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Thrombolytic activity of cheonggukjang kinase in recovery from brain damage in a rat cerebral embolic stroke model

Neural Regeneration Research 2010年第24期5卷 1875-1882页

作者： Angella M Anthony jalin Chae Kwan Lee Chae Yeon Lee A Reum Kang Chung Mu Park jae Ho Cha jeong Hwan Kim Soo Woong Lee young Sun Song jong Tae Lee Sung goo Kang School of Biological Sciences First Research GroupInje University Institute of Environmental and Occupational Medicine & Department of Occupational and Environmental Medicine Pusan Paik HospitalInje University Department of Smart Foods & Drugs Inje University Department of Microbiology Pusan National University Division of Applied Life Science Gyeongsang National University Advanced Research Center for Multiple Myeloma Department of MicrobiologyBio-Marker Research Center for Personalized TherapyCollege of MedicineInje University

Cheonggukjang is a soybean paste made by fermenting whole cooked soybeans with Bacillus subtilis. Cheonggukjang contains a fibrinolytic enzyme that could provide clinical applications for removing blood clots. In the present study, the term ＂cheonggukjang kinase＂（CGK） was used to refer to this fibrinolytic enzyme. The thrombolytic effects of CGK were analyzed in a rat model of cerebral embolic stroke produced by middle cerebral artery occlusion （MCAO）. Results from fibrin and platelet-rich clot lysis assays demonstrated that thrombolytic activity was greatest in CGKs, which were cultured for 40 hours. In addition, T50, the time needed to decompose 50% of the clot, did not change with plasminogen treatment, indicating that CGK was not a plasminogen activator, but was rather presumed to act as a plasmin-like protein. An intravenous infusion of CGK （1 U plasmin-like activity/100 μg CGK/kg） at 1 hour after MCAO resulted in removal of clots in a rat model of cerebral embolic stroke. CGK-treated groups exhibited a significant dose-dependent reduction in infarct volume. CGK treatment also improved functional recovery, as assessed by neurological deficit scores. Decreased infarct volume and improved functional recovery following CGK treatment was greater compared with recombinant tissue plasminogen activator （10 mg/kg）. These results suggested that CGK effectively reduced infarct volume and improved functional recovery following ischemic brain injury. CGK exhibits a number of potential clinical applications ir the treatment of cerebral embolic stroke.

关键词： brain damage cheonggukjang kinase fibrin clot lysis assay middle cerebral artery occlusion platelet rich clot lysis assay thrombolytic activity

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Optimal deployment schedule of an active twist rotor for performance enhancement and vibration reduction in high-speed flights

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Chinese journal of Aeronautics 2017年第4期30卷 1427-1440页

作者： young H.YOU Sung N.jUNG Chang j.KIM Department of Aerospace Information Engineering Konkuk University Seoul 05019 Republic of Korea

The best active twist schedules exploiting various waveform types are sought taking advantage of the global search algorithm for the reduction of hub vibration and/or power required of a rotor in high-speed conditions. The active twist schedules include two non-harmonic inputs formed based on segmented step functions as well as the simple harmonic waveform input. An advanced Particle Swarm assisted Genetic Algorithm（PSGA） is employed for the optimizer. A rotorcraft Computational Structural Dynamics（CSD） code CAMRAD II is used to perform the rotor aeromechanics analysis. A Computation Fluid Dynamics（CFD） code is coupled with CSD for verification and some physical insights. The PSGA optimization results are verified against the parameter sweep study performed using the harmonic actuation. The optimum twist schedules according to the performance and/or vibration reduction strategy are obtained and their optimization gains are compared between the actuation cases. A two-phase non-harmonic actuation schedule demonstrates the best outcome in decreasing the power required while a four-phase non-harmonic schedule results in the best vibration reduction as well as the simultaneous reductions in the power required and vibration. The mechanism of reduction to the performance gains is identified illustrating the section airloads, angle-of-attack distribution, and elastic twist deformation predicted by the present approaches.

关键词： Active twist High-speed flight Hub vibration Non-harmonic Power required

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Aerodynamic force generation of an insect-inspired flapper actuated by a compressed unimorph actuator

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Chinese Science Bulletin 2009年第16期54卷 2871-2879页

作者： NGUYEN Quoc-Viet PARK Hoon C goo Nam S BYUN Doyoung Department of Advanced Technology Fusion Konkuk University National Research Laboratory for Biomimetics and Intelligent Microsystems Konkuk University Department of Aerospace Engineering Konkuk University

We examined experimentally the flapping performance in terms of aerodynamic force generation of an insect-inspired flapper actuated by both of original LIPCA and compressed LIPCA. Flapping tests for two artificial wing shapes of horse botfly and hawk moth were conducted at the wing rotation angle of 60° and a flapping frequency range from 6 Hz to 12 Hz to find the optimum flapping frequency and to investigate the effect of compressed LIPCA and wing shape on the force generation. Flapping tests in the vacuum were also undertaken to measure the induced inertia force. The aerodynamic force was calculated by subtracting the inertia force from the total force measured in the air. It was found that the average inertia force was relatively small when compared with the average total force. The use of the compressed LIPCA could significantly improve the flapping angle of the flapper from 110° to 130° (18.2% increase) resulting in 24.5% increase in the average aerodynamic force. It was also found that flapper with hawk moth wings could produce larger force than the flapper with horse botfly wings.

