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Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications

Nano-Micro Letters 2025年第5期17卷 145-192页

作者： Wei Yue Yunjian Guo Jong‐Chul Lee Enkhzaya Ganbold Jia-Kang Wu Yang Li Cong Wang Hyun Soo kim young-Kee Shin Jun-Ge Liang Eun-Seong kim Nam-young kim RFIC Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Jiangnan UniversityWuxi 214122People’s Republic of China School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China Department of Electronics Engineering Kwangwoon UniversitySeoul 01897South Korea Laboratory of Molecular Pathology and Cancer Genomics Department of Molecular Medicine and Biopharmaceutical SciencesGraduate School of Convergence Science and TechnologySeoul National UniversitySeoul 08826South Korea

Recent advancements in passive wireless sensor technology have significantly extended the application scope of sensing,particularly in challenging environments for monitoring industry and healthcare *** systems are equipped with battery-free operation,wireless connectivity,and are designed to be both miniaturized and *** features enable the safe,real-time monitoring of industrial environments and support high-precision physiological measurements in confined internal body spaces and on wearable epidermal *** the exploration into diverse application environments,the development of a systematic and comprehensive research framework for system architecture remains elusive,which hampers further optimization of these *** review,therefore,begins with an examination of application scenarios,progresses to evaluate current system architectures,and discusses the function of each component—specifically,the passive sensor module,the wireless communication model,and the readout module—within the context of key implementations in target sensing ***,we present case studies that demonstrate the feasibility of proposed classified components for sensing scenarios,derived from this systematic *** outlining a research trajectory for the application of passive wireless systems in sensing technologies,this paper aims to establish a foundation for more advanced,user-friendly applications.

关键词： Wireless sensing Passive detection Harsh environment Biomedical monitoring Flexible sensors

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Cellulose Elementary Fibrils as Deagglomerated Binder for High-Mass-Loading Lithium Battery Electrodes

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Nano-Micro Letters 2025年第5期17卷 281-296页

作者： young-Kuk Hong Jung-Hui kim Nag-young kim Kyeong-Seok Oh Hong-I kim Seokhyeon Ryu Yumi Ko Ji-young kim Kwon-Hyung Lee Sang-young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Advanced Analysis and Data Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Ulsan Advanced Energy Technology R&D Center Korea Institute of Energy Research(KIER)Ulsan 44776Republic of Korea Department of Battery Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea

Amidst the ever-growing interest in high-mass-loading Li battery electrodes,a persistent challenge has been the insufficient continuity of their ion/electron conduction ***,we propose cellulose elementary fibrils(CEFs)as a class of deagglomerated binder for high-mass-loading *** from natural wood,CEF represents the most fundamental unit of cellulose with nanoscale *** preparation of the CEFs involves the modulation of intermolecular hydrogen bonding by the treatment with a proton acceptor and a hydrotropic *** elementary deagglomeration of the cellulose fibers increases surface area and anionic charge density,thus promoting uniform dispersion with carbon conductive additives and suppressing interfacial side reactions at ***,a homogeneous redox reaction is achieved throughout the *** resulting CEF-based cathode(overlithiated layered oxide(OLO)is chosen as a benchmark electrode active material)exhibits a high areal-mass-loading(50 mg cm^(-2),equivalent to an areal capacity of 12.5 mAh cm^(-2))and a high specific energy density(445.4 Wh kg–1)of a cell,which far exceeds those of previously reported OLO *** study highlights the viability of the deagglomerated binder in enabling sustainable high-mass-loading electrodes that are difficult to achieve with conventional synthetic polymer binders.

关键词： Cellulose elementary fibrils Deagglomeration Electrode binders Lithium batteries High-mass-loading

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Clinical and endoscopic characteristics of colorectal traditional serrated adenomas with dysplasia/adenocarcinoma in a Korean population

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 119-131页

作者： Ki-Hyun kim Eun Myung Hyung Hoon Oh chan-Muk Im young-Eun Seo Je-Seong kim Chae-June Lim Ga-Ram You Sung-Bum Cho Wan-Sik Lee Myung-Giun Noh Kyung-Hwa Lee young-Eun Joo Department of Internal Medicine Chonnam National University Medical SchoolHwasun-eup 58128South Korea Department of Pathology Chonnam National University Medical SchoolHwasun-eup 58128South Korea

