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Nomogram predicting the prognosis of primary liver cancer after radiofrequency ablation combined with transcatheter arterial chemoembolization

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2630-2639页

作者： Hai-Hua Shen Yu-Rong hong Wen Xu Lei Chen jun-Min Chen Zhi-Gen Yang Cai-hong Chen Department of Ultrasound Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina Department of Ultrasound The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Nursing Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina

BACKGROUND The incidence and mortality rates of primary hepatocellular carcinoma(HCC)are high,and the conventional treatment is radiofrequency ablation(RFA)with transcatheter arterial chemoembolization(TACE);however,the 3-year survival rate is still ***,there are no visual methods to effectively predict their *** To explore the factors influencing the prognosis of HCC after RFA and TACE and develop a nomogram prediction *** Clinical and follow-up information of 150 patients with HCC treated using RFA and TACE in the Hangzhou Linping Hospital of Traditional Chinese Medicine from May 2020 to December 2022 was retrospectively collected and *** examined their prognostic factors using multivariate logistic regression and created a nomogram prognosis prediction model using the R software(version 4.1.2).Internal verification was performed using the bootstrapping *** prognostic efficacy of the nomogram prediction model was evaluated using the concordance index(CI),calibration curve,and receiver operating characteristic RESULTS Of the 150 patients treated with RFA and TACE,92(61.33%)developed recurrence and *** regression analysis identified six variables,and a predictive model was *** internal validation results of the model showed a CI of *** correction curve trend of the prognosis prediction model was always near the diagonal,and the mean absolute error before and after internal validation was *** area under the curve of the prediction model after internal verification was 0.882[95%confidence interval(95%CI):0.820-0.945],with a specificity of 0.828 and sensitivity of *** to the Hosmer-Lemeshow test,χ^(2)=3.552 and P=*** predictive model demonstrated a satisfactory calibration,and the decision curve analysis demonstrated its clinical *** The prognosis of patients with HCC after RFA and TACE is affected by several *** developed prediction model ba

关键词： Nomogram Primary liver cancer Radiofrequency ablation Transcatheter arterial chemoembolization Prognosis Influencing factors Decision curve analysis

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Angiosperm-wide analysis of fruit and ovary evolution aided by a new nuclear phylogeny supports association of the same ovary type with both dry and fleshy fruits

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Journal of Integrative Plant Biology 2024年第2期66卷 228-251页

作者： Yezi Xiang Taikui Zhang Yiyong Zhao hongjin Dong hongyi Chen Yi Hu Chien-Hsun Huang jun Xiang hong Ma State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity and Ecological EngineeringInstitute of Plant BiologyCenter of Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biology Howard Hughes Medical InstituteDuke UniversityDurhamNC 27708USA Department of Biology the Eberly College of Scienceand the Huck Institutes of the Life Sciencesthe Pennsylvania State UniversityUniversity ParkPA 16802USA Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization College of Biology and Agricultural ResourcesHuanggang Normal UniversityHuanggang 438000China

Fruit functions in seed protection and dispersal and belongs to many dry and fleshy types,yet their evolutionary pattern remains unclear in part due to uncertainties in the phylogenetic relationships among several orders and *** we used nuclear genes of 502 angiosperm species representing 231 families to reconstruct a well supported phylogeny,with resolved relationships for orders and families with previously uncertain *** this phylogeny as a framework,molecular dating supports a Triassic origin of the crown angiosperms,followed by the emergence of most orders in the Jurassic and Cretaceous and their rise to ecological dominance during the Cretaceous Terrestrial *** robust phylogeny allowed an examination of the evolutionary pattern of fruit and ovary types,revealing a trend of parallel carpel fusions during early diversifications in eudicots,monocots,and ***,taxa in the same order or family with the same ovary type can develop either dry or fleshy fruits with strong correlations between specific types of dry and fleshy fruits;such associations of ovary,dry and fleshy fruits define several ovaryfruit"modules"each found in multiple *** of the frequent modules has an ovary containing multiple ovules,capsules and berries,and another with an ovary having one or two ovules,achenes(or other single-seeded dry fruits)and *** new perspective of relationships among fruit types highlights the closeness of specific dry and fleshy fruit types,such as capsule and berry,that develop from the same ovary type and belong to the same module relative to dry and fleshy fruits of other modules(such as achenes and drupes).Further analyses of gene families containing known genes for ovary and fruit development identified phylogenetic nodes with multiple gene duplications,supporting a possible role of whole-genome duplications,in combination with climate changes and animal behaviors,in angiosperm fruit and ovary diversificat

关键词： angiosperm fruit evolution MADS-box molecular clock nuclear phylogeny ovary and fruit developmental genes

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Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 1-13页

