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Chinese Chemical Letters 2015年第2期26卷 173-176页

作者： Eun Joo Yoo Boknam Chae young mee jung Seung Woo Lee School of Chemical Engineering Yeungnam University Pohang Accelerator Laboratory Department of Chemistry Kangwon National University

This paper reports the pH-induced structural changes in the surface immobilized poly（L-lysine）（PLL）***-dimensional（2D） correlation analysis was applied to the Fourier transform infrared（FTIR）spectra of the surface-immobilized PLL film to examine the spectral changes induced by the alternations of the protonation state of the amino group in the side *** spectral changes in the FTIR spectra of the PLL film were observed between pH 7 and *** decrease in the protonation state of the amino group in the side chain induced spectral changes in the amino group as well as conformational changes in the alky]group in the side *** pH 1-8,the spectral changes in the amino and alkyl groups in the side chain occurred before those of the amide group in the main chain of the surface immobilized PLL film.

关键词： Poly(L-lysine)(PLL) Surface-immobilized polypeptide FT-IR spectroscopy 2D correlation spectroscopy

Thermal Behavior and Crystal Transition of Biodegradable Poly(butylenes adipate)Revealed by Two-Dimensional Correlation Spectroscopy

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光谱学与光谱分析 2016年第S1期36卷 139-140页

作者： CHEN Yu-jing Isao Noda young mee jung Department of Chemistry Kangwon National University Department of Materials Science and Engineering University of Delaware

In the present study,thermal behavior and crystal transition of pure poly(butylene adipate)(PBA)upon heating process were investigated by FTIR *** gain further insight into the thermal behavior alteration and the phase transition of PBA,we performed two-dimensional(2D)correlation *** found thatβ-form PBA crystal undergoes not only the melting process but also crystal transition upon the heating process.

关键词： Poly(butylene adipate) Thermal behavior Crystal transition Two-dimensional correlation spec-troscopy

Applications of 2D correlation analysis in Raman spectroscopy

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Applications of 2D correlation analysis in Raman spectroscop...

原位红外反射-吸收光谱研究PEG对PHBHx薄膜的热性能影响

第十九届全国光散射学术会议

作者： young mee jung Department of Chemistry Kangwon National University

＜正＞2D correlation spectroscopy（2DCOS）is one of the popular techniques to analyze a set of spectra obtained under the influence of external perturbations in various spectroscopic *** 1 shows the general scheme

关键词： 2D correlation spectroscopy Raman spectroscopy battery materials protein

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光谱学与光谱分析 2020年第S1期40卷 39-40页

作者：陈玉静区菊花孔振兴杨锐戴子林 Isao Noda young mee jung 广东省稀土开发及应用研究重点实验室广东省稀有金属研究所广东广州510651 Department of Materials Science and Engineering University of DelawareNewarkDE 19716USA Department of Chemistry Kangwon National UniversityChunchon 24341Korea

聚合物薄膜在界面受限效应作用下的成核结晶与其体材料有显著差异,从而导致其形貌,取向和热性能呈现独特性质。最近我们课题组研究分子量为400的聚乙二醇(PEG)对6.9 mol%3-羟基己酸与3-羟基丁酸共聚酯(PHBHx6.9)薄膜的影响,发现与10 wt%... 详细信息

聚合物薄膜在界面受限效应作用下的成核结晶与其体材料有显著差异,从而导致其形貌,取向和热性能呈现独特性质。最近我们课题组研究分子量为400的聚乙二醇(PEG)对6.9 mol%3-羟基己酸与3-羟基丁酸共聚酯(PHBHx6.9)薄膜的影响,发现与10 wt%的PEG共混后,PHBHx薄膜在Si基底上规整的侧立型结构被破坏。当PEG加入量达到30 wt%时,PHBHx的分子链折叠位于水平和垂直方向之间,这种独特的折叠方式在100℃以下稳定存在。鉴于3-羟基己酸(HHx)单体的摩尔量对PHBHx性质有显著影响,将在前面研究基础拓展PEG对不同HHx含量的PHBHx薄膜性能的影响。利用原位红外-反射吸收光谱(IRRAS)研究PEG对增加3-羟基己酸(HHx)摩尔量至13 mol%后PHBHx的热性能影响。

关键词：红外反射-吸收光谱(IRRAS) 界面受限 3-羟基己酸与3-羟基丁酸共聚酯(PHBHx) 聚乙二醇(PEG) 热性能

红外吸收峰的位置波动:归因于单一谱带的频移还是重叠谱带相对强度的变化?

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生命科学仪器 2011年第3期9卷 14-16页

作者： Soo Ryeon Ryu Isao Noda young mee jung Department of Chemistry and Institute for Molecular Science and Fusion Technology Kangwon National University The Procter&Gamble Co.

红外吸收峰的位置波动可能由单一谱带的实际频移或是邻近重叠谱带相对强度的变化而产生。本文通过主成分分析法(PCA)有力地证明了光谱位置波动的根源往往归因于后一种机理。PCA能灵敏有效地区分单一谱带的实际频移与由重叠谱带相对强度... 详细信息

红外吸收峰的位置波动可能由单一谱带的实际频移或是邻近重叠谱带相对强度的变化而产生。本文通过主成分分析法(PCA)有力地证明了光谱位置波动的根源往往归因于后一种机理。PCA能灵敏有效地区分单一谱带的实际频移与由重叠谱带相对强度变化所产生的最大峰移。对于由分子相互作用强度变化所诱导,并在振动光谱领域较为常见的所谓"带移"的概念,往往由于其隐含了谱带的固有频移而有些概念误导。在许多红外光谱中,峰极大值表面的位移,一般产生于两条重叠谱带相对贡献的变化,而不是分子相互作用强度变化所诱导的单一谱带的缓慢频移。这个观点可以帮助我们解释振动光谱所探测到的分子相互作用。

