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Treatment of laryngopharyngeal reflux disease: A systematic review

World Journal of Clinical Cases 2019年第19期7卷 2995-3011页

作者： Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez young-gyu eun Sven Saussez Laboratory of Anatomy and Cell Biology Faculty of MedicineUMONS Research Institute for Health Sciences and TechnologyUniversity of MonsMons 7000Belgium Laryngopharyngeal Reflux Study Group of young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies Paris 75000France Department of Otolaryngology-Head and Neck Surgery CHU de LilleLille 59000France Division of Phoniatrics and Audiology Department of Mental and Physical Health and Preventive MedicineUniversity of L.VanvitelliNaples 80100Italy ENT Audiology and Phoniatric Unit University of PisaPisa 56100Italy Larynx Function and Acoustic Voice Laboratory Department of Speech TherapySchool of RehabilitationTehran 11369Iran Department of Otolaryngology Marmara University Pendik Training and Research HospitalIstanbul 34722Turkey Department of Otology Neurotology and Skullbase SurgeryMadras ENT Research FoundationTamil Nadu 60028India Department of Otorhinolaryngology and Head and Neck Surgery Hospital Complex of Santiago de CompostelaSantiago de Compostela 15700Spain Department of Otorhinolaryngology and Head and Neck Surgery Kyung Hee University Medical CenterSeoul 130702Korea

BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success *** To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD *** Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of *** prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed *** criteria for considering studies for the review were based on the population,intervention,comparison,and outcome *** The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 *** most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor *** Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux.

关键词： Laryngopharyngeal Reflux Laryngitis Treatment Proton pump inhibitors

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid eun Jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

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Neural Regeneration Research 2012年第22期7卷 1715-1721页

作者： Sung eun Kim ll gyu Ko Mal Soon Shin Chang Ju Kim young Gwan Ko Hanjin Cho Department of Physiology College of Medicine Kyung Hee University Department of Emergency Medicine College of Medicine Kyung Hee University Department of Emergency Medicine Korea University Ansan Hospital

Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyI-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.

关键词： wintracerebral hemorrhage organotypic hippocampal slice culture bovine colostrum apoptotic celldeath N-methyI-D-aspartic acid caspase-3 hippocampus memory

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Detecting IoT Botnet in 5G Core Network Using Machine Learning

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Computers, Materials & Continua 2022年第9期72卷 4467-4488页

作者： Ye-eun Kim Min-gyu Kim Hwankuk Kim Department of Electronics Information and System Engineering Sangmyung UniversityCheonan-siKorea Department of Information Security Engineering Sangmyung UniversityCheonan-siKorea

As Internet of Things(IoT)devices with security issues are connected to 5G mobile networks,the importance of IoT Botnet detection research in mobile network environments is ***,the existing research focused on AI-based IoT Botnet detection research in wired network *** addition,the existing research related to IoT Botnet detection in ML-based mobile network environments have been conducted up to ***,this paper conducts a study on ML-based IoT Botnet traffic detection in the 5G core *** binary and multiclass classification was performed to compare simple normal/malicious detection and normal/threetype IoT Botnet malware *** both classification methods,the IoT Botnet detection performance using only 5GC’s GTP-U packets decreased by at least 22.99%of accuracy compared to detection in wired network *** addition,by conducting a feature importance experiment,the importance of feature study for IoT Botnet detection considering 5GC network characteristics was *** this paper analyzed IoT botnet traffic passing through the 5GC network using ML and presented detection results,think it will be meaningful as a reference for research to link AI-based security to the 5GC network.

