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Absence of enhancement in a lesion does not preclude primary central nervous system T-cell lymphoma:A case report

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World Journal of Clinical Cases 2024年第2期12卷 374-382页

作者： Chan-Seop Kim Chi-Hoon Choi Kyung Sik Yi Yook Kim Jisun lee Chang Gok Woo young Hun Jeon Department of Radiology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Radiology Seoul National University HosptialSeoul 03080South Korea

BACKGROUND Primary central nervous system lymphoma(PCNSL)is a non-Hodgkin lymphoma that originates in the central nervous system(CNS)and is exclusively limited to the *** most PCNSLs are diffuse large B-cell lymphomas,primary CNS T-cell lymphomas(PCNSTLs)are *** typically demonstrate some degree of enhancement on contrast-enhanced magnetic resonance imaging(MRI).To the best of our knowledge,non-enhancing PCNSTL has not been reported *** SUMMARY A 69-year-old male presented to the neurology department with complaints of mild cognitive impairment and gradual onset of left lower leg weakness over a span of two *** MRI showed asymmetric T2-hyperintense lesions within the *** enhancement was observed on the contrast-enhanced T1 *** initial diagnosis was neuro-Behçet’s *** high-dose steroid therapy,no alterations in the lesions were identified on initial *** patient’s symptoms deteriorated *** MRI performed one month after the initial scan revealed an increased lesion ***,brain biopsy confirmed the diagnosis of *** patient underwent definitive combined ***,the patient developed bacteremia and died of septic shock approximately three months after *** The absence of enhancement in the lesion did not rule out PCNSTL.A biopsy approach is advisable for pathological confirmation.

关键词： Central nervous system neoplasms Non-Hodgkin Lymphoma T-cell Lymphoma Primary central nervous system lymphoma Primary central nervous system T-cell lymphoma Case report

Neural network modeling and prediction of HfO2 thin film properties tuned by thermal annealing

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High Power Laser Science and Engineering 2024年第2期12卷 79-86页

作者： min Gao Chaoyi Yin Jianda Shao Meiping Zhu School of Microelectronics Shanghai UniversityShanghaiChina Laboratory of Thin Film Optics Key Laboratory of Materials for High Power LaserShanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhouChina

Plasma-enhanced atomic layer deposition (PEALD) is gaining interest in thin films for laser applications, and post-annealing treatments are often used to improve thin film properties. However, research to improve thin film properties is often based on an expensive and time-consuming trial-and-error process. In this study, PEALD-HfO2 thin film samples were deposited and treated under different annealing atmospheres and temperatures. The samples were characterized in terms of their refractive indices, layer thicknesses and O/Hf ratios. The collected data were split into training and validation sets and fed to multiple back-propagation neural networks with different hidden layers to determine the best way to construct the process–performance relationship. The results showed that the three-hidden-layer back-propagation neural network (THL-BPNN) achieved stable and accurate fitting. For the refractive index, layer thickness and O/Hf ratio, the THL-BPNN model achieved accuracy values of 0.99, 0.94 and 0.94, respectively, on the training set and 0.99, 0.91 and 0.90, respectively, on the validation set. The THL-BPNN model was further used to predict the laser-induced damage threshold of PEALD-HfO2 thin films and the properties of the PEALD-SiO2 thin films, both showing high accuracy. This study not only provides quantitative guidance for the improvement of thin film properties but also proposes a general model that can be applied to predict the properties of different types of laser thin films, saving experimental costs for process optimization.

关键词： laser-induced damage threshold laser thin film neural network plasma-enhanced atomic layer deposition

Microstructure evolution and mechanical properties of brazing joint for ultra-thin-walled Inconel 718 considering grain size effect and brazing temperature

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Chinese Journal of Aeronautics 2024年第2期37卷 541-556页

作者： Rui ZHAO Yueshuai SONG Hui KANG min WAN School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Jiangxi 330000China

The systematic investigation of the mechanical properties and microstructure evolution process of ultra-thin-walled Inconel 718 capillary brazing joints is of great significance because of the exceptionally high demands on its *** achieve this objective,this study investigates the impact of three distinct brazing temperatures and five typical grain sizes on the brazed joints’mechanical properties and microstructure evolution *** evolution analysis was conducted based on Electron Back Scatter Diffraction(EBSD),Scanning Electron Microscopy(SEM),X-Ray Diffraction(XRD),High-Resolution Transmission Electron Microscopy(HRTEM),and Focused Ion Beam(FIB).Besides,the mechanical properties and fracture behavior were studied based on the uniaxial tension tests and in-situ tension *** findings reveal that the brazing joint’s strength is higher for the fine-grain capillary than the coarse-grain one,primarily due to the formation of a dense branch structure composed of G-phase in the brazing *** effects of grain size,such as pinning and splitting,are amplified at higher brazing ***,micro-cracks initiate around brittle intermetallic compounds and propagate through the eutectic zone,leading to a cleavage fracture *** fracture stress of fine-grain specimens is higher than that of coarse-grain due to the complex micro-crack ***,this study contributes significantly to the literature by highlighting the crucial impact of grain size on the brazing properties of ultra-thin-walled Inconel 718 structures.

