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Role of oxygen free radicals in patients with acute pancreatitis

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World Journal of Gastroenterology 2003年第10期9卷 2266-2269页

作者： Byung Kyu Park Jae Bock Chung Jin Heon Lee Jeong Hun Suh Seung woo Park Si young Song Hyeyoung Kim Kyung Hwan Kim Jin Kyung kang Department of Internal Medicine Institute of GastroenterologyCollege of MedicineYonsei UniversitySeoulKorea Department of Pharmacology College of MedicineYonsei UniversitySeoulKorea Departmentof Internal Medicine Institute of GastroenterologyCollege of MedicineYonsei UniversitySeoulKorea

AIM:The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis. METHODS:The plasma levels of C-reactive protein(CRP), lipid peroxide(LPO),myeloperoxidase(MPO)and superoxide dismutase(SOD)were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. RESULTS:Among the patients with acute pancreatitis,there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild ***,there was no significant difference in the serum marker of oxidative stress no matter what the etiology *** LPO level was especially correlated with the concentration of serum CRP and CT severity index. CONCLUSION:The oxygen free radicals may be closely associated with inflammatory process and the severity of acute ***,the concentration of plasma LPO is a meaningful index for determining the severity of the disease.

关键词： Oxidative Stress Severity of Illness Index Acute Disease Adult Aged Female Humans Lipid Peroxides Male Middle Aged Pancreatitis Peroxidase Predictive Value of Tests Prognosis Reactive Oxygen Species Superoxide Dismutase

^(27)Al MAS-NMR study of inorganic polymer formation at ambient temperature

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 182-187页

作者： Sang-wook AHN Hee-Soo LEE Wan-Hee YANG Jung-woo LEE young-Keun JEONG National Core Research Center for Hybrid Materials Solution Pusan National University School of Material Science and Engineering Pusan National University INTChem Co. Ltd.

Inorganic polymers are a novel class of materials formed by the polymerization of silicon, aluminium and oxygen species to form an amorphous three-dimensional framework structure. The basis of this process is the alkaline solutions to induce a certain amount of Si and AI atoms to dissolve from a feedstock such as aluminosilicate. A study of 27A1 MAS-NMR was carried out in an attempt to understand the reaction mechanism of the inorganic polymerization at ambient temperature. Scanning electron microscopy （SEM） and X-ray diflYactometry （XRD） were also employed to establish the composition and microstructure of the inorganic polymerization. Specimens were prepared with different A1/Si mole ratios from the starting materials. The higher the AI content, the more sufficient the AI atoms that can combine with SiO4, and the longer the reaction time, the more the bonded Si--O--A1--O polymer structure, and then the higher the A1 content, the fewer the octahedral A1 with a uniform Si--O--A1--O structure in four directions, because four AI atoms are combined with SiO4, resulting in a uniform Si--O--AI--O structure in four directions. The results show that they have an amorphous microstructure.

关键词： inorganic polymer amorphous tetrahedral

Super-resolution localization photoacoustic microscopy using intrinsic red blood cells as contrast absorbers

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Light(Science & Applications) 2019年第1期8卷 212-222页

作者： Jongbeom Kim Jin young Kim Seungwan Jeon Jin woo BAIK Seong Hee Cho Chulhong Kim Departments of Creative IT Engineering Electrical EngineeringMechanical Engineeringand Interdisciplinary Bioscience and BioengineeringPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea

Photoacoustic microscopy(PAM)has become a premier microscopy tool that can provide the anatomical,functional,and molecular information of animals and humans in ***,conventional PAM systems suffer from limited temporal and/or spatial ***,we present a fast PAM system and an agent-free localization method based on a stable and commercial galvanometer scanner with a custom-made scanning mirror(L-PAM-GS).This novel hardware implementation enhances the temporal resolution significantly while maintaining a high signal-to-noise ratio(SNR).These improvements allow us to photoacoustically and noninvasively observe the microvasculatures of small animals and humans in ***,the functional hemodynamics,namely,the blood flow rate in the microvasculature,is successfully monitored and quantified in *** importantly,thanks to the high SNR and fast B-mode rate(500 Hz),by localizing photoacoustic signals from captured red blood cells without any contrast agent,unresolved microvessels are clearly distinguished,and the spatial resolution is improved by a factor of 2.5 in ***-GS has great potential in various fields,such as neurology,oncology,and pathology.

关键词： resolution absorber scanner

Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up

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World Journal of Gastroenterology 2004年第2期10卷 223-226页

作者： Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon young Myoung Moon Jin Kyung kang In-Suh Park Chang Ok Suh woo Ik Yang Division of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoulSouth Korea Department of Internal Medicine NHIC Ilsan HospitalIlsanSouth Korea Department of Radiation Oncology Yonsei University College of MedicineSeoulSouth Korea Department of Pathology Yonsei University College of MedicineSeoulSouth Korea

AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities. METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed. RESULTS:Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori (Hpylori) regimen *** duration to reach complete remission was 12 months (85 percentile,2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases. CONCLUSION:Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloriinfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication.