BACKGROUND Traditional serrated adenoma(TSA)is a rare and precancerous lesion of colorectal *** clinical and endoscopic differentiations between TSAs without dysplasia or adenocarcinoma(TSAOs)and TSAs with dysplasia or adenocarcinoma(TSADs)remain *** To evaluate the characteristics of colorectal TSAs and compare the characteristics of TSAOs with those of *** This retrospective study included 193 patients who underwent endoscopic resection and received a pathologic diagnosis of *** reviewed the medical,endoscopic,and histopathologic records of patients who underwent endoscopic resection of TSAs between January 2010 and December *** TSAs were more frequently located in the rectosigmoid *** TSAs had 0-Ip,0-Isp,or 0-Is *** TSAD lesions were larger than TSAO *** lesions more commonly had a red color and an irregular border than TSAO *** were usually treated using conventional endoscopic mucosal resection,whereas TSADs were treated using conventional endoscopic mucosal resection,endoscopic submucosal dissection,and ***-polypectomy bleeding was more common with TSADs than with *** analysis showed that gastrointestinal bleeding,red color,0-IIa,irregular border,and lobular mucosal surface were significantly associated with *** analysis showed that gastrointestinal bleeding,an irregular border,and a lobular mucosal surface were significantly associated with *** TSAs with gastrointestinal bleeding,an irregular border,and a lobular mucosal surface are associated with an increased risk of dysplasia or adenocarcinoma.

关键词： Traditional serrated adenoma Dysplasia Carcinoma Endoscopic features Gastrointestinal bleeding

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun Sung kim Gye Ryeol Park Jae Eun Ryu Ji Eun kim In young Kang Hye young kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

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World Journal of Stem Cells 2025年第1期17卷 40-52页

作者： Seoung-Woo Lee young-Ju Lim Hee-Yeon kim Wansoo kim Wook-Tae Park Min-Jung Ma Junho Lee Min-Soo Seo young In kim Sangbum Park Seong-Kyoon Choi Gun Woo Lee Core Protein Resources Center Daegu-Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 42415South Korea Department of Veterinary Pathology College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea School of Life Science BK21 FOUR KNU Creative BioResearch GroupKyungpook National UniversityDaegu 41566South Korea Laboratory of Veterinary Tissue Engineering College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea College of Veterinary Medicine Kyungpook National UniversityDaegu 41566South Korea Department of Veterinary Tissue Engineering Kyungpook National UniversityDaegu 41566South Korea Cellexobio. Ltd.Daegu 42415South Korea Michigan State University Institute for Quantitative Health Science&EngineeringEast LansingMI 48824United States Department of Orthopedic Surgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory *** molecular characteristics of MSCs are influenced by their ***,epidural fat(EF)and EF-derived MSCs(EF-MSCs)have garnered attention due to their potential benefits to the spinal microenvironment and their high expression of neural SC ***,their clinical applications are limited due to cell senescence and limited accessibility of *** many studies have attempted to establish an immortalized,stable SC line,the characteristics of immortalized EF-MSCs remain to be *** To establish and analyze stable immortalized *** The phenotypes of EF-MSCs were analyzed using optical *** immortalization was performed using lentiviral *** biomolecular characteristics of the cells were analyzed by immunoblotting,quantitative PCR,and *** The immortalized EF-MSCs demonstrated a significantly extended lifespan compared to the control group,with well-preserved adipogenic potential and SC surface marker *** of human telomerase reverse transcriptase genes markedly increased the lifespan of *** analysis revealed substantial increase in the expression of DNA replication pathway components in immortalized *** Immortalized EF-MSCs exhibited significantly enhanced proliferative capacity,retained adipogenic potential,and upregulated the expression of DNA replication pathway components.

关键词： Immortalization Transfection Stem cell Epidural fat Proteomics

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Identification of patients with advanced pancreatic cancer who might benefit from third-line chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 74-83页

作者： Bomi kim Jaihwan kim Soomin Yang Jinwoo Ahn Kwangrok Jung Jong-chan Lee Jin-Hyeok Hwang Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

