGraduate Research Assistant Department of Civil Engineering University of Manitoba Winnipeg MB R3L5V6 Canada Assistant Professor Department of Civil and Environmental Engineering Worcester Polytechnic Institute (WPI) Worcester MA 01609-2280 USA Department of Civil and Environmental Engineering Worcester Polytechnic Institute (WPI) Worcester MA 01609-2280 USA Graduate Research Assistant

In this paper, a wavelet-fi ltered genetic-neuro-fuzzy(WGNF) control system design framework for response control of a highway bridge under various earthquake loads is discussed. The WGNF controller is developed by combining fuzzy logic, discrete wavelet transform, genetic algorithms, and neural networks for use as a control algorithm. To evaluate the performance of the WGNF algorithm, it is tested on a highway bridge equipped with hydraulic actuators. It controls the actuators installed on the abutments of the highway bridge structure. Various earthquakes used as input signals include an artifi cial earthquake, the El-Centro, Kobe, North Palm Springs, Turkey Bolu, Chi-Chi, and Northridge earthquakes. It is proved that the WGNF control system is effective in mitigating the vibration of the highway bridge under a variety of seismic excitation.

关键词： structural control wavelet transform genetic algor

Ethanol extracts of Hizikia fusiforme induce apoptosis in human prostate cancer PC3 cells via modulating a ROS-dependent pathway

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 78-86页

作者： Eun ok Choi Hyesook Lee Cheol Park Gi-young Kim Hee-Jae cha Suhkmann Kim Heui-Soo Kim You-Jin Jeon Hye Jin Hwang Yung Hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Department of Molecular Biology College of Natural SciencesDong-eui UniversityBusan 47340Republic of Korea Laboratory of Immunobiology Department of Marine Life SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics Kosin University College of MedicineBusan 49267Republic of Korea Department of Chemistry College of Natural SciencesCenter for Proteome Biophysics and Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether ethanol extracts of Hizikia fusiforme could induce apoptosis in human prostate cancer PC3 ***:Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium *** and mitochondrial membrane potential(MMP)were measured using flow cytometry in PC3 *** damage was assessed by nuclear staining and DNA fragmentation *** of apoptosis-associated proteins were determined by Western blotting *** of caspase-3,-8,and-9 were determined by colorimetric ***,intracellular reactive oxygen species(ROS)generation was detected using a flow cytometer and fluorescence ***:Treatment of PC3 cells with ethanol extracts of Hizikia fusiforme inhibited proliferation,which was associated with induction of apoptosis,and accompanied by increased expression of Fas,Fas-ligand(Fas L),Bax and t Bid,and decreased expression of *** addition,ethanol extracts of Hizikia fusiforme reduced c-Flip expression and activated caspase-8,-9 and-3,resulting in an increase in poly(ADP-ribose)polymerase(PARP)***,in the presence of a pan-caspase inhibitor,ethanol extracts of Hizikia fusiforme-mediated growth inhibition and apoptosis were significantly *** extracts of Hizikia fusiforme also destroyed the integrity of mitochondria due to the loss of MMP,leading to cytosolic release of cytochrome ***,the levels of ROS were markedly increased by treatment with ethanol extracts of Hizikia fusiforme,which was significantly suppressed by the ROS scavenger *** investigation of whether ethanol extracts of Hizikia fusiforme-induced apoptosis was related to the generation of ROS was conducted and the results showed that N-acetyl-L-cysteine fully blocked ethanol extracts of Hizikia fusiforme-induced apoptotic events including loss of MMP,activation of caspase-3,the cytosolic release of cytochrome c and ***:E

关键词： Hizikia fusiforme Apoptosis Prostate cancer cells Caspase Reactive oxygen species

Size-dependent transition of the deformation behavior of Au nanowires

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Nano Research 2015年第3期8卷 941-947页

作者： Na-young Park Ho-Seok Nam PiI-Ryung cha Seung-Cheol Lee School of Advanced Materials Engineering Kookmin University Seou1136-702 R. O. Korea Future Convergence Research Division Korea Institute of Science and Technology (KIST) Seou1136-791 R. O. Korea Indo-Korea Science and Technology Center Korea Institute of Science and Technology (KIST) Seou1136-791 R. O. Korea

Inspired by the controversy over tensile deformation modes of single-crystalline 〈110〉/{111} Au nanowires, we investigated the dependency of the deformation mode on diameters of nanowires using the molecular dynamics technique. A new criterion for assessing the preferred deformation mode-slip or twin propagation--of nanowires as a function of nanowire diameter is presented. The results demonstrate the size-dependent transition, from superplastic deformation mediated by twin propagation to the rupture by localized slips in deformed region as the nanowire diameter decreases. Moreover, the criterion was successfully applied to explain the superplastic deformation of Cu nanowires.