关键词：红外光谱相对强度吸收峰谱带频移波动位置归因

原位红外反射-吸收光谱研究PEG对PHBHx薄膜的热性能影响

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原位红外反射-吸收光谱研究PEG对PHBHx薄膜的热性能影响

Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers

第21届全国分子光谱学学术会议暨2020年光谱年会

作者：陈玉静区菊花孔振兴杨锐戴子林 Isao Noda young mee jung 广东省稀土开发及应用研究重点实验室广东省稀有金属研究所 Department of Materials Science and Engineering University of Delaware Department of Chemistry Kangwon National University

关键词：红外反射-吸收光谱(IRRAS) 界面受限 3-羟基己酸与3-羟基丁酸共聚酯(PHBHx) 聚乙二醇(PEG) 热性能

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World Journal of Gastroenterology 2012年第34期18卷 4751-4757页

作者： jung Il Lee Jin-Woo Lee Joon mee Kim Ja Kyung Kim Hyun jung Chung young Soo Kim Department of Internal Medicine School of MedicineInha UniversityIncheon 400-711South Korea Department of Pathology School of MedicineInha UniversityIncheon 400-711South Korea Department of Internal Medicine Yonsei University College of MedicineGangnam Severance HospitalSeoul 135-720South Korea

AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively).

关键词： Cytokeratin 19 Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver cancers Hepa-tectomy

Sutureless contact lens-type amniotic membrane for persistent epithelial defects after infectious keratitis

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1404-1406页

作者： jung Hye Shin young-Ho jung Hyun Beom Song mee Kum Kim Chang Ho Yoon Department of Ophthalmology Seoul National University Hospital101 Daehak-roJongno-guSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Laboratory of Ocular Regenerative Medicine and Immunology Biomedical Research InstituteSeoul National University Hospital101 Daehak-roJongno-guSeoul 03080Republic of Korea Department of Medical Science Seoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea

Dear Editor,We are writing to present two case reports of persistent epithelial defect after infectious keratitis successfully treated with sutureless contact lens-type amniotic membrane(AM)*** keratitis is one of the leading causes of corneal *** disrupts the normal corneal healing process and induces inflammation,limbal cell dysfunction,and corneal surface irregularity,which can lead to corneal opacities or persistent epithelial defects(PEDs)[1].Untreated PED can cause corneal thinning,resulting in corneal perforation.

关键词： keratitis healing corneal

Fabrication of periodically aligned vertical singlecrystalline anatase TiO2 nanotubes with perfect hexagonal open-ends using chemical capping materials

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Nano Research 2014年第1期7卷 104-109页

作者： Hui Song Kyubong Jo Bock young jung Gun young jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul Republic of Korea Department of General Dentistry College of Dentistry Yonsei University Seoul Republic of Korea

A vertically aligned anatase TiO2 （A-TiO2） nanotube array has been fabricated by coating a ZnO nanorod （NR） template with a TiO2 precursor solution. After coating, the ZnO NR cores were selectively etched in an acidic environment to form TiO2 nanotubes （NTs）. More specifically, after growing the ZnO NRs via a hydrothermal method, one drop of the TiO2 precursor solution was cast to coat the ZnO NRs, the tops of which were previously covered with chemical capping materials by electrostatic interaction, and then the sample was sintered. Finally, the sample was immersed in an acidic solution resulting in selective etching of the ZnO NR cores. Thus, only TiO2 NTs remained on the substrate. The capping material is effectively used to create a perfect, hexagonal open-ended TiO2 NT array, which interestingly extends onset absorption towards the visible region.

关键词： TiO2 nanotubes chemical capping material ZnO nanorod template laser interferencelithography

Diagnostic accuracy of administrative database for bile duct cancer by ICD-10 code in a tertiary institute in Korea

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 575-580页

作者： young-Jae Hwang Seon mee Park Soomin Ahn Jongchan Lee young Soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnamKorea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongjuKorea Department of Pathology Seoul National University Bundang HospitalSeoungnamKorea Department of Internal Medicine and Institute of Liver Research Seoul National University College of MedicineSeoulKorea Tumor Microenvironment Global Core Research Center Seoul National UniversitySeoulKorea

Background:Administrative database provides valuable information for large cohort studies,especially when tissue diagnosis is rather difficult such as the diagnosis for bile duct cancer(BDC).The aim of this study was to evaluate the diagnostic accuracy of administrative database for BDC by International Classification of Diseases(ICD)-10 codes in a tertiary ***:BDC and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of BDC were identified in the National Health Insurance Service(NHIS)database by ICD 10-code supported by V *** control group was selected from cases without ICD-10 codes for BDC.A definite or possible diagnosis was defined according to pathologic *** records,images,and pathology reports were analyzed to evaluate ICD-10 codes for ***,specificity,positive predictive value,and negative predictive value for BDC were analyzed according to diagnostic criteria and cancer ***:A total of 1707 patients with BDC and 1707 controls were *** those with BDC,1320(77.3%)were diagnosed by definite ***(99.4%)of them had *** of definite diagnosis was the highest for ampulla of Vater(88.9%),followed by that for extrahepatic(84.9%)and intrahepatic(68.3%)*** positive cases commonly had hepatocellular *** overall diagnosis of BDC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.94%,98.33%,98.30%,and 99.94%,*** accuracies were similar regardless of diagnostic criteria or tumor ***:Administrative database for BDC collected according to ICD-10 code with V code shows good accuracy.

关键词： National Health Insurance Service Bile duct cancer ICD-10