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Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

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中国有色金属学会会刊：英文版 2009年第B9期19卷 271-275页

作者： Jeong-soo LEE young-soo RYU Nam-In KIM Bong-Joon KIM Yoo-Kyung KIM Myung-Hyun KIM Hanjin Heavy Industries & Construction Co. Ltd Department of Naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

Chemical composition and antioxidant capacity of the aqueous extract of Phellodendron amurense

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Journal of Forestry Research 2018年第4期29卷 1033-1040页

作者： Natarajan Velmurugan Duraisamy Kalpana Jae young Cho Yang soo Lee Department of Forestry College of Agriculture and Life Sciences Chonbuk National University Jeonju 54896 Republic of Korea Branch Laboratory-Itanagar CSIR-North East Institute of Science and Technology Naharlagun Arunachal Pradesh 791 110 India Department of Agricultural Chemistry Chonbuk National University Jeonju 54896 Republic of Korea

The aqueous extract of Phellodendron amurense Rupr. （Amur Cork Tree） provides a rich source of antioxidants and chemical compounds, and can be used for food and wood preservative materials. In this study, we characterized the chemical composition of this extract by GC and GC/MS. The antioxidant capacity was evaluated using a variety of antioxidant assays （superoxide radical, hydroxyl radical, nitric oxide radical, and DPPH radical scavenging activity）. Additionally, total polyphenolic content was determined. Phenolic acids and acetone derivatives were major compounds of the extract capable of scavenging the DPPH free radical and reducing ferric ions. DPPH and ferric ion reduction results were strongly correlated with total phenolic content of the extract which also exhibited strong nitric oxide, hydroxyl radical scavenging and superoxide anion radical scavenging activities.

关键词： Phellodendron amurense Aqueous extract Chemical characterization Antioxidant activity

Map-based control method for vehicle stability enhancement

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Journal of Central South University 2015年第1期22卷 114-120页

作者： Moon-young yoon Seung-Hwan Baek Kwang-Suk Boo Heung-Seob Kim Graduate school of Mechanical Engineering Inje University 607 High Safety Vehicle Core Technology Research Center Inje University 607

This work proposes a map-based control method to improve a vehicle's lateral stability, and the performance of the proposed method is compared with that of the conventional model-referenced control method. Model-referenced control uses the sliding mode method to determine the compensated yaw moment; in contrast, the proposed map-based control uses the compensated yaw moment map acquired by vehicle stability analysis. The vehicle stability region is calculated by a topological method based on the trajectory reversal method. A 2-DOF vehicle model and Pacejka's tire model are used to evaluate the proposed map-based control method. The properties of model-referenced control and map-based control are compared under various road conditions and driving inputs. Model-referenced control uses a control input to satisfy the linear reference model, and it generates unnecessary tire lateral forces that may lead to worse performance than an uncontrolled vehicle with step steering input on a road with a low friction coefficient. However, map-based control determines a compensated yaw moment to maintain the vehicle within the stability region,so the typical responses of vehicle enable to converge rapidly. The simulation results with sine and step steering show that map-based control provides better the tracking responsibility and control performance than model-referenced control.

关键词： model-referenced control map-based control vehicle stability yaw moment

Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun Kang Dong Ho Lee Dong Hyun Oh Hyuk yoon Cheol Min Shin young soo Park Nayoung Kim Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

ASpediaFI:Functional Interaction Analysis of Alternative Splicing Events

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 466-482页

作者： Kyubin Lee Doyeong Yu Daejin Hyung soo young Cho Charny Park Bioinformatics Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea

