检索结果-南通市图书馆

Dual inhibition of sirtuins 1 and 2:reprogramming metabolic energy dynamics in chronicmyeloid leukemia as an immunogenic anticancer strategy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第8期44卷 921-925页

作者： Michael Schnekenburger Anne Lorant Sruthi Reddy Gajulapalli Ridhika Rajora jin-young lee Aloran Mazumder Haeun Yang Christo Christov Hyoung jin Kang Bernard Pirotte Marc Diederich Laboratoire de Biologie Moleculaire et Cellulaire du Cancer LuxembourgLuxembourg Research Institute of Pharmaceutical Sciences&Natural Products Research Institute College of PharmacySeoul National UniversitySeoulRepublic of Korea Faculte de Medecine Universite de LorraineVandoeuvre-les-NancyFrance Department of Pediatrics Seoul National University College of MedicineSeoul National University Cancer Research InstituteSeoul National University Children’s HospitalSeoulRepublic of Korea Laboratory of Medicinal Chemistry Center for Interdisciplinary Research on Medicines(CIRM)University of LiegeLiegeBelgium

Chronicmyeloid leukemia(CML)is a lethal hematopoietic malignancy with a global incidence primarily attributed to the breakpoint cluster region-Abelson(BCR-ABL1)fusion oncogene in over 95%of *** introduction of tyrosine kinase inhibitors(TKIs)has revolutionized CML management;however,a subset of patients encounters challenges such as resistance and relapse,hindering the achievement of complete *** these challenges in CML also requires addressing persistent leukemia stem cells(LSCs)with inherent resistance *** regulators of LSC metabolism,proliferation,and survival,as well as genetic and epigenetic alterations,provide potential targets[1].

关键词： metabolism myeloid alterations

Exploring perspectives in assessing the quality of governance of the Reducing Emissions from Deforestation and Forest Degradation (REDD+) pilot project in Cambodia: Use of Q Methodology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2020年第1期17卷 95-116页

作者： Sareth NHEM young-jin lee Graduate School National University of Ma nagementPhnom Penh 1220Cambodia Techo Sen School of Government&/nrernadona/Relations The University of CambodiaPhnom Penh 1220Cambodia College of Industrial Science Graduate School of Natural SciencesDepartment of Forest ResourcesKonju National UniversityYesan-gun 32439South Korea

Public and policy makers alike are concerned about national and global deforestation and forest degradation. These issues pose a significant threat to social, economic and environmental *** to prevent forest loss and increased attention to pilot REDD+ projects in community forestry sites would both deliver rural livelihood benefits and help to reduce adverse climate ***, there has been no significant exploration of the viewpoints of local experts to determine the monitoring and action needed to support communitybased forestry and improve the governance of REDD+pilot projects in Cambodia. Therefore, this study aimed to assess the perceptions of local stakeholders towards the quality of governance of the first community forest REDD+ pilot project in Cambodia,employing Q-methodology. We adapted 11 indicators of the hierarchical framework of assessment of governance quality to design 40 Q-statements related to REDD+ governance or achievements. The 52 P-set ranked these Q-statements with respect to the community-based REDD+ pilot project. Our study revealed that local stakeholders held four distinct, and partially opposite, views, that:(1) the REDD+ project is successful because it is inclusiveness and capable of causing behavioral change;(2) REDD+ pilot projects should be led by government, not external or locally;and needs more resources;(3) the REDD+ pilot project has raised unrealistic expectations, would likely be a source of corruption and will probably not be successful for local people or halting deforestation;and(4) the REDD+ pilot project is inclusive but not very transparent and probably ineffective at protecting forest. Through these four varied perspectives from local people involved in the project,we can see that there remain serious challenges to the future of pilot community forestry REDD+ projects,including the complex interaction between the multinational actors and the local socio-ecological *** move forwards, this study

关键词： REDD+ Governance quality Indicator Q-Methodology Deforestation Cambodia

Development of a novel electrolytic process for producing high-purity magnesium metal from magnesium oxide using a liquid tin cathode