关键词： EYWORDS Ultra-thin-walled structure Brazing Inconel 718 Grain size effect Brazing temperature

A Study on How Urban Rail Operators Can Secure New Growth Engines for the Future Approach: The Case of Underground Urban Logistics System

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Journal of Traffic and Transportation Engineering 2024年第3期12卷 130-140页

作者： Su min Hong Oek Seok Jeon young Soo Na Metro Research Institute Seoul MetroSeoul 04806Korea Department of Transportation Engineering University of SeoulSeoul 02504Korea

Seoul Metro is Seoul’s leading metro company, transporting up to 3 billion people annually. However, future ridership is expected to plummet due to an aging and shrinking population with one of the fastest declining total fertility rates in the world. The COVID-19 pandemic in 2019 accelerated this phenomenon. On the contrary, the e-commerce and home delivery industries have developed significantly since COVID-19. Seoul’s current logistics infrastructure cannot handle it. Under the inflection point of declining passenger transportation demand and increasing urban logistics demand, urban rail operators need new growth engines. Therefore, it is necessary to consider the introduction of an UULS (underground urban logistics system) that transports parcels instead of passengers through urban railways. If the UULS becomes a reality, it can be expected to secure scarce logistics land in cities, protect the environment and prevent traffic congestion by operating eco-friendly mass urban transportation, and acquire new revenue sources for urban rail operators. The UULS’s B/C ratio is 1.32. The sensitivity analysis shows that the ratio is above 1 in most cases where the unit cost of transportation is not significantly reduced.

关键词： UULS metro new growth engines COVID-19 traffic congestion environment.

Benefit in physical function and quality of life to nonsurgical treatment of varicose veins: Pilot study

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World Journal of Clinical Cases 2024年第3期12卷 517-524页

作者： Gwon-min Kim BoKun Kim minwoo Jang Jong-Hwan Park Miju Bae Chung Won lee Jong Won Kim Up Huh Medical Research Institute Pusan National University School of MedicineYangsan 50612South Korea Future Convergence Research Institute Changwon National UniversityChangwon 51140South Korea Department of Convergence Medical Science School of MedicinePusan National UniversityYangsan 50612South Korea Health Convergence Medicine Laboratory Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Studies on varicose veins have focused its effects on physical function;however,whether nonsurgical treatments alter muscle oxygenation or physical function remains ***,the differences in such functions between individuals with varicose veins and healthy individuals remain *** To investigate changes in physical function and the quality of life(QOL)following nonsurgical treatment of patients with varicose veins and determine the changes in their muscle oxygenation during *** We enrolled 37 participants(those with varicose veins,n=17;healthy individuals,n=20).We performed the following measurements pre-and post-nonsurgical treatment in the varicose vein patients and healthy individuals:Calf muscle oxygenation during the two-minute step test,open eyes one-leg stance,30 s sit-to-stand test,visual analog scale(VAS)for pain,Pittsburgh sleep quality index,physical activity assessment,and QOL *** Varicose veins patients and healthy individuals differ in most variables(physical function,sleep quality,and QOL).Varicose veins patients showed significant differences between pre-and post-nonsurgical treatment—results in the 30 sit-to-stand test[14.41(2.45)to 16.35(4.11),P=0.018],two-minute step test[162.29(25.98)to 170.65(23.80),P=0.037],VAS for pain[5.35(1.90)to 3.88(1.73),P=0.004],and QOL[39.34(19.98)to 26.69(17.02),P=0.005];however,no significant difference was observed for muscle *** Nonsurgical treatment improved lower extremity function and QOL in varicose veins patients,bringing their condition close to that of healthy *** studies should include patients with severe varicose veins requiring surgery to confirm our findings.

关键词： Varicose vein Nonsurgical treatment Physical function Quality of life Near infrared spectroscopy

From molecule to cell:the expanding frontiers of plant immunity

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Journal of Genetics and Genomics 2024年第7期51卷 680-690页

作者： Lei Li Jing Liu Jian-min Zhou Key Laboratory of Seed Innovation Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

In recent years,the field of plant immunity has witnessed remarkable *** the co-evolution between plants and pathogens,plants have developed a wealth of intricate defense mechanisms to safeguard their *** identified immune receptors have added unexpected complexity to the surface and intracellular sensor networks,enriching our understanding of the ongoing plant–pathogen *** the molecular mechanisms of resistosome shapes our understanding of these mysterious molecules in plant ***,technological innovations are expanding the horizon of the plant–pathogen battlefield into spatial and temporal *** the development provides new opportunities for untangling the complex realm of plant immunity,challenges remain in uncovering plant immunity across spatiotemporal dimensions from both molecular and cellular levels.

关键词： Plant immunity Calcium Spatiotemporal Biomolecular condensate Immune receptor Resistosome

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-young Park Chulhwan Kwak Yoonji lee Dae-Geun Song Jae Woo Jung Haesong lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

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Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu Congnuan Liu Song Hao lee Lewis Sze Chun Choi Michael T.Wilson Dirk U.Pfeiffer Yun young Go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina Center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina College of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： He Li Chao Li Di Sun Zhi min Yang Department of Biochemistry and Molecular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human *** genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted *** study investigated a functionally uncharacterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of ***20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd *** expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd *** of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of ***,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and *** results suggest that OsPDR20 is actively involved in Cd accumulation and homeostasis in rice *** increased Cd accumulation in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accumulation Phytoremediation