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Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise

Journal of Sport and Health Science 2017年第2期6卷 225-230页

作者： Hee-Tae Roh Su-youn Cho Wi-young So Department of Physical Education Dong-A University Busan 604-714 Republic of Korea School of Taekwondo College of Creative Human ResourcesYoungsan UniversityYangsan-si 626-790Republic of Korea Sports and Health Care Major College of Humanities and ArtsKorea National University of TransportationChungju-si 380-702Republic of Korea

Purpose: The purpose of this study was to investigate the effects of obesity and high-intensity acute exercise on oxidant-antioxidant status,neurotrophic factor expression, and blood-brain barrier(BBB) ***: Twenty-four healthy, untrained men(12 non-obese(mean 14.9% body fat) and 12 obese subjects(mean 29.8% body fat)) performed20 min of continuous submaximal aerobic exercise at 85% maximal oxygen consumption. Blood sampling was performed to examine the oxidant-antioxidant status(reactive oxygen species(ROS) and superoxide dismutase(SOD)), neurotrophic factors(brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF)), and BBB disruption(S100β and neuron-specific enolase) before and after acute ***: The obese group showed significantly higher pre-exercise serum ROS levels and significantly lower pre-exercise serum SOD levels than the non-obese group(p < 0.05). Serum ROS, SOD, BDNF, NGF, and S100β levels were significantly increased post-exercise compared with pre-exercise levels in both the non-obese and the obese groups(p < 0.05). The obese group showed significantly higher serum ROS, BDNF, NGF,and S100β levels post-exercise compared to the non-obese group(p < 0.05).Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption,and it is assumed that oxidative stress was the main cause of this BBB disruption.

关键词： Antioxidant enzyme Blood-brain barrier Exercise Neurotrophic factor Obesity Oxidative stress

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Concomitant acute myocardial infarction and descending thoracic aorta penetrating ulcer

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Journal of Geriatric Cardiology 2016年第11期13卷 935-937页

作者： Yong hoon Kim Ae-young Her Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea

Acute coronary syndrome （ACS） refers to a spectrum of clinical presentations ranging from unstable angina to non-ST-segment elevation myocardial infarction （NSTEMI） to ST-segment elevation myocardial infarction （STEMI）. Aortic dissection, intramural hematoma and penetrating atherosclerotic ulcer （PAU） are three major acute aortic syndromes （AAS）.

关键词： Myocardial infarction Penetrating aortic ulcer Stent grafts

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Bowel preparations as quality indicators for colonoscopy

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World Journal of Gastroenterology 2014年第11期20卷 2746-2750页

作者： Jae young Jang hoon Jai Chun Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee UniversitySeoul 130-701South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

Colonoscopy is the principal investigative procedure for colorectal neoplasms because it can detect and remove most precancerous *** effectiveness of colonoscopy depends on the quality of the *** preparation is an essential part of high-quality colonoscopies because only an optimal colonic cleansing allows the colonoscopist to clearly view the entire colonic mucosa and to identify any polyps or other *** bowel preparation not only prolongs the overall procedure time,decreases the cecal intubation rate,and increases the costs associated with colonoscopy but also increases the risk of missing polyps or adenomas during the ***,a repeat examination or a shorter colonoscopy follow-up interval may be suitable strategies for a patient with suboptimal bowel preparation.

关键词： Colonoscopy Colorectal neoplasm Bower preparation Quality

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Epidural blood patch for spontaneous intracranial hypotension with subdural hematoma: A case report and review of literature

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World Journal of Clinical Cases 2022年第1期10卷 388-396页

作者： Se Hee Choi youn young Lee Won-Joong Kim Anesthesiology and Pain Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Anesthesiology and Pain Medicine School of MedicineEwha Womans UniversitySeoul 07985South Korea

BACKGROUND Cerebrospinal fluid(CSF)leakage at C1/2 in spontaneous intracranial hypotension(SIH)is *** hematoma(SDH),a serious complication of SIH,may lead to neurological *** report presents a case of SDH after spontaneous C1/2 CSF leakage,which was treated with a targeted epidural blood patch(EBP).CASE SUMMARY A 60-year-old man with no history of trauma was admitted to our hospital with orthostatic headache,nausea,and *** computed tomography imaging revealed bilateral,subacute to chronic *** magnetic resonance imaging(MRI)findings were SDH with dural enhancement in the bilateral cerebral convexity and posterior fossa and mild sagging,suggesting *** the patient underwent burr hole trephination,the patient’s orthostatic headache was *** myelography led to a suspicion of CSF leakage at C1/***,we performed a targeted cervical EBP using an epidural catheter under fluoroscopic *** 5 d after EBP,a follow-up MR myelography revealed a decrease in the interval size of the CSF *** his symptoms improved,the patient still complained of headaches;therefore,we repeated the targeted cervical EBP 6 d after the initial ***,his headache had almost disappeared on the 8th day after the repeated *** Targeted EBP is an effective treatment for SDH in patients with SIH due to CSF leakage at C1/2.