关键词： IoT botnet 5G B5G malware machine learning

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Tensor based non-photo realistic rendering for Korean architectural images

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Journal of Central South University 2014年第10期21卷 3805-3810页

作者： Do Kyung Shin eun young Ahn Deprtment of Computer Science and Engineering Hanyang University Deprtment of Communication Infromation & Computer Engineering Hanbat National University

Existing pen and ink sketch technologies can be applied to general images, but they could not produce optimal output for images of traditional architecture, because most images consist of exquisite straight lined patterns in traditional architecture, such as root tiles and window bars. The lines of roofs and eaves need to be described delicately to express pen and ink sketch most effectively. Therefore, by proposing a method to create white noise for light and shade of input images, to extract input vector directions from the white noise, and to determine the direction and length of stroke, a new expression technique is proposed for pen and ink sketch that could best reflect the characteristics of traditional architecture.

关键词： non-photo realistic rendering pen and ink sketch tensor

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Epidemic obesity in children and adolescents:risk factors and prevention

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Frontiers of Medicine 2018年第6期12卷 658-666页

作者： eun young Lee Kun-Ho Yoon Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Korea Institute of Catholic Ubiquitous Health Care The Catholic University of KoreaSeoul 06591Korea

The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, with more than 100 million affected in 2015. Moreover, the epidemic of obesity in this population has been an important public health problem in developed and developing countries for the following reasons. Childhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseases, including type 2 diabetes, hypertension, and cardiovascular disease. Furthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death. Although an imbalance between caloric intake and physical activity is a principal cause of childhood and adolescent obesity, environmental factors are exclusively important for development of obesity among children and adolescents. In addition to genetic and biological factors, socioenvironmental factors, including family, school, community, and national policies, can play a crucial role. The complexity of risk factors for developing obesity among children and adolescents leads to difficulty in treatment for this population. Many interventional trials for childhood and adolescent obesity have been proven ineffective. Therefore, early identification and prevention is the key to control the global epidemic of obesity. Given that the proportion of overweight children and adolescents is far greater than that of obesity, an effective prevention strategy is to focus on overweight youth, who are at high risk for developing obesity. Multifaceted, comprehensive strategies involving behavioral, psychological, and environmental risk factors must also be developed to prevent obesity among children and adolescents.

关键词： obesity children adolescents epidemiology risk factor prevention

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Electrochemical processing of spent nuclear fuels:An overview of oxide reduction in pyroprocessing technology

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Progress in Natural Science:Materials International 2015年第6期25卷 572-582页

作者： eun-young Choi Sang Mun Jeong Korea Atomic Energy Research Institute Department of Chemical Engineering Chungbuk National University

The electrochemical reduction process has been used to reduce spent oxide fuel to a metallic form using pyroprocessing technology for a closed fuel cycle in combination with a metal-fuel fast *** the electrochemical reduction process,oxides fuels are loaded at the cathode basket in molten LiO–LiCl salt and electrochemically reduced to the metal *** approaches based on thermodynamic calculations and experimental studies have been used to understand the electrode reaction and efficiently treat spent *** factors that affect the speed of the electrochemical reduction have been determined to optimize the process and scale-up the electrolysis *** addition,demonstrations of the integrated series of processes(electrorefining and salt distillation) with the electrochemical reduction have been conducted to realize the oxide fuel *** overview provides insight into the current status of and issues related to the electrochemical processing of spent nuclear fuels.

关键词： Pyroprocessing Electrochemical reduction Electrorefining Molten salt Spent oxide fuel

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Effect of Lycopus lucidus *** on gut microflora and short chain fatty acid composition in Crj:CD-1 mice

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BIOCELL 2022年第9期46卷 2101-2109页

作者： eun NA SUN young LIM Ocean Science and Technology School Korea Maritime&Ocean UniversityBusanKorea2 Division of Convergence on Marine ScienceKorea Maritime&Ocean UniversityBusanKorea