关键词： Adult Aged Endoscopy, Digestive System Follow-Up Studies Gastric Mucosa Helicobacter Infections Helicobacter pylori Humans Lymphoma, Mucosa-Associated Lymphoid Tissue Middle Aged Pyloric Antrum Remission Induction Retrospective Studies Stomach Ulcer

Hybrid energy harvesting systems for self-powered sustainable water purification by harnessing ambient energy

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Frontiers of Environmental Science & Engineering 2023年第10期17卷 1-16页

作者： Zhengyang Huo young Jun Kim Yuying Chen Tianyang Song Yang Yang Qingbin Yuan Sang woo Kim School of Environment and Natural Resources Renmin University of ChinaBeijing 100872China School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China Institute of Scientific and Technical Information of China Beijing 100038China

The development of self-powered water purification technologies for decentralized applications is crucial for ensuring the provision of drinking water in resource-limited regions. The elimination of the dependence on external energy inputs and the attainment of self-powered status significantly expands the applicability of the treatment system in real-world scenarios. Hybrid energy harvesters, which convert multiple ambient energies simultaneously, show the potential to drive self-powered water purification facilities under fluctuating actual conditions. Here, we propose recent advancements in hybrid energy systems that simultaneously harvest various ambient energies (e.g., photo irradiation, flow kinetic, thermal, and vibration) to drive water purification processes. The mechanisms of various energy harvesters and point-of-use water purification treatments are first outlined. Then we summarize the hybrid energy harvesters that can drive water purification treatment. These hybrid energy harvesters are based on the mechanisms of mechanical and photovoltaic, mechanical and thermal, and thermal and photovoltaic effects. This review provides a comprehensive understanding of the potential for advancing beyond the current state-of-the-art of hybrid energy harvester-driven water treatment processes. Future endeavors should focus on improving catalyst efficiency and developing sustainable hybrid energy harvesters to drive self-powered treatments under unstable conditions (e.g., fluctuating temperatures and humidity).

关键词： Piezocatalysis Solar energy Waste heat Decentralized water treatment Point-of-use Nanogenerator

Electrocatalytic and stoichiometric reactivity of 2D layered siloxene for high-energy-dense lithium-sulfur batteries

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Carbon Energy 2021年第6期3卷 976-990页

作者： Hui-Ju kang Jae-woo Park Hyun Jin Hwang Heejin Kim Kwang-Suk Jang Xiulei Ji Hae Jin Kim Won Bin Im young-Si Jun Department of Advanced Chemicals&Engineering Chonnam National UniversityGwangjuRepublic of Korea Division of Analytical Science Korea Basic Science Institute(KBSI)DaejeonRepublic of Korea Department of Applied Chemistry Hanyang UniversityAnsanGyeonggi-doRepublic of Korea Department of Chemistry Oregon State UniversityCorvallisOregonUSA Division of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea

Lithium-sulfur batteries(LSBs)have emerged as promising power sources for high-performance devices such as electric ***,the poor energy density of LSBs owing to polysulfide shuttling and passivation has limited their further market *** mitigate this challenge,two-dimensional(2D)siloxene(2DSi),a Si-based analog of graphene,is utilized as an additive for sulfur *** 2DSi is fabricated on a large scale by simple solvent extraction of calcium disilicide to form a thin-layered structure of Si planes functionalized with vertically aligned hydroxyl groups in the *** stoichiometric reaction of 2DSi with polysulfides generates a thiosulfate redox mediator,secures the intercalation pathway,and reveals Lewis acidic sites within the siloxene *** 2DSi utilizes the corresponding in-situ-formed electrocatalyst,the 2D confinement effect of the layered structure,and the surface affinity based on Lewis acid-base interaction to improve the energy density of 2DSi-based LSB *** with the commercial carbon-based current collector,2DSi-based LSB cells achieve a volumetric energy density of 612 Wh Lcell^(−1) at 1 mA cm^(−2) with minor degradation of 0.17%per cycle,which rivals those of state-of-the-art *** study presents a method for the industrial production of high-energy-dense LSBs.

