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Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma

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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho Choi Hyo Won Lee Kyung Yul Hur Jae Joon Kim Gyeong-Sin Park Si-Hyong Jang young soo song Ki-Seok Jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi soo-Ho Choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Discrete Numerical Study on Type II Fracture of Partially Detached Concrete Panels in Cold Region

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Structural Durability & Health Monitoring 2025年第1期19卷 167-191页

作者： Huayi Zhang Maobin song Lei Shen Nizar Faisal Alkayem Maosen Cao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210024China Haihe River Huaihe River and Xiaoqinghe River Basin Water Conservancy Management and Service Center of Shandong ProvinceJinan250100China College of Mechanics and Engineering Science Hohai UniversityNanjing211100China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-ﬁlled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during con-struction,the inﬂuence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefﬁcient on the bending stiffness are analyzed parametrically by the numerical simula-tion technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placementﬁrst and then prestress-tensioning is proposed.

关键词： Beam-string structure(BSS) concrete-ﬁlled steel tube(CFST) bending stiffness timing of concrete placement prestress-tensioning

Interaction of Streamwise and Wall-Normal Velocities in Combined Wave-Current Motion

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China Ocean Engineering 2005年第4期19卷 557-570页

作者： In-soo KIM Daniel S.KOH young-Chae song Division of Construction and Environmental Engineering College of EngineeringKorea Maritime University Busan606791Korea

The aim of this paper is to present an analytical expression for the streamwise velocity distribution in a non-uniform flow in the presence of waves; the correlation between the horizontal and vertical velocity components has been compreheusively examined. Different from previous researches which attributed the deviation of velocity from the classical log-law to the wave Reynolds stress, i.e. - ρ uv^- only, this study demonstrates that the momentum flux caused by mean velocities, i.e., u^- and v^-, is also responsible for the velocity deviation, and it is found that the streamwise velocity for a flow in the presence of non-zero wall-normal velocity does not follow the classical log-law, but the modified log-law proposed in this study based on simplified mixing-length theorem. The validity of the modified log-law has been verified by use of available experimental data from published sources for combined wave-current flows, and good agreement between the predicted and observed velocity profiles has been achieved.

关键词： streamwise velocity distribution wave-current flow Reynolds shear stress non-zero wall-normal velocity

Fabrication of Near Net Shape Metallic Foam via Plaster Mould

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Journal of Materials Science & Technology 2008年第3期24卷 335-339页

作者： young-Hwan song Hwan-Goo Seon soo-Han Parka Min-Jae Jeong Bo-young Hur i-Cube Center School of Nano and Advanced Materials EngineeringGyeongsang National University ERIC School of Nano and Advanced Materials EngineeringGyeongsang National University

Fabrication characteristics are unstable in direct foaming method. Therefore, most of near net-shape metallic foams are produced, and investigated by powder metallurgy. Direct foaming method, however, has many benefits （i.e. reduce the unit cost of goods and fabrication process etc.） to fabrication of metallic foams. In this article, the fabrication characteristic of near net-shape metallic foams by direct foaming method was evaluated. Al and Plaster was used for base material and mould material respectively. Ca and TiH2 were added to molten Al as thickening and blowing agent for stable condition of bubbles. Thickening time was about 10 min with a stirring speed of 600 r/min. Foaming time was 30-120 s for evaluation of the optimum foaming condition. Amount of agent was selected by pre-experimental data. Porosity of near net-shape goods was measured by Archimedes method. On the other hand, it seems that increasing poring time and thickening agent make the poor porosity

关键词： Metal foam Near net shape foam Porosity

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Refining the American Urological Association and American Society for Radiation Oncology guideline for adjuvant radiotherapy after radical prostatectomy using the pathologic Gleason score

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Asian Journal of Andrology 2017年第1期19卷 20-25页

作者： Wan song young Suk Kwon Seong soo Jeon Isaac Yi Kim Section of Urologic Oncology Rutgers Cancer Institute of New Jersey Rutgers The State University of New Jersey New Brunswick NJ 08903 USA Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea.

