检索结果-南通市图书馆

MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development

在线全文

学校读者我要写书评

暂无评论

Insect Science 2023年第5期30卷 1431-1444页

作者： Do-Hwan lim Min-Seok Choi Ji Won Jeon young Sik Lee School of Systems Biomedical Science Soongsil UniversitySeoulRepublic of Korea College of Life Sciences and Biotechnology Korea UniversitySeoulRepublic of Korea Institute of Animal Molecular Biotechnology Korea UniversitySeoulRepublic of Korea

The Notch signaling pathway plays a central role in the development of various ***,dysregulation of microRNAs(miRNAs),which are crucial regulators of gene expression,can disrupt signaling pathways at all stages of *** Notch signaling is involved in wing development in Drosophila,the mechanism underlying miRNA-based regulation of the Notch signaling pathway is ***,we report that loss of Drosophila miR-252 increases the size of adult wings,whereas the overexpression of miR-252 in specific compartments of larval wing discs leads to patterning defects in the adult *** miR-252 overexpression-induced wing phenotypes were caused by aberrant Notch signaling with intracellular accumulation of the full-length Notch receptor during development,which could be due to defects in intracellular Notch trafficking associated with its recycling to the plasma membrane and autophagy-mediated ***,we identified Rab6 as a direct target of miR-252-5p;Rab6 encodes a small Ras-like GTPase that regulates endosomal trafficking *** with this finding,RNAi-mediated downregulation of Rab6 led to similar defects in both wing patterning and Notch ***,co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression,further supporting that Rab6 is a biologically relevant target of miR-252-5p in the context of wing ***,our data indicate that the miR-252-5p-Rab6 regulatory axis is involved in Drosophila wing development by controlling the Notch signaling pathway.

关键词： Drosophila miR-252-5p Notch signaling Rab6 wing development

Defect-Detection Model for Underground Parking Lots Using Image Object-Detection Method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第3期66卷 2493-2507页

作者： Hyun Kyu Shin Si woon Lee Goo Pyo Hong Lee Sael Sang Hyo Lee Ha young Kim Architectural Engineering Hanyang UniversityERICAAnsan15588Korea Department of Artificial Intelligence Ajou UniversitySuwon16499Korea Division of Architecture and Civil Engineering Kangwon National UniversitySamcheok25913Korea Division of Smart Convergence Engineering Hanyang UniversityERICAAnsan15588Korea Graduate School of Information Yonsei UniversitySeoul03722Korea

The demand for defect diagnoses is gradually gaining ground owing to the growing necessity to implement safe inspection methods to ensure the durability and quality of ***,conventional manpower-based inspection methods not only incur considerable cost and time,but also cause frequent disputes regarding defects owing to poor ***,the demand for an effective and efficient defect-diagnosis model for concrete structures is imminent,as the reduction in maintenance costs is significant from a long-term ***,this paper proposes a deep learning-based image objectidentification method to detect the defects of paint peeling,leakage peeling,and leakage traces that mostly occur in underground parking lots made of concrete *** deep learning-based object-detection method can replace conventional visual inspection methods.A faster region-based convolutional neural network(R-CNN)model was used with a training dataset of 6,281 images that utilized a region proposal network to objectively localize the regions of interest and detect the surface *** defects were classified according to their type,and the learning of each exclusive model was ensured through test sets obtained from real underground parking *** a result,average precision scores of 37.76%,36.42%,and 61.29%were obtained for paint peeling,leakage peeling,and leakage trace defects,***,this study verified the performance of the faster RCNN-based defect-detection algorithm along with its applicability to underground parking lots.