BACKGROUND Survival rates of patients with advanced pancreatic cancer(APC)have been improved with palliative chemotherapy *** current preferred first-line regimen consists of combination therapy of 5-fluorouracil(5-FU)/leucovorin(LV),irinotecan,and oxaliplatin(FOLFIRINOX)or gemcitabine plus albumin-bound paclitaxel(GNP).After failure of first-line chemotherapy,there are a few options for subsequent therapy including switch to the unused first-line regimen or nanoliposomal irinotecan and 5-FU/***,there are limited studies on the efficacy of third-line chemotherapy after failure of second-line *** To identify patients with APC who might benefit from third-line *** Medical records from a single tertiary hospital were retrospectively reviewed between 2012 and *** study included patients with histologically or cytologically confirmed metastatic or locally APC who underwent first-line FOLFIRINOX or GNP and subsequently received third-line *** survival(OS)after diagnosis and OS after third-line chemotherapy(OS3)were defined as the interval from the diagnosis to all-cause death and the time between the initiation of the third-line chemotherapy to all-cause death,*** A total of 141 patients were *** median patient age at diagnosis was 61.8 years(36.0-86.0),and 54.9%were *** first-line regimen was FOLFIRINOX(67.4%)or GNP(32.6%).The second-line regimen was FOLFIRINOX(27.0%),GNP(52.5%),or other(20.6%).The median OS was 19.0 months,and the median OS3 and progression-free survival after third-line treatment were 15.3 and 7.3 weeks,*** regard to the best tumor response during third-line chemotherapy,1.4%had partial response,24.8%had stable disease,and 59.6%had progressive *** following clinical factors before third-line chemotherapy affected OS3:Good performance status(PS),serum carbohydrate antigen 19-9(CA19-9)level<1000 U/mL,duration of second-line chemotherapy≥

关键词： Pancreatic cancer Chemotherapy Survival Performance status Carbohydrate antigen 19-9

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Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 69-80页

作者： Ji Hyun Song Su-Yeon Choi young Sun kim Sun young Yang Kyung-Do Han Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 06236South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains *** To elucidate the relationship between CVD risk scores and CRC *** In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until *** cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by *** primary outcome was incidence of newly diagnosed *** Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 *** by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,Pyounger populations,and non-statin ***,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关键词： Colorectal cancer Cardiovascular disease Cohort study Age Gender

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Molecules“buckle up”to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第1期68卷 3-4页

作者： Seokhyoung kim Department of Chemistry Michigan State UniversityEast LansingMI 48824USA

Layered 2D metal halide perovskites(MHPs)are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic *** properties are readily tunable by controlling the halide composition,number of inorganic layers,and the chemistry of organic *** key element that can substantially impact the materials’functionalities is crystal morphology^([1]).

关键词： nanowires perovskite halide

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Extended protective effects of three dimensional cultured human mesenchymal stromal cells in a neuroinflammation model

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World Journal of Stem Cells 2025年第1期17卷 53-65页

作者： Ok-Hyeon kim Hana Kang Eun Seo chang younghyun Lim young-Jin Seo Hyun Jung Lee Department of Anatomy and Cell Biology College of MedicineChung-Ang UniversitySeoul 06974South Korea Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul 06974South Korea Department of Life Science Chung-Ang UniversitySeoul 06974South Korea

BACKGROUND Human mesenchymal stromal cells(MSCs)possess regenerative potential due to pluripotency and paracrine ***,their stemness and immunomod-ulatory capabilities are sub-optimal in conventional two-dimensional(2D)*** To enhance the efficiency and therapeutic efficacy of MSCs,an in vivo-like 3D culture condition was *** MSCs were cultured on polystyrene(2D)or in a gellan gum-based 3D *** vitro,prostaglandin-endoperoxide synthase 2,indoleamine-2,3-dioxygenase,heme oxygenase 1,and prostaglandin E synthase gene expression was quantified by quantitative real-time polymerase chain *** were incubated with lipopolysaccharide(LPS)-treated mouse splenocytes,and prostaglandin E2 and tumor necrosis factor-alpha levels were measured by enzyme linked immuno-sorbent *** vivo,LPS was injected into the lateral ventricle of mouse brain,and MSCs were administered intravenously the next *** were sacrificed and analyzed on days 2 and *** Gellan gum polymer-based 3D culture significantly increased expression of octamer-binding transcription factor 4 and Nanog homeobox stemness markers in human MSCs compared to 2D *** 3D environment also heightened expression of cyclooxygenase-2 and heme-oxygenase 1,enzymes known for immunomodulatory functions,including production of prostaglandins and heme degradation,*** in 3D culture secreted more prostaglandin E2 and effectively suppressed tumor necrosis factor-alpha release from LPS-stimulated splenocytes and surpassed the efficiency of MSCs cultured in *** a murine neuroinflammation model,intravenous injection of 3D-cultured MSCs significantly reduced ionized calcium-binding adaptor molecule 1 and glial fibrillary acidic protein expression,mitigating chronic inflammation more effectively than 2D-cultured *** The microenvironment established in 3D culture serves as an in vivo mimetic,enhancing the immunomodulatory function of *** sugge

关键词： Mesenchymal stromal cells Three-dimensional culture Immunomodulatory function Neuroinflammation Cell therapy

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