关键词：空气动力驱动器插板压缩部队昆虫压电片单层

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Mimicking unfolding motion of a beetle hind wing

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Chinese Science Bulletin 2009年第14期54卷 2416-2424页

作者： MUHAMMAD Azhar PARK Hoon C HWANG Do Y BYUN Doyoung goo Nam S Department of Advanced Technology Fusion Konkuk University National Research Laboratory for Biomimetics and Microsystems Konkuk University Artificial Muscle Research Center Konkuk University Department of Aerospace Engineering Konkuk University

This paper presents an experimental research aiming to realize an artificial hind wing that can mimic the wing unfolding motion of Allomyrina dichotoma, an insect in coleopteran order. Based on the understanding of working principles of beetle wing folding/unfolding mechanisms, the hind wing unfolding motion is mimicked by a combination of creative ideas and state-of-art artificial muscle actuator. In this work, we devise two types of artificial wings and the successfully demonstrate that they can be unfolded by actuation of shape memory alloy wires to provide actuation force at the wing base and along the leading edge vein. The folding/unfolding mechanisms may provide an insight for portable nano/micro air vehicles with morphing wings.

关键词：后翅甲虫运动模仿形状记忆合金丝人工肌肉微型飞行器驱动器

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Improvement of Artificial Foldable Wing Models by Mimicking the Unfolding/Folding Mechanism of a Beetle Hind Wing

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journal of Bionic Engineering 2010年第2期7卷 134-141页

作者： Azhar Muhammad Quoc Viet Nguyen Hoon Cheol Park Do Y.Hwang Doyoung Byun Nam Seo goo Department of Advanced Technology Fusion Konkuk University National Research Laboratory for Biomimetics and Microsystems Konkuk University Artificial Muscle Research Center Konkuk University Departmenet of Aerospace Engineering Konkuk University

In an attempt to realize a flapping wing micro-air vehicle with morphing wings, we report on improvements to our previousfoldable artificial hind *** hinges, which were implemented to mimic the bending zone of a beetle hind wing, weremade of small composite hinge plates and tiny aluminum *** buck-tails of rivets were flared after the hinge plates wereassembled with the rivets so that the folding/unfolding motions could be completed in less time, and the straight shape of theartificial hind wing could be maintained after *** and unfolding actions were triggered by electrically-activatedShape Memory Alloy (SMA) *** wing folding, the actuation characteristics of the SMA wire actuator were modifiedthrough heat *** a series of flapping tests, we confirmed that the artificial wings did not fold back and arbitrarilyfluctuate during the flapping motion.

关键词： hind wing unfolding folding shape memory alloy folding ratio artificial wing

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Computed tomography-based radiomics diagnostic approach for differential diagnosis between early-and late-stage pancreatic ductal adenocarcinoma

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World journal of Gastrointestinal Oncology 2024年第4期16卷 1256-1267页

作者： Shuai Ren Li-Chao Qian Ying-Ying Cao Marcus j Daniels Li-Na Song Ying Tian Zhong-Qiu Wang Department of Radiology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND One of the primary reasons for the dismal survival rates in pancreatic ductal adenocarcinoma(PDAC)is that most patients are usually diagnosed at late *** is an urgent unmet clinical need to identify and develop diagnostic methods that could precisely detect PDAC at its earliest *** A total of 71 patients with pathologically proved PDAC based on surgical resection who underwent contrast-enhanced computed tomography(CT)within 30 d prior to surgery were included in the *** staging was performed in accordance with the 8th edition of the American joint Committee on Cancer staging *** features were extracted from the region of interest(ROI)for each patient using Analysis Kit *** most important and predictive radiomics features were selected using Mann-Whitney U test,univar-iate logistic regression analysis,and minimum redundancy maximum relevance(MRMR)*** forest(RF)method was used to construct the radiomics model,and 10-times leave group out cross-validation(LGOCV)method was used to validate the robustness and reproducibility of the *** A total of 792 radiomics features(396 from late arterial phase and 396 from portal venous phase)were extracted from the ROI for each patient using Analysis Kit *** most important and predictive features were selected using Mann-Whitney U test,univariate logistic regression analysis,and MRMR *** method was used to construct the radiomics model with the nine most predictive radiomics features,which showed a high discriminative ability with 97.7%accuracy,97.6%sensitivity,97.8%specificity,98.4%positive predictive value,and 96.8%negative predictive *** radiomics model was proved to be robust and reproducible using 10-times LGOCV method with an average area under the curve of 0.75 by the average performance of the 10 newly built *** The radiomics model based on CT could serve as a promising non-invasive method in differential diag