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2021年第5期9卷 1661-1672页

作者： Tae-Hyuk lee Toru H.Okabe jin-young lee young Min Kim Jungshin Kang Korea Institute of Geoscience and Mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan University of Science and Technology 217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam51508Republic of Korea

The current electrolytic processes for magnesium(Mg)metal have several disadvantages,such as anhydrous magnesium chloride(MgCl_(2))preparation and generation of harmful chlorine(Cl_(2))*** overcome these drawbacks,a novel Mg production process to produce high-purity Mg metal directly from magnesium oxide(MgO)was investigated in this *** electrolysis of MgO was conducted using a liquid tin(Sn)cathode and a carbon(C)anode in the eutectic composition of a magnesium fluoride(MgF_(2))-lithium fluoride(LiF)molten salt under an applied voltage of 2.5 V at 1053-1113 *** certain conditions,the Mg-Sn alloys with Mg_(2)Sn and Mg(Sn)phases were obtained with a current efficiency of 86.6%at 1053 *** produce high-purity Mg metal from the Mg-Sn alloy,vacuum distillation was conducted at 1200-1300 K for a duration of 5-10 *** the vacuum distillation,the concentration of Mg in the Mg-Sn alloy feed decreased from 34.1 to 0.17 mass%,and Mg metal with a purity of 99.999%was obtained at 1200 ***,the electrolytic process developed here is feasible for the production of high-purity Mg metal from MgO using an efficient method.

关键词： Magnesium Magnesium oxide Electrolytic process Liquid tin cathode Vacuum distillation

Policy implications for community-managed forestry in Cambodia from experts＇ assessments and case studies of community forestry practice

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2018年第11期15卷 2531-2551页

作者： Sareth NHEM young jin lee Sopheap PHIN Department of Forest Resources Kongju National Uniuersity 54 Daehak-ro Yesan-eup Yesan-gun Chungnam 32439South Korea Department of Natural Resource Management and Development Faculty of Development Studies Royal University of Phnom Penh Toul Kork 1215o Phnom Penh Cambodia French Cooperation in Economics and Management Royal University of Law and Economics Tonle BasacChamkamon 12300 Phnom Penh Cambodia Prek Leap National College of Agriculture National Road No.6 Chroy Chang Va 12110 Phnom Penh Cambodia

Over the last 40 years, it has been shown at the global level that sustainable forestry can be achieved through comprehensive forest management,with the decentralized institutional arrangements of community-managed forestry coordinated by effective policy implementation. However, there is still a shortage of evidence regarding whether communitybased forestry is well characterized by forest policies,assessing what action is most needed and how best to address the challenges faced by community-based forestry in halting deforestation and promoting rural livelihoods. The study analyzed experts' assessments of the characteristics and success of communitymanaged forestry in Cambodia and explored three case studies of community-managed forestry practice to identify priorities for addressing forest policy implementation inadequacies in halting deforestation and promoting rural livelihoods. There were two methods of data collection. Firstly, this study used a survey of 27 experts to analyze perceptions about how far forest policy supported community-managed forestry effectively, the major challenges faced by the national community-managed forestry program, and the community-managed forestry contribution to halting deforestation and reducing rural ***, data was collected by content analysis of three case studies to explore the knowledge and practical experience of local experts about community-managed forestry practice at local *** study employed Kendall's Coefficient of Concordance to analyze the level of concordance of experts on related forest policies(n=15) considering community-managed forestry, the challenges faced by the national community-managed forestry program,and the actions required to enable communitymanaged forestry to support communities. Analysis revealed that experts were in moderate agreement,denoted by Kendall's W=0.152, on how well forest policies articulate and implement the characteristics of community-managed forestry. Ranking of the

关键词： Kendall's W Content analysis method Forest policy Deforestation Sustainable forestry Cambodia

Production of high-purity Mg metal from dolomite through novel molten salt electrolysis and vacuum distillation

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第4期11卷 1308-1320页

作者： Hyeong-Jun Jeoung Tae-Hyuk lee jin-young lee Kyung-Woo Yi Jungshin Kang Korea Institute of Geoscience and Mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132Republic of Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Resources Engineering University of Science and Technology217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea School of Materials Science and Engineering Pusan National University2 Busandaehak-roGeumjeong-guBusan 46241Republic of Korea