作者： Li Xu Wen-jun Chen Cai-jun Tian Yan Zhang Yan Ma Tian-Hao Li hong-Jie Liu Zhe Zhang Department of the First College English College of Foreign LanguageShandong University of Traditional Chinese MedicineJinanChina Department of Oncology Linyi People's HospitalLinyiChina Department of Internal Medicine of Traditional Chinese Medicine The First Clinical CollegeShandong University of Traditional Chinese MedicineJinanChina Department of Chinese Materia Medica College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Department of Medicinal Chemistry College of PharmacyShandong University of Traditional Chinese MedicineJinanChina Community Healthcare Center Shenzhen Traditional Chinese Medicine HospitalShenzhenChina Department of Fundamentals of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Shandong Co-Innovation Center of Classic TCM Formula College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina

Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve randomized controlled trials(RCTs)of CHMs combined with tacrine,galantamine,rivastigmine,donepezil,or memantine,following strict inclusion and exclusion *** research papers published in English,Chinese,and Japanese were *** primary outcome was the mini-mental state examination(MMSE)score and the secondary outcomes were AD assessment scale cognitive subscale(ADAS-Cog)score and safety ***-analysis was carried out using Rev Man 5.3 and subgroup analysis was conducted to identify the sources of ***:A total of 15 RCTs with 1386 participants were included in this *** donepezil was used in the retrieved ***-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score(Z=9.45;P<0.00001;weighted mean difference[WMD]=2.68,95%confidence interval[CI]:2.12-3.24)and a significant decrease in the ADAS-Cog score(Z=5.53;P<0.00001;WMD=-3.79;95%CI:-5.13--2.44).Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia(risk ratio[RR]=0.20,95%CI:0.06-0.68;P=0.01)and hive(RR=0.10;95%CI:0.01-0.73;P=0.02).Conclusions:The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.

关键词： Alzheimer's disease Chinese herbal medicine donepezil memantine meta-analysis randomized controlled trials rivastigmine

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Research on the solid particle erosion wear of pipe steel for hydraulic fracturing based on experiments and numerical simulations

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Petroleum Science 2024年第4期21卷 2779-2792页

作者： Si-Qi Yang Jian-Chun Fan Ming-Tao Liu De-Ning Li jun-Liang Li Li-hong Han Jian-jun Wang Shang-Yu Yang Si-Wei Dai Lai-Bin Zhang State Key Laboratory of Oil and Gas Equipment CNPC Tubular Goods Research Institute Key Laboratory of Oil and Gas Safety and Emergency Technology China University of Petroleum Oil Production Technology Research Institute of Liaohe Oilfield Company Tianjin Gas Storage Branch PetroChina Dagang Oilfield Company Petroleum Production Engineering Research Institute Daqing Oilfield Company

Erosion wear is a common failure mode in the oil and gas industry. In the hydraulic fracturing, the fracturing pipes are not only in high-pressure working environment, but also suffer from the impact of the high-speed solid particles in the fracturing fluid. Beneath such complex conditions, the vulnerable components of the pipe system are prone to perforation or even burst accidents, which has become one of the most serious risks at the fracturing site. Unfortunately, it is not yet fully understood the erosion mechanism of pipe steel for hydraulic fracturing. Therefore, this article provides a detailed analysis of the erosion behavior of fracturing pipes under complex working conditions based on experiments and numerical simulations. Firstly, we conducted erosion experiments on AISI 4135 steel for fracturing pipes to investigate the erosion characteristics of the material. The effects of impact angle, flow velocity and applied stress on erosion wear were comprehensively considered. Then a particle impact dynamic model of erosion wear was developed based on the experimental parameters, and the evolution process of particle erosion under different impact angles, impact velocities and applied stress was analyzed. By combining the erosion characteristics, the micro-structure of the eroded area, and the micro-mechanics of erosion damage, the erosion mechanism of pipe steel under fracturing conditions was studied in detail for the first time. Under high-pressure operating conditions, it was demonstrated through experiments and numerical simulations that the size of the micro-defects in the eroded area increased as the applied stress increased, resulting in more severe erosion wear of fracturing pipes.