关键词： Au nanowire molecular dynamics size-dependent transition tensile deformationmechanism

Effects of Initial and Boundary Conditions on Heavy Rainfall Simulation over the Yellow Sea and the Korean Peninsula:Comparison of ECMWF and NCEP Analysis Data Effects and Verification with Dropsonde Observation

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Advances in Atmospheric Sciences 2024年第9期41卷 1787-1803页

作者： Jiwon HWANG Dong-Hyun cha Donghyuck YOON Tae-young GOO Sueng-Pil JUNG Department of Civil Urban Earth and Environmental Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNew Jersey 08544USA National Institute of Meteorological Sciences NIMSJeju 63568South Korea

This study evaluated the simulation performance of mesoscale convective system(MCS)-induced precipitation,focusing on three selected cases that originated from the Yellow Sea and propagated toward the Korean *** evaluation was conducted for the European Centre for Medium-Range Weather Forecasts(ECMWF)and National Centers for Environmental Prediction(NCEP)analysis data,as well as the simulation result using them as initial and lateral boundary conditions for the Weather Research and Forecasting ***,temperature and humidity profiles from 3D dropsonde observations from the National Center for Meteorological Science of the Korea Meteorological Administration served as validation *** showed that the ECMWF analysis consistently had smaller errors compared to the NCEP analysis,which exhibited a cold and dry bias in the lower levels below 850 *** model,in terms of the precipitation simulations,particularly for high-intensity precipitation over the Yellow Sea,demonstrated higher accuracy when applying ECMWF analysis data as the initial *** advantage also positively influenced the simulation of rainfall events on the Korean Peninsula by reasonably inducing convective-favorable thermodynamic features(i.e.,warm and humid lower-level atmosphere)over the Yellow *** conclusion,this study provides specific information about two global analysis datasets and their impacts on MCS-induced heavy rainfall simulation by employing dropsonde observation ***,it suggests the need to enhance the initial field for MCS-induced heavy rainfall simulation and the applicability of assimilating dropsonde data for this purpose in the future.

关键词： initial conditions dropsonde heavy rainfall forecast global model analysis evaluation

Improvement in Sensitivity and Recovery of Single-Walled Carbon Nanotube-Based Gas Sensors

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稀有金属材料与工程 2006年第A03期35卷 188-189页

作者： Hong-Quang Nguyen Geon-young cha Joon-Boo Yu Jeung-Soo Huh Department of Materials Science and Metallurgy Kyungpook National UniversitySangyuk-DongBukgu 1370Daegu 702-701Korea

In this paper,an improvement in sensitivity and recovery of the single-walled carbon nanotube (SWNT)-based gas sensors was *** sensors were fabricated from SWNT powder by a screen-printing method,followed by annealing for 2 h in open-air at various *** Raman spectra of the SWNT bundles and the response to ammonia (NH_3) exposure of the sensors indicated that the annealing at a relevant temperature improved the sensor *** sensor annealed at 200℃exhibited a high sensitivity in NH_3 *** 20 min of exposure to NH_3 at room temperature,the resistance of the sensor increased up to 12% in comparison with its initial *** evacuating combined with maintaining the flux of carrier gas at 300 sccm,the sensor recovery was significantly *** sensor resistance retrieved to its initial value after only 25 min degassing. These results would be considered in the development of the SWNT-based gas sensors.

关键词： carbon nanotubes gas adsorption recovery sensitivity sensor

Comparison of the Bright Band characteristics Measured by Micro Rain Radar (MRR) at a Mountain and a Coastal Site in South Korea

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Advances in Atmospheric Sciences 2009年第2期26卷 211-221页

作者： Joo-Wan cha Ki-Ho chaNG Seong Soo YUM young-Jean CHOI Department of Atmospheric Sciences Yonsei University Global Environment System Research Laboratory NIMR/KMA

Data from a long term measurement of Micro Rain Radar （MRR） at a mountain site （Daegwallyeong, DG, one year period of 2005） and a coastal site （Haenam, HN, three years 2004-2006） in South Korea were analyzed to compare the MRR measured bright band characteristics of stratiform precipitation at the two sites. On average, the bright band was somewhat thicker and the sharpness （average gradient of reflectivity above and below the reflectivity peak） was slightly weaker at DG, compared to those values at HN. The peak reflectivity itself was twice as strong and the relative location of the peak reflectivity within the bright band was higher at HN than at DG. Importantly, the variability of these values was much larger at HN than at DG. The key parameter to cause these differences is suggested to be the difference of the snow particle densities at the two sites, which is related to the degree of riming. Therefore, it is speculated that the cloud microphysical processes at HN may have varied significantly from un-rimed snow growth, producing low density snow particles, to the riming of higher density particles, while snow particle growth at DG was more consistently affected by the riming process, and therefore high density snow particles. Forced uplifting of cloudy air over the mountain area around DG might have resulted in an orographic supercooling effect that led to the enhanced riming of supercooled cloud drops.

