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Predictability of polygenic risk score for progression to dementia and its interaction with APOEε4 in mild cognitive impairment

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Translational Neurodegeneration 2021年第3期10卷 412-420页

作者： Jung‑Min Pyun young ho park Keon‑Joo Lee SangYun Kim Andrew J.Saykin Kwangsik Nho Department of Neurology Uijeongbu Eulji Medical CenterEulji UniversityUijeongbuRepublic of Korea Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medi‑cineSeongnamRepublic of Korea Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease CenterIndiana University School of MedicineIndianapolisINUSA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisINUSA Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisINUSA.

Background:The combinatorial efect of multiple genetic factors calculated as a polygenic risk score(PRS)has been studied to predict disease progression to Alzheimer’s disease(AD)from mild cognitive impairment(MCI).Previous studies have investigated the performance of PRS in the prediction of disease progression to AD by including and excluding single nucleotide polymorphisms within the region surrounding the APOE *** studies may have missed the APOE genotype-specifc predictability of PRS for disease progression to ***:We analyzed 732 MCI from the Alzheimer’s Disease Neuroimaging Initiative cohort,including those who progressed to AD within 5 years post-baseline(n=270)and remained stable as MCI(n=462).The predictability of PRS including and excluding the APOE region(PRS_(+APOE) and PRS_(−APOE))on the conversion to AD and its interaction with the APOEε4 carrier status were assessed using Cox regression ***:PRS_(+APOE)(hazard ratio[HR]1.468,95%CI 1.335-1.615)and PRS_(−APOE)(HR 1.293,95%CI 1.157-1.445)were both associated with a signifcantly increased risk of MCI progression to *** interaction between PRS_(+APOE) and APOEε4 carrier status was signifcant with a P-value of *** association of PRSs with the progression risk was stronger in APOEε4 non-carriers(PRS_(+APOE):HR 1.710,95%CI 1.244-2.351;PRS_(−APOE):HR 1.429,95%CI 1.182-1.728)than in APOEε4 carriers(PRS_(+APOE):HR 1.167,95%CI 1.005-1.355;PRS_(−APOE):HR 1.172,95%CI 1.020-1.346).Conclusions:PRS could predict the conversion of MCI to dementia with a stronger association in APOEε4 noncarriers than APOEε4 *** indicates PRS as a potential genetic predictor particularly for MCI with no APOEε4 alleles.

关键词： Polygenic risk score Mild cognitive impairment Alzheimer’s disease Disease progression APOEε4

Rapid, simple, low-cost smartphone-based fluorescence detection of Escherichia coli

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International Journal of Agricultural and Biological Engineering 2021年第3期14卷 189-193页

作者： Dante Rojas-Barboza Edward park Rolfe Sassenfeld Jeremy Winder Geoffrey B.Smith Delia Valles-Rosalles Efren Delgado young ho park Family and Consumer Science Department New Mexico State UniversityLas CrucesNM 883003USA Biology Department University of PennsylvaniaPhiladelphiaPA 19104USA Electronics&Computer Engineering Technology New Mexico State UniversityLas CrucesNM 88003USA Biology Department New Mexico State UniversityLas CrucesNM 88003USA Industrial Engineering Department New Mexico State UniversityLas CrucesNM 88003USA Mechanical Engineering Department New Mexico State UniversityLas CrucesNM 88003USA

Food and waterborne diseases pose considerable public health threats even in highly industrialized parts of the *** of these pathogens in food can be Escherichia coli O157:H7,Salmonella sp.,and Listeria ***,reliable detection of pathogens mitigates serious health problems and economic losses due to outbreaks and robust tests safeguard the food *** this study,a smartphone-based apparatus was employed to demonstrate quantitative detection of *** validate the applicability of the present smartphone-based fluorescence device,RNA was extracted from the *** K-12 strain and amplified using two different primers(dnaK and rpoA)via quantitative polymerase chain reaction(qPCR).Serial dilutions of RNA from 10 to 0.0001 ng/μL were prepared at the start of the PCR amplification and the PCR products were detected by CYBR Green1-based *** a proof-of-concept test for the smartphone system,samples from these PCR products were then *** detection system employed a novel algorithm to analyze fluorescence signals and read changes in *** DNA *** correlations between the fluorescence percentage and DNA concentrations were R=0.945 for the dnaK primer and R=0.893 for the rpoA primer,*** this new fluorescent analysis technique resulted in comparable accuracy to the real-time PCR fluorescent signal *** key innovation of this approach was to combine efficient image processing encoded into a smartphone application with a low-cost 3-D printed device that allowed quantification of bacterial nucleic acid.

关键词： smartphone fluorescence E.coli low-cost 3D-print

Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis

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World Journal of Hepatology 2014年第2期6卷 98-106页

作者： Joo-Hyun Kim Hye-Jun Shin Hye-Lin Ha young-ho park Tae-ho Kwon Mi-Ra Jung Hyung-Bae Moon Eun-Sang Cho Hwa-young Son Dae-Yeul Yu Aging Research Center Korea Research Institute of Bioscience and Biotechnology College of Veterinary Medicine Chungnam National University Wonkwang University College of Medicine

AIM:To investigate the effect of methylsulfonylmethane(MSM), recently reported to have anti-cancer effects, in liver cancer cells and transgenic mice. METhoDS: Three liver cancer cell lines, HepG2, Huh7-Mock and Huh7-H-rasG12V, were used. Cell growth was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly(ADP-ribose) polymerase(PARP), and B-cell lymphoma2(Bcl-2) expressions. For in vivo study, we administered MSM to H-ras12V transgenic mice for 3 mo. RESULTS: MSM decreased the growth of HepG2, Huh7-Mock and Huh7-H-rasG12V cells in a dose-dependent manner. That was correlated with significantly increased apoptosis and reduced cell numbers in MSM treated cells. Cleaved caspase-8, cleaved caspase-3 and cleaved PARP were remarkably increased in the liver cancer cells treated with 500 mmol/L of MSM; however, Bcl-2 was slightly decreased in 500 mmol/L. Liver tumor development was greatly inhibited in the H-ras12V transgenic mice treated with MSM, compared to control, by showing reduced tumor size and number. Cleaved PARP was significantly increased in non-tumor treated with MSM compared to control. CONCLUSION: Liver injury was also significantly attenuated in the mice treated with MSM. Taken together, all the results suggest that MSM has anti-cancer effects through inducing apoptosis in liver cancer.

