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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man Yoon young kyu park In Gyu Kwon Sung Hoon Noh kyung Hee Lee In Cho Myoung Won Son Jong Won Kim young-Woo Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

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Numerical Visualization of Air Intake Induced by Free Surface Vortex

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Journal of Thermal Science 2017年第6期26卷 540-544页

作者： young kyu park Mohan Kumar Dey Yoon Hwan Choi Yeon Won Lee Research Institute of Industrial Science & Technology Pukyong National University Busan Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Korea Department of Mechanical Design Engineering Pukyong National University Busan Korea

Free surface vortex control is vital in a pump sump system because the air absorbed by free surface vortex induc- es noise, vibration, and cavitation corrosion on the pumping system. In this study, the change of free surface vor- tex and air absorption in a pump intake has been investigated by the Volume of Fraction （VOF） method with steady multiphase flow model in order to represent the behavior of the free surface vortex exactly. The homoge- neous free surface model is used to apply interactions of air and water. The results show that air intake by the free surface vortex motion can be visualized using the iso-surface of air volume fraction. The vortices make an air column from the free surface to the pump intake. Also, it was found that the flee surface vortex can be controlled by installing curtain walls.

关键词： free surface vortex numerical visualization curtain wall air intake

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Panax ginseng induces the expression of CatSper genes and sperm hyperactivation

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Asian Journal of Andrology 2014年第6期16卷 845-851页

作者： Eun Hwa park Do Rim Kim Ha young Kim Seong kyu park Mun Seog Chang Department of Prescriptionology College of Korean Medicine Kyung Hee Unversity Seoul Korea.

The cation channel of sperm （CatSper） protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of Panax ginseng treatment on the expression of CatSper genes and sperm hyperactivation in male mice, sperm motility and CatSper gene expression were assessed using a computer-assisted semen analysis system, a Fluoroskan Ascent microplate fluorometer to assess Ca2＊ influx, *** polymerase chain reaction, Western blotting and immunofluorescence. The results suggested that the Ca2＊ levels of sperm cells treated with P. ginseng were increased significantly compared with the normal group. The P. ginseng-treated groups showed increased sperm motility parameters, such as the curvilinear velocity and amplitude of lateral head displacement. Taken together, the data suggest that CatSper messenger ribonucleic acid levels were increased significantly in mouse testes in the P. ginseng-treated group, as was the protein level, with the exception of CatSper2. In conclusion, P. ginseng plays an important role in improving sperm hyperactivation via CatSper gene expression.

关键词： Ca2+ CatSper hyperactivation panax Einseng

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Colonoscopy procedural skills and training for new beginners

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World Journal of Gastroenterology 2014年第45期20卷 16984-16995页

作者： Seung-Hwa Lee young-kyu park Duck-Joo Lee Kwang-Min Kim Center for Health Promotion Ajou University School of Medicine Center for Health Promotion Bundang Jesaeng Hospital

The incidence of colorectal cancer has been increasing in the developed world including South Korea and *** allows for greater diagnostic specificity and sensitivity compared with other types of examinations,such as the stool occult blood test,barium enema,and computed tomography ***,in recent years,the demand for colonoscopies has grown *** beginners including primary care physicians may help meet the increasing demand by performing ***,it is a challenge to learn the procedure due to the long learning-curve and the high rate of complications,such as perforation and bleeding,as compared to ***,considerable training and experience are required for optimal performance of *** order to perform a complete colonoscopic examination,there were a few important thingsto learn and remember,such as the position of examinee(e.g.,left and right decubitus,supine,and prone)and examiner(two-man method vs one-man standing method vs one-man sitting method),basic skills(e.g.,tip deflection,push forward and pull back,torque,air suction and insufflation),advanced skills(e.g.,jiggling and shaking,right and left turn shortening,hooking,and slide-by technique),assisting skills(e.g.,position change of examinee,abdominal compression,breathing-holding,and liquid-infusion technique),and intubation techniques along the lower gastrointestinal *** this article,we attempt to describe the methods of insertion and advancement of the colonoscope to the new beginners including primary care *** believe that this article may be helpful to the new beginners who wish to learn the procedure.