关键词： Cerebrospinal fluid Chronic subdural hematoma Epidural blood patch Myelography Spontaneous intracranial hypotension Case report

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Effect of Doubling the Ensemble Size on the Performance of Ensemble Prediction in the Warm Season Using MOGREPS Implemented at the KMA

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Advances in Atmospheric Sciences 2013年第5期30卷 1287-1302页

作者： Jun Kyung KAY Hyun Mee KIM young-youn PARK Joohyung SON Department of Atmospheric Sciences Yonsei University Korea Meteorological Administration

Using the Met Office Global and Regional Ensemble Prediction System （MOGREPS） implemented at the Korea Meteorological Administration （KMA）, the effect of doubling the ensemble size on the performance of ensemble prediction in the warm season was evaluated. Because a finite ensemble size causes sampling error in the full forecast probability distribution function （PDF）, ensemble size is closely related to the efficiency of the ensemble prediction system. Prediction capability according to doubling the ensemble size was evaluated by increasing the number of ensembles from 24 to 48 in MOGREPS implemented at the KMA. The initial analysis perturbations generated by the Ensemble Transform Kalman Filter （ETKF） were integrated for 10 days from 22 May to 23 June 2009. Several statistical verification scores were used to measure the accuracy, reliability, and resolution of ensemble probabilistic forecasts for 24 and 48 ensemble member forecasts. Even though the results were not significant, the accuracy of ensemble prediction improved slightly as ensemble size increased, especially for longer forecast times in the Northern Hemisphere. While increasing the number of ensemble members resulted in a slight improvement in resolution as forecast time increased, inconsistent results were obtained for the scores assessing the reliability of ensemble prediction. The overall performance of ensemble prediction in terms of accuracy, resolution, and reliability increased slightly with ensemble size, especially for longer forecast times.

关键词： ensemble prediction ensemble size ensemble transform Kalman filter

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Effects of ethanol on insulin-like growth factor-Ⅰ system in primary cultured rat hepatocytes: Implications of JNK1/2 and alcoholdehydrogenase

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World Journal of Gastroenterology 2008年第27期14卷 4324-4331页

作者： young-Il Oh Jong-hoon Kim Chang-Won Kang Department of Veterinary Physiology College of Veterinary Medicine Bio-Safety Research Institute Chonbuk National University

AIM: To evaluate the effects of ethanol on the insulin- like growth factor-Ⅰ (IGF-Ⅰ) system involved in c-Jun N-terminal kinase (JNK1/2) and alcoholdehydrogenase (ADH) activity in primary cultured rat hepatocytes. METHODS: Hepatocytes isolated from male Sprague-Dawley rats were incubated with various concentrations of ethanol for different durations of time. The cells were pretreated with SP600125 (10 μmol/L) and 4-MP (200 μmol/L), and then treated with ethanol (200 mmol/L). We then measured IGF-Ⅰ secretion, IGF-Ⅰ mRNA expression, cell viability and JNK1/2 activity by radioimmunoassay, RT-PCR, MTT assay and Western blot, respectively (n = 6). RESULTS: Ethanol induced the activity of phospho (p)-JNK1/2, reaching a maximum at 60 min and then decreasing at 180 min. The effects of ethanol on the IGF-Ⅰ system were increased at 60 min (secretion: 7.11 ± 0.59 ng/mg protein vs 4.91 ± 0.51 ng/mg, mRNA expression: 150.2% ± 10.2% vs 101.5% ± 11.3%, P = 0.045) and then decreased at 180 min (secretion: 3.89 ± 0.25 ng/mg vs 5.4 ± 0.54 ng/mg protein; mRNA expression: 41.5% ± 10.4% vs 84.7% ± 12.1%, P = 0.04), however cell viability was decreased in a dose- and time-dependent manner. SP600125 blocked the ethanol-induced changes (at 60 min). Additionally, 4-methylpyrazole prevented the ethanol-induced decreases in the IGF-Ⅰ system, cell viability and p-JNK1/2 activity (at 180 min). CONCLUSION: This study suggests that ethanol- induced p-JNK1/2 activation is associated with the IGF-Ⅰ system and cell viability in hepatocytes. Furthermore, alcohol dehydrogenase is involved in the relationship between ethanol-induced inactivation of p-JNK1/2 and the changes of the IGF-Ⅰ system and cell viability.