Recently, it has been suggested that the guideline for adjuvant radiotherapy （ART） following radical prostatectomy （RP） sponsored by the American Urological Association and American Society for Radiation Oncology （AUA/ASTRO） may result in a significant overtreatment. Thus, the objective of the present study was to refine the AUA/ASTRO guideline for ART in patients at risk for biochemical recurrence （BCR） after RP. To this end, we reviewed our prospectively maintained database and selected 193 patients who met the AUA/ASTRO ART criteria. With a median follow-up of 24.0 months, BCR rate was 17.6% （34/193）. When stratified by the Gleason score, BCR rate in men with Gleason score 6 was 6.8%. There was no significant association between BCR-free survival and surgical margin （P= 0.690） and pathologic stage （P= 0.353） in patients with the Gleason score 6. However, in patients with positive surgical margins （PSMs）/pathologic stage ≥T3, there was a significant difference in BCR-free survival according to Gleason score （≤7 vs8-10, P= 0.047）. Multivariate Cox regression analysis demonstrated that pathologic stage ≥T3 （HR = 2.106; P = 0.018）, PSMs （HR = 2.411; P = 0.003）, and pathologic Gleason score 8-10 （HR = 4.715; P 〈 0.001） were independent predictors of BCR after RP. Therefore, in addition to pathologic stage 〉T3 and PSMs, Gleason score 8-10 predicts 8CR after RP. In patients with Gleason score 6, observation rather than ART may be more appropriate regardless of stage and surgical margin status.

关键词： adjuvant radiotherapy biochemical recurrence radical prostatectomy

SEDIMENT TRANSPORT CAPACITY-AN IMPROVED BAGNOLD FORMULA

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International Journal of Sediment Research 2007年第1期22卷 27-38页

作者： Sung-Cheol KOH In-soo KIM young-Chae song

This paper re-examines Bagnold’s theorem of sediment transport. Different from the stream power defined by Bagnold, i.e., τoV, this study shows that the total load of sediment-laden flow, gt, is related to near bed energy dissipation rate, i.e., τou*’. An attempt is made to explain the empirical relation. The ratio (=k) of measured total load, gt, to the product of near bed velocity, u*’, and energy dissipation rate, τou*’, is analyzed. It is found that k is independent of the Rouse number, Z, if Z is greater than 2.6, but the coefficient k decreases with the increase of Z when Z < 2.6. An empirical relation between k and Z is developed. A systematic and thorough analysis of 1,458 sets of data collected from 16 rivers and canals confirms that the proposed formula can be used to compute the total load with accuracy.

关键词： Sediment transport River flow Total sediment discharge Stream power

Exit options sustain altruistic punishment and decrease the second-order free-riders, but it is not a panacea

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Science China(Information Sciences) 2025年第1期68卷 278-291页

作者： Chen SHEN Zhao song Lei SHI Jun TANIMOTO Zhen WANG Faculty of Engineering Sciences Kyushu University School of Statistics and Mathematics Yunnan University of Finance and Economics School of Computing Engineering and Digital Technologies Teesside University School of Artificial Intelligence OPtics and Electro Nics (iOPEN) Northwestern Polytechnical University

Why do humans punish free riders at their own expense? This behavior represents an evolutionary puzzle in human societies. This study explores the role of exit strategies in fostering altruistic punishment within evolutionary game theory. We extend the traditional prisoner's dilemma model by incorporating exiters, players who opt out for a small payoff while nullifying their opponent's payoff, and altruistic punishers who cooperate and punish non-cooperators. Our findings indicate that in well-mixed populations, exiters destabilize defection but do not promote altruistic punishment. In social networks, however,exiters enable altruistic punishment via cyclic dominance among altruistic punishers, defectors, and exiters. Notably, this cyclic dominance is sensitive to exit payoffs; adjustments can lead to cyclic dominance of non-punishing cooperators, defectors, and exiters, or to a bi-stable state between these two types of cyclic dominance. These results highlight the nuanced impact of exiters on altruistic punishment, emphasizing the need for careful incentivization of exit behavior. While exiters can support altruistic punishment in networked populations, their effectiveness is not a panacea and is highly sensitive to exit payoffs, indicating limits to the voluntary participation mechanism.

关键词： evolutionary game theory altruistic punishment coexistence cyclic dominance bi-stable