In this study,a novel Mg production process for producing high-purity Mg metal from dolomite was *** the electrolysis of calcined dolomite was conducted using Cu cathode and C anode in MgF_(2)–LiF molten salt at 1083–1173 K by applying an average current of 1.42–1.46 A for 9.50–21.0 h,the current efficiency of 66.4–88.6%was *** produced Mg alloys consisted of MgCu_(2)and Cu(Mg)or MgCu_(2)and CuMg_(2)phases,depending on the Mg concentration in the Mg *** the electrolysis of calcined dolomite was conducted in MgF_(2)–LiF–CaF_(2)molten salt at 1083 K,the current efficiency was 40.9–71.4%,owing to undesired reactions such as electroreduction of Ca^(2+)or/and CO_(3)^(2−)***,the current efficiency increased from 40.9%to 63.2%by utilizing a Pt anode,because the occurrence of CO_(3)^(2−)ions in the molten salt was *** vacuum distillation of the obtained Mg alloys at 1300 K for 10 h,Mg metal with a purity of 99.9996–99.9998%was ***,the feasibility of this novel process for the production of high-purity Mg metal from dolomite was demonstrated.

关键词： High-purity magnesium Dolomite Magnesium oxide Electrolytic process Copper metal cathode Vacuum distillation

Compatible taper and stem volume equations for Larix kaempferi(Japanese larch) species of South Korea

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2017年第7期14卷 1341-1349页

作者： Nova D.DOYOG young jin lee Sun Joo lee jin Taek KANG Sung Yong KIM Department of Forest Resources College of Industrial Science Kongju National University National Institute of Forest Science

In this study, compatible taper and stem volume equations were developed for Larix kaempferi species of South Korea. The dataset was split into two groups： 80% of the data were used in model fitting and the remaining 2o% were used for validation. The compatible MB76 equations were used to predict the diameter outside bark to a specific height, the height to a specific diameter and the stem volume of the species. The result of the stem volume analysis was compared with the existing stem volume model of Larix kaempferi species of South Korea which was developed by the Korea Forest Research Institute and with a simple volume model that was developed with fitting dataset in this study. The compatible model provided accurate prediction of the total stem volume when compared to the existing stem volume model and with a simple volume model. It is concluded that the compatible taper and stem volume equations are more convenient to use and therefore it is recommended to be applied in the Larix kaempferi species of South Korea.

关键词： Larix kaempferi Taper volume equation Tree stem volume equation Compatible volume Segmented model Merchantable volume estimation

Endovascular treatment of traumatic renal artery pseudoaneurysm with a Stanford type A intramural haematoma:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第27期10卷 9760-9767页

作者： Yook Kim jin young lee jin Suk lee jin Bong Ye Se Heon Kim young Hoon Sul Su young Yoon Jung Hee Choi Hanlim Choi Department of Radiology Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Trauma Surgery Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Trauma Surgery College of MedicineChungbuk National UniversityCheongju-si 28644Chungcheongbuk-doSouth Korea Cardiovascular and Thoracic Surgery Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Anesthesiology and Pain Medicine Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Surgery Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea

BACKGROUND Aortic intramural hematoma(IMH) associated with aortic branch tear and intramurally located pseudoaneurysm after blunt trauma has not been ***,we report a case of progressive type A aortic IMH associated with a pseudoaneurysm arising from the injured proximal renal artery after blunt *** SUMMARY During logging operations,a 66-year-old man experienced blunt force trauma after being injured by a fallen *** arrived at our trauma center with a left flank pain *** tomography(CT) revealed a pseudoaneurysm arising from the proximal renal artery(localized within the aortic media) and Stanford type A IMH.A covered stent was deployed along the left main renal artery,bridging the pseudoaneurysm and covering the parent artery,successfully excluding the pseudoaneurysm as confirmed using ***,although the degree of the pseudoaneurysm decreased,follow-up CT revealed remnant pseudoaneurysm,likely caused by an ***,a covered stent was additionally installed through the previously deployed covered *** exclusion of the pseudoaneurysm was confirmed using final *** the 7-mo follow-up CT scan,the IMH and pseudoaneurysm completely disappeared with no evidence of stent-related *** Endovascular treatment such as stent-graft placement can be an effective and safe treatment for traumatic renal artery injury.