关键词： Methylsulfonylmethane Anti-cancer effects Liver cancer cells Transgenic mice Hepatic tumorigenesis

Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo young Cho Dong Hae ho Sae Byeok Jo Jeong ho Cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

SOME PERMUTING TRINOMIALS OVER FINITEFIELDS

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Acta Mathematica Scientia 1997年第3期17卷 250-254页

作者： June Bok Lee(Dept. of Math., Yonsei University, Seoul, 120-749,Korea)young ho park (Dept. of Math., Kangwon National University, Chuncheon, 200-701,Korea) Dept. of Math. Yonsei University Seoul 120-749 Korea Dept. of Math. Kangwon National University Chuncheon 200-701 Korea

Trinomial permutation polynomials of the form xr(ax2s + bxs + c) over Fq have been studied where 3|q-1 and s = (q-1)/3. We derive some necessary and sufficient conditions for these trinomials to be permutation polynomials, and construct some examples. Moreover, we discuss the relationship between permutation trinomials of the given type over a tower of finite fields.

关键词： Math SOME PERMUTING TRINOMIALS OVER FINITEFIELDS

Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： young-Joon park Bo Eun Nam Chung-Mo park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

Construction of a High‑Performance Composite Solid Electrolyte Through In‑Situ Polymerization within a Self‑Supported Porous Garnet Framework

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Nano-Micro Letters 2024年第5期16卷 56-70页

作者： An‑Giang Nguyen Min‑ho Lee Jaekook Kim Chan‑Jin park Department of Materials Science and Engineering Chonnam National University77 Yongbong‑roBuk‑guGwangju 61186South Korea

Composite solid electrolytes(CSEs)have emerged as promising candidates for safe and high-energy–density solid-state lithium metal batteries(SSLMBs).however,concurrently achieving exceptional ionic conductivity and interface compatibility between the electrolyte and electrode presents a significant challenge in the development of high-performance CSEs for *** overcome these challenges,we present a method involving the in-situ polymerization of a monomer within a self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZT)to produce the *** synergy of the continuous conductive LLZT network,well-organized polymer,and their interface can enhance the ionic conductivity of the CSE at room ***,the in-situ polymerization process can also con-struct the integration and compatibility of the solid electrolyte–solid electrode *** synthesized CSE exhibited a high ionic conductivity of 1.117 mS cm^(-1),a significant lithium transference number of 0.627,and exhibited electrochemical stability up to 5.06 V ***/Li+at 30℃.Moreover,the Li|CSE|LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cell delivered a discharge capacity of 105.1 mAh g^(-1) after 400 cycles at 0.5 C and 30℃,corresponding to a capacity retention of 61%.This methodology could be extended to a variety of ceramic,polymer electrolytes,or battery systems,thereby offering a viable strategy to improve the electrochemical properties of CSEs for high-energy–density SSLMBs.

关键词： Scalable tape-casting method Self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) Composite solid electrolyte LiF-and B-rich interphase layers

Indolocarbazole-Based Small Molecule Cathode-Active Material Exhibiting Double Redox for High-Voltage Li-Organic Batteries

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Energy & Environmental Materials 2024年第5期7卷 90-98页

作者： Hyunji park Hyojin Kye Jong-Sung Lee young-Chang Joo Dong Joo Min Bong-Gi Kim Soo young park Ji Eon Kwon Laboratory for Supramolecular Optoelectronic Materials (LSOM) Department of Materials Science and Engineering Research Institute of Advanced Materials (RIAM) Seoul National University Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite Materials Korea Institute of Science and Technology (KIST) Department of Organic and Nano System Engineering Konkuk University Department of Materials Science and Engineering Seoul National University Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University

Most organic electrode materials （OEMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited <3.0 V versus Li+/Li. however, p-type materials possessing high redox ... 详细信息

Most organic electrode materials （OEMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited however, p-type materials possessing high redox potentials experience low specific capacities because they are capable of only a single redox reaction within the stable electrochemical window of typical ***, we report 5,11-diethyl-5,11-dihydroindolo[3,2-b]carbazole （DEICZ） as a novel p-type OEM, exhibiting stable plateaus at high discharge potentials of3.44 and 4.09 V versus Li+/Li. Notably, the second redox potential of DEICZ is within the stable electrochemical window. The mechanism of the double redox reaction is investigated using both theoretical calculations and experimental measurements, including density functional theory calculations, ex situ electron spin resonance, and X-ray photoelectron spectroscopy. Finally,hybridization with single-walled carbon nanotubes （SWCNT） improves the cycle stability and rate performance of DEICZ owing to theπ–πinteractions between the SWCNT and co-planar molecular structure of DEICZ, preventing the dissolution of active materials into the electrolyte. The DEICZ/SWCNT composite electrode maintains 70.4%of its initial specific capacity at 1-C rate and also exhibits high-rate capability, even performing well at 100-C rate.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem Solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun Kyung Hwang Ik Jae park Se Won Seo Jae Hyun park So Jeong park Jin young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control