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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with self‑supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑young Kim Yang Li Guozhen shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea school of Microelectronics Shandong UniversityJinan 250101People’s Republic of China state Key Laboratory of Integrated Chips and systems Fudan UniversityShanghai 200433People’s Republic of China school of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

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机械应力调控血管平滑肌细胞的凋亡

中国组织工程研究 2025年第5期29卷 1064-1072页

作者：徐飞闫金强柴守栋北京航空航天大学生物与医学工程学院北京市100083 聊城市人民医院中心实验室山东省聊城市252000 聊城市人民医院病理科山东省聊城市252000 聊城市人民医院心外科山东省聊城市252000

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的... 详细信息

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的研究现状,寻找临床治疗潜在靶分子和信号通路,以期改善临床动脉粥样硬化及再狭窄等心血管疾病的临床治疗效果。方法:检索1992年1月至2023年5月在中国知网、PubMed及scienceDirect数据库收录的文献。中文检索词为“血管平滑肌细胞,机械应力,剪切力,牵张力,凋亡”;英文检索词为“vascular smooth muscle cell,mechanical stress,shear stress,stretch stress,apoptosis”,最终纳入63篇文献进行综述分析。结果与结论:①血管平滑肌细胞的生理性和病理性凋亡都是为了适应血管力学变化而发生的适应性重构。不同部位的平滑肌细胞承受不同的力学刺激,其发病机制也不同。②低剪切力、生理剪切力和高剪切力可通过直接与平滑肌细胞表面分子、受体及蛋白等作用调控凋亡信号分子和抑制增殖实现对血管平滑肌细胞凋亡的调控,该部分未对促进增殖的研究进行综述。③低牵张力、生理牵张力和高牵张力可导致平滑肌细胞凋亡,但仍存在争议。平滑肌表面存在多种力学感受分子(如整合素及受体络氨酸激酶等)可以将力学信号转导为细胞内的化学信号(如Hippo通路),启动平滑肌细胞的凋亡信号,调控平滑肌细胞的凋亡。④总之,不同力学刺激通过多种信号分子,启动多个信号通路共同作用,调控平滑肌细胞的凋亡,例如剪切力主要通过刺激分泌前列腺素、转化生长因子等影响Fas/FasL、Akt通路;而牵张力主要通过Yes相关蛋白等调控YAP通路和Notch通路等。这些分子在不同的作用时间,或不同作用强度下可能发挥相反的双向作用,比如,小鼠血管平滑肌细胞受到10%生理牵张1 h时,其增殖增加;然而,人的血管平滑肌细胞牵张12 h后可以减少其增殖。临床可以通过寻找其关键作用时间点干扰力学转导关键分子,达到预防和治疗临床心血管疾病的目的。

关键词：血管平滑肌细胞机械应力凋亡牵张力剪切应力整合素受体络氨酸激酶 G蛋白偶联受体和G蛋白离子通道

High-temperature Oxidation Behavior of Zircaloy-4 and Zirlo in steam Ambient

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Journal of Materials science & Technology 2010年第9期26卷 827-832页

作者： Hyung Hoon Kim Jun Ho Kim Jin young Moon Ho seong Lee Jeong Joo Kim young suck chai school of Materials science and Engineering Kyungpook National University school of Mechanical Engineering Yeungnam University214-1 Dae-dongGyeongsan-si

The oxidation characteristics for Zircaloy-4 and Zirlo in the temperature range of 700-1200°C under steam supply condition were investigated by using a modified thermo-gravimetric *** specimens were oxidized for 3600 s at each temperature and then quenched in a *** oxidation rate constants were measured from the weight gains to evaluate the oxidation behavior in Zircaloy-4 and *** weight gain rates of Zirlo were lower than those of Zircaloy-4,leading to the low rate *** different oxidation behaviors between both cladding materials were considered to be due to the difference in their chemical compositions.