关键词： Faster R-CNN deep learning defect detection concrete structures

Single-step Preparation of Nano-homogeneous NiO/YSZ Composite Anode for Solid Oxide Fuel Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2013年第2期5卷 111-116页

作者： Jung-Hoon Song Mi young Park Hye Won Park Hyung-Tae lim Research Institute of Industrial Science and Technology (RIST) Fuel Cell Project Changwon National University School of Nano & Advanced Materials Engineering

Homogeneous co-precipitation and hydrothermal treatment were used to prepare nano- and highly dispersed Ni O/YSZ(yttria-stabilized zirconia) composite powders. Composite powders of size less than 100 nm were successfully prepared. This process did not require separate sintering of the YSZ and Ni O to be used as the raw materials for solid oxide fuel cells. The performance of a cell fabricated using the new powders(*** density ~0.87 W/cm^2) was higher than that of a cell fabricated using conventional powders(max. power density ~0.73 W/cm^2). Co-precipitation and hydrothermal treatment proved to be very effective processes for reducing cell production costs as well as improving cell performance.

关键词： Fuel cells Powder processing Electrochemistry Hydrothermal process NiO/YSZ composite anode

Six-year trends and intersectional correlates of meeting 24-Hour Movement Guidelines among South Korean adolescents:Korea Youth Risk Behavior Surveys,2013-2018

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2023年第2期12卷 255-265页

作者： Eun young Lee Asaduzzaman Khan Riaz Uddin Eva lim Lauren George School of Kinesiology and Health Studies Queen’s UniversityKingstonON K7L3N6Canada Department of Gender Studies Queen’s UniversityKingstonON K7L3N6Canada School of Health and Rehabilitation Sciences The University of QueenslandBrisbaneQLD 4072Australia Active Healthy Kids Bangladesh(AHKBD) Dhaka 1206Bangladesh Institute for Physical Activity and Nutrition(IPAN) School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3220Australia Faculty of Health Sciences Queen’s UniversityKingstonON K7L3N6Canada

Background:Grounded in intersectionality theory,this study examined the 6-year prevalence trend and correlates in meeting Canada’s 24-Hour Movement Guidelines(Guidelines hereafter)in a nationally representative adolescent samples of South Korea(officially the Republic of Korea).Methods:Self-reported,annually repeated cross-sectional data collected between 2013 and 2018 were used(n=372,433,12-17 years old,47.9%females).Adolescents were categorized as meeting or not meeting different sets of physical activity,screen time(ST),and sleep recommendations within the Guidelines,separately for weekdays and weekend *** correlates included sex and social class(i.e.,family economic status,parental education level,and academic performance).Multiple logistic regression analyses were ***:Overall,the proportion of adolescents meeting physical activity,ST,and sleep recommendations were 5.3%,60.3%,and 10.2%on weekdays and 5.3%,28.2%,and 46.4%on weekend days,*** 2013 and 2018,no substantial changes were observed for meeting the physical activity or sleep recommendation,while meeting the ST recommendation was markedly lower in *** proportion of meeting all 3 recommendations were 0.5%for weekdays and 0.8%for weekend ***,compared to female adolescents,male adolescents were consistently associated with more favorable patterns of meeting different sets of recommendations,regardless of social *** females only,social class appeared to be not important or even detrimental in meeting different sets of *** male,compounded with social class,was associated with meeting the ST ***:Less than 1%of Korean adolescents met the overall ***-based analysis and intervention may be important in promoting healthy active lifestyles among South Korean adolescents.

关键词： Intersectionality theory Physical activity Sedentary behavior Sleep Social determinants of health

Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2023年第4期6卷 114-120页

作者： Jihong Kim Sung Min Wi Jong-Guk Ahn Sangjun Son Hee young lim Yeonsu Park Hye Ji Eun Jong Bae Park Hyunseob lim Sangyeon Pak A-Rang Jang young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju 61005Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Korea Prof.S.Pak School of Electronic and Electrical Engineering Hongik UniversitySeoul 04066Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Korea

In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable *** implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power ***,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing *** sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of *** electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 *** further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air *** results present an important pathway for designing electrodes in various energy storage devices.