关键词： Insulin-like growth factor-Ⅰ Insulin-like growth factor-Ⅰ receptor C-Jun N-terminal kinase Hepatocyte Ethanol

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Prevention and management of adverse events following COVID-19 vaccination using traditional Korean medicine:An online survey of public health doctors

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World Journal of Clinical Cases 2022年第28期10卷 10053-10065页

作者： Byungsoo Kang Hongmin Chu Bo-young youn Jungtae Leem College of Korean Medicine Dongshin UniversityNaju-si 58245South Korea Daecheong Public Health Subcenter Ongjin Public HealthcenterIncheon 23105IncheonSouth Korea Department of Preventive Medicine College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea College of Korean Medicine Wonkwang UniversityIksan 54538Jeollabuk-doSouth Korea

BACKGROUND Since February 2021,vaccination against coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 has started in *** To perform a questionnaire survey about the prevention and management of adverse events of COVID-19 vaccination among public health doctors of Korean Medicine(PHKMDs).METHODS An online questionnaire was developed,comprising categories about adverse events of vaccination(AEVs)and perception of using Korean medicine(KM)in managing vaccine adverse events(AEs)among ***’experience of AEVs,usage of Korean medicine for AEVs,and perception and attitude in using KM for AEVs were *** survey web-link was emailed to the association of *** links were sent through Survey Monkey to all PHKMDs in *** A total of 143 participants were recruited for this study;65%of participants were vaccinated at the same of the survey(n=93).Although most participants did not take any medication for prevention of the adverse events,62%(n=58)of participants had taken herbal medicine to treat the adverse events(n=52).Approximately 35%of participants(n=33)said that they would recommend taking herbal medicine to prevent any *** various KM interventions,the participants strongly recommended taking an herbal medicine(n=69,74.19%)to treat AEs,and the second-highest was acupuncture treatment(n=19,20.43%).CONCLUSION Overall,this research demonstrated a high prevalence of KM usage by the ***,this study’s results may serve as fundamental evidence for health professionals to consider using KM treatments when treating or preventing AEVs in the near future.

关键词： COVID-19 Vaccination Adverse events Herbal medicine Korean medicine

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Selective laser melting of Fe-Ni-Cr layer on AISI H13 tool steel

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中国有色金属学会会刊：英文版 2009年第4期19卷 921-924页

作者： Byeong-Don JOO Jeong-Hwan JANG Jae-Ho LEE young-Myung SON young-hoon MOON School of Mechanical Engineering Pusan National University

An attempt to fabricate Fe-Ni-Cr coating on AISI H13 tool steel was performed with selective laser ***-Ni-Cr coating was produced by experimental facilities consisting of a 200 W fiber laser which can be focused to 80 μm and atmospheric chamber which can control atmospheric pressure with N2 or *** layer was fabricated with various process parameters such as laser power,scan rate and fill *** quality and coating thickness were measured and *** different surface patterns,such as typeⅠ,typeⅡand type Ⅲ,are shown with various test conditions and smooth regular pattern is obtained under the conditions as 10 μm of fill spacing,50-350 mm/s of scan rate and 40 μm of fill spacing,10-150 mm/s of scan *** maximum coating thickness is increased with power elevation or scan rate drop,and average thickness of 10 μm fill spacing is lower than that of 40 μm fill spacing.

关键词：镍铬涂层工具钢激光熔融社会扫描速度铁涂层厚度光纤激光器

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Laser surface hardening of AISI H13 tool steel

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中国有色金属学会会刊：英文版 2009年第4期19卷 917-920页

作者： Jae-Ho LEE Jeong-Hwan JANG Byeong-Don JOO young-Myung SON young-hoon MOON School of Mechanical Engineering Pusan National University

An attempt was made to improve the surface hardness and wear properties of AISI H13 tool steel through solid solution hardening and refinement of microstructures using a 200 W fiber laser as a heat generating *** hardness of laser melted zone was *** order to identify the effect of heat input on the laser melting zone,scanning conditions were *** results show that,the hardness of as-received AISI H13 tool steel is approximately Hv 240,and the hardness after laser surface heat treatment is around Hv *** hardening depth and width are increased with the increase in the heat input *** of experimental results will be considered in tooling industry.

关键词：激光表面硬化工具钢 H13 激光表面热处理表面硬度信息社会光纤激光器固溶强化

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Effect of Laser Parameters on Sintered Powder Morphology

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Journal of Materials Science & Technology 2010年第4期26卷 375-378页

作者： Byeong-Don Joo Jeong-Hwan Jang Jae-Ho Lee young-Myung Son young-hoon Moon Engineering Research Center for Net Shape and Die Manufacturing School of Mechanical EngineeringPusan National University

Selective laser sintering is a kind of rapid prototyping process whereby a three-dimensional part is built layerwise by laser scanning a powder. This process is highly inffuenced by powder and laser parameters such as laser power, scan rate, spot size and layer thickness. Therefore a study on fabricating a line with Fe-Ni-Cr powder on AISI H13 tool steel has been performed by selective laser sintering. In this study, fabrication was performed by experimental facilities consisting of a 200W fiber laser which can be focused to 0.08 mm and atmospheric chamber which can control atmospheric pressure with argon. The line was fabricated with various laser power, scan rate and layer thickness. Line width and surface quality were investigated. With power increase or layer thickness decrease, line width was decreased and line surface quality was improved with scan rate optimization.

关键词： Selective laser sintering Direct fabrication Fiber laser

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