关键词： Pancreatic ductal adenocarcinoma Radiomics Computed tomography American joint Committee on Cancer staging

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Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation

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Cellular & Molecular Immunology 2018年第2期15卷 111-119页

作者： Huijeong Ahn Seung goo Kang Sung-il Yoon Pyeung-Hyeun Kim Doo Kim Geun-Shik Lee College of Veterinary Medicine and Institute of Veterinary Science Kangwon National UniversityChuncheon24341GangwonRepublic of Korea Department of Systems Immunology College of Biomedical ScienceKangwon National UniversityChuncheon24341GangwonRepublic of Korea Department of Molecular Bioscience School of Biomedical ScienceKangwon National UniversityChuncheon24341GangwonRepublic of Korea

Poly-gamma-glutamic acid(γ-PGA)is a natural,edible and non-toxic polymer synthesized by Bacillus subtilis and is suggested as a safe biomaterial for the use in hydrogels and vaccine ***,the effect ofγ-PGA on inflammasome activation has not yet been studied in ***,which are intracellular multi-protein complexes,promote acute and chronic inflammation via interleukin-1βor interleukin-18 maturation,and they are known targets for metabolic syndromes and *** this study,we observed thatγ-PGA attenuated NLRP3,NLRC4 and AIM2 inflammasome activation,whereas it upregulated pro-inflammatory cytokine expression in human and murine ***γ-PGA had conflicting effects on cytokine production and maturation,it clearly alleviated the severity of lipopolysaccharide-induced endotoxin shock in an animal ***,we suggestγ-PGA as a candidate to control inflammasome-mediated disorders.

关键词： Cheonggukjang cytokines inflammasome macrophages poly-gamma-glutamate

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A High Dielectric N-Type Small Molecular Acceptor Containing Oligoethyleneglycol Side-Chains for Organic Solar Cellst

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Chinese journal of Chemistry 2018年第3期36卷 199-205页

作者： Bomee jang Changyeon Lee young Woong Lee Donguk Kim Mohammad Afsar Uddin Felix Sunjoo Kim Bumjoon j. Kim Han young Woo Department of Chemistry Korea University Seoul 02841 Republic of Korea Department of Chemical and Biornolecular Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea School of Chemical Engineering and Materials Science Chung-Ang UniversitySeoul 06974 Republic of Korea

We report a new small molecular acceptor, ITIC-OEG, which is based on indacenodithieno[3,2-b]thiophene and 1,1-（dicyanomethylene）-3- indanone including oligoethyleneglycol （OEG） side-chains. ITIC-OEG was found to have higher dielectric constant （ε1=5.6} than that of a reference molecule of ITIC with normal alkyl substituents （ε1=3.9）. The dielectric constant of medium influences significantly the exciton binding energy and the resulting charge separation and recombination. The optical, electrochemical and morphological properties of ITIC-OEG and its photovoltaic characteristics were investigated by blending with a semi-crystalline donor polymer, PPDT2FBT, with comparison to those of ITIC. ITIC-OEG shows more red-shifted absorption and stronger crystalline packing than ITIC. However, the lower photovoltaic performance （with 1.58% power conversion efficiency, PCE） was measured for PPDT2FBT-ITIC-OEG, compared to PPDT2FBT：ITIC （5..52% PCE）. The incompatibility between PPDT2FBT and ITIC-OEG （due to high hydrophilic nature of OEG chains） resulted in poor intermixing with large domain separation over 300 nm, showing inefficient charge separation and significant charge recombination. Therefore, to investigate the effect of dielectric constant of the materials on the charge separation and recombination, the blend morphology of the PPDT2FBT：ITIC-OEG should be optimized first by improving their miscibility and phase separation.

关键词： N-type small molecule dielectric constant morphology organic solar cells

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Some New Inverse-type Hilbert-Pachpatte Integral Inequalities

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Acta Mathematica Sinica,English Series 2004年第1期20卷 57-62页

作者： young Ho KIM Department of Applied Mathematics Changwon National UniversityChangwon 641-773Korea

In this paper, some new generalizations of inverse type Hilbert-Pachpatte integral inequalities are proved. The results of this paper reduce to those of Pachpatte (1998, j. Math. Anal. Appl. 226, 166–179) and Zhao an... 详细信息

关键词： Hilbert’s double integral inequality H(?)lder integral inequality jensen’s inequality Power mean inequality

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Commuting Structure jacobi Operator for Real Hypersurfaces in Complex Two-plane Grassmannians

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Acta Mathematica Sinica,English Series 2015年第1期31卷 111-122页

作者： Carlos j.G.MACHADO juan de Dios PREZ young jin SUH Departamento de Geometria y Topologia Universidad de Granada Kyungpook National University Department of Mathematics

We classify real hypersurfaces in complex two-plane Grassmannians whose structure jacobi operator commutes either with any other jacobi operator or with the normal jacobi operator.

关键词： Real hypersurfaces complex two-plane Grassmannians structure jacobi operator normal jacobi operator

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