关键词： Micro Rain Radar bright band thickness and sharpness cloud microphysical processes local characteristics

Double guidewire technique vs transpancreatic precut sphincterotomy in difficult biliary cannulation

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World Journal of Gastroenterology 2013年第1期19卷 108-114页

作者： young Wook Yoo Sang-Woo cha Woong Cheul Lee Sae Hee Kim Anna Kim young Deok Cho Department of Internal Medicine Gastroenterology and Hepatobiliary CenterCheongju St.Mary's HospitalCheongju 360-568South Korea Department of Internal Medicine Soonchunhyang University College of MedicineInstitute for Digestive ResearchDigestive Disease CenterSoonchunhyang University HospitalSeoul 140-743South Korea Division of Gastroenterology Department of Internal MedicineEulji University College of MedicineEulji University HospitalDaejeon 302-799South Korea

AIM:To compare the outcomes between doubleguidewire technique(DGT) and transpancreatic precut sphincterotomy(TPS) in patients with difficult biliary ***:This was a prospective,randomized study conducted in single tertiary referral hospital in *** January 2005 and September 2010.A total of 71 patients,who bile duct cannulation was not possible and selective pancreatic duct cannulation was achieved,were randomized into DGT(n = 34) and TPS(n = 37) *** or TPS was done for selective biliary *** measured the technical success rates of biliary cannulation,median cannulation time,and procedure related ***:The distribution of patients after randomization was balanced,and both groups were comparable in baseline characteristics,except the higher percentage of endoscopic nasobiliary drainage in the DGT group(55.9% vs 13.5%,P < 0.001).Successful cannulation rate and mean cannulation times in DGT and TPS groups were 91.2% vs 91.9% and 14.1 ± 13.2 min vs 15.4 ± 17.9 min,P = 0.732,*** was no significant difference between the two *** overall incidence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis was 38.2% vs 10.8%,P < 0.011 in the DGT group and the TPS group;post-procedure pancreatitis was significantly higher in the DGT *** the overall incidence of post-ERCP hyperamylasemia was no significant difference between the two groups;DGT group vs TPS group:14.7% vs 16.2%,P < ***:When free bile duct cannulation was difficult and selective pancreatic duct cannulation was achieved,DGT and TPS facilitated biliary cannulation and showed similar success ***,post-procedure pancreatitis was significantly higher in the DGT group.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Duoble guidewire technique Transpancrestic precut sphincterotomy

Origami multi-layer space shield for cylindrical space structure

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Chinese Journal of Aeronautics 2024年第10期37卷 294-312页

作者： Ji-Hun cha Ji-Sub NOH Sarath Kumar SATHISH KUMAR Dohyeon JIN Dae-young LEE Chun-Gon KIM Department of Aerospace Engineering Chosun UniversityGwangju 61452Republic of Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityGyeongsangnam-do 52828Republic of Korea Department of Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Aerospace Engineering KAISTDaejeon 34141Republic of Korea

The multidisciplinary space environment,encompassing orbital debris,cosmic radiation,and solar radiative heat,poses significant risks to spacecraft and astronauts,necessitating efficient and effective shielding solutions.A multi-layer shield with wide spacing has been proven to be an effective way to shield the spacecraft from space debris impact;however,due to the limited volume of the payload fairing,it was not feasible to apply a multi-layer shield to the spacecraft *** the origami design,the shield maintains a compact form during launch and subsequently expands in outer space to enhance *** geometric analysis,it has been confirmed that the deployable multi-layer space shield can occupy less space than conventional space shield structures while expanding into wider shield intervals and multiple *** hypervelocity impact experiments,it was confirmed that as the bumper spacing of the multi-layer space shield expands,its ballistic performance becomes superior to conventional space *** deployable multi-layer space shield can reduce not only hypervelocity impacts but also solar radiative heat using the same mechanism as multi-layer *** cosmic radiation dose analysis,it has been confirmed that the multi-layer space shield is effective in cosmic radiation shielding compared to conventional space structures.

关键词： Hybrid composite Origami Hypervelocity impact Space environment Space debris Cosmic radiation

Wireless phototherapeutic contact lenses and glasses with red light-emitting diodes

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Nano Research 2020年第5期13卷 1347-1353页

作者： young-Geun Park Eunkyung cha Hyeon Seok An Kyoung-Pil Lee Myoung Hoon Song Hong Kyun Kim Jang-Ung Park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Department of Ophthalmology School of MedicineKyungpook National UniversityDaegu41944Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Light-mediated therapeutics have attracted considerable attention as a method for the treatment of ophthalmologic diseases,such as age-related macular degeneration,because of their non-invasiveness and the effectiveness to ameliorate the oxidative stress of retinal ***,the current phototherapeutic devices are opaque,bulky,and tethered forms,so they are not feasible for use in continuous treatment during the patient’s daily ***,we report wireless,wearable phototherapeutic devices with red light-emitting diodes for continuous *** light-emitting diodes were formed to be conformal to three-dimensional surfaces of glasses and contact ***,fabricated light-emitting diodes had either transparency or a miniaturized size so that the user’s view is not ***,these devices were operated wirelessly with control of the light *** addition,in-vitro and in-vivo tests using human retinal epithelial cells and a live rabbit demonstrated the effectiveness and reliable operation as phototherapeutic devices.

关键词： transparent electronics wearable healthcare red light-emitting diodes phototherapies