We investigated the diversity and composition of microflora in feces of Lycopus lucidus Turcz.-fed *** addition,we evaluated the production of major cytokines(Interleukin-6 and-10)which are related to inflammation and fatty acid composition of several tissues.16S ribosomal DNA sequencing-based microbiome taxonomic profiling analysis was performed utilizing the EzBioCloud data *** mice fed on *** showed a significantly reduced number of lactic acid bacteria and coliform in the feces compared with the control group(p<0.05).16S rDNA sequencing analysis of fecal samples showed that *** supplementation decreased the community of harmful microflora(Enterobacteriaceae including Escherichia coli and Bacteroides sp.)in feces compared with the control group(p<0.05).There were no significant differences in mRNA expression of cytokine IL-6 and IL-10 between the control and *** fed *** fecal fatty acid composition in the *** group had percentages of 4:0,6:0,8:0 and 10:0 in the intestine but those short chain fatty acids were not detected in the control *** results showed that *** supplementation influenced gut environment by decreasing harmful microflora and increased the percentages of several short fatty acids.

关键词： Lycopus lucidus Turcz Fatty acid composition Intestinal microflora 16S rDNA sequencing Cytokines

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Extraction and Purification of Depigmenting Agents from Chinese Plants

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Chemical Research in Chinese Universities 2006年第2期22卷 162-167页

作者： AHN So-young ROW Kyung-ho KIM eun-ki School of Chemical and Biological Engineering Center for Advanced Bioseparation Technology Inha University Nam-Ku Incheon 402-751 Korea

Depigmenting agents were solvent-extracted and purified by preparative and analytical HPLC from three Chinese plants; Chrysanthemum morifolium Ramat（ Xizang Caijuhua）, Rhodiola sachalinensis, and Terminalia chebula Retzius. Four fractions obtained from the ethyl ether layer of C. m. Rama and two fractions from the ethyl acetate layer of Rhodiola salientness show depigmenting effects. At 8 200, the ethyl acetate layers of Chrysanthemum morifolium Ramat, Rhodiola sachalinensis and the methanol extract of Terminalia chebula Retzius, can inhibit the melanin production of mouse B16 melanoma cells by 92%, 60% and 90%, respectively, whereas 46% inhibition was observed by commercially available depigmenting agents（arbutin）. These results show the potential of these three Chinese plants as a novel resource for depigmenting agents in the cosmetic industry.

关键词： Chrysanthemum Morifolium Ramat Rhodiola Sachalinensis Terminalia Chebula Retzius Melanin Inhibitory Effect HPLC

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Differential diagnosis and treatment of foot drop caused by an extraneural ganglion cyst above the knee:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7539-7544页

作者： Ki Hong Won eun young Kang Department of Rehabilitation Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND One of the causes of foot drop is compression of the common peroneal nerve caused by space-occupying lesions such as a synovial cyst or a ganglion *** previous reports have involved compressive common peroneal neuropathy by intraneural ganglion cysts and synovial *** of the peroneal nerve by extraneural ganglion cysts is *** report a rare case of compressive common peroneal neuropathy by an extraneural ganglion *** SUMMARY A 46-year-old man was hospitalized after he reported a right foot drop for 1 *** muscle testing revealed scores of 1/5 on dorsiflexion of the right *** and paresthesia on the right lateral leg and foot dorsum were *** was diagnosed with a popliteal cyst by using electrophysiologic study and popliteal ultrasound(US).To facilitate common peroneal nerve(CPN)decompression,2 cc of sticky gelatinous material was aspirated from the cyst under US *** stimulation and passive and assisted active ROM exercises of the right ankle and strengthening exercises for weak muscles using elastic band were prescribed based on the change of muscle power.A posterior leaf spring ankle-foot orthosis was prescribed to assist the weak dorsiflexion of the ***-up US revealed that the cystic lesion was growing and magnetic resonance imaging demonstrated compression of the CPN by the cystic *** cyst was resected to prevent impending compression of the *** Precise diagnosis and immediate treatment are important in cases of compressive common peroneal neuropathy caused by an extraneural cyst.

关键词： Foot drop Extranueral ganglion cyst Common peroneal neuropathy Popliteal ultrasound Electrodiagnostic study Cystectomy Case report

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