Alternative splicing(AS)regulates biological processes governing phenotypes and *** AS(DAS)gene test methods have been developed to investigate important exonic expression from high-throughput ***,the DAS events extracted using statistical tests are insufficient to delineate relevant biological *** this study,we developed a novel application,Alternative Splicing Encyclopedia:Functional Interaction(ASpediaFI),to systemically identify DAS events and co-regulated genes and *** establishes a heterogeneous interaction network of genes and their feature nodes(i.e.,AS events and pathways)connected by coexpression or pathway gene set ***,ASpediaFI explores the interaction network using the random walk with restart algorithm and interrogates the proximity from a query gene ***,ASpediaFI extracts significant AS events,genes,and *** evaluate the performance of our method,we simulated RNA sequencing(RNA-seq)datasets to consider various conditions of sequencing depth and sample *** performance was compared with that of other ***,we analyzed three public datasets of cancer patients or cell lines to evaluate how well ASpediaFI detects biologically relevant *** exhibits strong performance in both simulated and public *** integrative approach reveals that DAS events that recognize a global co-expression network and relevant pathways determine the functional importance of spliced genes in the *** is publicly available at https://***/packages/ASpediaFI.

关键词： Alternative splicing RNA-seq Heterogeneous interaction network Random walk with restart Gene set enrichment analysis

Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome

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World Journal of Gastroenterology 2009年第15期15卷 1869-1875页

作者： Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji young Park Byung Kwan Son Seong Hwan Kim yoon Ju Jo young sook Park Yong soo Kim Department of Internal Medicine Eulji University School of Medicine Department of Radiology Eulji University School of Medicine Department of Family Medicine Eulji University School of Medicine Department of Occupational and Environmental Medicine College of MedicineSoonchunhyang University Department of Radiology Hanyang University School of Medicine

AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and *** pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on *** a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid *** incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal *** pancreas also showed a strong correlation with metabolic syndrome.

关键词： Fatty pancreas Metabolic syndrome Insulin resistance

Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea

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World Journal of Gastroenterology 2012年第16期18卷 1946-1952页

作者： Hana Park Jin young yoon Kyeong Hye Park Do young Kim Sang Hoon Ahn Kwang-Hyub Han Chae yoon Chon Jun Yong Park Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Brain South Korea 21 Project for Medical Science Seoul 120-752South Korea

AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and ***:We analyzed 67 patients with BCS between June 1988 and May *** diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or *** median follow-up period was 103 ± 156 [interquartile range(IQR)] ***:The median age of the patients was 47 ± 16(IQR) *** diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class *** the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 *** patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 ***:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South *** HVPG is expected to provide additional information for predicting HCC development in BCS patients.

关键词： Budd-Chiari syndrome Hepatocellular carcinoma Prognosis

Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 90-97页

作者： Vo-Van Giau yoon-Hee Park Kyu-Hwan Shim Sang-Wook Son Seong-soo A. An Department of Bionanotechnology and Gachon Medical Research Institute Gachon University and Gachon Medical Research Institute Seongnam Korea Laboratory of Cell Signaling and Nanomedicine Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science Korea University College of Medicine Seoul Korea

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomatcrial's surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography-mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

关键词： ZnONPs nanoparticles protein corona ClueGO

Reconstruction of the lower back wound with delayed infection after spinal surgery:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6646-6652页

作者： DoWon Kim sooA Lim SuRak Eo Jung soo yoon Department of Plastic and Reconstructive Surgery DongGuk University Ilsan HospitalGoyang 10326South Korea

BACKGROUND Orthopedic surgeries after device implantation are susceptible to infections and may require device removal in the worst *** this reason,many efforts are being made to control infections after spinal surgery;however,the number of infec-tion cases is increasing owing to the increasing number of elderly *** SUMMARY A 75-year-old male with a chronic spinal defect due to previous spine surgery underwent reconstruction using a perforator-based island *** bursectomy and confirmation that there was no connection with the deep tissue,reconstruction was ***,wound disruption occurred with abscess formation on postoperative day 29,which led to an imaging workup revealing delayed deep tissue *** Infection is one of the most common causes of surgical wound dehiscence and is associated with devastating results if not controlled promptly and *** should always suspect delayed infections when reconstructing chronic soft tissue defects.

关键词： Surgical wound dehiscence Surgical wound infection Lumbar spine Complications Abscess Case report