关键词： Colonoscopy Beginner Training Proce-dural skills

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Characterizing and Mitigating Chemomechanical Degradation in High-Energy Lithium-Ion Battery Cathode Materials

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Accounts of Materials Research 2022年第5期3卷 511-524页

作者： Norman S.Luu kyu-young park Mark C.Hersam Department of Materials Science and Engineering Northwestern UniversityEvanstonIllinois 60208United States Graduate Institute of Ferrous and Energy Materials Technology Pohang University of Science and TechnologyPohangKyungbuk 37673Republic of Korea Department of Chemistry and Department of Electrical and Computer Engineering Northwestern UniversityEvanstonIllinois 60208United

Lithium-ion batteries(LIBs)are nearly ubiquitous energy storage solutions,powering devices ranging from consumer electronics to electric *** advance these applications,current LIB research efforts are directed toward improving energy and power densities,cyclic lifetimes,charging speeds,and *** parameters are intrinsically tied to properties of the active electrode materials,such as the redox mechanism,chemical composition,and crystal *** particularly challenging issue is that the active electrode materials that possess higher theoretical energy densities are generally more susceptible to degradation during cycling.A notable example is the family of layered multicomponent transition metal oxides,which is the incumbent class of active LIB cathode materials for electric *** increase their theoretical capacities,the transition metal fraction in these materials is trending toward higher Ni ***,Ni-rich chemistries suffer from electrochemical,crystallographic,and mechanical degradation that increase in severity with increasing Ni ***,alternative high-energy cathode materials,including overlithiated layered oxides and disordered rock salt materials,present additional stability challenges that must be overcome before they can be realistically incorporated into LIB *** chemomechanical degradation in high-energy LIB cathode materials occurs at multiple length *** defects,such as antisite defects or vacancies,are commonly generated during electrochemical cycling and can contribute to the loss of cyclable active *** both the primary and secondary particle level,electrochemical cycling also induces significant volumetric changes and state-of-charge heterogeneity,generating regions of high stress and strain that are precursors to mechanical ***,at the electrode level,nonuniform charge transfer reactions throughout the electrode can lead to locally overcharged regions that become

关键词： Battery electrode cycling

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Mixed-dimensional stacked nanocomposite structures for a specific wavelength-selectable ambipolar photoresponse

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Nano Research 2024年第6期17卷 5549-5558页

作者： young Jae park Jaeho Shim Joo Song Lee kyu Seung Lee Ji-Yeon Kim Kang Bok Ko Sang-Youp Yim Seongjun Kim Hoon-kyu Shin Donghee park Yong Ju Yun Dong Ick Son Institute of Advanced Composite Materials Korea Institute of Science and TechnologyJeollabuk-do 55324Republic of Korea National Institute for Nanomaterials Technology Pohang University of Science and TechnologyGyeongsangbuk-do 37673Republic of Korea Department of Semiconductor Science and Technology Semiconductor Physics Research CenterJeonbuk National UniversityJeonju 54896Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Center for Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Republic of Korea KIST School Department of Nanomaterials and Nano ScienceUniversity of Science and Technology(UST)Daejeon 34113Republic of Korea

Mixed-dimensional composite structures using zero-dimensional(0D)quantum dots(QDs)and two-dimensional(2D)transition metal dichalcogenides(TMDs)materials are expected to attract great interest in optoelectronics due to the potential to generate new optical ***,we report on the unique optical characteristics of a devices with mixed dimensional vertically stacked structures based on tungsten diselenide(WSe_(2))/CdSeS QDs monolayer/molybdenum disulfide(MoS_(2))(2D/0D/2D).Specifically,it exhibits an ambipolar photoresponse characteristic,with a negative photoresponse observed in the 400-600 nm wavelength range and a positive photoresponse appeared at 700 nm *** resulted in the high negative responsivity of up to 52.22 mA·W^(−1)under 400 nm,which is 163 times higher than that of the photodetector without CdSeS *** also demonstrated the negative photoresponse,which could be due to increased carrier collision probability and non-radiative *** modeling and simulation reveal that Auger recombination among the types of non-radiative recombination is the main cause of negative photocurrent ***,we discovered ambipolar photoresponse near a specific wavelength corresponding to the energy of quantum *** study revealed interesting phenomenon in the mixed low-dimensional stacked structure and paved the way to exploit it for the development of innovative photodetection materials as well as for optoelectronic applications.

关键词： mixed-dimension quantum dot heterostructure photodetector ambipolar photoresponse

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High morbidity in myocardial infarction and heart failure patients after gastric cancer surgery

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World Journal of Gastroenterology 2015年第21期21卷 6631-6638页

作者： Sang-Ho Jeong young-Woo Kim Wansik Yu Sang Ho Lee young kyu park Seong-Heum park In Ho Jeong Sang Eok Lee Yongwhi park young-Joon Lee Department of Surgery Gyengsang National University Department of Surgery Gastric Cancer BranchNational Cancer Center Department of Surgery Kyungpook National University Hospital Deparment of Surgery Kosin University College of Medicine Department of Surgery Chonnam National University Hwasun Hospital Department of Surgery South Korea University College of Medicine South Korea University Ansan hospital Department of Surgery Cheju National University Department of Surgery Konyang University Hospital Department of Cardilolgy Gyengsang National University