关键词： electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes

Distribution of dinoflagellate cysts in Yellow Sea sediments

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2013年第9期32卷 91-98页

作者： SHIN Hyeon Ho lim Dhongil PARK Soung-Yun HEO Seung KIM So-young Library of Marine Samples Korea Institute of Ocean Science and Technology West Sea Fisheries Research Institute National Fisheries Research&Development Institute Division of Polar Climate Research Korea Polar Research Institute

To investigate the distribution, abundance, and species composition of dinoflagellate cysts in the Yellow Sea, surface sediment samples were collected at 37 sites, including the Korean dump site. Twenty-one di- noflagellate cyst taxa were identified, with the assemblages dominated mainly by Spiniferites bulloideus, Operculodinium centrocarpum, and cyst of Alexandrium catenella/tarnarense type. A high frequency of O. centrocarpum in the Yellow Sea was observed for the first time, and it is likely that this can be attributed to the dynamics of the Yellow Sea Cold Water Mass and the Changjiang （Yangtze） River runoff. Total cyst concentrations ranged from 23 to 48 442 cysts/g dry weight, and high cyst concentrations were recorded adjacent to the dumping site. This result suggests that anthropogenic activities such as ocean dumping s- timulate the growth of dinoflagellates in the Yellow Sea, which in turn leads to high levels of dinoflagellate cyst production.

关键词： Yellow Sea dumping site dinoflagellate cyst Alexandrium catenella/tamarense type Operculo- dinium centrocarpum

Usefulness of the acromioclavicular joint cross-sectional area as a diagnostic image parameter of acromioclavicular osteoarthritis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第7期10卷 2087-2094页

作者： young Joo Jee Youn Moon Jung Youn Han Yun-Sic Bang Keum Nae Kang young Su lim young-SoonChoi young-Uk Kim Department of Anesthesiology and Pain Medicine CHA Ilsan Medical CenterSchool of MedicineCHA UniversityIlsanGyeonggi-do 10414South Korea Department of Anesthesiology and Pain Medicine Seoul National University Hospital College of MedicineSeoul 03080South Korea Department of Anesthesiology and Pain Medicine CHA Bundang Medical CenterSchool of MedicineSeongnamGyeonggi-do 13496South Korea Department of Anesthesiology and Pain Medicine National Police HospitalSeoul 05715South Korea Department of Anesthesiology and Pain Medicine Catholic Kwandong UniversityCollege of MedicineInternational St.Mary’s HospitalIncheon 22711South Korea

BACKGROUND Acromioclavicular joint(ACJ)space narrowing has been considered to be an important diagnostic image parameter of ACJ osteoarthritis(ACJO).However,the morphology of the ACJ space is irregular because of osteophyte formation,subchondral irregularity,capsular distention,sclerosis,and ***,we created the ACJ cross-sectional area(ACJCSA)as a new diagnostic image parameter to assess the irregular morphologic changes of the *** To hypothesize that the ACJCSA is a new diagnostic image parameter for *** ACJ samples were obtained from 35 patients with ACJO and 30 healthy individuals who underwent shoulder magnetic resonance(S-MR)imaging that revealed no evidence of *** coronal,T2-weighted,fat-suppressed SMR images were acquired at the ACJ level from the two *** measured the ACJCSA and the ACJ space width(ACJSW)at the ACJ on the S-MR images using our imaging analysis *** ACJCSA was measured as the cross-sectional area of the *** ACJSW was measured as the narrowest point between the acromion and the *** The average ACJCSA was 39.88±10.60 mm;in the normal group and 18.80±5.13 mm;in the ACJO *** mean ACJSW was 3.51±0.58 mm in the normal group and 2.02±0.48 mm in the ACJO *** individuals had significantly lower ACJCSA and ACJSW than the healthy *** operating characteristic curve analyses demonstrated that the most suitable ACJCSA cutoff score was 26.14 mm^(2),with 91.4%sensitivity and 90.0%*** The optimal ACJSW cutoff score was 2.37 mm,with 88.6%sensitivity and 96.7%*** though both the ACJCSA and ACJSW were significantly associated with ACJO,the ACJCSA was a more sensitive diagnostic image parameter.