关键词： 2D confinement effects Lewis acid-base interactions lithium-sulfur batteries siloxenes thiosulfate-polythionate redox couple

Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第43期18卷 6284-6289页

作者： Se young Jang Hyun Gu Park Min Kyu Jung Chang Min Cho Soo young Park Seong woo Jeon Won young Tak young Oh Kweon Sung Kook Kim young Hoon Jeon Department of Internal Medicine Kyungpook National University School of Medicine Daegu 700-721 South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University School of Dentistry Daegu 700-721 South Korea

AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and 30 November 2010. This was a randomized cross-over study, in which each patient underwent ERCP twice, once with BIS monitoring and once with control monitoring. Whether BIS monitoring was done during the first or second ERCP procedure was random. Patients were intermittently administered a mixed regimen including midazolam, pethidine, and propofol by trained nurses. The nurse used a routine practice to monitor sedation using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale or the BIS monitoring. The total amount of midazolam and propofol used and serious side effects were compared between the BIS and control groups. RESULTS:The mean total propofol dose administered was 53.1 ± 32.2 mg in the BIS group and 54.9 ± 30.8 mg in the control group (P = 0.673). The individual propofol dose received per minute during the ERCP procedure was 2.90 ± 1.83 mg/min in the BIS group and 3.44 ± 2.04 mg in the control group (P = 0.103). The median value of the MOAA/S score during the maintenance phase of sedation was comparable for the two groups. The mean BIS values throughout the procedure (from insertion to removal of the endoscope) were 76.5 ± 8.7 for all 59 patients in using the BIS monitor. No significant differences in the frequency of < 80% oxygen saturation, hypotension (< 80 mmHg), or bradycardia (< 50 beats/min) were observed between the two study groups. Four cases of poor cooperation occurred, in which the procedure should be stopped to add the propofol dose. After adding the propofol, the procedure could be conducted successfully (one case in the BIS group, three cases in the control group). The endoscopist rated patient sedation as exc

关键词： Conscious sedation Bispectral index monitors Pancreatic neoplasm Endoscopic retrograde cholangiopancreatography

AKT regulates IL-1β-induced proliferation and activation of hepatic stellate cells

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BIOCELL 2023年第3期47卷 669-676页

作者： YONGDAE YOON SOONJAE HWANG FATEMA TUJ SAIMA MOON young KIM SOON KOO BAIK young woo EOM Regeneration Medicine Research Center Yonsei University Wonju College of MedicineWonju26426Korea Department of Biochemistry Lee Gil Ya Cancer and Diabetes InstituteGAISTGachon University College of MedicineIncheon21999Korea Cell Therapy and Tissue Engineering Center Yonsei University Wonju College of MedicineWonju26426Korea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju26426Korea

Background:Activated hepatic stellate cells(HSCs)are closely involved in the initiation,perpetuation,and resolution of liver ***-inflammatory cytokine levels are positively correlated with the transition from liver injury to fibrogenesis and contribute to HSC pathophysiology in liver ***:In this study,we investigated the effect of the pro-inflammatory cytokine interleukin(IL)-1βon the proliferation and signaling pathways involved in fibrogenesis in LX-2 cells,an HSC cell line,using western blotting and cell proliferation ***:IL-1βincreased the proliferation rate andα-smooth muscle actin(SMA)expression of LX-2 cells in a dose-dependent *** 1 h after IL-1βtreatment,c-Jun N-terminal kinase(JNK),p38,and nuclear factor-κB(NF-κB)signaling was activated in LX-2 ***,protein kinase B(AKT)phosphorylation and an increase inα-SMA expression were observed in LX-2 *** inhibitor of JNK,p38,or NF-κB decreased cell proliferation,AKT phosphorylation,andα-SMA expression in IL-1β-treated LX-2 ***:These results indicate that JNK,p38,and NF-κB signals converge at AKT phosphorylation,leading to LX-2 activation by IL-1β.Therefore,the AKT signaling pathway can be used as a target for alleviating liver fibrosis by the inflammatory cytokine IL-1β.

关键词： Hepatic stellate cell Interleukin-1β AKT Cell proliferation Fibrosis

Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel

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China Foundry 2010年第2期7卷 178-182页

作者： Youn-Soo Ham Jeong-Tae Kim Si-young Kwak Jeong-Kil Choi woo-young Yoon Daeyang R-Tech.Co. Ltd290-28Daehwa-DongDaeduk-GuDaejeonKorea e-Design Center KITECH7-47Songdo-DongYeonsu-GuIncheon 406-800Korea Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul 136-701Korea

Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy,image analyzer and numerical *** efficient heat treatment analysis program including temperature-dependent material properties was developed for the prediction of cooling rate and probability of carbide precipitation during quenching by finite difference ***-dependent heat transfer coefficient was adopted to achieve more precise *** ratio of carbide precipitation was measured by image analyzer to determine the critical point of carbide ***-dependent critical cooling rate at that point was calculated by the developed numerical ***,the probability of carbide precipitation on the whole area of specimen can be predicted by the proposed numerical program and the numerical result of a specimen was compared with the experimental result.

关键词： austenitic manganese steel carbide precipitation quenching critical cooling rate