AIM:To evaluate to morbidity and mortality differences between 4 underlying heart diseases,myocardial infarction(MI),angina pectoris(Angina),heart failure(HF),and atrial fibrillation(AF),after radical surgery for gastric ***:We retrospectively collected data from 221 patients of a total of 15167 patients who underwent radical gastrectomy and were preoperatively diagnosed with a history of Angina,MI,HF,or AF in 8 ***:We find that the total morbidity rate is significantly higher in the MI group(44%) than the Angina(15.7%),AF(18.8%),and HF(23.1%) groups(P < 0.01).Moreover,we note that the risk for postoperative cardiac problems is higher in patients with a history of HF(23.1%) than patients with a historyof Angina(2.2%),AF(4.3%),or MI(6%; P = 0.01).The HF and MI groups each have 1 case of cardiogenic ***:We conclude that MI patients have a higher risk of morbidity,and HF patients have a higher risk of postoperative cardiac problems than Angina or AF.

关键词： Stomach neoplasm Comorbidity Morbidity Heart disease Heart failure

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Clinicopathologic characteristics of gastric carcinoma in elderly patients: A comparison with young patients

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World Journal of Gastroenterology 2005年第1期11卷 22-26页

作者： Dong-Yi Kim Jae-Kyoon Joo Seong-Yeob Ryu young-kyu park young-Jin Kim Shin-Kon Kim Division of Gastroenterologic Surgery

AIM:To examine the clinicopathologic features of elderly patients with gastric carcinoma and to investigate the relationship between prognosis and ***: We reviewed the hospital records of 2 014patients with gastric carcinoma retrospectively to compare the clinicopathologic findings in elderly (age ＞70 years) and young (age ＜36 years) patients during the period from 1986 to 2000 in a tertiary referral center in Gwangju, Korea. Overall survival was the main outcome ***: Of the 2 014 patients, 194 (9.6%) were in the elderly group and 137 (6.8%) were in the young *** elderly and young patients had similar distributions with respect to depth of invasion, nodal involvement, hepatic metastasis, peritoneal dissemination, tumor stage at the initial diagnosis, and type of surgery. Synchronous multiple carcinomas were found in 14/194 (7.2%) of the elderly group and 4/137 (2.9%) of the young group (P＜0.05). Using the Borrmann classification, type Ⅳ was more frequent in the young patients than in the elderly patients (P＜0.05).Significantly more elderly patients had a well or moderately differentiated histology, and more young patients had a poorly differentiated histology and signet ring cell carcinoma (P＜0.001). The 5-year survival rates of elderly and young patients did not differ statistically (52.8% vs 46.5%,P = 0.5290). Multivariate analysis showed that the histologic type, nodal involvement and operative curability were significant prognostic factors, and age itself was not an independent prognostic factor of survival for elderly gastric carcinoma ***: Elderly patients with gastric carcinoma do not have a worse prognosis than young patients. The important prognostic factor is whether the patients undergo a curative resection.

关键词： Gastric carcinomas Prognosis Age Surgery

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Glutathione-S-transferase (GSTM1,GSTT1) and the risk of gastrointestinal cancer in a Korean population

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World Journal of Gastroenterology 2009年第45期15卷 5716-5721页

作者： Jin-Mei Piao Min-Ho Shin Sun-Seog Kweon Hee Nam Kim Jin-Su Choi Woo-kyun Bae Hyun-Jeong Shim Hyeong-Rok Kim young-kyu park Yoo-Duk Choi Soo-Hyun Kim Department of Preventive Medicine Chonnam National University Medical School Gwangju 501-746 South Korea Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Genome Research Center for Hematopoietic Diseases Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Surgery Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Department of Pathology Chonnam National University Medical School Gwangju 501-746 South Korea Department of Laboratory Medicine Chormam National University Medical School Gwangju 501-746 South Korea

AIM： To evaluate the association of glutathione S-trans-ferase mu （GSTM1） and glutathione S-transferase theta （GSTT1） null genotypes with the risk of gastric cancer （GC） and colorectal cancer （CRC） in a South Korean population. METHODS： We conducted a population-based, large- scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSI-F1 were determined using realtime PCR. RESULTS： The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric （OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively） or colorectal cancer （OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively）. The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer. CONCLUSION： GSTM1 and GSCI-1 null genotypes were not associated with increased risk of GC or CRC in Koreans.

关键词： Glutathione S-transferase mu Glutathione S-transferase theta Gastric cancer Colorectal cancer South Korean population

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Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-Micro Letters 2024年第12期16卷 468-514页

作者： Jung Hwan park Srinivas Pattipaka Geon-Tae Hwang Minok park Yu Mi Woo young Bin Kim Han Eol Lee Chang kyu Jeong Tiandong Zhang Yuho Min Kwi-Il park Keon Jae Lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(LMIs),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate LMI parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by LMI technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with LMIs,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices

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