关键词： Acromioclavicular joint Osteoarthritis Cross-sectional area Diagnosis

Sorption enhanced catalytic CF4 hydrolysis with a three-stage catalyst-adsorbent reactor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2017年第4期11卷 537-544页

作者： Jae-Yun Han Chang-Hyun Kim Boreum Lee Sung-Chan Nam Ho-young Jung Hankwon lim Kwan-young Lee Shin-Kun Ryi . Advanced Materials and Devices Laboratory Korea Institute of Energy Research (KIER) Daejeon 34129 Korea.. Department of Advanced Materials and Chemical Engineering Catholic University of Daegu Gyeongbuk 38430 Korea.. Department of Environment and Energy Engineering Chonnam National University Gwangju 61186 Korea.. Department of Chemical and Biological Engineering Korea University Seoul 136-701 Korea

In this study, we developed a three-stage catalyst-adsorbent reactor for the catalytic hydrolysis of CF4. Each stage is composed of a catalyst bed followed by an adsorbent bed using Ca（OH）2 to remove HF. The three stages are connected in series to enhance the hydrolysis of CF4 and eliminate a scrubber to dissolve HF in water at the same time. With a 10 wt-% Ce/AlaO3 catalyst prepared by the incipient wetness method using boehmite and a granular calcium hydroxide as an adsorbent, the CF4 conversion in our proposed reactor was 7%-23% higher than that in a conventional single-bed catalytic reactor in the temperature range of 923-1023 K. In addition, experimental and numerical simulation （Aspen HYSYS） results showed a reasonable trend of increased CF4 conversion with the adsorbent added and these results can be used as a useful design guideline for our newly proposed multistage reactor system.

关键词： PFCs catalytic hydrolysis calcium hydro-xide sorption enhanced process simulation

Factors associated with use of gastric cancer screening services in Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第29期15卷 3653-3659页

作者： young Min Kwon Hyung Taek lim Kiheon Lee Be Long Cho Min Sun Park Ki young Son Sang Min Park Department of Family Medicine Seoul National University Hospital Seoul National University College of Medicine 28 Yunkeon-dong Jongro-gu Seoul 110-744 South Korea Department of Medicine Yonsei University College of Medicine 134 Shinchon-dong Seodaemun-gu Seoul 120-752 South Korea Department of Family Medicine Seoul National University Bundang Hospital and Department of the History of Medicine and Medical Humanities Seoul National University College of Medicine 166 Gumi-ro Bundang-gu Seongnam-si Gyeonggi-do 463-707 South Korea

AIM: To identify the factors associated with participation in gastric cancer screening programs. METHODS: Using data from the Korea National Health and Nutrition Examination Survey 2005 (KNHANES Ⅲ), a nationwide health-related surveyin Korea, a cross-sectional study was performed to investigate the multiple factors associated with gastric cancer screening attendance among persons aged at least 40 years. The study population included 4593 individuals who completed a gastric cancer screening questionnaire and had no previous cancer history. Four groups ofindividual-level or environmental level covariates were considered as potential associated ***: Using KNHANES Ⅲdata, an estimated31.71% of Korean individuals aged at least 40 years adhered to gastric cancer screening recommendations. Subjects who graduated from elementary school[adjusted odds ratio (aOR), 1.66; 95% CI: 1.21-2.26], middle/high school (aOR, 1.38; 95% CI: 1.01-1.89), and university or higher (aOR, 1.64; 95% CI: 1.13-2.37) were more likely to undergo gastric cancer screening than those who received no formal education at all. The population with the highest income tertile had more attendance at gastric screening compared to those with the lowest income tertile (aOR, 1.36; 95% CI: 1.06-1.73). Gastric screening was also negatively associated with excessive alcohol consumption (aOR, 0.71; 95% CI: 0.53-0.96). A positive attitude to preventive medical evaluation was significantly associated with better participation in gastric cancer screening programs (aOR, 5.26; 95% CI: 4.35-6.35). CONCLUSION: Targeted interventions for vulnerable populations and public campaigns about preventive medical evaluation are needed to increase gastric cancer screening participation and reduce gastric cancer mortality.

关键词： Socioeconomic factors Health behavior Health status disparity Mental health Early detectionof cancer