关键词： Erosion wear Applied stress Particle impact dynamics Erosion mechanism

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Relationship between postoperative rehabilitation style, gastrointestinal function, and inflammatory factor levels in children with intussusception

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2640-2648页

作者： Xue-Yan Wei hong-Chang Huo Xin Li Su-Li Sun jun Zhang Department of Outpatient Shijiazhuang Maternal and Child Health HospitalShijiazhuang 050090Hebei ProvinceChina Department of Pediatric Surgery Shijiazhuang Maternal and Child Health HospitalShijiazhuang 050090Hebei ProvinceChina Department of Nursing Shijiazhuang Maternal and Child Health HospitalShijiazhuang 050090Hebei ProvinceChina

BACKGROUND Intussusception occurs in children and progresses *** not treated in time,it may lead to secondary complications such as intestinal perforation,which affect the quality of life and health of *** is the most common clinical treatment and has a good ***,the postoperative prognosis of children with intussusception has a correlation with the postoperative rehabilitation ***,in this study,we explored the relationship between postopera-tive rehabilitation,gastrointestinal function,and the expression of inflammatory factors in children with *** medical records of 18 children who were admitted to our hospital for intussusception surgery between October 2022 and May 2024 were retrospectively *** patients were divided into the routine nursing group(n=6)and rehabilitation training group(n=12)according to the postoperative rehabilitation *** general data,gastrointestinal function,and inflammatory factor levels of the two groups were statistically *** correlation analysis of gastrointestinal function,inflammatory factors,and postoperative rehabil-itation was *** We found no significant intergroup differences in sex,age,or disease course(P>0.05).The times to first defecation,bowel sound recovery,and anal exhaust were shorter and inflammatory factor levels were lower in the rehabilitation training group than in the routine nursing group(P<0.05).Pearson correlation analysis showed that gastrin and motilin levels were positively correlated with postoperative rehabilitation(P<0.05).Interleukin(IL)-2,IL-4,IL-6,IL-10,high-sensitivity C-reactive protein,and tumor necrosis factor-αlevels were negatively correlated with postoperative rehabilitation(P<0.05).Gastrointestinal function was positively correlated(P<0.05),and levels of inflammatory factors were negatively correlated with postoperative recovery time(P<0.05).CONCLUSION We found a positive correlation between gastrointe

关键词： Children with intussusception Postoperative rehabilitation mode Gastrointestinal function Inflammatory factors

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Fe-N-C heterogeneous Fenton-like catalyst for the degradation of tetracycline:Fe-N coordination and mechanism studies

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Chinese Chemical Letters 2024年第9期35卷 309-314页

作者： Weichen Zhu Wei Zuo Pu Wang Wei Zhan jun Zhang Lipin Li Yu Tian hong Qi Rui Huang State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Guangdong Yuehai Water Investment Co. Ltd.Shenzhen 518021China National Engineering Research Center of Urban Water Resources Co. Ltd.Harbin Institute of TechnologyHarbin 150090China

Fe-N-C materials have received increasing attention,due to its distinctive catalytic ***,the Fe-N coordination number dependence of catalytic ability and mechanism for H_(2)O_(2)activation remain ***,a series of Fe-N-C heterogeneous Fenton-like catalysts with different Fe-N coordination number were prepared for tetracycline *** results demonstrated that samples with Fe-N4 structure exhibited high *** excellent performance was mainly ascribed to the high adsorption capacity and the formation of superoxide radicals(•O_(2)^(−))catalyzed by Fe linked to pyridinic *** intermediates and degradation pathways of tetracycline degradation by Fe-N-C/H_(2)O_(2)system were analyzed by liquid chromatography coupled to tandem mass spectrometry(LC-MS/MS).Furthermore,we applied our Fe-N-C catalysts to treat simulated pharmaceutical wastewater with high tetracycline degradation capacity despite high concentrations of organic matter such as oxalic acid and various ionic *** work reveals the dependence of the activation H_(2)O_(2)on the Fe-N coordination environment and the degradation mechanism of these *** provides insights into the prospects for tuning the catalyst in practical applications.

关键词： H_(2)O_(2)activation Advanced oxidation process Superoxide radicals Degradation pathways EXAFS

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Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： hong Geum-Lan KIM Kyung-Hyun CHO Sung-Pil LEE Hui-Ju KIM Yae-Ji junG Ju-young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

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Core-shell heterostructure engineering of CoP nanowires coupled NiFe LDH nanosheets for highly efficient water/seawater oxidation

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Chinese Chemical Letters 2024年第8期35卷 549-553页

作者： Guo-hong Gao Run-Ze Zhao Ya-jun Wang Xiao Ma Yan Li Jian Zhang Ji-Sen Li School of Chemistry Chemical Engineering and MaterialsJining UniversityQufu 273155China Institute of Physical Education Jining UniversityQufu 273155China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

Searching for efficient nonprecious metal-based catalysts toward oxygen evolution reaction(OER)are of significance for seawater ***,a core-shell-structured hybrid of cobalt phosphide nanowires@NiFe layered double hydroxide nanosheets grown on conductive nickel foam(CoP@NiFe LDH/NF)is prepared by a feasible approach at low *** charming structure can provide numerous phosphide/hydroxide heterogenous interfaces,expose abundant active sites,and boost elec-tron/mass transfer,synergistically enhancing catalytic OER *** employed as an electrocatalyst toward the OER,the resultant CoP@NiFe LDH/NF only requires a small overpotential of 287 mV to pro-vide 300 mA/cm^(2)current density as well as long-time durability in 1.0 mol/L KOH *** regula-tion of electronic states and surface reconstruction synergistically contribute to highly efficient seawater *** work provides an opportunity to construct efficient and inexpensive electrocatalysts for hydrogen production.

