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Recurrent massive bleeding due to dissecting intramural hematoma of the esophagus: Treatment with therapeutic angiography

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World Journal of Gastroenterology 2009年第41期15卷 5232-5235页

作者： Jaejun Shim Jae young Jang young Hwangbo Seok Ho Dong Joo Hyeong Oh Hyo Jong Kim Byung-Ho Kim young woon chang Rin chang Department of Internal Medicine Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoongu Seoul 130-702 South Korea Department of Diagnostic Radiology Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoon-gu Seoul 130-702 South Korea

Spontaneous or traumatic intramural bleeding of the esophagus, which is often associated with overlying mucosal dissection, constitutes a rare spectrum of esophageal injury called dissecting intramural hematoma of the esophagus (DIHE). Chest pain, swallowing diffi culty, and minor hematemesis are common, which resolve spontaneously in most cases. This case report describes a patient with spontaneous DIHE with recurrent massive bleeding which required critical management and highlights a potential role for therapeutic angiography as an alternative to surgery.

关键词： Esophagus Intramural hematoma Therapeutic angiography

Oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor: A case report

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World Journal of Gastroenterology 2015年第16期21卷 5099-5104页

作者： Tae-In Lee Jae-young Jang Seungmin Kim Jung-Wook Kim young-woon chang Youn-Wha Kim Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee University Department of Pathology College of MedicineKyung Hee University

Gastric adenocarcinoma is one of the most common malignancies *** and immunohistologic analyses classify the phenotypes of gastric adenocarcinoma into several groups based on the variable clinical and pathologic features.A new and rare variant of gastric adenocarcinoma with chief cell differentiation(GA-CCD)has recently been *** reporting the distinct clinicopathologic characteristics proposed the term oxyntic gland polyp/adenoma because of the benign nature of the ***,GA-CCD is a solitary mucosal lesion that develops either in the gastric cardia or ***,this lesion is characterized by tightly clustered glands and anastomosing cords of chief ***,GA-CCD is diffusely positive for mucin(MUC)6 and negative for MUC2and ***,other gastric tumors such as a gastric neuroendocrine tumor or fundic gland polyp have been difficult to *** GA-CCD tends to be endoscopically misdiagnosed as a neuroendocrine tumor or fundic gland polyp,comprehensive assessment and observation by an endoscopist are strongly ***,we report a rare case of oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor that was successfully removed by endoscopic mucosal resection.

关键词： Chief cell differentiation Gastric carcinoma Mucin 6 Neuroendocrine tumor Oxyntic gland adenoma

Recurrent gastric neuroendocrine tumors treated with total gastrectomy

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World Journal of Gastroenterology 2015年第46期21卷 13195-13200页

作者： Myounghwa Jung Jung-Wook Kim Jae-young Jang young woon chang Sun Hee Park Yong Ho Kim Youn Wha Kim Department of Internal Medicine College of MedicineKyung Hee University Department of Surgery College of MedicineKyung Hee University Department of Pathology College of MedicineKyung Hee University

Gastric neuroendocrine tumors are rare; however,the incidence has recently increased due to the increasing use of upper endoscopy. Neuroendocrine tumors arise from the excess proliferation of enterochromaffinlike(ECL) cells. The proliferative changes of enterochromaffin cells evolve through a hyperplasiadysplasia-neoplasia sequence that is believed to underlie the pathogenesis of gastric neuroendocrine tumors. Endoscopic resection is recommended as the initial treatment if the tumor is not in an advanced stage. However,there is no definite guideline for the treatment of recurrent gastric neuroendocrine tumors following endoscopic resection. Here,we report a rare case of gastric neuroendocrine tumors in a 56-yearold male who experienced two recurrences within 11 years after endoscopic resection. The patient finally underwent a total gastrectomy. The pathological features of the resected stomach exhibited the full hyperplasia-dysplasia-neoplasia sequence of the ECL cells in a single specimen.

关键词： Neuroendocrine tumor Hyperplasia of neuroendocrine

A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer

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World Journal of Gastroenterology 2006年第40期12卷 6536-6539页

作者： Sun young Yi woon Jung Lee Department of Internal Medicine and Medical Research Center College of Medicine Ewha Womans University Seoul Korea

AIM: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients. METHODS: DNA was extracted from blood samples of gastric cancer patients (n = 291) and controls (n = 216). In the p53 codon 72 genotypes were determined by ***: Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P = 0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine) allele (P = 0.038) than EGC and a similar Pro/Pro allele. The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P = 0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI, 1.3-15.4, P = 0.039) when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI, 1.8-19.6, P = 0.021). CONCLUSION: The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC.

关键词： p53 gene Polymorphism Gastric cancer

Preparation and characterization of SMA/S-POSS hybrid membranes for direct methanol fuel cell applications

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Rare Metals 2006年第Z1期25卷 224-228页

作者： chang young-wook Department of Chemical Engineering Hanyang University AnSan 425-791 South Korea

A novel sulfonated polyhedral oligomeric silsesquioxane(S-POSS) monomer was synthesized successfully in this article. S-POSS acted as a donor of sulfonic acid group and reacted with poly(styrene-co-maleic anhydride) (SMA). FT-IR spectroscopy confirmed the modification through introduction of peaks characteristic of ester linkages and carboxylic groups. The SMA/S-POSS hybrid membranes were fabricated from different S-POSS contents. The proton conductivity and methanol permeability of the hybrid membranes were studied with changing S-POSS content from 5wt.% to 30wt.%. It was found that the proton conductivity and the methanol permeability were dependent on the S-POSS content. Both of proton conductivity and methanol permeability properties improve with increasing S-POSS content. The proton conductivities of the hybrid membranes are in the range of 10-3-10-2 S·cm-1, and the range of methanol permeabilities was between 10-8 and 10-7 cm2·s-1. The membranes show good thermal properties characterized by thermogravimetric analysis (TGA).