关键词： Aortic intramural hematoma Blunt trauma Intimomedial tear Renal arterial injury Stent-graft Case report

Use of various MgO resources for high-purity Mg metal production through molten salt electrolysis and vacuum distillation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2023年第2期11卷 562-579页

作者： Hyeong-Jun Jeoung Tae-Hyuk lee youngjae Kim jin-young lee young Min Kim Toru HOkabe Kyung-Woo Yi Jungshin Kang Korea Institute of Geoscience and Mineral Resources 124 Gwahak-ro Yuseong-guDaejeon 34132South Korea Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826South Korea Department of Resources Engineering University of Science and Technology217 Gajeong-ro Yuseong-guDaejeon 34113South Korea Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam 51508South Korea Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan School of Materials Science and Engineering Pusan National University2 Busandaehak-roGeumjeong-guBusan 44241South Korea

A green and effective electrolytic process was developed to produce high-purity Mg metal using primary and secondary resources containing Mg O as a feedstock. The electrolysis of various Mg O resources was conducted using a Cu cathode in MgF2– LiF – KCl molten salt at 1043 K by applying an average current of 1.44 A for 12.5 h. The electrolysis of calcined North Korean magnesite and seawater Mg O clinker yielded Mg alloys of MgCu2and(Cu) phases with current efficiencies of 89.6–92.4%. The electrolysis of oxidized Mg O-C refractory brick, aged ferronickel slag, and ferronickel slag yielded Mg alloys of MgCu2and(Cu) phases with current efficiencies of 59.3–92.3%. The vacuum distillation of Mg alloys obtained was conducted at 1300 K for 10 h to produce high-purity Mg metal. After vacuum distillation, Mg metal with a purity of above 99.994% was obtained. Therefore, this study demonstrates the feasibility of the production of high-purity Mg metal from various Mg O resources using a novel electrolytic process with a Cu cathode, followed by vacuum distillation.

关键词： High-purity magnesium Magnesium oxide resources Electrolytic process Metal cathode Vacuum distillation

Bronchial Washing to Diagnose Smear-Negative Pulmonary Tuberculosis

在线全文

学校读者我要写书评

暂无评论

Journal of Tuberculosis Research 2019年第3期7卷 143-147页

作者： jin young lee Department of Internal Medicine College of Medicine Kosin University Busan Republic of Korea

Introduction: Bronchoscopy with bronchial washing is useful for the diagnosis of pulmonary tuberculosis (TB) when sputum smears are negative. However, its indication has not been standardized. Therefore, we conducted a retrospective study to assess the diagnostic value of bronchial washing in patients suspected with pulmonary TB. Methodology: A retrospective analysis was performed on patients diagnosed with pulmonary TB in Kosin university gospel hospital, a tertiary hospital with 969 beds in South Korea, from March 2017 to December 2018. We obtained three serial sputum samples for acid-fast bacilli (AFB) smear and culture, and all patients underwent bronchoscopy with bronchial washing for AFB smear and culture. Results: Fifty-six patients were enrolled in the study. Smear-negative pulmonary TB (SNPT) was diagnosed in 42/56 (75%) patients. Among the patients with smear-positive sputum, 14/14 (100%) showed culture-positive sputum, while smear- and culture-positive bronchial washing were seen in 7/14 (50%) and 12/14 (85.7%) patients, respectively. Among the patients with SNPT, 17/42 (40.47%) had culture-negative sputum and were diagnosed using the bronchoscopic washing. Conclusions: For patients with smear-negative sputum, it is necessary to perform bronchoscopic washing to increase the diagnostic rate of pulmonary TB. To control the transmission of pulmonary TB, it is necessary to use a fast and accurate examination method.

关键词： Bronchial Washing Pulmonary Tuberculosis Sputum Smear Negative