关键词： Zircaloy-4 Zirlo Oxidation

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young Choi Department of Brain science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

UNIFORM DECAY RATE FOR THE TRANsMIssION WAVE EQUATIONs WITH VARIABLE COEFFICIENTs

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Journal of systems science & Complexity 2011年第2期24卷 253-260页

作者： shugen chai school of Mathevaatical sciences Shanxi University Taiyuan 030006 China

This paper considers the stabilization of the transmission problem of wave equations with variable coefficients. By introducing both boundary feedback control and distribute feedback control near the transmission boun... 详细信息

关键词： Feedback stabilization transmission problem wave equation.

宋代“鞫谳分司”制下司法参军的司法实践——以毛滂的“检法”实例为视角

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河北大学学报（哲学社会科学版） 2025年第1期50卷 44-52页

作者：柴荣陈泽北京师范大学法学院北京100875

在重视法律的历史背景下,宋代形成了以“防止奸弊”为目的,以“听”“断”分离为形式的“鞫谳分司”制度。司法参军作为“谳司”官员,是宋代地方州一级的重要司法属官,主要负责对“检出”的量刑法条进行核定与“驳正”。出生于簪缨之家... 详细信息

在重视法律的历史背景下,宋代形成了以“防止奸弊”为目的,以“听”“断”分离为形式的“鞫谳分司”制度。司法参军作为“谳司”官员,是宋代地方州一级的重要司法属官,主要负责对“检出”的量刑法条进行核定与“驳正”。出生于簪缨之家的毛滂,深受当时社会环境和家庭的影响,养成了较高的法律素养。分析毛滂在司法参军任上的“检法”实例,可以看出他在遵守法律的前提下,对“止杀”“仁民”“爱物”等司法活动多重价值的权衡取舍。结合具体的司法实践,可以更加深入地认识宋代重视法律的历史背景和“鞫谳分司”的运行机制,以及其与司法官员之间相互影响、相互作用的紧密关系。

关键词：重视法律 “鞫谳分司” 司法参军改易风俗

Hysteresis and Multi-state Behavior of Counterflow Flame in a Blowing Cylindrical Burner

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Journal of Thermal science 2009年第3期18卷 276-283页

作者： Hsing-sheng chai General Education Division Aletheia University

This study focuses on flame hysteresis over a porous cylindrical burner. The hysteresis results from different operation procedure of the experiment. Gradually increasing inflow velocity can transform the envelope flame into a wake flame. The blow-off curve can be plotted by determining every critical inflow velocity that makes an envelope flame become a wake flame at different fuel-ejection velocities. In contrast, decreasing the inflow veiocity can transform the wake or lift-off flame into an envelope one. The reattachment curve can be obtained by the same method to explore the blow-off curve, but the intake process is reverse. However, these two curves are not coincident, except the origin. The discrepancy between them is termed as hysteresis, and it results from the difference between the burning velocities associated with both curves. At the lowest fuel-ejection velocity, no hysteresis exists between both curves owing to nearly no burning velocity difference there. Then, raising the fuel-ejection velocity enhances hysteresis and the discrepancy between the two curves. However, as fuel-ejection velocity exceeds a critical value, the intensity of hysteresis almost keeps constant and causes the two curves to be parallel to each other.

关键词： Hysteresis Blow-off curve Reattachment curve Cylindrical burner Counterflow flame

Exact Controllability of Wave Equations with Interior Degeneracy and One-sided Boundary Control

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Journal of systems science & Complexity 2023年第2期36卷 656-671页

作者： BAI Jinyan chai shugen school of Mathematical sciences Shanxi UniversityTaiyuan 030006China school of Mathematics Jinzhong UniversityTaiyuan 030006China

In this paper,the authors mainly consider the exact controllability for degenerate wave equation,which degenerates at the interior point,and boundary controls acting at only one of the boundary *** main results are that,it is possible to control both the position and the velocity at every point of the body and at a certain time T for the wave equation with interior weakly ***,it is shown that the exact controllability fails for the wave equation with interior strongly *** order to steer the system to a certain state,one needs controls to act on both boundary points for the wave equation with interior strongly *** difficulties are addressed by means of spectral analysis.

关键词： Boundary control degenerate wave equation exact controllability interior degeneracy