关键词： SMA sulfonated polyhedral oligomeric silsesquioxane proton conductivity methanol permeability

Bi-directional and concurrent proof of ownership for stronger storage services with de-duplication

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Science China(Information Sciences) 2018年第3期61卷 84-94页

作者： Taek-young YOUN Ku-young chang Electronics and Telecommunications Research Institute

In storage service, data de-duplication is a specialized technique for eliminating duplicate copies of repeating data in storage. Especially, client-side de-duplication has more merits than server-side deduplication since they can improve both the space efficiency and the communication bandwidth. For secure client-side de-duplication, we need a way to prove the ownership of a file to be stored. In the upload step,the server should verify the ownership of a client to give the right of the file without uploading it. On the contrary, the client also want to verify the retrievability for the file since he will delete it from his storage after protocol execution. Existing proof of ownership techniques have been designed for server's need. In this paper, we first point out that we need the second property in client's view point, and give a very simple and practical solution which can support the server and the client to prove that they have the same file. We first describe a generic strategy which can help us to construction a bi-directional and concurrent proof of ownership technique from an ordinary proof of ownership technique, and then give an efficient hash-based scheme with security proof in the random oracle model.

关键词： cloud storage secure de-duplication data out-source proof of ownership bi-directional and concurrent proof

Room-temperature giant magnetotranstance effect in single-phase multiferroics

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Science China(Physics,Mechanics & Astronomy) 2021年第3期64卷 105-110页

作者： Yan-Fen chang young Sun Beijing National Laboratory for Condensed Matter Physics and Beijing Advanced Innovation Center for Materials Genome Engineering Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Science University of Chinese Academy of SciencesBeijing 100190China Center of Quantum Materials and Devices Chongqing UniversityChongqing 401331China

Single-phase multiferroic materials are usually considered useless because of the weak magnetoelectric effects,low operating temperature,and small electric polarization induced by magnetic *** a result,current studies on applications of the magnetoelectric effects are mainly focusing on multiferroic heterostructures and *** we report a room-temperature giant effect in response to external magnetic fields in single-phase multiferroics.A low magnetic field of 1000 Oe applied on the spin-driven multiferroic hexaferrites BaSrCo_(2) Fe_(11)AlO_(22) and Ba_(0.9)Sr_(1.1)Co_(2) Fe_(11)AlO_(22)is able to cause a huge change in the linear magnetoelectric coefficient(α_(E)=dE/dH) by several orders,leading to a giant magnetotranstance(GMT) effect at room *** GMT effect is comparable to the well-known giant magnetoresistance(GMR) effect in magnetic multilayers,and thus opens up a door toward practical applications for single-phase multiferroics.

关键词： multiferroic magnetoelectric effect transtor

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu chang Lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Two-stage dynamic recrystallization and texture evolution in Al-7Mg alloy during hot torsion

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1900-1911页

作者： Kwang Tae Son chang Hee Cho Myoung Gyun Kim Ji woon Lee School of Mechanical Industrialand Manufacturing EngineeringOregon State UniversityCorvallis OR 97331USA Department of Materials Science Engineering Northwestern UniversityEvanston IL 60208USA Research Institute of Industrial Science and Technology(RIST) Pohang 37673Rep.of Korea Division of Advanced Materials Engineering Kongju National UniversityCheonan 31080Rep.of Korea Center for Advanced Materials and Parts of Powders Kongju National UniversityCheonan 31080Rep.of Korea

Hot torsion tests were performed on the Al-7Mg alloy at the temperature ranging from 300 to 500℃ and strain rates between 0.05 and 5 s^(-1) to explore the progressive dynamic recrystallization(DRX)and texture *** DRX behavior of the alloy manifested two distinct stages:Stage 1 at strain of≤2 and Stage 2 at strains of≥*** Stage 1,there was a slight increase in the DRXed grain fraction(X_(DRX))with predominance of discontinuous DRX(DDRX),followed by a modest change in X_(DRX) until the transition to Stage *** 2 was marked by an accelerated rate of DRX,culminating in a substantial final X_(DRX) of~*** backscattered diffraction(EBSD)analysis on a sample in Stage 2 revealed that continuous DRX(CDRX)predominantly occurred within the(121)[001]grains,whereas the(111)[110]grains underwent a geometric DRX(GDRX)evolution without a noticeable sub-grain ***,a modified Avrami’s DRX kinetics model was utilized to predict the microstructural refinement in the Al-7Mg alloy during the DRX *** this kinetics model did not accurately capture the DDRX behavior in Stage 1,it effectively simulated the DRX rate in Stage *** texture index was employed to assess the evolution of the texture isotropy during hot-torsion test,demonstrating significant improvement(>75%)in texture randomness before the commencement of Stage *** initial texture evolution is attributed to the rotation of parent grains and the substructure evolution,rather than to an increase in X_(DRX).

关键词： Al-7Mg alloys hot deformation hot torsion tests dynamic recrystazlliation microstructure texture