关键词： Cobalt phosphide NiFe layered double hydroxide Interfacial engineering Oxygen evolution reaction Seawater oxidation

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Systematic study of cluster radioactivity within the generalized liquid drop model

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Chinese Physics C 2024年第6期48卷 118-129页

作者：邓军刚程俊皓包小军张鸿飞 College of Science China Three Gorges UniversityYichang 443002China Center for Astronomy and Space Sciences China Three Gorges UniversityYichang 443002China Department of Physics National University of Defense TechnologyChangsha 410073China Department of Physics Collaborative Innovation Center for Quantum Effectsand Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationHunan Normal UniversityChangsha 410081China School of Physics Xi'an Jiaotong UniversityXi'an 710049China

Cluster radioactivity is studied within the generalized liquid drop model(GLDM),in which the shell correction energy,pairing energy,and cluster preformation factor are *** calculations show significant improvements and can reproduce the experimental data within a factor of 8.04 after considering these physical *** addition,the systematic trend of the cluster preformation factors is discussed in terms of the N_(p)N_(n)scheme to study the influence of the valence proton-neutron interaction and shell effect on cluster *** is found that log10Pcis linearly related to N_(p)N_(n).This is in agreement with a recent study[*** et al.,***.C 108,014325(2023)],in which log10Pc,obtained using different theoretical models and treatment methods than those used in this study,also had a linear relationship with N_(p)N_(n).Combined with the work by Qi et al.,this study suggests that the linear relationship between log10Pcand N_(p)N_(n)is model-independent and both the shell effect and valence proton-neutron interaction play essential roles in cluster *** analytical formula is proposed to calculate the cluster preformation factor based on the N_(p)N_(n)*** addition,the cluster preformation factors and the cluster radioactivity half-lives of some heavy nuclei are predicted,which can provide a reference for future experiments.

关键词： cluster radioactivity cluster preformation factor shell effect generalized liquid drop model

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Defect Engineering in Earth-Abundant Cu_(2)ZnSnSe_(4) Absorber Using Efficient Alkali Doping for Flexible and Tandem Solar Cell Applications

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Energy & Environmental Materials 2024年第2期7卷 249-256页

作者： Muhammad Rehan Ara Cho Inyoung Jeong Kihwan Kim Asmat Ullah jun-Sik Cho Joo Hyung Park Yunae Jo Sung jun hong Seung Kyu Ahn SeJin Ahn Jae Ho Yun Jihye Gwak Donghyeop Shin Photovoltaics Research Department Korea Institute of Energy Research(KIER)152-Gajeong-roYuseong-guDaejeon 34129Korea Department of Renewable Energy Engineering University of Science and Technology(UST)217-Gajeong-roYuseong-guDaejeon 34113Korea Korea Institute of Energy Technology(KENTECH) 50772 Ujeong-roNaju Jeonnam 58217Korea

To demonstrate flexible and tandem device applications,a low-temperature Cu_(2)ZnSnSe_(4)(CZTSe)deposition process,combined with efficient alkali doping,was ***,high-quality CZTSe films were grown at 480℃by a single co-evaporation,which is applicable to polyimide(PI)*** of the alkali-free substrate,Na and K alkali doping were systematically studied and optimized to precisely control the alkali distribution in *** bulk defect density was significantly reduced by suppression of deep acceptor states after the(NaF+KF)*** the low-temperature deposition with(NaF+KF)PDTs,the CZTSe device on glass yields the best efficiency of 8.1%with an improved Voc deficit of 646 *** developed deposition technologies have been applied to *** the first time,we report the highest efficiency of 6.92%for flexible CZTSe solar cells on ***,CZTSe devices were utilized as bottom cells to fabricate four-terminal CZTSe/perovskite tandem cells because of a low bandgap of CZTSe(~1.0 eV)so that the tandem cell yielded an efficiency of 20%.The obtained results show that CZTSe solar cells prepared by a low-temperature process with in-situ alkali doping can be utilized for flexible thin-film solar cells as well as tandem device applications.

关键词： alkali doping Earth-abundant Cu_(2)ZnSnSe_(4) flexible solar cells four-terminal tandem cells low-temperature process

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